{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:18:02Z","timestamp":1777414682194,"version":"3.51.4"},"reference-count":34,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T00:00:00Z","timestamp":1655251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Background: Hip fragility fractures are becoming one of the main health care problems in countries with an aging population. This study aimed to evaluate the clinical characteristics and the usefulness of bone turnover markers in patients with a hip fracture. Methods: In a cohort of 363 patients (84.1 \u00b1 9.2 years) with hip fractures we measured 25-hydroxyvitamin D (25OHD), bone alkaline phosphatase, type I collagen \u03b2 carboxy telopeptide (\u03b2CTX), and parathyroid hormone (PTH). We recorded patients\u2019 Charlson Comorbidity Index (CCI) and previous history of fragility fractures. Results: Vitamin D and PTH levels were inversely correlated (r = \u2212024; p &lt; 0.001). The prevalence of 25OHD deficiency was 57.8%, the PTH levels greater than 65 pg\/mL was in 47.0 %, and in those who had \u03b2CTX values the upper limit was 61.8%. Moreover, 62% of patients with a fragility hip fracture had a history of a previous fracture. The 25OHD serum levels were inversely associated with CCI and a previous fragility fracture. On the contrary, PTH and \u03b2CTX serum levels showed a positive significant correlation with CCI and previous fragility fractures. Conclusion: This study confirmed the usefulness of a bone turnover markers assessment, along with the comorbidities and history of previous fragility fractures in order to better identify the risk of hip fracture.<\/jats:p>","DOI":"10.3390\/ijerph19127362","type":"journal-article","created":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T22:17:01Z","timestamp":1655331421000},"page":"7362","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The Phenotype of Bone Turnover in Patients with Fragility Hip Fracture: Experience in a Fracture Liaison Service Population"],"prefix":"10.3390","volume":"19","author":[{"given":"Carla","family":"Caffarelli","sequence":"first","affiliation":[{"name":"Department of Medicine, Surgery and Neuroscience, Section of Internal Medicine, University of Siena, 53100 Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0684-4197","authenticated-orcid":false,"given":"Nicola","family":"Mondanelli","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Neurosciences, Section of Orthopedics and Traumatology, University of Siena, 53100 Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Crainz","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology, Section of Orthopedics and Traumatology, University Hospital of Siena, 53100 Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Giannotti","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Neurosciences, Section of Orthopedics and Traumatology, University of Siena, 53100 Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Frediani","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Neurosciences, Rheumatology Unit, University of Siena, 53100 Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Gonnelli","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Neuroscience, Section of Internal Medicine, University of Siena, 53100 Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S0140-6736(18)32112-3","article-title":"Osteoporosis","volume":"393","author":"Compston","year":"2019","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/S0140-6736(02)08657-9","article-title":"Epidemiology and outcomes of osteoporotic fractures","volume":"359","author":"Cummings","year":"2002","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1056\/NEJMcp1611090","article-title":"Management of acute hip fracture","volume":"377","author":"Bhandari","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"715.e7","DOI":"10.1016\/j.jamda.2015.05.013","article-title":"Risk of nursing home admission after femoral fracture compared with stroke, myocardial infarction, and pneumonia","volume":"16","author":"Rapp","year":"2015","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1007\/s40520-020-01497-0","article-title":"Updated incidence and costs of hip fractures in elderly Italian population","volume":"32","author":"Piscitelli","year":"2020","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s42000-021-00276-4","article-title":"Bone metabolism subgroups identified as hip fracture patients via clustering","volume":"20","author":"Papakitsou","year":"2021","journal-title":"Hormones"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1007\/s001980200084","article-title":"Does a fracture at one site predict later fractures at other sites? A British cohort study","volume":"13","author":"Leufkens","year":"2002","journal-title":"Osteoporos. Int."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.bone.2004.03.024","article-title":"A meta-analysis of previous fracture and subsequent fracture risk","volume":"35","author":"Kanis","year":"2004","journal-title":"Bone"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1007\/s00223-015-0049-7","article-title":"The Trochanteric Localization is a Mediator of Slower Short-Term Functional Recovery in Overweight and Obese Elderly Women with Recent Hip Fracture: The BREAK Study","volume":"97","author":"Gonnelli","year":"2015","journal-title":"Calcif. Tissue Int."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s00198-012-2090-y","article-title":"Models of care for the secondary prevention of osteoporotic fractures: A systematic review and meta-analysis","volume":"24","author":"Ganda","year":"2013","journal-title":"Osteoporos. Int."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1016\/j.injury.2018.04.014","article-title":"Orthogeriatric co-management-managing frailty as well as fragility","volume":"49","author":"Pioli","year":"2018","journal-title":"Injury"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Swart, K., Van Vilsteren, M., Van Hout, W., Draak, E., Van Der Zwaard, B.C., Van Der Horst, H.E., Hugtenburg, J.G., and Elders, P.J. (2018). Factors related to intennational of bisphosphonate treatment in patients with a high fracture risk in primary care: A qualitative study. BMC Fam. Pract., 19.","DOI":"10.1186\/s12875-018-0828-0"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation","volume":"40","author":"Charlson","year":"1987","journal-title":"J. Chronic. Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e65","DOI":"10.1097\/MLR.0b013e318297429c","article-title":"Why summary comorbidity measures such as the Charlson comorbidity index and Elixhauser score work","volume":"53","author":"Austin","year":"2015","journal-title":"Med. Care"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s11154-019-09532-w","article-title":"Consensus statement from 2nd International Conference on Controversies in Vitamin D","volume":"21","author":"Giustina","year":"2020","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1111\/bcp.13652","article-title":"Vitamin D assays and the definition of hypovitaminosis D: Results from the First International Conference on Controversies in Vitamin D","volume":"84","author":"Sempos","year":"2018","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1007\/s00223-014-9902-3","article-title":"Gender-specific associations of appendicular muscle mass with BMD in elderly Italian subjects","volume":"95","author":"Gonnelli","year":"2014","journal-title":"Calcif. Tissue Int."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1007\/s00198-006-0167-1","article-title":"Vitamin D and intact PTH status in patients with hip fracture","volume":"17","author":"Sakuma","year":"2006","journal-title":"Osteoporos. Int."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.bone.2010.04.610","article-title":"Hip fracture type: Important role of parathyroid hormone (PTH) response to hypovitaminosis D","volume":"47","author":"Fisher","year":"2010","journal-title":"Bone"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s12603-012-0088-y","article-title":"Parathyroid hormone response to severe Vitamin D deficiency is sex associated: An observational study of 571 hip fracture inpatients","volume":"17","author":"Castiglioni","year":"2013","journal-title":"J. Nutr. Health Aging"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1007\/s40618-015-0320-9","article-title":"Parathyroid hormone response to two levels of vitamin D deficiency is associated with high risk of medical problems during hospitalization in patients with hip fracture","volume":"38","author":"Hoyos","year":"2015","journal-title":"J. Endocrinol. Investig."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1007\/s40520-019-01132-7","article-title":"The role of parathyroid hormone (PTH) and Vitamin D in falls and hip fracture type","volume":"31","author":"Dretakis","year":"2019","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1007\/s40520-016-0681-8","article-title":"Prescription of anti-osteoporosis medications after hospitalization for hip fracture: A multicentre Italian survey","volume":"29","author":"Gonnelli","year":"2017","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s00198-012-2011-0","article-title":"Impaired bone mineralization accompanied by low Vitamin D and secondary hyperparathyroidism in patients with femoral neck fracture","volume":"24","author":"Seitz","year":"2013","journal-title":"Osteoporos. Int."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.injury.2018.03.005","article-title":"Usefulness of simple biomarkers at admission as independent indicators and predictors of in-hospital mortality in older hip fracture patients","volume":"49","author":"Fisher","year":"2018","journal-title":"Injury"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1210\/edrv.22.4.0437","article-title":"Vitamin D deficiency and secondary hyperparathyroidism in the elderly: Consequences for bone loss and fractures and therapeutic implications","volume":"22","author":"Lips","year":"2001","journal-title":"Endocr. Rev."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.bone.2007.10.026","article-title":"Severe Vitamin D deficiency in swiss hip fracture patients","volume":"42","author":"Can","year":"2008","journal-title":"Bone"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.maturitas.2014.07.006","article-title":"Microstructural trabecular bone from patients with osteoporotic hip fracture or osteoarthritis: Its relationship with bone mineral density and bone remodelling markers","volume":"79","author":"Montoya","year":"2014","journal-title":"Maturitas"},{"key":"ref_29","first-page":"e49","article-title":"Predictors of Mortality and Refracture in Patients Older than 65 Years with a Proximal Femur Fracture","volume":"1","author":"Guerra","year":"2022","journal-title":"J. Clin. Rheumatol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1007\/s00198-003-1452-x","article-title":"Osteoporotic fracture: Missed opportunity for intervention","volume":"14","author":"Port","year":"2003","journal-title":"Osteoporos. Int."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1097\/BLO.0b013e3180534269","article-title":"Prior fractures are common in patients with subsequent hip fractures","volume":"461","author":"Edwards","year":"2007","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1007\/s00198-012-2119-2","article-title":"The assessment of vertebral fractures in elderly women with recent hip fractures: The BREAK Study","volume":"24","author":"Gonnelli","year":"2013","journal-title":"Osteoporos. Int."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1157\/13109839","article-title":"Prevalence of vertebral fractures in hip fracture patients","volume":"207","author":"Sosa","year":"2007","journal-title":"Rev. Clin. Esp."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"133S","DOI":"10.1016\/8756-3282(95)00490-4","article-title":"Are the aetiologies of cervical and trochanteric hip fractures different?","volume":"18","author":"Mautalen","year":"1996","journal-title":"Bone"}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/12\/7362\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:32:21Z","timestamp":1760139141000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/12\/7362"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,15]]},"references-count":34,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,6]]}},"alternative-id":["ijerph19127362"],"URL":"https:\/\/doi.org\/10.3390\/ijerph19127362","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,15]]}}}