{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:26:02Z","timestamp":1785403562998,"version":"3.56.0"},"reference-count":45,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T00:00:00Z","timestamp":1649894400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>In the COVID-19 pandemic, there was an increase in consultations for precocious puberty. We aim to analyze differences in female puberty before and during the COVID-19 pandemic. A cross-sectional analytical study was designed at the Pediatric Endocrinology Clinic of the University Hospital of the Federal University of Maranh\u00e3o in S\u00e3o Luis, Brazil. We included 55 girls with precocious puberty, 22 who started puberty during the pandemic and 33 who started puberty before the pandemic. Clinical, anthropometric, laboratory and imaging variables were compared between groups. Statistics were performed to determine if there was a statistical difference between the groups. Girls with puberty during the pandemic had higher Z-scores for weight (1.08 \u00b1 1.29 versus 0.69 \u00b1 0.83; p = 0.04), lower ovarian volume (1.88 \u00b1 0.95 versus 3.15 \u00b1 2.31; p = 0.01), and smaller differences between thelarche noticed by the parents and the diagnosis (6.63 \u00b1 5.21 versus 12.15 \u00b1 9.96; p = 0.02). The association between precocious puberty during the pandemic with higher Z-scores for weight, lower ovarian volume, and a reduction in the time between the perception of pubertal findings by parents and the diagnosis suggests the influence of the pandemic on the normal time of puberty.<\/jats:p>","DOI":"10.3390\/ijerph19084733","type":"journal-article","created":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T21:44:06Z","timestamp":1649972646000},"page":"4733","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Differences in Puberty of Girls before and during the COVID-19 Pandemic"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6726-4786","authenticated-orcid":false,"given":"Clariano Pires de","family":"Oliveira Neto","sequence":"first","affiliation":[{"name":"Service of Endocrinology, University Hospital, Federal University of Maranh\u00e3o, S\u00e3o Luis 65020-070, Brazil"},{"name":"Research Group in Clinical and Molecular Endocrinology and Metabology (ENDOCLIM), S\u00e3o Luis 65020-070, Brazil"},{"name":"Postgraduate Program in Health Sciences, Federal University of Maranh\u00e3o, S\u00e3o Luis 65080-805, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6097-8145","authenticated-orcid":false,"given":"Rossana Santiago de Sousa","family":"Azulay","sequence":"additional","affiliation":[{"name":"Service of Endocrinology, University Hospital, Federal University of Maranh\u00e3o, S\u00e3o Luis 65020-070, Brazil"},{"name":"Research Group in Clinical and Molecular Endocrinology and Metabology (ENDOCLIM), S\u00e3o Luis 65020-070, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4049-4629","authenticated-orcid":false,"given":"Ana Greg\u00f3ria Ferreira Pereira de","family":"Almeida","sequence":"additional","affiliation":[{"name":"Service of Endocrinology, University Hospital, Federal University of Maranh\u00e3o, S\u00e3o Luis 65020-070, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria da Gl\u00f3ria Rodrigues","family":"Tavares","sequence":"additional","affiliation":[{"name":"Service of Endocrinology, University Hospital, Federal University of Maranh\u00e3o, S\u00e3o Luis 65020-070, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana Helena Gama","family":"Vaz","sequence":"additional","affiliation":[{"name":"Service of Pediatric Endocrinology, University Hospital, Federal University of Maranh\u00e3o, S\u00e3o Luis 65020-070, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ianik Rafaela Lima","family":"Leal","sequence":"additional","affiliation":[{"name":"Service of Pediatric Endocrinology, University Hospital, Federal University of Maranh\u00e3o, S\u00e3o Luis 65020-070, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9968-6214","authenticated-orcid":false,"given":"Monica Elinor Alves","family":"Gama","sequence":"additional","affiliation":[{"name":"Department of Medicine III, Federal University of Maranh\u00e3o, S\u00e3o Luis 65020-240, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4289-4527","authenticated-orcid":false,"given":"Mariz\u00e9lia Rodrigues Costa","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Medicine III, Federal University of Maranh\u00e3o, S\u00e3o Luis 65020-240, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilvan Cort\u00eas","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Service of Endocrinology, University Hospital, Federal University of Maranh\u00e3o, S\u00e3o Luis 65020-070, Brazil"},{"name":"Research Group in Clinical and Molecular Endocrinology and Metabology (ENDOCLIM), S\u00e3o Luis 65020-070, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Research Group in Clinical and Molecular Endocrinology and Metabology (ENDOCLIM), S\u00e3o Luis 65020-070, Brazil"},{"name":"Clinical Research Center, University Hospital, Federal University of Maranh\u00e3o, S\u00e3o Luis 65020-070, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wellyandra Costa dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Research Group in Clinical and Molecular Endocrinology and Metabology (ENDOCLIM), S\u00e3o Luis 65020-070, Brazil"},{"name":"Clinical Research Center, University Hospital, Federal University of Maranh\u00e3o, S\u00e3o Luis 65020-070, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre Nogueira","family":"Facundo","sequence":"additional","affiliation":[{"name":"Service of Endocrinology, University Hospital, Federal University of Maranh\u00e3o, S\u00e3o Luis 65020-070, Brazil"},{"name":"Research Group in Clinical and Molecular Endocrinology and Metabology (ENDOCLIM), S\u00e3o Luis 65020-070, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel dos Santos","family":"Faria","sequence":"additional","affiliation":[{"name":"Research Group in Clinical and Molecular Endocrinology and Metabology (ENDOCLIM), S\u00e3o Luis 65020-070, Brazil"},{"name":"Postgraduate Program in Health Sciences, Federal University of Maranh\u00e3o, S\u00e3o Luis 65080-805, Brazil"},{"name":"Clinical Research Center, University Hospital, Federal University of Maranh\u00e3o, S\u00e3o Luis 65020-070, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9311-5047","authenticated-orcid":false,"given":"D\u00e9bora Cristina Ferreira","family":"Lago","sequence":"additional","affiliation":[{"name":"Research Group in Clinical and Molecular Endocrinology and Metabology (ENDOCLIM), S\u00e3o Luis 65020-070, Brazil"},{"name":"Service of Pediatric Endocrinology, University Hospital, Federal University of Maranh\u00e3o, S\u00e3o Luis 65020-070, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1590\/2359-3997000000018","article-title":"Puberty: When Is It Normal?","volume":"59","author":"Brito","year":"2015","journal-title":"Arch. 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