{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:01:07Z","timestamp":1787166067038,"version":"build-2736575974"},"reference-count":67,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T00:00:00Z","timestamp":1649030400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>At present, 19.2% of the Spanish population is aged 65 or older. Polypharmacy is a frequent condition among the elderly, especially in those living in nursing homes, which is associated with adverse outcomes, such as adverse drug events or drug-drug interactions. This study aimed to assess the pattern of polypharmacy in a nursing home in Leon, one of Spain\u2019s most ageing regions, and its relationship with different drug-related problems. A descriptive, observational, and cross-sectional study design was used; 222 residents were involved in this study. Data on drug use were collected from medical charts. Information was screened with the software CheckTheMeds, BOT PLUS and Drug-Reax. Residents were on a median of 7 medicines. Polypharmacy and inappropriate medications were present in 78.8% and 96.8% of residents, respectively. Drug-related problems were present in almost all the populations evaluated. Drug-drug interactions were very common in participants (81.1%), being severe\/moderate in 24.7%. A high prevalence of polypharmacy and drug-related problems in the nursing home population assessed has been observed. A significantly higher risk of suffering drug-drug interactions was revealed for increasing polypharmacy and anticholinergic risk. A regular evaluation of drug prescribing in nursing home residents is necessary to minimize drug-related problems risk.<\/jats:p>","DOI":"10.3390\/ijerph19074313","type":"journal-article","created":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T05:50:43Z","timestamp":1649051443000},"page":"4313","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Drug-Related Problems and Polypharmacy in Nursing Home Residents: A Cross-Sectional Study"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3729-5431","authenticated-orcid":false,"given":"Raquel","family":"D\u00edez","sequence":"first","affiliation":[{"name":"Pharmacology, Department of Biomedical Sciences, Faculty of Health Sciences, Institute of Biomedicine (IBIOMED), University of Le\u00f3n, 24071 Le\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Cadenas","sequence":"additional","affiliation":[{"name":"Pharmacology, Department of Biomedical Sciences, Faculty of Health Sciences, Institute of Biomedicine (IBIOMED), University of Le\u00f3n, 24071 Le\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0904-8644","authenticated-orcid":false,"given":"Julen","family":"Susperregui","sequence":"additional","affiliation":[{"name":"Applied Mathematics, Department of Mathematics, University of Le\u00f3n, 24071 Le\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3311-4226","authenticated-orcid":false,"given":"Ana M.","family":"Sahag\u00fan","sequence":"additional","affiliation":[{"name":"Pharmacology, Department of Biomedical Sciences, Faculty of Health Sciences, Institute of Biomedicine (IBIOMED), University of Le\u00f3n, 24071 Le\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1225-4097","authenticated-orcid":false,"given":"N\u00e9lida","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Pharmacology, Department of Biomedical Sciences, Faculty of Health Sciences, Institute of Biomedicine (IBIOMED), University of Le\u00f3n, 24071 Le\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7821-9502","authenticated-orcid":false,"given":"Juan J.","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Pharmacology, Department of Biomedical Sciences, Faculty of Health Sciences, Institute of Biomedicine (IBIOMED), University of Le\u00f3n, 24071 Le\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0208-9542","authenticated-orcid":false,"given":"Matilde","family":"Sierra","sequence":"additional","affiliation":[{"name":"Pharmacology, Department of Biomedical Sciences, Faculty of Health Sciences, Institute of Biomedicine (IBIOMED), University of Le\u00f3n, 24071 Le\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6229-9560","authenticated-orcid":false,"given":"Cristina","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Pharmacology, Department of Biomedical Sciences, Faculty of Health Sciences, Institute of Biomedicine (IBIOMED), University of Le\u00f3n, 24071 Le\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,4]]},"reference":[{"key":"ref_1","unstructured":"Statista (2022, January 25). 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