{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T09:49:39Z","timestamp":1769852979810,"version":"3.49.0"},"reference-count":79,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T00:00:00Z","timestamp":1649894400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008781","name":"Pomeranian Medical University","doi-asserted-by":"publisher","award":["FSN-212-02\/19"],"award-info":[{"award-number":["FSN-212-02\/19"]}],"id":[{"id":"10.13039\/501100008781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>We nowadays record growing numbers of e-cigarette users. The development of nicotine dependence is a result of many factors, including genetics and personality. In this study we analyzed two polymorphisms\u2014rs1985242 and rs1062613\u2014in the serotonin receptor HTR3A gene in a group of e-cigarette users (n = 135) and controls (n = 106). Personality traits were measured using the NEO Five-Factor Inventory. The comparison of e-cigarette users with the control group indicates that the former showed significantly higher scores on the neuroticism scale and lower scores on the scales of extraversion and conscientiousness of the NEO-FFI. Homozygote variants of rs1985242 were more frequent in the study group. The results of the 2 \u00d7 3 factorial ANOVA for e-cigarette users and the control group as well as interaction between the HTR3A rs1985242 variants were found for the NEO-FFI conscientiousness scale. These results allow us to conclude that the combination of psychological factors and genetic data creates a possibility for making more complete models of substance use disorders.<\/jats:p>","DOI":"10.3390\/ijerph19084746","type":"journal-article","created":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T21:44:06Z","timestamp":1649972646000},"page":"4746","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Serotonin Receptor HTR3A Gene Polymorphisms rs1985242 and rs1062613, E-Cigarette Use and Personality"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7137-1429","authenticated-orcid":false,"given":"Aleksandra","family":"Suchanecka","sequence":"first","affiliation":[{"name":"Independent Laboratory of Health Promotion, Pomeranian Medical University in Szczecin, 11 Chlapowskiego St., 70-204 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3285-5313","authenticated-orcid":false,"given":"Jolanta","family":"Chmielowiec","sequence":"additional","affiliation":[{"name":"Department of Hygiene and Epidemiology, Collegium Medicum, University of Zielona G\u00f3ra, Zyty 28 St., 65-046 Zielona Gora, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4254-5466","authenticated-orcid":false,"given":"Krzysztof","family":"Chmielowiec","sequence":"additional","affiliation":[{"name":"Department of Hygiene and Epidemiology, Collegium Medicum, University of Zielona G\u00f3ra, Zyty 28 St., 65-046 Zielona Gora, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3900-4901","authenticated-orcid":false,"given":"Grzegorz","family":"Trybek","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery, Pomeranian Medical University in Szczecin, 72 Powstanc\u00f3w Wlkp. St., 70-111 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7727-6388","authenticated-orcid":false,"given":"Aleksandra","family":"Jaro\u0144","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery, Pomeranian Medical University in Szczecin, 72 Powstanc\u00f3w Wlkp. St., 70-111 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9481-7609","authenticated-orcid":false,"given":"Wojciech","family":"Czarny","sequence":"additional","affiliation":[{"name":"Faculty of Physical Education, University of Rzesz\u00f3w, Towarnickiego 3 St., 35-959 Rzesz\u00f3w, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawe\u0142","family":"Kr\u00f3l","sequence":"additional","affiliation":[{"name":"College of Medical Sciences, Institute of Physical Culture Studies, University of Rzeszow, St. Towarnickiego 3, 35-955 Rzesz\u00f3w, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jolanta","family":"Masiak","sequence":"additional","affiliation":[{"name":"Neurophysiological Independent Unit, Department of Psychiatry, Medical University of Lublin, 20-093 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2633-520X","authenticated-orcid":false,"given":"Anna","family":"Grzywacz","sequence":"additional","affiliation":[{"name":"Independent Laboratory of Health Promotion, Pomeranian Medical University in Szczecin, 11 Chlapowskiego St., 70-204 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1001\/jama.2018.4658","article-title":"Changes in Electronic Cigarette Use Among Adults in the United States, 2014\u20132016","volume":"319","author":"Bao","year":"2018","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/nri803","article-title":"Effects of cigarette smoke on the immune system","volume":"2","author":"Sopori","year":"2002","journal-title":"Nat. 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