{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T04:11:24Z","timestamp":1778299884948,"version":"3.51.4"},"reference-count":22,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T00:00:00Z","timestamp":1649116800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/igo\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>A significant drop in tuberculosis (TB) case-finding has been widely reported during the period of the COVID-19 pandemic. To address a decrease in TB notification, Belarus introduced laboratory TB testing in patients with the laboratory-confirmed coronavirus disease 2019 (COVID-19). We conducted a secondary analysis of health records among 844 patients with laboratory-confirmed COVID-19 diagnosis who were admitted to repurposed departments at TB hospitals and who were tested by Xpert MTB\/RIF (Cepheid Inc., Sunnyvale, CA, USA) in five Belarus regions between April and October 2021. Quantitative analysis followed by 13 individual interviews with health managers, physicians, and nurses participating in the intervention. Most patients were male (64%) and mean age was 43.5 \u00b1 16 years. One in twenty (n = 47, 5.6%) patients were co-infected with active pulmonary TB, and over one-third of them (n = 18) had rifampicin resistance. In-hospital mortality was comparable in patients with and without TB co-infection (2.1% and 2.3% respectively, p &gt; 0.99). Laboratory TB testing among patients with COVID-19 at repurposed departments of TB hospitals is feasible in Belarus and may improve TB case-finding.<\/jats:p>","DOI":"10.3390\/ijerph19074370","type":"journal-article","created":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T11:26:07Z","timestamp":1649157967000},"page":"4370","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Tuberculosis Co-Infection Is Common in Patients Requiring Hospitalization for COVID-19 in Belarus: Mixed-Methods Study"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4017-4561","authenticated-orcid":false,"given":"Yuliia","family":"Sereda","sequence":"first","affiliation":[{"name":"World Health Organization Regional Office for Europe, Marmorvej 51, DK-2100 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oleksandr","family":"Korotych","sequence":"additional","affiliation":[{"name":"World Health Organization Regional Office for Europe, Marmorvej 51, DK-2100 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0222-5583","authenticated-orcid":false,"given":"Dzmitry","family":"Klimuk","sequence":"additional","affiliation":[{"name":"Republican Scientific and Practical Centre for Pulmonology and Tuberculosis, 157 Dolginovskij trakt, 220053 Minsk, Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dzmitry","family":"Zhurkin","sequence":"additional","affiliation":[{"name":"Republican Scientific and Practical Centre for Pulmonology and Tuberculosis, 157 Dolginovskij trakt, 220053 Minsk, Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1655-4000","authenticated-orcid":false,"given":"Varvara","family":"Solodovnikova","sequence":"additional","affiliation":[{"name":"Republican Scientific and Practical Centre for Pulmonology and Tuberculosis, 157 Dolginovskij trakt, 220053 Minsk, Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malgorzata","family":"Grzemska","sequence":"additional","affiliation":[{"name":"World Health Organization Regional Office for Europe, Marmorvej 51, DK-2100 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9891-2718","authenticated-orcid":false,"given":"Viatcheslav","family":"Grankov","sequence":"additional","affiliation":[{"name":"World Health Organization Country Office in Belarus, Fabriciusa str. 28 (Room 401), 220007 Minsk, Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hennadz","family":"Hurevich","sequence":"additional","affiliation":[{"name":"Republican Scientific and Practical Centre for Pulmonology and Tuberculosis, 157 Dolginovskij trakt, 220053 Minsk, Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Askar","family":"Yedilbayev","sequence":"additional","affiliation":[{"name":"World Health Organization Regional Office for Europe, Marmorvej 51, DK-2100 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alena","family":"Skrahina","sequence":"additional","affiliation":[{"name":"Republican Scientific and Practical Centre for Pulmonology and Tuberculosis, 157 Dolginovskij trakt, 220053 Minsk, Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,5]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2021). Global Tuberculosis Report, WHO."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"S155","DOI":"10.1016\/j.ijtb.2020.07.003","article-title":"COVID-19\u2014Tuberculosis interactions: When dark forces collide","volume":"67","author":"Udwadia","year":"2020","journal-title":"Indian J. Tuberc."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1080\/23744235.2020.1806353","article-title":"Previous and active tuberculosis increases risk of death and prolongs recovery in patients with COVID-19","volume":"52","author":"Sy","year":"2020","journal-title":"Infect. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Sheerin, D., Abhimanyu, W.X., Johnson, W.E., and Coussens, A. (2020). Systematic evaluation of transcriptomic disease risk and diagnostic biomarker overlap between COVID-19 and tuberculosis: A patient-level meta-analysis. MedRxiv [Preprint].","DOI":"10.1101\/2020.11.25.20236646"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.pulmoe.2020.12.012","article-title":"Tuberculosis and COVID-19 interaction: A review of biological, clinical and public health effects","volume":"27","author":"Visca","year":"2021","journal-title":"Pulmonology"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Glaziou, P. (2020). Predicted impact of the COVID-19 pandemic on global tuberculosis deaths in 2020. MedRxiv [Preprint].","DOI":"10.1101\/2020.04.28.20079582"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"100603","DOI":"10.1016\/j.eclinm.2020.100603","article-title":"The potential impact of the COVID-19 pandemic on the tuberculosis epidemic a modelling analysis","volume":"28","author":"Cilloni","year":"2020","journal-title":"EClinicalMedicine"},{"key":"ref_8","unstructured":"World Health Organization (2020). Information Note. Tuberculosis and COVID-19, WHO."},{"key":"ref_9","unstructured":"WHO (2022, February 13). COVID-19 Dashboard. Available online: https:\/\/covid19.who.int\/."},{"key":"ref_10","unstructured":"(2022, February 13). COVID-19 Vaccine Tracker. Available online: https:\/\/covid19.trackvaccines.org\/."},{"key":"ref_11","unstructured":"WHO (2022, February 13). Europe COVID-19 Vaccine Programme Monitor. Available online: https:\/\/worldhealthorg.shinyapps.io\/EURO_COVID-19_vaccine_monitor\/."},{"key":"ref_12","unstructured":"World Health Organization (2021). Consolidated Guidelines on Tuberculosis. Module 3: Diagnosis-Rapid Diagnostics for Tuberculosis Detection, WHO."},{"key":"ref_13","unstructured":"Association of Public Health Laboratories (2010). Guidelines for Submission of Sputum Specimens for Tuberculosis Testing, APHL TB Steering Committee."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Aggarwal, A.N., Agarwal, R., Dhooria, S., Prasad, K.T., Sehgal, I.S., and Muthu, V. (2021). Active pulmonary tuberculosis and coronavirus disease 2019: A systematic review and meta-analysis. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0259006"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1086\/378676","article-title":"Virological and immunological impact of tuberculosis on human immunodeficiency virus type 1 disease","volume":"188","author":"Toossi","year":"2003","journal-title":"J. Infect. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ijid.2021.12.344","article-title":"Risk factors for types of recurrent tuberculosis (reactivation versus reinfection): A global systematic review and meta-analysis","volume":"116","author":"Qiu","year":"2021","journal-title":"Int. J. Infect. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1164\/rccm.201706-1208OC","article-title":"Differential recognition of mycobacterium tuberculosis\u2013specific epitopes as a function of tuberculosis disease history","volume":"196","author":"Scriba","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1002\/jmv.26740","article-title":"Impact of COVID-19 in patients with concurrent co-infections: A systematic review and meta-analyses","volume":"93","author":"Sarkar","year":"2021","journal-title":"J. Med. Virol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Mesas, A.E., Cavero-Redondo, I., \u00c1lvarez-Bueno, C., Cabrera, M.A.S., de Andrade, S.M., Sequ\u00ed-Dominguez, I., and Mart\u00ednez-Vizca\u00edno, V. (2020). Predictors of in-hospital COVID-19 mortality: A comprehensive systematic review and meta-analysis exploring differences by age, sex and health conditions. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0241742"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"100198","DOI":"10.1016\/j.puhip.2021.100198","article-title":"Experience of integrated screening and testing for TB and COVID19 from Kerala, India","volume":"2","author":"Khobragade","year":"2021","journal-title":"Public Health Pract."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1111\/all.14697","article-title":"Multidisciplinary consensus on sputum induction biosafety during the COVID-19 pandemic","volume":"76","author":"Plaza","year":"2021","journal-title":"Allergy"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"698","DOI":"10.9745\/GHSP-D-21-00121","article-title":"Implementation of GenExpert for tuberculosis testing in low and middle-income countries: A systematic review","volume":"9","author":"Brown","year":"2021","journal-title":"Glob. Health Sci. Pract."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/7\/4370\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:48:40Z","timestamp":1760136520000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/7\/4370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,5]]},"references-count":22,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,4]]}},"alternative-id":["ijerph19074370"],"URL":"https:\/\/doi.org\/10.3390\/ijerph19074370","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,5]]}}}