{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T05:44:57Z","timestamp":1776059097799,"version":"3.50.1"},"reference-count":46,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T00:00:00Z","timestamp":1656720000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Periodontitis is a multifactorial disease causing inflammatory destruction of supporting structures of the dentition and eventually leading to its loss. This study was designed to evaluate common risk factors for periodontitis and acute coronary syndrome in the study population and demonstrate the systemic impact of periodontitis on the occurrence of acute coronary syndrome. A total of 160 patients (35 female and 125 male) were enrolled in the study. Considering the age range, the largest group of patients (118 patients) was between 55 and 65 years, which accounted for 73.8% of the total study population. There were 35 patients (21.9%) in the age group of 45 to 54 years, while the youngest age group of 35 to 44 years had as many as seven patients. Medical history and physical examination, including periodontal status, were performed. API, PD, CAL, and CPITN were evaluated. Common risk factors for periodontitis and acute coronary syndrome were assessed. The study assessed risk factors such as hypertension, diabetes, dyslipidemia, general health, smoking, height, weight, and hip circumference. In light of the above-described etiopathogenesis of atherosclerotic disease and its association with periodontal disease, it is important to emphasize preventing and treating periodontitis, especially in patients in the so-called high-risk group for cardiovascular disease. Dentists\u2019 introduction of an appropriate prophylactic and therapeutic plan may constitute both primary and secondary prevention of cardiovascular diseases.<\/jats:p>","DOI":"10.3390\/ijerph19138139","type":"journal-article","created":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T22:50:46Z","timestamp":1656888646000},"page":"8139","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Evaluation of Common Factors of Periodontitis and Cardiovascular Disease in Patients with the Acute Coronary Syndrome"],"prefix":"10.3390","volume":"19","author":[{"given":"El\u017cbieta","family":"Dembowska","sequence":"first","affiliation":[{"name":"Departament of Periodontology, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland"},{"name":"Specjalistyczne Centrum Stomatologii El\u017cbieta Dembowska, Bohater\u00f3w Warszawy 11b\/5, 70-370 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7727-6388","authenticated-orcid":false,"given":"Aleksandra","family":"Jaro\u0144","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Gabrysz-Trybek","sequence":"additional","affiliation":[{"name":"Indywidualna Specjalistyczna Praktyka Lekarska Ewa Gabrysz-Trybek, 70-111 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0597-8457","authenticated-orcid":false,"given":"Joanna","family":"Bladowska","sequence":"additional","affiliation":[{"name":"Department of General and Interventional Radiology and Neuroradiology, Wroclaw Medical University, M. Curie-Sk\u0142odowskiej 68, 50-369 Wroc\u0142aw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3900-4901","authenticated-orcid":false,"given":"Grzegorz","family":"Trybek","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/prd.12221","article-title":"Periodontitis: Facts, fallacies and the future","volume":"75","author":"Slots","year":"2017","journal-title":"Periodontol. 2000"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/idj.12630","article-title":"Current Concepts in the Management of Periodontitis","volume":"71","author":"Kwon","year":"2021","journal-title":"Int. Dent. J."},{"key":"ref_3","first-page":"3","article-title":"Risk factors for periodontitis","volume":"7","author":"Sheilesh","year":"2005","journal-title":"J. Int. Acad. Periodontol."},{"key":"ref_4","unstructured":"Banach, J., Dembowska, E., G\u00f3rska, R., Konopka, T., Szymanska, J., Zi\u0119tek, M., and Janczuk, Z. (2004). Praktyczna periodontologia kliniczna, Wyd. 1, Kwintesencja."},{"key":"ref_5","first-page":"671","article-title":"Rola zapalenia w patogenezie mia\u017cd\u017cycy","volume":"58","author":"Banach","year":"2004","journal-title":"Przegl. Epidemiol."},{"key":"ref_6","first-page":"40","article-title":"Overview of risk factor for periodontal disease and implications for diabetes and cardiovasculor disease","volume":"19","author":"Genco","year":"1998","journal-title":"Comp. Cont. Ed. Dent."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/j.1600-0757.1997.tb00199.x","article-title":"Advances inthe pathogenesis of periodontitis: Summary of developments, clinical implications and future directions","volume":"14","author":"Page","year":"1997","journal-title":"Periodontol. 2000"},{"key":"ref_8","unstructured":"Wolf, H., Rateitschak, E.M., and Rateitschak, K.H. (2006). Periodontologia, Wyd. 1 Pol., Czelej."},{"key":"ref_9","unstructured":"Mandecki, T. (2005). Kardiologia. Wyd. 2, PZWL."},{"key":"ref_10","unstructured":"Opolski, G. (2021). Kardiologia. Kompendium, PZWL."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1161\/hc0902.104353","article-title":"Inflammation and atherosclerosis","volume":"105","author":"Libby","year":"2002","journal-title":"Circulation"},{"key":"ref_12","first-page":"147","article-title":"Moleku\u0142y adhezyjne a mia\u017cd\u017cyca i choroba wie\u0144cowa","volume":"60","author":"Goliszek","year":"2003","journal-title":"Przegl. Lek."},{"key":"ref_13","first-page":"1123","article-title":"Periodontal disease and cardiovascular disease","volume":"67","author":"Beck","year":"1996","journal-title":"J. Periodontol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1136\/bmj.306.6879.688","article-title":"Dental disease and risk of coronary heart disease and mortality","volume":"306","author":"DeStefano","year":"1993","journal-title":"Br. Med. J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1093\/clinids\/20.3.588","article-title":"Dental infection and risk of coronary artery disease","volume":"20","author":"Mattila","year":"1995","journal-title":"Clin. Infect. Dis."},{"key":"ref_16","first-page":"426","article-title":"Malattia parodontale e malattia cardiovascolare: Correlazione o semplice coincidenza? [Periodontal disease and cardiovascular disease: Correlation or simple coincidence?]","volume":"98","author":"Guiglia","year":"2007","journal-title":"Recenti. Prog. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1902\/jop.1996.67.10s.1138","article-title":"Effects oral flora on platelets: Possible consequences in cardiovascular disease","volume":"67","author":"Herzberg","year":"1996","journal-title":"J. Periodontol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/prd.12299","article-title":"Periodontal therapy and cardiovascular risk","volume":"83","author":"Orlandi","year":"2020","journal-title":"Periodontol. 2000"},{"key":"ref_19","first-page":"281","article-title":"Development of the World Health Organization (WHO) community periodontal index of treatment needs (CPITN)","volume":"32","author":"Ainamo","year":"1982","journal-title":"Int. Dent. J."},{"key":"ref_20","first-page":"44","article-title":"Klinische Bewertungsverfahren zur Objektivierung der Mundhygiene","volume":"32","author":"Lange","year":"1977","journal-title":"Dtsch Zahnarztl Z"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1902\/jop.2007.060264","article-title":"Case Definitions for Use in Population-Based Surveillance of Periodontitis","volume":"78","author":"Page","year":"2007","journal-title":"J. Periodontol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1600-051X.1977.tb01888.x","article-title":"Experimental transient bacteriemias in human subjects with varying degrees of plaque accumulation and gingival inflammation","volume":"4","author":"Silver","year":"1997","journal-title":"J. Clin. Periodontol."},{"key":"ref_23","first-page":"26","article-title":"Stan przyz\u0119bia i potrzeby lecznicze u pacjent\u00f3w w ostrej fazie choroby niedokrwiennej serca","volume":"6","author":"Czerniuk","year":"2003","journal-title":"Nowa Stomatol."},{"key":"ref_24","first-page":"12","article-title":"Zapalenia przyz\u0119bia a choroby og\u00f3lnoustrojowe-przegl\u0105d pi\u015bmiennictwa","volume":"8","author":"Konopka","year":"2001","journal-title":"Stom. Wsp\u00f3\u0142czesna"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1034\/j.1399-302x.2000.150610.x","article-title":"Porphyromonas gingivalis platelet aggregation activity: Outer membrane vesicles are potent activators of murine platelets","volume":"15","author":"Sharma","year":"2000","journal-title":"Oral Microbiol. Immuno."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/0030-4220(77)90055-X","article-title":"Influence of obesity and hypertension on the severity of periodontitis in rats","volume":"43","author":"Perlstein","year":"1977","journal-title":"Oral Surg. Oral Med. Oral Pathol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1902\/jop.2005.76.10.1721","article-title":"Over weight and obesity as a risk indicator for periodontitis in adults","volume":"76","author":"Susin","year":"2005","journal-title":"J. Periodontol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1902\/jop.2005.76.11-S.2075","article-title":"A proposed model linking inflammation to obesity, diabetes and periodontal infection","volume":"76","author":"Genco","year":"2005","journal-title":"J. Periodontol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/j.1600-051X.2007.01075.x","article-title":"Obesity and periodontitis in 60\u201370 years old men","volume":"34","author":"Linden","year":"2007","journal-title":"J. Clin. Periodontol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1902\/jop.2010.100274","article-title":"Periodontitis and obesity: A study of the Fourth Korean National Health and Nutrition Examination Survey","volume":"82","year":"2011","journal-title":"J. Periodontol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1902\/jop.2010.090594","article-title":"A cohort study on the association between periodontal disease and the development of metabolic syndrome","volume":"81","author":"Merita","year":"2010","journal-title":"J. Periodontol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/j.1600-0528.1993.tb00748.x","article-title":"Stress measures as predictors of periodontal disease a preliminary communication","volume":"21","author":"Freeman","year":"1993","journal-title":"Community Dent. Oral Epidemiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1902\/jop.1999.70.7.711","article-title":"Relationship of stress, distress and inadequate coping behaviours to periodontal disease","volume":"70","author":"Genco","year":"1999","journal-title":"J. Periodontol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1080\/08870449608400264","article-title":"The relationship between marital quality and oral health status","volume":"11","author":"Marcene","year":"1996","journal-title":"Psychol. Health"},{"key":"ref_35","first-page":"370","article-title":"Zale\u017cno\u015b\u0107 mi\u0119dzy stresem a zapaleniem dzi\u0105se\u0142","volume":"9","author":"Borkowska","year":"2011","journal-title":"Porad. Stomatol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s11517-009-0447-y","article-title":"Relationship between salivary Chromogranin-A and stress induced by simulated monotonous driving","volume":"47","author":"Yamakoshi","year":"2008","journal-title":"Med. Biol. Eng. Comput."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"9090","DOI":"10.1073\/pnas.1531903100","article-title":"Chronic stress and age-related increases in the proinflammatory cytokine IL-6","volume":"100","author":"Preacher","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1093\/gerona\/54.9.M434","article-title":"Life Stress, Mood Disturbance, and Elevated Interleukin-6 in Healthy Older Women","volume":"54","author":"Lutgendorf","year":"1999","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_39","first-page":"17","article-title":"Pacjenci z zawa\u0142em mi\u0119\u015bnia sercowego\u2014Charakterystyka grupy w aspekcie stanu przyz\u0119bia i periodontologicznych potrzeb leczniczych","volume":"63","author":"Kurnatowska","year":"2007","journal-title":"Poradnik Stom."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1161\/01.STR.0000085086.50957.22","article-title":"Relationship between periodontal disease, tooth loos and coronary artery plaque: The Oral and Vascular Disease Epidemiology Study (INVEST)","volume":"34","author":"Desvarieux","year":"2003","journal-title":"Stroke"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1161\/01.STR.0000236495.82545.2e","article-title":"Dental and periodontal status and risk for atherosclerosis: The inflammation and carotid artery study dental study","volume":"37","author":"Schillinger","year":"2006","journal-title":"Stroke"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1902\/jop.2010.090680","article-title":"Number of teeth as a predictor of cardiovascular mortality in a cohort of 7674 subjects followed for 12 years","volume":"81","author":"Holmlund","year":"2010","journal-title":"J. Periodontol."},{"key":"ref_43","first-page":"613","article-title":"Ocena stanu przyz\u0119bia u mieszka\u0144c\u00f3w wsi wojew\u00f3dztwa gda\u0144skiego w ageu 35\u201344 lat oraz 60 lat i powy\u017cej","volume":"49","author":"Witek","year":"1996","journal-title":"Czas. Stomat."},{"key":"ref_44","unstructured":"Bochniak, M. (2007). Periodontal Pathological Changes as One of the Possible Risk Factors for Ischemic Disease and Myocardial Infarction. [Ph.D. Thesis, Akademia Medyczna w Gda\u0144sku, Medical Academy in Gda\u0144sk, Faculty of Medicine with Division of Stomatology]."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/j.1600-0765.2004.00766.x","article-title":"Periodontitis as risk factor for acute myocardial infarction. A case control study of Spanish adults","volume":"40","author":"Cueto","year":"2005","journal-title":"J. Periodontal. Res."},{"key":"ref_46","first-page":"130","article-title":"I Wsp.: Brak \u015bwiadomo\u015bci pacjent\u00f3w na temat korelacji pomi\u0119dzy cukrzyc\u0105, chorobami uk\u0142adu sercowo naczyniowego a zapaleniem przyz\u0119bia\u2013problem pacjent\u00f3w czy lekarza?","volume":"15","year":"2010","journal-title":"Nowa Stomatol."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/13\/8139\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:42:06Z","timestamp":1760139726000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/13\/8139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,2]]},"references-count":46,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2022,7]]}},"alternative-id":["ijerph19138139"],"URL":"https:\/\/doi.org\/10.3390\/ijerph19138139","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,2]]}}}