{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T23:35:51Z","timestamp":1773358551766,"version":"3.50.1"},"reference-count":21,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T00:00:00Z","timestamp":1651190400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Higher Education (MOHE)","award":["FRGS\/1\/2019\/SKK13\/UKM\/02\/1"],"award-info":[{"award-number":["FRGS\/1\/2019\/SKK13\/UKM\/02\/1"]}]},{"name":"Ministry of Higher Education (MOHE)","award":["GUP-2020-026"],"award-info":[{"award-number":["GUP-2020-026"]}]},{"name":"Ministry of Higher Education (MOHE)","award":["FF-2020-123"],"award-info":[{"award-number":["FF-2020-123"]}]},{"name":"Universiti Kebangsaan Malaysia (UKM) University Research","award":["FRGS\/1\/2019\/SKK13\/UKM\/02\/1"],"award-info":[{"award-number":["FRGS\/1\/2019\/SKK13\/UKM\/02\/1"]}]},{"name":"Universiti Kebangsaan Malaysia (UKM) University Research","award":["GUP-2020-026"],"award-info":[{"award-number":["GUP-2020-026"]}]},{"name":"Universiti Kebangsaan Malaysia (UKM) University Research","award":["FF-2020-123"],"award-info":[{"award-number":["FF-2020-123"]}]},{"name":"Faculty of Medicine, UKM Research","award":["FRGS\/1\/2019\/SKK13\/UKM\/02\/1"],"award-info":[{"award-number":["FRGS\/1\/2019\/SKK13\/UKM\/02\/1"]}]},{"name":"Faculty of Medicine, UKM Research","award":["GUP-2020-026"],"award-info":[{"award-number":["GUP-2020-026"]}]},{"name":"Faculty of Medicine, UKM Research","award":["FF-2020-123"],"award-info":[{"award-number":["FF-2020-123"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Introduction: Cyclophilin A was reported to be increased in the serum of mothers with preeclampsia, and is implicated in its pathogenesis. This study aimed to determine the expression of cyclophilin A in the placenta of mothers with and without hypertension, and to correlate its expression with maternal complications and adverse perinatal outcomes. Materials and Methods: This study consisted of a total of 70 cases (35 cases of mothers with hypertension, and 35 normotensive mothers as a control). Cyclophilin A immunohistochemistry was performed on a paraffin-embedded tissue section of placenta submitted at full thickness in order to evaluate the expression in fetal endothelial cells, cytotrophoblasts, syncytiotrophoblasts, maternal endothelial cells and decidual cells. The cyclophilin A expression was scored as weak, moderate or strong intensity. Results: The hypertensive group was more likely to have preterm deliveries (p &lt; 0.0001), caesarean sections (p &lt; 0.0001), and infants admitted to the intensive care unit (p &lt; 0.001). Fifty-one percent of the fetal endothelial cells and cytotrophoblasts expressed cyclophilin A in the hypertensive group, compared to only 28.6% in the normotensive group. However, the difference was not statistically significant (p = 0.086). Conclusion: We found no significant difference in placental cyclophilin A expression between hypertensive and normotensive mothers. There was also no difference in expression in mothers with and without maternal complications and adverse perinatal outcomes.<\/jats:p>","DOI":"10.3390\/ijerph19095448","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T16:49:57Z","timestamp":1651250997000},"page":"5448","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Placental Cyclophilin A Expression in Pregnancies Complicated with Hypertension"],"prefix":"10.3390","volume":"19","author":[{"given":"Elia Shazniza","family":"Shaaya","sequence":"first","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azyani","family":"Yahaya","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muaatamarulain","family":"Mustangin","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nurwardah","family":"Alfian","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8050-4150","authenticated-orcid":false,"given":"Azimatun Noor","family":"Aizuddin","sequence":"additional","affiliation":[{"name":"Department of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4897-9927","authenticated-orcid":false,"given":"Yin Ping","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2289-7619","authenticated-orcid":false,"given":"Geok Chin","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e213808","DOI":"10.1001\/jamanetworkopen.2021.3808","article-title":"Prevalence of Hypertension Among Pregnant Women When Using the 2017 American College of Cardiology\/American Heart Association Blood Pressure Guidelines and Association With Maternal and Fetal Outcomes","volume":"4","author":"Bello","year":"2021","journal-title":"JAMA Netw. 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