{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T09:14:40Z","timestamp":1767863680868,"version":"3.49.0"},"reference-count":43,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,5,7]],"date-time":"2022-05-07T00:00:00Z","timestamp":1651881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Background: The aim of our observational study is to compare the therapeutic efficacy of combined treatment of oxygen\u2013ozone therapy and oral treatment with alpha-lipoic acid (ALA) + palmitoylethanolamide (PEA) and myrrh in patients with peripheral neuropathic pain (sciatica) on radicular disc conflict from disc herniation and the results obtained with oxygen\u2013ozone treatment alone. Methods: We enrolled 318 patients with the neuroradiological diagnosis of disc herniation performed with computed tomography (CT) or magnetic resonance imaging (MRI) and symptoms characterized by low back pain complicated by sciatica, which we divided into two groups. Group A was composed of 165 patients who were treated only with oxygen\u2013ozone therapy with CT-guided intraforaminal technique, while the remaining 153 (Group B) have undergone combined oral treatment with ALA + PEA and myrrh. Follow-up visits for the evaluation of the clinical outcome of the treatment were conducted after 60 \u00b1 8 days using a modified version of McNab\u2019s method. Results: At the clinical check-up, 126\/165 patients included in Group A had a complete remission of pain (76.4%), while in Group B, 119\/153 (77.8%) had a complete remission of pain. Conclusion: The results highlight how the treatment associated with ozone therapy and oral administration of alpha-lipoic acid + palmitoylethanolamide and myrrh is preferred over the simple treatment with only ozone in such patients in the phase of greatest acuity of the disease, where the pain appears to be better controlled.<\/jats:p>","DOI":"10.3390\/ijerph19095716","type":"journal-article","created":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T08:04:21Z","timestamp":1651997061000},"page":"5716","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Oxygen\u2013Ozone Therapy Associated with Alpha Lipoic Acid Plus Palmitoylethanolamide and Myrrh versus Ozone Therapy in the Combined Treatment of Sciatic Pain Due to Herniated Discs: Observational Study on 318 Patients"],"prefix":"10.3390","volume":"19","author":[{"given":"Matteo","family":"Bonetti","sequence":"first","affiliation":[{"name":"Neuroradiology Service Istituto Clinico Citt\u00e0 di Brescia, 25128 Brescia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3550-1812","authenticated-orcid":false,"given":"Dorina","family":"Lauritano","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gian Maria","family":"Ottaviani","sequence":"additional","affiliation":[{"name":"Emergency and Urgency Department, Spedali Civili di Brescia, 25123 Brescia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Fontana","sequence":"additional","affiliation":[{"name":"Neuroradiology Service Istituto Clinico Citt\u00e0 di Brescia, 25128 Brescia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessio","family":"Zambello","sequence":"additional","affiliation":[{"name":"Anesthesia and Pain Therapy Service, Casa di Cura Borghi, 21020 Brebbia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Della Gatta","sequence":"additional","affiliation":[{"name":"Neuroradiology Department, Ospedale Cardarelli Napoli, 80131 Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Muto","sequence":"additional","affiliation":[{"name":"Neuroradiology Department, Ospedale Cardarelli Napoli, 80131 Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Carinci","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,7]]},"reference":[{"key":"ref_1","first-page":"996","article-title":"Minimally Invasive Oxygen-Ozone Therapy for Lumbar Disk Herniation","volume":"24","author":"Andreula","year":"2003","journal-title":"AJNR"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ejrad.2003.10.013","article-title":"Interventional spinal procedures","volume":"50","author":"Andreula","year":"2004","journal-title":"Eur. 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