{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T06:31:28Z","timestamp":1782714688912,"version":"3.54.5"},"reference-count":36,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:00:00Z","timestamp":1653955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Psychobiological research is a systems approach that aims to integrate the biological, psychological and social systems that may influence health or pathology, particularly in chronic diseases and physical and\/or psychiatric disorders. In this approach, we can expect to be able to deduce a \u2018biological signature\u2019 associated with particular symptom clusters. Similarly, psychosocial factors such as life events, health attitudes and behaviours, social support, psychological well-being, spirituality and personality are to be considered in terms of their influence on individual vulnerability to disease. At the psychophysiological level, it is important to understand, for example, the pathways that link the effects of chronic stress, social support and health, through the neuroendocrine and autonomic mechanisms that determine stress responses. At the macroscopic level, the role of individual socio-demographic variables such as personality, treatment modalities and health promotion through psycho-educational interventions needs to be explored.<\/jats:p>","DOI":"10.3390\/ijerph19116728","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T09:24:29Z","timestamp":1653989069000},"page":"6728","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Psychobiological Factors in Global Health and Public Health"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5439-8689","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9ric","family":"Denis","sequence":"first","affiliation":[{"name":"Department of Odontology, Tours University Hospital Center, 37000 Tours, France"},{"name":"Faculty of Dentistry, Nantes University, 44000 Nantes, France"},{"name":"EA 75-05 Education, Ethics, Health, Faculty of Medicine, Fran\u00e7ois-Rabelais University, 37000 Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachid","family":"Mahalli","sequence":"additional","affiliation":[{"name":"Department of Odontology, Tours University Hospital Center, 37000 Tours, France"},{"name":"U1253, iBrain, CIC1415, Inserm, University Hospital Centre, Universit\u00e9 de Tours, 37000 Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Delpierre","sequence":"additional","affiliation":[{"name":"Department of Odontology, Tours University Hospital Center, 37000 Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Romagna","sequence":"additional","affiliation":[{"name":"Department of Odontology, Tours University Hospital Center, 37000 Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Selimovic","sequence":"additional","affiliation":[{"name":"Department of Odontology, Tours University Hospital Center, 37000 Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Renaud","sequence":"additional","affiliation":[{"name":"Laboratory Bioengineering Nanosciences LBN, University of Montpellier, 34193 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,31]]},"reference":[{"key":"ref_1","first-page":"198","article-title":"American Psychologist","volume":"46","author":"Dewsbury","year":"1991","journal-title":"Psychobiology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1038\/nrn1257","article-title":"The legacy of Donald O. 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