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Collective prolonged multimodal trauma on this scale is likely to elicit symptomatology in the general population consistent with post-traumatic stress disorder (PTSD), somatization, anxiety, and stress. The psychological component of this response contributes substantially to the burden of this disease worldwide. This cross-sectional study examines the relationship between COVID-19-related concern, anxiety, and perceived stress on PTSD-like symptomatology over the course of the COVID-19 pandemic. Participants were recruited via social media within the United States of America between 8th May 2020 and 11th August 2021 to complete an internet questionnaire including mood, personality, and COVID-19-specific scales. General anxiety and PTSD-like symptomatology were above the screening cutoffs for most respondents. These measures increased in severity over the pandemic, with the change point of our Concern scale preceding that of the other significant measures. Measures of COVID-19-related concern, generalized anxiety, and PTSD-like symptomatology were strongly correlated with each other. Anxiety, perceived stress, and PTSD-like symptomatology are strongly interrelated, increase with pandemic length, and are linked to reported levels of concern over COVID-19. These observations may aid future research and policy as the pandemic continues.<\/jats:p>","DOI":"10.3390\/ijerph19127178","type":"journal-article","created":{"date-parts":[[2022,6,11]],"date-time":"2022-06-11T09:33:26Z","timestamp":1654940006000},"page":"7178","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["A Cross-Sectional Time Course of COVID-19 Related Worry, Perceived Stress, and General Anxiety in the Context of Post-Traumatic Stress Disorder-like Symptomatology"],"prefix":"10.3390","volume":"19","author":[{"given":"Roger J.","family":"Mullins","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Johns Hopkins University, Baltimore, MD 21287, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1833-6536","authenticated-orcid":false,"given":"Timothy J.","family":"Meeker","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Johns Hopkins University, Baltimore, MD 21287, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paige M.","family":"Vinch","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Johns Hopkins University, Baltimore, MD 21287, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5321-8121","authenticated-orcid":false,"given":"Ingrid K.","family":"Tulloch","sequence":"additional","affiliation":[{"name":"Department of Psychology, Morgan State University, Baltimore, MD 21251, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark I.","family":"Saffer","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Johns Hopkins University, Baltimore, MD 21287, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jui-Hong","family":"Chien","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Johns Hopkins University, Baltimore, MD 21287, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. Joseph","family":"Bienvenu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD 21287, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick A.","family":"Lenz","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Johns Hopkins University, Baltimore, MD 21287, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,11]]},"reference":[{"key":"ref_1","first-page":"1767","article-title":"The COVID-19 Pandemic in the US: A Clinical Update","volume":"323","author":"Omer","year":"2020","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1080\/10410230701283272","article-title":"After 9\/11: Goal disruption, emotional support, and psychological health in a lower exposure sample","volume":"21","author":"MacGeorge","year":"2007","journal-title":"Health Commun."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4172\/1522-4821.1000404","article-title":"Re-experiencing 9\/11-Related PTSD Symptoms Following Exposure to Hurricane Sandy","volume":"20","author":"Li","year":"2018","journal-title":"Int. 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