{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:49:59Z","timestamp":1790704199552,"version":"4.1.0"},"reference-count":22,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T00:00:00Z","timestamp":1654819200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Post-marketing safety surveillance of new vaccines aimed to be administered during pregnancy is crucial to orchestrate efficient adverse events evaluation. This is of special relevance in the current landscape of new vaccines being introduced in the pregnant women population, and particularly due to the recent administration of COVID-19 vaccines in pregnant women. This multi-center prospective cohort study, nested within the WHO-Global Vaccine Safety-MCC study, involved two hospitals in the Valencia region. Hereby, the incidence rates of seven perinatal and neonatal outcomes in the Valencia region are presented. The pooled data analysis of the two Valencian hospitals allowed the estimation of incidence rates in the Valencia Region (per 1000 live births): 86.7 for low birth weight, 78.2 for preterm birth, 58.8 for small for gestational age, 13 for congenital microcephaly, 0.4 for stillbirth, 1.2 for neonatal death and 6.5 for neonatal infection. These figures are in line with what is expected from a high-income country and the previously reported rates for Spain and Europe, except for the significantly increased rate for congenital microcephaly. Regarding the data for maternal immunization, the vaccination status was collected for 94.4% of the screened pregnant women, highlighting the high quality of the Valencian Vaccine Registry. The study also assessed the Valencian hospitals\u2019 capacity for identifying and collecting data on maternal immunization status, as well as the applicability of the GAIA definitions to the identified outcomes.<\/jats:p>","DOI":"10.3390\/ijerph19127132","type":"journal-article","created":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T10:25:12Z","timestamp":1654856712000},"page":"7132","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Risk Measurement of Perinatal and Neonatal Morbidity Characteristics and Applicability of GAIA Case Definitions: Results and Lessons Learnt of a Hospital-Based Prospective Cohort Study in the Valencia Region (2019\u20132020)"],"prefix":"10.3390","volume":"19","author":[{"given":"Antonio","family":"Carmona","sequence":"first","affiliation":[{"name":"Vaccines Research Department, Fundaci\u00f3n Para el Fomento de la Investigaci\u00f3n Sanitaria y Biom\u00e9dica de la Comunitat Valenciana (Fisabio), Av. de Catalunya, 21, 46020 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Latorre Tejerina","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hospital General Universitario de Castell\u00f3n, Avinguda de Benic\u00e0ssim, 128, 12004 Castell\u00f3 de la Plana, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Mart\u00ednez Sebasti\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hospital Universitario Doctor Peset, Av. de Gaspar Aguilar, 90, 46017 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dafina","family":"Dobreva","sequence":"additional","affiliation":[{"name":"P95 Pharmacovigilance and Epidemiology, 3010 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina P.","family":"Jurca","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hospital General Universitario de Castell\u00f3n, Avinguda de Benic\u00e0ssim, 128, 12004 Castell\u00f3 de la Plana, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Huerta Barber\u00e1","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hospital General Universitario de Castell\u00f3n, Avinguda de Benic\u00e0ssim, 128, 12004 Castell\u00f3 de la Plana, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Bernat Montoya","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hospital General Universitario de Castell\u00f3n, Avinguda de Benic\u00e0ssim, 128, 12004 Castell\u00f3 de la Plana, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Aristoy Zabaleta","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hospital General Universitario de Castell\u00f3n, Avinguda de Benic\u00e0ssim, 128, 12004 Castell\u00f3 de la Plana, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Pineda Caplliure","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hospital Universitario Doctor Peset, Av. de Gaspar Aguilar, 90, 46017 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7414-6115","authenticated-orcid":false,"given":"Beatriz","family":"Mansilla Roig","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hospital Universitario Doctor Peset, Av. de Gaspar Aguilar, 90, 46017 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Nav\u00edo Anaya","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hospital Universitario Doctor Peset, Av. de Gaspar Aguilar, 90, 46017 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Tosca-Segura","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hospital General Universitario de Castell\u00f3n, Avinguda de Benic\u00e0ssim, 128, 12004 Castell\u00f3 de la Plana, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Tortajada-Girb\u00e9s","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hospital Universitario Doctor Peset, Av. de Gaspar Aguilar, 90, 46017 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1008-3922","authenticated-orcid":false,"given":"Javier","family":"D\u00edez-Domingo","sequence":"additional","affiliation":[{"name":"Vaccines Research Department, Fundaci\u00f3n Para el Fomento de la Investigaci\u00f3n Sanitaria y Biom\u00e9dica de la Comunitat Valenciana (Fisabio), Av. de Catalunya, 21, 46020 Valencia, Spain"},{"name":"Universidad Cat\u00f3lica de Valencia San Vicente M\u00e1rtir, Carrer de Quevedo, 2, 46001 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3780-3187","authenticated-orcid":false,"given":"Alejandro","family":"Orrico-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Vaccines Research Department, Fundaci\u00f3n Para el Fomento de la Investigaci\u00f3n Sanitaria y Biom\u00e9dica de la Comunitat Valenciana (Fisabio), Av. de Catalunya, 21, 46020 Valencia, Spain"},{"name":"Universidad Cat\u00f3lica de Valencia San Vicente M\u00e1rtir, Carrer de Quevedo, 2, 46001 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,10]]},"reference":[{"key":"ref_1","unstructured":"WHO (2022, April 20). 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