{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T03:25:02Z","timestamp":1790220302848,"version":"4.1.0"},"reference-count":40,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T00:00:00Z","timestamp":1655683200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"SOBI (Swedish Orphan Biovitrum)","award":["200002018"],"award-info":[{"award-number":["200002018"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Some patients with moderate haemophilia (PWMH) report joint damage potentially responsible for gait disorders. Three-dimensional gait analysis (3DGA) is a relevant tool for the identification of complex musculoskeletal impairment. We performed an evaluation with 3DGA of 24 PWMH aged 44.3 \u00b1 16.1 according to their joint status [Haemophilia Joint Health Score (HJHS) &lt; 10 or HJHS \u2265 10] and assessed the correlation with the radiological and clinical parameters. Sixteen had HJHS &lt; 10 (group 1) and eight had HJHS \u2265 10 (group 2). They were compared to 30 healthy subjects of a normative dataset. Both knee and ankle gait variable scores were increased in group 2 compared to the controls (p = 0.02 and p = 0.04, respectively). The PWMH of group 2 had a significant increase in their stance phase, double support duration, and stride width compared to the controls and group 1 (p &lt; 0.01). Very low correlations were found for the ankle gait variable score with the ankle Pettersson sub-score (r2 = 0.250; p = 0.004) and ankle HJHS sub-score (r2 = 0.150; p = 0.04). For the knee, very low correlation was also found between the knee gait variable score and its HJHS sub-score (r2 = 0.290; p &lt; 0.0001). Patients with moderate haemophilia presented a gait alteration in the case of poor lower limb joint status.<\/jats:p>","DOI":"10.3390\/ijerph19127527","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T01:43:27Z","timestamp":1655775807000},"page":"7527","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Gait Alteration Due to Haemophilic Arthropathies in Patients with Moderate Haemophilia"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8139-814X","authenticated-orcid":false,"given":"Alban","family":"Fouasson-Chailloux","sequence":"first","affiliation":[{"name":"Inserm, UMR 1229, RMeS, Regenerative Medicine and Skeleton, Nantes Universit\u00e9, ONIRIS, 44042 Nantes, France"},{"name":"Service de M\u00e9decine Physique et R\u00e9adapatation Locomotrice et Respiratoire, CHU Nantes, Nantes Universit\u00e9, 44093 Nantes, France"},{"name":"Service de M\u00e9decine du Sport, CHU Nantes, Nantes Universit\u00e9, 44093 Nantes, France"},{"name":"Institut R\u00e9gional de M\u00e9decine du Sport, 44093 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6483-9150","authenticated-orcid":false,"given":"Fabien","family":"Leboeuf","sequence":"additional","affiliation":[{"name":"Movement-Interactions-Performance (MIP), EA 4334, CHU Nantes, Nantes Universit\u00e9, 44000 Nantes, France"},{"name":"School of Health & Society, The University of Salford, Salford M6 6PU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Maugars","sequence":"additional","affiliation":[{"name":"Inserm, UMR 1229, RMeS, Regenerative Medicine and Skeleton, Nantes Universit\u00e9, ONIRIS, 44042 Nantes, France"},{"name":"Service de Rhumatologie, CHU Nantes, Nantes Universit\u00e9, 44000 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Trossaert","sequence":"additional","affiliation":[{"name":"Centre R\u00e9gional de Traitement de l\u2019H\u00e9mophilie, CHU Nantes, Nantes Universit\u00e9, 44000 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Menu","sequence":"additional","affiliation":[{"name":"Inserm, UMR 1229, RMeS, Regenerative Medicine and Skeleton, Nantes Universit\u00e9, ONIRIS, 44042 Nantes, France"},{"name":"Service de M\u00e9decine Physique et R\u00e9adapatation Locomotrice et Respiratoire, CHU Nantes, Nantes Universit\u00e9, 44093 Nantes, France"},{"name":"Service de M\u00e9decine du Sport, CHU Nantes, Nantes Universit\u00e9, 44093 Nantes, France"},{"name":"Institut R\u00e9gional de M\u00e9decine du Sport, 44093 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Rannou","sequence":"additional","affiliation":[{"name":"Service de R\u00e9\u00e9ducation et de R\u00e9adaptation de l\u2019Appareil Locomoteur et des Pathologies du Rachis, H\u00f4pitaux Universitaires-Paris Centre, Groupe Hospitalier Cochin, Assistance Publique\u2014H\u00f4pitaux de Paris, 75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6063-9901","authenticated-orcid":false,"given":"Claire","family":"Vinatier","sequence":"additional","affiliation":[{"name":"Inserm, UMR 1229, RMeS, Regenerative Medicine and Skeleton, Nantes Universit\u00e9, ONIRIS, 44042 Nantes, France"},{"name":"UFR Odontologie, CHU Nantes, Nantes Universit\u00e9, 44042 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9rome","family":"Guicheux","sequence":"additional","affiliation":[{"name":"Inserm, UMR 1229, RMeS, Regenerative Medicine and Skeleton, Nantes Universit\u00e9, ONIRIS, 44042 Nantes, France"},{"name":"UFR Odontologie, CHU Nantes, Nantes Universit\u00e9, 44042 Nantes, France"},{"name":"CHU Nantes, PHU4 OTONN, 44093 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Gross","sequence":"additional","affiliation":[{"name":"Movement-Interactions-Performance (MIP), EA 4334, CHU Nantes, Nantes Universit\u00e9, 44000 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Dauty","sequence":"additional","affiliation":[{"name":"Inserm, UMR 1229, RMeS, Regenerative Medicine and Skeleton, Nantes Universit\u00e9, ONIRIS, 44042 Nantes, France"},{"name":"Service de M\u00e9decine Physique et R\u00e9adapatation Locomotrice et Respiratoire, CHU Nantes, Nantes Universit\u00e9, 44093 Nantes, France"},{"name":"Service de M\u00e9decine du Sport, CHU Nantes, Nantes Universit\u00e9, 44093 Nantes, France"},{"name":"Institut R\u00e9gional de M\u00e9decine du Sport, 44093 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1055\/s-0037-1615621","article-title":"Definitions in Hemophilia. Recommendation of the Scientific Subcommittee on Factor VIII and Factor IX of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis","volume":"85","author":"White","year":"2001","journal-title":"Thromb. Haemost."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1053\/j.seminhematol.2015.10.005","article-title":"Advances and Challenges in Hemophilic Arthropathy","volume":"53","author":"Wyseure","year":"2016","journal-title":"Semin. 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Hemost."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1055\/s-0037-1614159","article-title":"Endogenous Clotting Factor Activity and Long-Term Outcome in Patients with Moderate Haemophilia","volume":"84","author":"Fischer","year":"2000","journal-title":"Thromb. Haemost."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1111\/j.1365-2516.2011.02539.x","article-title":"Clinical Severity of Haemophilia A: Does the Classification of the 1950s Still Stand?","volume":"17","author":"Roosendaal","year":"2011","journal-title":"Haemophilia"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1365-2516.2008.01837.x","article-title":"Clinical Outcome of Moderate Haemophilia Compared with Severe and Mild Haemophilia","volume":"15","author":"Fischer","year":"2009","journal-title":"Haemophilia"},{"key":"ref_9","first-page":"s330","article-title":"Outcome in Moderate Haemophilia","volume":"12","author":"Biesma","year":"2014","journal-title":"Blood Transfus. Trasfus. Sangue"},{"key":"ref_10","first-page":"17","article-title":"Non-Severe Haemophilia: Is It Benign?\u2014Insights from the PROBE Study","volume":"17","author":"Noone","year":"2020","journal-title":"Haemophilia"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1111\/hae.14114","article-title":"Joint Health and Treatment Modalities in Nordic Patients with Moderate Haemophilia A and B\u2014The MoHem Study","volume":"26","author":"Berntorp","year":"2020","journal-title":"Haemophilia"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1111\/hae.14279","article-title":"Isokinetic Knee Strength Deficit in Patients with Moderate Haemophilia","volume":"27","author":"Maugars","year":"2021","journal-title":"Haemophilia"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/ejh.13763","article-title":"Pain and Functional Disability amongst Adults with Moderate and Severe Haemophilia from the Irish Personalised Approach to the Treatment of Haemophilia (IPATH) Study","volume":"108","author":"Kennedy","year":"2022","journal-title":"Eur. J. Haematol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.joca.2013.12.014","article-title":"Age-Related Differences in Sagittal-Plane Knee Function at Heel-Strike of Walking Are Increased in Osteoarthritic Patients","volume":"22","author":"Favre","year":"2014","journal-title":"Osteoarthr. Cartil."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.apmr.2011.11.029","article-title":"Gait Differs between Unilateral and Bilateral Knee Osteoarthritis","volume":"93","author":"Creaby","year":"2012","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Fouasson-Chailloux, A., Menu, P., and Dauty, M. (2022). Lower-Limb Arthropathies and Walking: The Use of 3D Gait Analysis as a Relevant Tool in Clinical Practice. Int. J. Environ. Res. Public. Health, 19.","DOI":"10.3390\/ijerph19116785"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1111\/hae.13563","article-title":"Clinical Relevance of 3D Gait Analysis in Patients with Haemophilia","volume":"24","author":"Maugars","year":"2018","journal-title":"Haemophilia"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e323","DOI":"10.1111\/hae.14154","article-title":"3D Gait Analysis, Haemophilia Joint Health Score, Leg Muscle Laterality and Biomarkers of Joint Damage: A Cross-Sectional Comparative Assessment of Haemophilic Arthropathy","volume":"26","author":"Putz","year":"2020","journal-title":"Haemophilia"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1111\/j.1365-2516.2007.01429.x","article-title":"Can Early Subclinical Gait Changes in Children with Haemophilia Be Identified Using the GAITRite Walkway","volume":"13","author":"Bladen","year":"2007","journal-title":"Haemophilia"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1111\/j.1365-2516.2010.02245.x","article-title":"Natural Progression of Blood-Induced Joint Damage in Patients with Haemophilia: Clinical Relevance and Reproducibility of Three-Dimensional Gait Analysis","volume":"16","author":"Lobet","year":"2010","journal-title":"Haemophilia"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e184","DOI":"10.1111\/hae.12920","article-title":"Gait Analysis in Children with Haemophilia: First Italian Experience at the Turin Haemophilia Centre","volume":"22","author":"Forneris","year":"2016","journal-title":"Haemophilia"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.gaitpost.2017.06.391","article-title":"An Open Source Implementation of the Conventional Gait Model in Python","volume":"57","author":"Leboeuf","year":"2017","journal-title":"Gait Posture"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/0021-9290(94)90191-0","article-title":"3-D Attitude Representation of Human Joints: A Standardization Proposal","volume":"27","author":"Woltring","year":"1994","journal-title":"J. Biomech."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.gaitpost.2009.05.020","article-title":"The Gait Profile Score and Movement Analysis Profile","volume":"30","author":"Baker","year":"2009","journal-title":"Gait Posture"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.gaitpost.2011.12.008","article-title":"The Minimal Clinically Important Difference for the Gait Profile Score","volume":"35","author":"Baker","year":"2012","journal-title":"Gait Posture"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/acr.20353","article-title":"Validation of a New Pediatric Joint Scoring System from the International Hemophilia Prophylaxis Study Group: Validity of the Hemophilia Joint Health Score","volume":"63","author":"Feldman","year":"2011","journal-title":"Arthritis Care Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/j.1365-2516.2006.01312.x","article-title":"Hemophilia Joint Health Score Reliability Study","volume":"12","author":"Hilliard","year":"2006","journal-title":"Haemoph. Off. J. World Fed. Hemoph."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.2147\/PPA.S141391","article-title":"Internal Consistency and Item-Total Correlation of Patient-Reported Outcome Instruments and Hemophilia Joint Health Score v2.1 in US Adult People with Hemophilia: Results from the Pain, Functional Impairment, and Quality of Life (P-FiQ) Study","volume":"11","author":"Wang","year":"2017","journal-title":"Patient Prefer. Adherence"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1182\/blood-2012-12-470898","article-title":"Intermediate-Dose versus High-Dose Prophylaxis for Severe Hemophilia: Comparing Outcome and Costs since the 1970s","volume":"122","author":"Fischer","year":"2013","journal-title":"Blood"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/00003086-198006000-00018","article-title":"A Radiologic Classification of Hemophilic Arthropathy","volume":"149","author":"Pettersson","year":"1980","journal-title":"Clin. Orthop."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1111\/j.1365-2516.2012.02909.x","article-title":"Guidelines for the Management of Hemophilia","volume":"19","author":"Srivastava","year":"2013","journal-title":"Haemophilia"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"214156","DOI":"10.1155\/2014\/214156","article-title":"Assessment of Waveform Similarity in Clinical Gait Data: The Linear Fit Method","volume":"2014","author":"Iosa","year":"2014","journal-title":"BioMed Res. Int."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/hae.13677","article-title":"Moderate Haemophilia in Focus","volume":"25","author":"Berntorp","year":"2019","journal-title":"Haemophilia"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e66","DOI":"10.1111\/hae.12001","article-title":"Impact of Multiple Joint Impairments on the Energetics and Mechanics of Walking in Patients with Haemophilia","volume":"19","author":"Lobet","year":"2013","journal-title":"Haemophilia"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.clinbiomech.2012.01.009","article-title":"Impact of Ankle Osteoarthritis on the Energetics and Mechanics of Gait: The Case of Hemophilic Arthropathy","volume":"27","author":"Lobet","year":"2012","journal-title":"Clin. Biomech."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1111\/j.1365-2516.2010.02433.x","article-title":"Body Structure versus Body Function in Haemophilia: The Case of Haemophilic Ankle Arthropathy","volume":"17","author":"Lobet","year":"2011","journal-title":"Haemophilia"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"178","DOI":"10.2478\/raon-2019-0027","article-title":"Diagnostic Accuracy of Haemophilia Early Arthropathy Detection with Ultrasound (HEAD-US): A Comparative Magnetic Resonance Imaging (MRI) Study","volume":"53","author":"Plut","year":"2019","journal-title":"Radiol. Oncol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/hae.13368","article-title":"Reliability and Clinical Features Associated with the IPSG MRI Tibiotalar and Subtalar Joint Scores in Children, Adolescents and Young Adults with Haemophilia","volume":"24","author":"Brunel","year":"2018","journal-title":"Haemophilia"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1160\/TH12-11-0874","article-title":"Development and Definition of a Simplified Scanning Procedure and Scoring Method for Haemophilia Early Arthropathy Detection with Ultrasound (HEAD-US)","volume":"109","author":"Martinoli","year":"2013","journal-title":"Thromb. Haemost."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0140-6736(14)60802-3","article-title":"Osteoarthritis","volume":"386","author":"Palmer","year":"2015","journal-title":"Lancet"}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/12\/7527\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:35:32Z","timestamp":1760139332000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/12\/7527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,20]]},"references-count":40,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,6]]}},"alternative-id":["ijerph19127527"],"URL":"https:\/\/doi.org\/10.3390\/ijerph19127527","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,20]]}}}