{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T21:22:19Z","timestamp":1779916939473,"version":"3.53.1"},"reference-count":25,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T00:00:00Z","timestamp":1651190400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"IRCCS Burlo-Garofolo Research Project"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>(1) Background: We find the incidence of clubfoot in Italy from \u201cCertificate of Delivery Care Registry (CeDAP)\u201d, a database of the Italian Ministry of Health, the most comprehensive public data available for this purpose. (2) Methods: The CeDAP registry is a web system that provides epidemiological and sociodemographic information about newborns. It started on 1 January 2002, following the ministerial Decree no. 349 of 16 July 2001. The certificate is structured into six sections; each collects specific information referring to the birthplace, parents, pregnancy, childbirth, newborn, and the possible presence of congenital malformations or the causes of neonatal mortality. The midwife or the doctor draws up the certificate no later than ten days after birth. Each region transmits the data every six months to the Ministry of Health. The period between 2013 and 2017 has been selected for the study, with every Italian region\u2019s data. We conducted a retrospective descriptive study. (3) Results: The overall rate in northern Italy is 1.09 (with some exceptions described), but we think it is essential to reevaluate this number again, given more accurate data collections by every Italian hospital. (4) Conclusions: This study intends to build a framework for future epidemiologic studies about clubfoot in Italy.<\/jats:p>","DOI":"10.3390\/ijerph19095406","type":"journal-article","created":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T23:52:30Z","timestamp":1651189950000},"page":"5406","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Incidence of Congenital Clubfoot: Preliminary Data from Italian CeDAP Registry"],"prefix":"10.3390","volume":"19","author":[{"given":"Daniela","family":"Dibello","sequence":"first","affiliation":[{"name":"Unit of Paediatric Orthopaedics and Traumatology, Giovanni XXIII Children\u2019s Hospital, Via Giovanni Amendola, 70126 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucio","family":"Torelli","sequence":"additional","affiliation":[{"name":"Clinical Department of Medical, Surgical and Health Sciences University of Trieste, Strada di Fiume, 34149 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Di Carlo","sequence":"additional","affiliation":[{"name":"Unit of Paediatric Orthopaedics and Traumatology, Institute for Maternal and Child Health\u2014IRCCS Burlo Garofolo, Via dell\u2019Istria, 34137 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9367-4909","authenticated-orcid":false,"given":"Adamo Pio","family":"d\u2019Adamo","sequence":"additional","affiliation":[{"name":"Clinical Department of Medical, Surgical and Health Sciences University of Trieste, Strada di Fiume, 34149 Trieste, Italy"},{"name":"Medical Genetics Unit, Institute for Maternal and Child Health\u2014IRCCS Burlo Garofolo, Via dell\u2019Istria, 34137 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1483-3612","authenticated-orcid":false,"given":"Flavio","family":"Faletra","sequence":"additional","affiliation":[{"name":"Medical Genetics Unit, Institute for Maternal and Child Health\u2014IRCCS Burlo Garofolo, Via dell\u2019Istria, 34137 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7910-1274","authenticated-orcid":false,"given":"Alessandro","family":"Mangogna","sequence":"additional","affiliation":[{"name":"Medical Genetics Unit, Institute for Maternal and Child Health\u2014IRCCS Burlo Garofolo, Via dell\u2019Istria, 34137 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Colin","sequence":"additional","affiliation":[{"name":"Unit of Orthopaedics and Traumatology, University of Trieste, Strada di Fiume, 34149 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s13018-018-0913-z","article-title":"The etiology of idiopathic congenital talipes equinovarus: A systematic review","volume":"13","author":"Pavone","year":"2018","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/BPB.0b013e328349927c","article-title":"Genetics of clubfoot","volume":"21","author":"Dobbs","year":"2012","journal-title":"J. Pediatr. Orthop. B"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"22","DOI":"10.4103\/0019-5413.38576","article-title":"Clubfoot: Etiology and treatment","volume":"42","author":"Anand","year":"2008","journal-title":"Indian J. Orthop."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1002\/jum.15136","article-title":"Clubfoot Versus Positional Foot Deformities on Prenatal Ultrasound Imaging","volume":"39","author":"Touleimat","year":"2020","journal-title":"J. Ultrasound. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1007\/s11999-009-0734-9","article-title":"Update on clubfoot: Etiology and treatment","volume":"467","author":"Dobbs","year":"2009","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s11832-014-0562-7","article-title":"Heritability of clubfoot: A twin study","volume":"8","author":"Engell","year":"2014","journal-title":"J. Child. Orthop."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/ppe.12163","article-title":"Maternal cigarette, alcohol, and coffee consumption in relation to risk of clubfoot","volume":"29","author":"Werler","year":"2015","journal-title":"Paediatr. Perinat. Epidemiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1002\/ajmg.a.35955","article-title":"Descriptive epidemiology of idiopathic clubfoot","volume":"161A","author":"Werler","year":"2013","journal-title":"Am. J. Med. Genet. A"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1007\/s10654-015-0065-y","article-title":"Selective serotonin reuptake inhibitor antidepressant use in first trimester pregnancy and risk of specific congenital anomalies: A European register-based study","volume":"30","author":"Wemakor","year":"2015","journal-title":"Eur. J. Epidemiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.ejogrb.2021.07.009","article-title":"Prenatal diagnosis of isolated clubfoot: Diagnostic accuracy and long-term postnatal outcomes","volume":"264","author":"Fantasia","year":"2021","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/jcu.22275","article-title":"Prenatal diagnosis of clubfoot: Chromosomal abnormalities associated with fetal defects and outcome in a tertiary center","volume":"44","author":"Gruchy","year":"2016","journal-title":"J. Clin. Ultrasound."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1002\/bdra.20625","article-title":"Multistate study of the epidemiology of clubfoot","volume":"85","author":"Parker","year":"2009","journal-title":"Birth. Defects Res. A Clin. Mol. Teratol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/tmi.12833","article-title":"Birth prevalence of congenital talipes equinovarus in low- and middle-income countries: A systematic review and meta-analysis","volume":"22","author":"Smythe","year":"2017","journal-title":"Trop. Med. Int. Health"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.2106\/JBJS.G.01346","article-title":"Polygenic threshold model with sex dimorphism in clubfoot inheritance: The Carter effect","volume":"90","author":"Kruse","year":"2008","journal-title":"J. Bone Jt. Surg. Am."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"21","DOI":"10.5704\/MOJ.1611.009","article-title":"Pattern of Presentation and Outcome of Short-term Treatment for Idiopathic Clubfoot \/ CTEV with Ponseti Method","volume":"10","author":"Gunalan","year":"2016","journal-title":"Malays. Orthop. J."},{"key":"ref_16","first-page":"144","article-title":"Club foot in the Maori: A genetic study of 50 kindreds","volume":"88","author":"Beals","year":"1978","journal-title":"N. Z. Med. J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1159\/000152236","article-title":"Genetic and epidemiological studies of clubfoot in Hawaii. General and medical considerations","volume":"19","author":"Chung","year":"1969","journal-title":"Hum. Hered."},{"key":"ref_18","first-page":"1853","article-title":"Congenital musculoskeletal malformation in South African Blacks: A study of incidence","volume":"50","year":"1976","journal-title":"S. Afr. Med. J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/BF01890110","article-title":"A clinical, genetic and epidemiologic study of congenital club foot","volume":"24","author":"Yamamoto","year":"1979","journal-title":"Jinrui Idengaku Zasshi"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1302\/0301-620X.89B8.19008","article-title":"Congenital talipes equinovarus: A review of current management","volume":"89","author":"Siapkara","year":"2007","journal-title":"J. Bone Jt. Surg Br."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1590\/S0102-311X2006001100016","article-title":"Congenital malformations in Rio de Janeiro, Brazil: Prevalence and associated factors","volume":"22","author":"Costa","year":"2006","journal-title":"Cad. Saude Publica"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"294","DOI":"10.3109\/17453674.2012.678797","article-title":"Congenital talipes equinovarus: An epidemiological study in Sicily","volume":"83","author":"Pavone","year":"2012","journal-title":"Acta Orthop."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/ajmg.a.61067","article-title":"Congenital clubfoot in Europe: A population-based study","volume":"179","author":"Wang","year":"2019","journal-title":"Am. J. Med. Genet. A"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s12687-018-0367-3","article-title":"Eurocat: An update on its functions and activities","volume":"9","author":"Tucker","year":"2018","journal-title":"J. Community Genet."},{"key":"ref_25","unstructured":"Italiana, R. (2022, March 13). Ministero Della Salute, Available online: Salute.gov.it."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/9\/5406\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:03:45Z","timestamp":1760137425000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/9\/5406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,29]]},"references-count":25,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,5]]}},"alternative-id":["ijerph19095406"],"URL":"https:\/\/doi.org\/10.3390\/ijerph19095406","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,29]]}}}