{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T17:35:56Z","timestamp":1783704956100,"version":"3.55.0"},"reference-count":25,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T00:00:00Z","timestamp":1657065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Education","award":["2015R1A03032522"],"award-info":[{"award-number":["2015R1A03032522"]}]},{"name":"Ministry of Education","award":["202015X36-03"],"award-info":[{"award-number":["202015X36-03"]}]},{"name":"Ministry of Health and Welfare","award":["2015R1A03032522"],"award-info":[{"award-number":["2015R1A03032522"]}]},{"name":"Ministry of Health and Welfare","award":["202015X36-03"],"award-info":[{"award-number":["202015X36-03"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>In orthopedics, a number of synthetic bone substitutes are being used for the repair and regeneration of damaged or diseased bone. The nature of the bone substitutes determines the clinical outcome and its application for a range of orthopedic clinical conditions. In this study, we aimed to demonstrate the possible applications of multichannel granular bone substitutes in different types of orthopedic clinical conditions, including bone tumor, fracture, and bone defect with arthroplasty. A clinical investigation on a single patient for every specific type of disease was performed, and patient outcome was evaluated by physical and radiographic observation. Brief physical characterization of the granular bone substitute and in vivo animal model investigation were presented for a comprehensive understanding of the physical characteristics of the granules and of the performance of the bone substitute in a physiological environment, respectively. In all cases, the bone substitute stabilized the bone defect without any complications, and the defect regenerated slowly during the postoperative period. Gradual filling of the defect with the newly regenerated bone was confirmed by radiographic findings, and no adverse effects, such as osteolysis, graft dispersion, and non-union, were observed. Homogeneous bone formation was observed throughout the defect area, showing a three-dimensional bone regeneration. High-strength multichannel granules could be employed as versatile bone substitutes for the treatment of a wide range of orthopedic conditions.<\/jats:p>","DOI":"10.3390\/ijerph19148228","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T05:41:06Z","timestamp":1657086066000},"page":"8228","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Bone Regeneration by Multichannel Cylindrical Granular Bone Substitute for Regeneration of Bone in Cases of Tumor, Fracture, and Arthroplasty"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8777-0603","authenticated-orcid":false,"given":"Ki-Jin","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, Soonchunhyang University Cheonan Hospital, Cheonan 31151, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swapan Kumar","family":"Sarkar","sequence":"additional","affiliation":[{"name":"Institute of Tissue Regeneration, College of Medicine, Soonchunhyang University, Cheonan 31538, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo-Jong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Soonchunhyang University Cheonan Hospital, Cheonan 31151, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo-Ram","family":"Kim","sequence":"additional","affiliation":[{"name":"Institute of Tissue Regeneration, College of Medicine, Soonchunhyang University, Cheonan 31538, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Seok","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Soonchunhyang University Cheonan Hospital, Cheonan 31151, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byong-Taek","family":"Lee","sequence":"additional","affiliation":[{"name":"Institute of Tissue Regeneration, College of Medicine, Soonchunhyang University, Cheonan 31538, Korea"},{"name":"Department of Regenerative Medicine, College of Medicine, Soonchunhyang University, Cheonan 31538, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,6]]},"reference":[{"key":"ref_1","unstructured":"United States Bone and Joint Initiative (2014). 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