{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T15:52:58Z","timestamp":1784649178448,"version":"3.55.0"},"reference-count":42,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,5,28]],"date-time":"2022-05-28T00:00:00Z","timestamp":1653696000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001262","name":"Baily Thomas Doctoral Fellowship","doi-asserted-by":"publisher","award":["TRUST\/VC\/AC\/SG\/5366-8393"],"award-info":[{"award-number":["TRUST\/VC\/AC\/SG\/5366-8393"]}],"id":[{"id":"10.13039\/501100001262","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UK Medicines and Healthcare products Regulatory Agency","award":["TRUST\/VC\/AC\/SG\/5366-8393"],"award-info":[{"award-number":["TRUST\/VC\/AC\/SG\/5366-8393"]}]},{"name":"University of Leicester","award":["TRUST\/VC\/AC\/SG\/5366-8393"],"award-info":[{"award-number":["TRUST\/VC\/AC\/SG\/5366-8393"]}]},{"name":"National Institute for Health Research (NIHR) Applied Research Collaboration (ARC) East Midlands","award":["TRUST\/VC\/AC\/SG\/5366-8393"],"award-info":[{"award-number":["TRUST\/VC\/AC\/SG\/5366-8393"]}]},{"name":"Leicester NIHR Biomedical Research Centre","award":["TRUST\/VC\/AC\/SG\/5366-8393"],"award-info":[{"award-number":["TRUST\/VC\/AC\/SG\/5366-8393"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Health needs are common in people living with intellectual disabilities, but we do not know how they contribute to life expectancy. We used the Clinical Practice Research Datalink (CPRD) linked with hospital\/mortality data in England (2017\u20132019) to explore life expectancy among people with or without intellectual disabilities, indicated by the presence or absence, respectively, of: epilepsy; incontinence; severe visual loss; severe visual impairment; severe mobility difficulties; cerebral palsy and PEG feeding. Life expectancy and 95% confidence intervals were compared using flexible parametric methods. At baseline, 46.4% (total n = 7794) of individuals with intellectual disabilities compared with 9.7% (total n = 176,807) in the comparison group had \u22651 health need. Epilepsy was the most common health need (18.7% vs. 1.1%). All health needs except hearing impairment were associated with shorter life expectancy: PEG feeding and mobility difficulties were associated with the greatest loss in life years (65\u201368% and 41\u201344%, respectively). Differential life expectancy attenuated but remained (\u224812% life years lost) even after restricting the population to those without health needs (additional years expected to live at 10 years: 65.5 [60.3, 71.1] vs. 74.3 [73.8, 74.7]). We conclude that health needs play a significant role but do not explain all of the differential life expectancy experienced by people with intellectual disabilities.<\/jats:p>","DOI":"10.3390\/ijerph19116602","type":"journal-article","created":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T08:50:51Z","timestamp":1653814251000},"page":"6602","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Health Needs and Their Relationship with Life Expectancy in People with and without Intellectual Disabilities in England"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2877-4342","authenticated-orcid":false,"given":"Freya","family":"Tyrer","sequence":"first","affiliation":[{"name":"Biostatistics Research Group, Department of Health Sciences, University of Leicester, Leicester LE1 7RH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Morriss","sequence":"additional","affiliation":[{"name":"Institute of Mental Health, University of Nottingham, Nottingham NG7 2TU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Kiani","sequence":"additional","affiliation":[{"name":"Leicestershire Learning Disability Services (Psychiatry), Leicestershire Partnership NHS Trust, Leicester LE4 8PQ, UK"},{"name":"Mental Health, Ageing, Public Health and Primary Care Research Group, Department of Health Sciences, University of Leicester, Leicester LE1 7RH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7034-4173","authenticated-orcid":false,"given":"Satheesh K.","family":"Gangadharan","sequence":"additional","affiliation":[{"name":"Leicestershire Learning Disability Services (Psychiatry), Leicestershire Partnership NHS Trust, Leicester LE4 8PQ, UK"},{"name":"Mental Health, Ageing, Public Health and Primary Care Research Group, Department of Health Sciences, University of Leicester, Leicester LE1 7RH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harish","family":"Kundaje","sequence":"additional","affiliation":[{"name":"Lakeside Healthcare, Cottingham Road, Corby NN17 2UR, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1557-6697","authenticated-orcid":false,"given":"Mark J.","family":"Rutherford","sequence":"additional","affiliation":[{"name":"Biostatistics Research Group, Department of Health Sciences, University of Leicester, Leicester LE1 7RH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,28]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization Commission on Social Determinants of Health (2021, April 22). Closing the Gap in a Generation: Health Equity through Action on the Social Determinants of Health. Available online: https:\/\/www.who.int\/social_determinants\/thecommission\/finalreport\/en\/."},{"key":"ref_2","unstructured":"United Nations General Assembly (2021, April 22). Political Declaration of the High-Level Meeting on Universal Health Coverage: \u201cUniversal Health Coverage: Moving Together to Build a Healthier World\u201d [A\/RES\/74\/]. Available online: https:\/\/www.un.org\/en\/ga\/74\/resolutions.shtml."},{"key":"ref_3","unstructured":"Department of Health and Social Care (2020, July 27). Advancing Our Health: Prevention in the 2020s\u2014Consultation Document, Available online: https:\/\/www.gov.uk\/government\/consultations\/advancing-our-health-prevention-in-the-2020s\/advancing-our-health-prevention-in-the-2020s-consultation-document."},{"key":"ref_4","unstructured":"European Commission (2021, December 02). The European Pillar of Social Rights in 20 Principles. Available online: https:\/\/ec.europa.eu\/info\/sites\/default\/files\/social-summit-european-pillar-social-rights-booklet_en.pdf."},{"key":"ref_5","unstructured":"European Commission (2021, November 30). Union of Equality. Strategy for the Rights of Persons with Disabilities 2021\u20132030. Available online: https:\/\/ec.europa.eu\/social\/BlobServlet?docId=23707&langId=en."},{"key":"ref_6","unstructured":"Office of Disease Prevention and Health Promotion, and U.S. Department of Health and Human Services (2021, November 30). Secretary\u2019s Advisory Committee for Healthy People 2030. Report 7: Reviewing and Assessing the Set of Proposed Objectives for Healthy People 2030, Available online: https:\/\/www.healthypeople.gov\/sites\/default\/files\/Report%207_Reviewing%20Assessing%20Set%20of%20HP2030%20Objectives_Formatted%20EO_508_05.21.pdf."},{"key":"ref_7","unstructured":"World Health Organization Regional Office for Europe (2021, December 03). Better Health, Better Lives: Research Priorities. Available online: https:\/\/apps.who.int\/iris\/handle\/10665\/107303."},{"key":"ref_8","unstructured":"Australian Civil Society CRPD Shadow Report Working Group (2022, January 14). Disability Rights Now. Australian Civil Society Shadow Report to the United Nations Committee on the Rights of Persons with Disabilities: UN CRPD Review. Available online: https:\/\/tbinternet.ohchr.org\/Treaties\/CRPD\/Shared%20Documents\/AUS\/INT_CRPD_CSS_AUS_35639_E.pdf."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Emerson, E., and Hatton, C. (2014). Health Inequalities and People with Intellectual Disabilities, Cambridge University Press.","DOI":"10.1017\/CBO9781139192484"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Cooper, S.-A., McLean, G., Guthrie, B., McConnachie, A., Mercer, S., Sullivan, F., and Morrison, J. (2015). Multiple physical and mental health comorbidity in adults with intellectual disabilities: Population-based cross-sectional analysis. BMC Fam. Pract., 16.","DOI":"10.1186\/s12875-015-0329-3"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1016\/j.ridd.2014.06.007","article-title":"The impact of health checks for people with intellectual disabilities: An updated systematic review of evidence","volume":"35","author":"Robertson","year":"2014","journal-title":"Res. Dev. Disabil."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1136\/jech-2021-216798","article-title":"Mortality disparities and deprivation among people with intellectual disabilities in England: 2000\u20132019","volume":"76","author":"Tyrer","year":"2022","journal-title":"J. Epidemiol. Community Health"},{"key":"ref_13","unstructured":"Heslop, P., Blair, P., Fleming, P., Hoghton, M., Marriott, A., and Russ, L. (2022, January 14). Confidential Inquiry into Premature Deaths of People with Learning Disabilities (CIPOLD). Norah Fry Research Centre, University of Bristol. Available online: http:\/\/www.bristol.ac.uk\/media-library\/sites\/cipold\/migrated\/documents\/fullfinalreport.pdf."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e013489","DOI":"10.1136\/bmjopen-2016-013489","article-title":"Cause of death and potentially avoidable deaths in Australian adults with intellectual disability using retrospective linked data","volume":"7","author":"Trollor","year":"2017","journal-title":"BMJ Open"},{"key":"ref_15","first-page":"9","article-title":"An evaluation of the effectiveness of annual health checks and quality of health care for adults with intellectual disability: An observational study using a primary care database","volume":"9","author":"Carey","year":"2017","journal-title":"NIHR J. Libr."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Benchimol, E.I., Smeeth, L., Guttmann, A., Harron, K., Moher, D., Petersen, I., S\u00f8rensen, H.T., von Elm, E., and Langan, S.M. (2015). The REporting of studies Conducted using Observational Routinely-collected health Data (RECORD) statement. PLoS Med., 12.","DOI":"10.1371\/journal.pmed.1001885"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1093\/ije\/dyv098","article-title":"Data resource profile: Clinical Practice Research Datalink (CPRD)","volume":"44","author":"Herrett","year":"2015","journal-title":"Int. J. Epidemiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/jar.12190","article-title":"Mortality among a cohort of persons with an intellectual disability in New South Wales, Australia","volume":"28","author":"Florio","year":"2015","journal-title":"J. Appl. Res. Intellect. Disabil."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e264","DOI":"10.3399\/bjgp16X684301","article-title":"Health characteristics and consultation patterns of people with intellectual disability: A cross-sectional database study in English general practice","volume":"66","author":"Carey","year":"2016","journal-title":"Br. J. Gen. Pract."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e20163908","DOI":"10.1542\/peds.2016-3908","article-title":"Incidence and Prevalence of Childhood Epilepsy: A Nationwide Cohort Study","volume":"139","author":"Aaberg","year":"2017","journal-title":"Pediatrics"},{"key":"ref_21","unstructured":"National Institute for Health and Care Excellence (NICE) (2022, March 18). Epilepsies: Diagnosis and Management, Clinical Guideline [CG137] [updated May 2021]. Available online: https:\/\/www.nice.org.uk\/guidance\/cg137."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Blair, E., Langdon, K., McIntyre, S., Lawrence, D., and Watson, L. (2019). Survival and mortality in cerebral palsy: Observations to the sixth decade from a data linkage study of a total population register and National Death Index. BMC Neurol., 19.","DOI":"10.1186\/s12883-019-1343-1"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Tyrer, F., Bhaskaran, K., and Rutherford, M.J. (2022). Immortal time bias for life-long conditions in retrospective observational studies using electronic health records. BMC Med. Res. Methodol., 22.","DOI":"10.1186\/s12874-022-01581-1"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Tyrer, F., Chudasama, Y., Lambert, P.C., and Rutherford, M.J. (2022). Flexible Parametric Methods for Calculating Life Expectancy in Small Populations, under review.","DOI":"10.21203\/rs.3.rs-1925341\/v1"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Chang, S.-R., Lin, W.-A., Lin, H.-H., Lee, C.-N., Chang, T.-C., and Lin, M.-I. (2021). Cumulative incidence of urinary incontinence and associated factors during pregnancy and after childbirth: A cohort study. Int. Urogynecology J., (online ahead of print).","DOI":"10.1007\/s00192-021-05011-6"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1097\/JU.0000000000000574","article-title":"Is There an Association between Urinary Incontinence and Mortality? A Retrospective Cohort Study","volume":"203","author":"Matta","year":"2020","journal-title":"J. Urol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1007\/s00455-009-9270-8","article-title":"Functional dysphagia therapy and PEG treatment in a clinical geriatric setting","volume":"26","author":"Becker","year":"2011","journal-title":"Dysphagia"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3109\/13668250.2020.1834946","article-title":"Mortality, predictors and causes among people with intellectual disabilities: A systematic narrative review supplemented by machine learning","volume":"46","author":"Tyrer","year":"2021","journal-title":"J. Intellect. Dev. Disabil."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.jpeds.2015.10.083","article-title":"Improved survival in Down syndrome over the last 60 years and the impact of perinatal Factors in recent decades","volume":"169","author":"Glasson","year":"2016","journal-title":"J. Pediatrics"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1212\/01.wnl.0000169018.44950.68","article-title":"Causes of death in remote symptomatic epilepsy","volume":"65","author":"Day","year":"2005","journal-title":"Neurology"},{"key":"ref_31","unstructured":"Public Health England (2021, February 23). COVID-19 Deaths of People Identified as Having Learning Disabilities: Report, Available online: https:\/\/www.gov.uk\/government\/publications\/covid-19-deaths-of-people-with-learning-disabilities\/covid-19-deaths-of-people-identified-as-having-learning-disabilities-summary."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/S0140-6736(21)01786-4","article-title":"Hospital-acquired SARS-CoV-2 infection in the UK\u2019s first COVID-19 pandemic wave","volume":"398","author":"Read","year":"2021","journal-title":"Lancet"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s001920070021","article-title":"Epidemiology and natural history of urinary incontinence","volume":"11","author":"Hunskaar","year":"2000","journal-title":"Int. Urogynecology J. Pelvic Floor Dysfunct."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e261","DOI":"10.1016\/j.ajog.2015.08.072","article-title":"Bridging the gap: Determinants of undiagnosed or untreated urinary incontinence in women","volume":"214","author":"Duralde","year":"2016","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1111\/j.1572-0241.2002.05778.x","article-title":"Percutaneous endoscopic gastrostomy: A prospective audit of the impact of guidelines in two district general hospitals in the United Kingdom","volume":"97","author":"Sanders","year":"2002","journal-title":"Am. J. Gastroenterol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1038\/sj.eye.6702059","article-title":"Prevalence of visual impairment in adults with intellectual disabilities in the Netherlands: Cross-sectional study","volume":"20","author":"Stilma","year":"2006","journal-title":"Eye"},{"key":"ref_37","first-page":"944","article-title":"Association of Hearing Impairment and Mortality in the National Health and Nutrition Examination Survey","volume":"141","author":"Contrera","year":"2015","journal-title":"JAMA Otolaryngol. Head Neck Surg."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/dmcn.12080","article-title":"An update on the prevalence of cerebral palsy: A systematic review and meta-analysis","volume":"55","author":"Oskoui","year":"2013","journal-title":"Dev. Med. Child Neurol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1080\/09638280500158422","article-title":"The epidemiology of cerebral palsy: Incidence, impairments and risk factors","volume":"28","author":"Odding","year":"2006","journal-title":"Disabil. Rehabil."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1111\/dmcn.13773","article-title":"Intellectual disability in cerebral palsy: A population-based retrospective study","volume":"60","author":"Reid","year":"2018","journal-title":"Dev. Med. Child Neurol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/jir.12718","article-title":"Diabetes in adults with intellectual disability: Prevalence and associated demographic, lifestyle, independence and health factors","volume":"64","author":"Tyrer","year":"2020","journal-title":"J. Intellect. Disabil. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1093\/gerona\/59.12.1295","article-title":"Variation in Thresholds for Reporting Mobility Disability Between National Population Subgroups and Studies","volume":"59","author":"Melzer","year":"2004","journal-title":"J. Gerontol. Ser. A"}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/11\/6602\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:20:37Z","timestamp":1760138437000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/11\/6602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,28]]},"references-count":42,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,6]]}},"alternative-id":["ijerph19116602"],"URL":"https:\/\/doi.org\/10.3390\/ijerph19116602","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,28]]}}}