{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T11:48:05Z","timestamp":1785930485482,"version":"3.56.0"},"reference-count":43,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T00:00:00Z","timestamp":1655164800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Cardiovascular diseases are the most common causes of death, in both Poland and the world. Their development and progression are largely influenced by the lifestyle with the presence\/occurrence of classic, modifiable risk factors. Among them, low physical activity plays a significant role. The aim of the study was to evaluate the expression of the endothelin-1 gene and its type A receptor, taking into account physical activity (International Physical Activity Questionnaire\u2014IPAQ) among patients with acute myocardial infarction. A total of 234 patients with acute myocardial infarction were examined, including 167 patients undergoing early post-hospital cardiac rehabilitation and 67 not participating in it. All of them were assessed with the IPAQ questionnaire and the quantitative real-time polymerase reaction method (QRT-PCR). Physical activity in the group of patients after early post-hospital cardiac rehabilitation increased after rehabilitation. Transcriptional activity of the endothelin-1 (ET-1) gene in both studied group of patients increased significantly, but in a group of patients not participating in early post-hospital cardiac rehabilitation more than in a group of patients participating in it. In our study, the expression of ET-1 was also significantly higher in the group of patients with acute myocardial infarction with ST-segment elevation, without diabetes, with lipid disorders, smoking, with normal body weight. Expression of the ENDRA (Endothelin receptor A) gene increased with age. These results prove the beneficial effect of rehabilitation and may indicate another pathomechanism of pro-atherogenic activity of above-mentioned factors.<\/jats:p>","DOI":"10.3390\/ijerph19127289","type":"journal-article","created":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T23:50:14Z","timestamp":1655250614000},"page":"7289","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Expression of the Endothelin-1 Gene and Its Type a Receptor including Physical Activity among Patients with Acute Myocardial Infarction"],"prefix":"10.3390","volume":"19","author":[{"given":"J\u00f3zefa","family":"D\u0105bek","sequence":"first","affiliation":[{"name":"Department of Cardiology, Faculty of Health Sciences in Katowice, Medical University of Silesia in Katowice, Zio\u0142owa Street 45-47, 40-635 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0996-7691","authenticated-orcid":false,"given":"Joanna","family":"Piotrkowicz","sequence":"additional","affiliation":[{"name":"Doctoral Studies, Faculty of Health Sciences in Katowice, Medical University of Silesia in Katowice, Medyk\u00f3w Street 12, 40-751 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"G\u0142ogowska-Ligus","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Faculty of Health Science in Bytom, Medical University of Silesia in Katowice, Piekarska 18, 41-902 Bytom, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9086-9970","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"Domagalska-Szopa","sequence":"additional","affiliation":[{"name":"Department of Medical Rehabilitation, Faculty of Health Sciences in Katowice, Medical University of Silesia in Katowice, Zapolskiej Street 3, 41-218 Sosnowiec, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1765-1622","authenticated-orcid":false,"given":"Andrzej","family":"Szopa","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, Faculty of Health Sciences in Katowice, Medical University of Silesia in Katowice, Medyk\u00f3w Street 12, 40-751 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutz","family":"Schreiber","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Klinikum Vest, Academic Teaching Hospital, Ruhr University Bochum Germany, 44801 Bochum, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e002495","DOI":"10.1161\/JAHA.115.002495","article-title":"Quantifying the Association between Physical Activity and Cardiovascular Disease and Diabetes: A Systematic Review and Meta-Analysis","volume":"5","author":"Wahid","year":"2016","journal-title":"J. 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