{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T20:14:37Z","timestamp":1783109677137,"version":"3.54.6"},"reference-count":68,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,4,16]],"date-time":"2022-04-16T00:00:00Z","timestamp":1650067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Cancers currently represent a leading cause of morbidity and mortality, and precisely estimating their burden is crucial for evidence-based decision-making. This study aimed at understanding the average costs of cancer-related disability-adjusted life years (DALYs) and highlighting possible differences in economic estimates obtained with diverse approaches. We searched four scientific databases to identify all the primary literature simultaneously investigating cancer-related costs and DALYs. In view of the different methodologies, studies were divided into two groups: those estimating costs starting from DALYs, and those independently performing cost and DALY analyses. The latter were pooled to compute costs per disease-related DALY: meta-analytic syntheses were performed for total costs and indirect costs, and in relation to the corresponding gross domestic product (GDP) per capita. The quality of included studies was assessed through the Quality of Health Economic Studies instrument. Seven studies were selected. Total and indirect pooled costs per DALY were, respectively, USD 9150 (95% CI: 5560\u201315,050) and USD 3890 (95% CI: 2570\u20135880). Moreover, the cost per cancer-related DALY has been found to be, on average, 32% (95% CI: 24\u201342%) of the corresponding countries\u2019 GDP per capita. Costs calculated a priori from DALYs may lead to results widely different from those obtained after data retrieval and model building. Further research is needed to better estimate the economic burden of cancer in terms of costs and DALYs.<\/jats:p>","DOI":"10.3390\/ijerph19084862","type":"journal-article","created":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T04:21:28Z","timestamp":1650255688000},"page":"4862","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Cancers: What Are the Costs in Relation to Disability-Adjusted Life Years? A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6331-8276","authenticated-orcid":false,"given":"Jacopo","family":"Garlasco","sequence":"first","affiliation":[{"name":"Department of Public Health Sciences and Paediatrics, University of Turin, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9345-4292","authenticated-orcid":false,"given":"Mario Cesare","family":"Nurchis","sequence":"additional","affiliation":[{"name":"Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A, Gemelli IRCCS, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1173-0469","authenticated-orcid":false,"given":"Valerio","family":"Bordino","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences and Paediatrics, University of Turin, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2576-4299","authenticated-orcid":false,"given":"Martina","family":"Sapienza","sequence":"additional","affiliation":[{"name":"Department of Health Sciences and Public Health, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6063-0544","authenticated-orcid":false,"given":"Gerardo","family":"Altamura","sequence":"additional","affiliation":[{"name":"Department of Health Sciences and Public Health, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3028-6188","authenticated-orcid":false,"given":"Gianfranco","family":"Damiani","sequence":"additional","affiliation":[{"name":"Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A, Gemelli IRCCS, 00168 Rome, Italy"},{"name":"Department of Health Sciences and Public Health, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Michela","family":"Gianino","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences and Paediatrics, University of Turin, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1001\/jamaoncol.2019.2996","article-title":"Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-Adjusted life-years for 29 cancer groups, 1990 to 2017: A systematic analysis for the global burden of disease study","volume":"5","author":"Fitzmaurice","year":"2019","journal-title":"JAMA Oncol."},{"key":"ref_3","unstructured":"Davies, S., Easterbrooke, L., and Taylor, S. (2022, April 13). The Financial Impacts of Cancer. Available online: https:\/\/www.bristol.ac.uk\/media-library\/sites\/geography\/pfrc\/pfrc1210-financial-impacts-of-cancer-report.pdf."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1146\/annurev.publhealth.22.1.91","article-title":"The Burden of Illness of Cancer: Economic Cost and Quality of Life","volume":"22","author":"Brown","year":"2001","journal-title":"Annu. Rev. Public Health"},{"key":"ref_5","unstructured":"Cole, A., Lundqvist, A., Lorgelly, P., Norrlid, H., Schaffer, S.K., Lewis, F., Hernandez-Villafuerte, K., Lindgren, P., Garau, M., and Welin, K.-O. (2022, April 13). Improving Efficiency and Resource Allocation in Future Cancer Care. Available online: https:\/\/www.ohe.org\/publications\/improving-efficiency-and-resource-allocation-future-cancer-care."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1093\/eurpub\/ckz216","article-title":"Cancer statistics: A comparison between World Health Organization (WHO) and Global Burden of Disease (GBD)","volume":"30","author":"Mattiuzzi","year":"2020","journal-title":"Eur. J. Public Health"},{"key":"ref_7","first-page":"429","article-title":"Quantifying the burden of disease: The technical basis for disability-adjusted life years","volume":"72","author":"Murray","year":"1994","journal-title":"Bull. World Health Organ."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0167-6296(97)00004-0","article-title":"Understanding DALYs","volume":"16","author":"Murray","year":"1997","journal-title":"J. Health Econ."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/s40140-018-0294-1","article-title":"Cancer Tsunami: Emerging Trends, Economic Burden, and Perioperative Implications","volume":"8","author":"McCormick","year":"2018","journal-title":"Curr. Anesthesiol. Rep."},{"key":"ref_10","unstructured":"(2022, January 28). National Cancer Institute Financial Burden of Cancer Care, Available online: https:\/\/progressreport.cancer.gov\/after\/economic_burden#field_most_recent_estimates."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Schlueter, M., Chan, K., Lasry, R., and Price, M. (2020). The cost of cancer\u2014A comparative analysis of the direct medical costs of cancer and other major chronic diseases in Europe. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0241354"},{"key":"ref_12","unstructured":"World Health Organization (WHO) (2021, December 08). Cancer\u2014Key Facts. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/cancer."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/0717-6287-48-10","article-title":"A snapshot of cancer in Chile: Analytical frameworks for developing a cancer policy","volume":"48","author":"Bastias","year":"2015","journal-title":"Biol. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_15","unstructured":"Wohlin, C. (2022, April 13). Guidelines for Snowballing in Systematic Literature Studies and a Replication in Software Engineering. Available online: https:\/\/www.wohlin.eu\/ease14.pdf."},{"key":"ref_16","unstructured":"(2021, October 20). The World Bank GDP per Capita (Constant 2010 US$). Available online: https:\/\/data.worldbank.org\/indicator\/NY.GDP.PCAP.KD."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1097\/00005650-200301000-00007","article-title":"Development and validation of a grading system for the quality of cost-effectiveness studies","volume":"41","author":"Chiou","year":"2003","journal-title":"Med. Care"},{"key":"ref_18","first-page":"53","article-title":"Examining the value and quality of health economic analyses: Implications of utilizing the QHES","volume":"9","author":"Ofman","year":"2003","journal-title":"J. Manag. Care Pharm."},{"key":"ref_19","first-page":"1","article-title":"Methods Research Report Best Practices for Conducting Economic Evaluations in Health Care: A Systematic Review of Quality Assessment Tools","volume":"12","author":"Walker","year":"2012","journal-title":"Agency Healthc. Res. Qual."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Weir, C.J., Butcher, I., Assi, V., Lewis, S.C., Murray, G.D., Langhorne, P., and Brady, M.C. (2018). Dealing with missing standard deviation and mean values in meta-analysis of continuous outcomes: A systematic review. BMC Med. Res. Methodol., 18.","DOI":"10.1186\/s12874-018-0483-0"},{"key":"ref_21","unstructured":"(2022, March 10). Organisation for European Co-operation and Development Purchasing Power Parities (PPP). Available online: https:\/\/data.oecd.org\/conversion\/purchasing-power-parities-ppp.htm."},{"key":"ref_22","unstructured":"Coin News, U.S. (2021, October 05). Inflation Calculator. Available online: https:\/\/www.usinflationcalculator.com."},{"key":"ref_23","unstructured":"(2021, October 05). U.S. Bureau of Labor Statistics Consumer Price Index (CPI), Available online: https:\/\/www.bls.gov\/cpi\/."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"6072","DOI":"10.1002\/sim.3427","article-title":"Meta-analysis of skewed data: Combining results reported on log-transformed or raw scales","volume":"27","author":"Higgins","year":"2008","journal-title":"Stat. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"469","DOI":"10.2307\/2530610","article-title":"Obtaining Confidence Intervals for the Risk Ratio in Cohort Studies","volume":"34","author":"Katz","year":"1978","journal-title":"Biometrics"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1136\/ebmental-2019-300117","article-title":"How to perform a meta-analysis with R: A practical tutorial","volume":"22","author":"Balduzzi","year":"2019","journal-title":"Evid. Based Ment. Health"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/jrsm.12","article-title":"A basic introduction to fixed-effect and random-effects models for meta-analysis","volume":"1","author":"Borenstein","year":"2010","journal-title":"Res. Synth. Methods"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.cct.2015.09.002","article-title":"Meta-analysis in clinical trials revisited","volume":"45","author":"DerSimonian","year":"2015","journal-title":"Contemp. Clin. Trials"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"ref_30","unstructured":"R Core Team (2022, February 10). R: A Language and Environment for Statistical Computing. Available online: https:\/\/www.r-project.org\/."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s40273-020-00993-5","article-title":"Multiple Myeloma in Portugal: Burden of Disease and Cost of Illness","volume":"39","author":"Neves","year":"2021","journal-title":"Pharmacoeconomics"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"141573","DOI":"10.1016\/j.scitotenv.2020.141573","article-title":"Estimating the disease burden of lung cancer attributable to residential radon exposure in Korea during 2006\u20132015: A socio-economic approach","volume":"749","author":"Noh","year":"2020","journal-title":"Sci. Total Environ."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"A756","DOI":"10.1016\/j.jval.2016.09.2337","article-title":"Burden of Early and Advanced Breast Cancer in The Netherlands","volume":"19","author":"Vondeling","year":"2016","journal-title":"Value Health"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.7314\/APJCP.2012.13.4.1525","article-title":"Health and economic burden of major cancers due to smoking in Korea","volume":"13","author":"Oh","year":"2012","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1007\/s10552-017-0965-0","article-title":"Economic and disease burden of breast cancer associated with suboptimal breastfeeding practices in Mexico","volume":"28","author":"Meza","year":"2017","journal-title":"Cancer Causes Control"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1200\/jco.2010.28.15_suppl.1561","article-title":"Economic value of disability adjusted life years lost to cancers","volume":"28","author":"John","year":"2010","journal-title":"J. Clin. Oncol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1097\/SLA.0000000000003662","article-title":"The Global Macroeconomic Burden of Breast Cancer","volume":"274","author":"Ranganathan","year":"2021","journal-title":"Ann. Surg."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"S129","DOI":"10.3346\/jkms.2016.31.S2.S129","article-title":"Disability weights measurement for 228 causes of disease in the Korean burden of disease study","volume":"31","author":"Ock","year":"2016","journal-title":"J. Korean Med. Sci."},{"key":"ref_39","unstructured":"Stouthard, M.E.A., Essink-Bot, M., Bonsel, G., Barendregt, J., Kramers, P., Van de Water, H., Gunning-Schepers, L., and Van Der Maas, P. (2022, March 01). Disability Weights for Diseases in the Netherlands. Available online: http:\/\/dare.uva.nl\/document\/174853."},{"key":"ref_40","unstructured":"(2021, December 14). EUROCARE Scientific Direction EUROCARE-4. Available online: http:\/\/www.eurocare.it\/Eurocare4\/tabid\/62\/Default.aspx."},{"key":"ref_41","unstructured":"(2021, December 14). EpiGear International Pty Ltd. DisMod II. Available online: http:\/\/www.epigear.com\/index_files\/dismod_ii.html."},{"key":"ref_42","unstructured":"Devleesschauwer, B., McDonald, S., Haagsma, J., Praet, N., Havelaar, A., and Speybroeck, N. (2021, December 14). The DALY Calculator\u2014A Graphical User Interface for Stochastic DALY Calculation in R. Available online: https:\/\/cran.r-project.org\/web\/packages\/DALY\/index.html."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1002\/hed.24430","article-title":"Head and neck cancer in South Asia: Macroeconomic consequences and the role of the head and neck surgeon","volume":"38","author":"Alkire","year":"2016","journal-title":"Head Neck"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.canep.2017.11.007","article-title":"Incidence, prevalence, mortality, disability-adjusted life years and risk factors of cancer in Australia and comparison with OECD countries, 1990\u20132015: Findings from the Global Burden of Disease Study","volume":"52","author":"Melaku","year":"2018","journal-title":"Cancer Epidemiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S2468-1253(19)30345-0","article-title":"The global, regional, and national burden of colorectal cancer and its attributable risk factors in 195 countries and territories, 1990\u20132017: A systematic analysis for the Global Burden of Disease Study","volume":"4","author":"Safiri","year":"2019","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/bmjopen-2019-036341","article-title":"Economic burden of cancers in Taiwan: A direct and indirect cost estimate for 2007\u20132017","volume":"10","author":"Huang","year":"2020","journal-title":"BMJ Open"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/S1470-2045(13)70442-X","article-title":"Economic burden of cancer across the European Union: A population-based cost analysis","volume":"14","author":"Leal","year":"2013","journal-title":"Lancet Oncol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1158\/1055-9965.EPI-11-0650","article-title":"Economic Burden of Cancer in the United States: Estimates, Projections, and Future Research","volume":"20","author":"Yabroff","year":"2011","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_49","unstructured":"World Health Organization (WHO)\u2014Department of Data and Analytics (2020). WHO Methods and Data Sources for Global Burden of Disease Estimates 2000\u20132019, WHO Press."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Murray, C.J.L., Salomon, J.A., Mathers, C.D., and Lopez, A.D. (2002). Accounting for time and age in summary measures of population health. Summary Measures of Population Health: Concepts, Ethics, Measurement and Applications, WHO Press.","DOI":"10.1016\/S1098-3015(10)61265-X"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0167-6296(97)00005-2","article-title":"Disability-adjusted life years: A critical review","volume":"16","author":"Anand","year":"1997","journal-title":"J. Health Econ."},{"key":"ref_52","first-page":"439","article-title":"DALYs: The age-weights on balance","volume":"74","author":"Barendregt","year":"1996","journal-title":"Bull. World Health Organ."},{"key":"ref_53","unstructured":"Callen, T. (2020, December 13). Gross Domestic Product: An Economy\u2019s All. Available online: https:\/\/www.imf.org\/external\/pubs\/ft\/fandd\/basics\/gdp.htm."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/tmi.12808","article-title":"Costs of diarrhoea and acute respiratory infection attributable to not handwashing: The cases of India and China","volume":"22","author":"Townsend","year":"2017","journal-title":"Trop. Med. Int. Health"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"487","DOI":"10.4236\/health.2015.74058","article-title":"Economic Burden of Disability Adjusted Life Years (DALYs) of Injuries","volume":"7","author":"Dalal","year":"2015","journal-title":"Health"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Mo, X., Gai, R.T., Tachibana, Y., Bolt, T., Takahashi, Y., and Nakayama, T. (2020). The burden of disease and the cost of illness attributable to child maltreatment in Japan: Long-term health consequences largely matter. BMC Public Health, 20.","DOI":"10.1186\/s12889-020-09397-8"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1257\/0002828041301984","article-title":"Estimating the Value of a Statistical Life: The Importance of Omitted Variables and Publication Bias","volume":"94","author":"Ashenfelter","year":"2004","journal-title":"Am. Econ. Rev."},{"key":"ref_58","unstructured":"Kniesner, T.J., and Viscusi, W.K. (2021, December 14). The Value of a Statistical Life. Vanderbilt Law Research Paper No. 19-15. Available online: https:\/\/law.vanderbilt.edu\/phd\/faculty\/w-kip-viscusi\/368_Value_of_Statistical_Life_Oxford.pdf."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.jhealeco.2008.10.013","article-title":"The value of a statistical life: A meta-analysis with a mixed effects regression model","volume":"28","author":"Bellavance","year":"2009","journal-title":"J. Health Econ."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.2147\/OPTH.S313719","article-title":"The impact of inherited retinal diseases in the united states of america (Us) and canada from a cost-of-illness perspective","volume":"15","author":"Gong","year":"2021","journal-title":"Clin. Ophthalmol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jsr.2014.04.002","article-title":"Costs of occupational injuries and diseases in Qu\u00e9bec","volume":"50","author":"Lebeau","year":"2014","journal-title":"J. Saf. Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"104862","DOI":"10.1016\/j.prevetmed.2019.104862","article-title":"Placing a monetary value on the human health component of zoonotic diseases: A methodological note with an application to cysticercosis in Africa","volume":"175","author":"Mikecz","year":"2020","journal-title":"Prev. Vet. Med."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Miller, T.R., Waehrer, G.M., Oh, D.L., Boparai, S.P., Walker, S.O., Marques, S.S., and Harris, N.B. (2020). Adult health burden and costs in California during 2013 associated with prior adverse childhood experiences. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0228019"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1177\/0272989X0002000310","article-title":"Willingness to pay for a quality-adjusted life year: In search of a standard","volume":"20","author":"Hirth","year":"2000","journal-title":"Med. Decis. Mak."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1017\/bca.2017.12","article-title":"Income Elasticities and Global Values of a Statistical Life","volume":"8","author":"Viscusi","year":"2017","journal-title":"J. Benefit-Cost Anal."},{"key":"ref_66","unstructured":"World Cancer Leaders\u2019 Summit (2022, April 13). The Economics of Cancer Prevention & Control. Available online: https:\/\/www.uicc.org\/sites\/main\/files\/atoms\/files\/WCLS2014_economics_of_cancer_FINAL.pdf."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1002\/1878-0261.12812","article-title":"Tackling the cancer burden: The economic impact of primary prevention policies","volume":"15","author":"Cheatley","year":"2021","journal-title":"Mol. Oncol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1056\/NEJMsb1609101","article-title":"Realizing the Potential of Cancer Prevention\u2014The Role of Implementation Science","volume":"376","author":"Emmons","year":"2017","journal-title":"N. Engl. J. Med."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/8\/4862\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:55:29Z","timestamp":1760136929000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/8\/4862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,16]]},"references-count":68,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2022,4]]}},"alternative-id":["ijerph19084862"],"URL":"https:\/\/doi.org\/10.3390\/ijerph19084862","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,16]]}}}