{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T16:42:53Z","timestamp":1777308173130,"version":"3.51.4"},"reference-count":35,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T00:00:00Z","timestamp":1650499200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Deanship of Scientific Research at Jouf University","award":["DSR-2021-01-0396"],"award-info":[{"award-number":["DSR-2021-01-0396"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>This meta-analysis aimed to compare Marfan syndrome (MFS) patients with non-MFS populations based on orofacial health status to combine publicly available scientific information while also improving the validity of primary study findings. A comprehensive search was performed in the following databases: PubMed, Google Scholar, Scopus, Medline, and Web of Science, for articles published between 1 January 2000 and 17 February 2022. PRISMA guidelines were followed to carry out this systematic review. We used the PECO system to classify people with MFS based on whether or not they had distinctive oral health characteristics compared to the non-MFS population. The following are some examples of how PECO is used: P denotes someone who has MFS; E stands for a medical or genetic assessment of MFS; C stands for people who do not have MFS; and O stands for the orofacial characteristics of MFS. Using the Newcastle\u2013Ottawa Quality Assessment Scale, independent reviewers assessed the articles\u2019 methodological quality and extracted data. Four case-control studies were analyzed for meta-analysis. Due to the wide range of variability, we were only able to include data from at least three previous studies. There was a statistically significant difference in bleeding on probing and pocket depth between MFS and non-MFS subjects. MFS patients are more prone to periodontal tissue inflammation due to the activity of FBN1 and MMPs. Early orthodontic treatment is beneficial for the correction of a narrow upper jaw and a high palate, as well as a skeletal class II with retrognathism of the lower jaw and crowding of teeth.<\/jats:p>","DOI":"10.3390\/ijerph19095048","type":"journal-article","created":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T05:07:22Z","timestamp":1650604042000},"page":"5048","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Oral Health Status in Marfan Syndrome: A Systematic Review and Meta-Analysis of 353 Cases"],"prefix":"10.3390","volume":"19","author":[{"given":"Mohammad Khursheed","family":"Alam","sequence":"first","affiliation":[{"name":"Orthodontics, Preventive Dentistry Department, College of Dentistry, Jouf University, Sakaka 72345, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed Ali","family":"Alfawzan","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry, College of Dentistry in Ar Rass, Qassim University, Ar Rass 52571, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1073-9920","authenticated-orcid":false,"given":"Deepti","family":"Shrivastava","sequence":"additional","affiliation":[{"name":"Periodontics, Preventive Dentistry Department, College of Dentistry, Jouf University, Sakaka 72345, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5969-6810","authenticated-orcid":false,"given":"Kumar Chandan","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Oral & Maxillofacial Surgery & Diagnostic Sciences, College of Dentistry, Jouf University, Sakaka 72345, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4387-7959","authenticated-orcid":false,"given":"Haytham Jamil","family":"Alswairki","sequence":"additional","affiliation":[{"name":"School of Dental Sciences, Universiti Sains Malaysia, Kota Bharu 16150, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samir","family":"Mussallam","sequence":"additional","affiliation":[{"name":"Orthodontist, Private Clinic in Dubai, Dubai P.O. Box 65882, United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huda","family":"Abutayyem","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Center of Medical and Bio-Allied Health Sciences Research, College of Dentistry, Ajman University, Ajman P.O. Box 346, United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0960-1123","authenticated-orcid":false,"given":"Naseer","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Altamash Institute of Dental Medicine, Karachi 75500, Pakistan"},{"name":"Prosthodontics Unit, School of Dental Sciences, Health Campus, Universiti Sains Malaysia, Kota Bharu 16150, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1007\/s12265-011-9314-y","article-title":"Mitral valve disease in Marfan syndrome and related disorders","volume":"4","author":"Judge","year":"2011","journal-title":"J. Cardiovasc. Transl. 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