{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:54:02Z","timestamp":1785524042896,"version":"3.56.0"},"reference-count":36,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T00:00:00Z","timestamp":1647475200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Introduction: Diagnosis of lung nodules is still under investigation. We use computed tomography scans and positron emission tomography in order to identify their origin. Patients and Methods: In our retrospective study, we included 248 patients with a single lung nodule or multiple lung nodules of size \u22651 cm. We used a radial-endobronchial ultrasound and a C-Arm. We used a 1.1 mm cryoprobe versus a 22G needle vs. forceps\/brush. We compared the sample size of each biopsy method with the number of cell-block slices. Results: Central lesions indifferent to the method provided the same mean number of cell-block slices (0.04933\u20130.02410). Cryobiopsies provide less sample size for peripheral lesions due to the higher incidence of pneumothorax (0.04700\u20130.02296). Conclusion: The larger the lesion \u22652 cm, and central, more cell-blocks are produced indifferent to the biopsy method (0.13386\u20130.02939). The time of the procedure was observed to be less when the C-Arm was used as an additional navigation tool (0.14854\u20130.00089).<\/jats:p>","DOI":"10.3390\/ijerph19063569","type":"journal-article","created":{"date-parts":[[2022,3,20]],"date-time":"2022-03-20T21:26:22Z","timestamp":1647811582000},"page":"3569","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Radial-EBUS: CryoBiopsy Versus Conventional Biopsy: Time-Sample and C-Arm"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5119-2207","authenticated-orcid":false,"given":"Paul","family":"Zarogoulidis","sequence":"first","affiliation":[{"name":"Pulmonary-Oncology Department, General Clinic Euromedica, Private Hospital, 54645 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoforos S.","family":"Kosmidis","sequence":"additional","affiliation":[{"name":"Surgical Department, University Hospital of Thessaloniki AHEPA, Aristotle University of Thessaloniki (AUTH), 1st St. Kiriakidi Street, 54621 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Hohenforst-Schmidt","sequence":"additional","affiliation":[{"name":"Sana Clinic Group Franken, Department of Cardiology\/Pulmonology\/Intensive Care\/Nephrology, \u201cHof\u201d Clinics, University of Erlangen, 91052 Hof, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Matthaios","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Rhodes General Hospital, 85133 Rhodes, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2050-8392","authenticated-orcid":false,"given":"Konstantinos","family":"Sapalidis","sequence":"additional","affiliation":[{"name":"Surgical Department, University Hospital of Thessaloniki AHEPA, Aristotle University of Thessaloniki (AUTH), 1st St. Kiriakidi Street, 54621 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Petridis","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology, International Hellenic University, 54621 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni-Isidora","family":"Perdikouri","sequence":"additional","affiliation":[{"name":"Oncology Department, General Hospital of Volos, 38222 Volos, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikos","family":"Courcoutsakis","sequence":"additional","affiliation":[{"name":"Department of Radiology and Medical Imaging, University Hospital of Alexandroupolis, Democritus University of Thrace, 68100 Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1435-2379","authenticated-orcid":false,"given":"Dimitris","family":"Hatzibougias","sequence":"additional","affiliation":[{"name":"Private Pathology Laboratory, \u201cMicrodiagnostics\u201d, 54621 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8714-2524","authenticated-orcid":false,"given":"Christos","family":"Arnaoutoglou","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, Papageorgiou Hospital, Aristotle University of Thessaloniki, 54621 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutz","family":"Freitag","sequence":"additional","affiliation":[{"name":"Pulmonary Department, University Hospital of Zurich, 8004 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aristeidis","family":"Ioannidis","sequence":"additional","affiliation":[{"name":"Department of Respiratory & Critical Care Medicine, Changhai Hospital, The Second Military Medical University, Shanghai 200001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haidong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Respiratory & Critical Care Medicine, Changhai Hospital, The Second Military Medical University, Shanghai 200001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Tolis","sequence":"additional","affiliation":[{"name":"Oncoderm Private Oncology Clinic, 45221 Ioannina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Respiratory & Critical Care Medicine, Changhai Hospital, The Second Military Medical University, Shanghai 200001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Francis","family":"Turner","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, TN 37001, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Venturelli, S., Leischner, C., Helling, T., Burkard, M., and Marongiu, L. (2021). Vitamins as Possible Cancer Biomarkers: Significance and Limitations. Nutrients, 13.","DOI":"10.3390\/nu13113914"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"109463","DOI":"10.1016\/j.cellsig.2019.109463","article-title":"Epithelial cell plasticity defines heterogeneity in lung cancer","volume":"65","author":"Sarode","year":"2020","journal-title":"Cell. 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