{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T09:50:59Z","timestamp":1786441859673,"version":"build-2736575974"},"reference-count":68,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T00:00:00Z","timestamp":1655251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Spanish Ministry of Economy and Competitiveness through the Carlos III Health Institute (ISCIII) and the European Regional Development Fund (ERDF)","award":["PI13\/02252"],"award-info":[{"award-number":["PI13\/02252"]}]},{"name":"Spanish Ministry of Economy and Competitiveness through the Carlos III Health Institute (ISCIII) and the European Regional Development Fund (ERDF)","award":["PI18\/01055"],"award-info":[{"award-number":["PI18\/01055"]}]},{"name":"Spanish Ministry of Economy and Competitiveness through the Carlos III Health Institute (ISCIII) and the European Regional Development Fund (ERDF)","award":["PI21\/00713"],"award-info":[{"award-number":["PI21\/00713"]}]},{"name":"Spanish Ministry of Economy and Competitiveness through the Carlos III Health Institute (ISCIII) and the European Regional Development Fund (ERDF)","award":["PI19\/00569"],"award-info":[{"award-number":["PI19\/00569"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Despite the negative influence of cannabis use on the development and prognosis of first-episode psychosis (FEP), there is little evidence on effective specific interventions for cannabis use cessation in FEP. The aim of this study was to compare the efficacy of a specific cognitive behavioral therapy (CBT) for cannabis cessation (CBT-CC) with treatment as usual (TAU) in FEP cannabis users. In this single-blind, 1-year randomized controlled trial, 65 participants were randomly assigned to CBT-CC or TAU. The primary outcome was the reduction in cannabis use severity. The CBT-CC group had a greater decrease in cannabis use severity and positive psychotic symptoms over time, and a greater improvement in functioning at post-treatment than TAU. The treatment response was also faster in the CBT-CC group, reducing cannabis use, anxiety, positive and general psychotic symptoms, and improving functioning earlier than TAU in the follow-up. Moreover, patients who stopped and\/or reduced cannabis use during the follow-up, decreased psychotic symptoms and increased awareness of disease compared to those who continued using cannabis. Early intervention based on a specific CBT for cannabis cessation, may be effective in reducing cannabis use severity, in addition to improving clinical and functional outcomes of FEP cannabis users.<\/jats:p>","DOI":"10.3390\/ijerph19127325","type":"journal-article","created":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T22:17:01Z","timestamp":1655331421000},"page":"7325","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Cognitive Behavioral Therapy Program for Cannabis Use Cessation in First-Episode Psychosis Patients: A 1-Year Randomized Controlled Trial"],"prefix":"10.3390","volume":"19","author":[{"given":"Itxaso","family":"Gonz\u00e1lez-Ortega","sequence":"first","affiliation":[{"name":"Centre for Biomedical Research in the Mental Health Network (CIBERSAM), 28029 Madrid, Spain"},{"name":"Bioaraba Research Institute, Department of Psychiatry, Araba University Hospital, 01004 Vitoria, Spain"},{"name":"Department of Personality, Assessment and Psychological Treatment, National University of Distance Education (UNED), 01008 Vitoria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7654-0781","authenticated-orcid":false,"given":"Enrique","family":"Echebur\u00faa","sequence":"additional","affiliation":[{"name":"Centre for Biomedical Research in the Mental Health Network (CIBERSAM), 28029 Madrid, Spain"},{"name":"Department of Personality, Assessment and Psychological Treatment, University of the Basque Country, Biodonostia, 20018 San Sebastian, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Alberich","sequence":"additional","affiliation":[{"name":"Centre for Biomedical Research in the Mental Health Network (CIBERSAM), 28029 Madrid, Spain"},{"name":"Bioaraba Research Institute, Department of Psychiatry, Araba University Hospital, 01004 Vitoria, Spain"},{"name":"Department of Fundamental Mathematics, National University of Distance Education (UNED), 01008 Vitoria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8748-6717","authenticated-orcid":false,"given":"Miguel","family":"Bernardo","sequence":"additional","affiliation":[{"name":"Centre for Biomedical Research in the Mental Health Network (CIBERSAM), 28029 Madrid, Spain"},{"name":"Department of Psychiatry, Hospital Clinic of Barcelona, Neuroscience Institute, University of Barcelona, 08036 Barcelona, Spain"},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0548-0053","authenticated-orcid":false,"given":"Eduard","family":"Vieta","sequence":"additional","affiliation":[{"name":"Centre for Biomedical Research in the Mental Health Network (CIBERSAM), 28029 Madrid, Spain"},{"name":"Department of Psychiatry, Hospital Clinic of Barcelona, Neuroscience Institute, University of Barcelona, 08036 Barcelona, Spain"},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6992-0767","authenticated-orcid":false,"given":"Gonzalo Salazar","family":"de Pablo","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King\u2019s College London, London SE5 8AB, UK"},{"name":"Early Psychosis: Interventions and Clinical-detection (EPIC) Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King\u2019s College London, London SE5 8AB, UK"},{"name":"Child and Adolescent Mental Health Services, South London & Maudsley NHS Trust, London SE11 6JJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Gonz\u00e1lez-Pinto","sequence":"additional","affiliation":[{"name":"Centre for Biomedical Research in the Mental Health Network (CIBERSAM), 28029 Madrid, Spain"},{"name":"Bioaraba Research Institute, Department of Psychiatry, Araba University Hospital, 01004 Vitoria, Spain"},{"name":"Department of Neurosciences, University of the Basque Country, 48940 Leioa, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/eip.12542","article-title":"The impact of tobacco, alcohol, and cannabis use in patients with first-episode psychosis: Data from the national RAISE-ETP study","volume":"13","author":"Oluwoye","year":"2019","journal-title":"Early Interv. 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