{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T03:10:15Z","timestamp":1792379415567,"version":"4.4.0"},"reference-count":44,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2022,7,10]],"date-time":"2022-07-10T00:00:00Z","timestamp":1657411200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Spanish Ministry of Economy and Competitiveness","award":["RTI2018-099574-B-C21"],"award-info":[{"award-number":["RTI2018-099574-B-C21"]}]},{"name":"Spanish Ministry of Economy and Competitiveness","award":["RTI2018-099574-B-C22"],"award-info":[{"award-number":["RTI2018-099574-B-C22"]}]},{"name":"Spanish Ministry of Economy and Competitiveness","award":["FPU19\/03758"],"award-info":[{"award-number":["FPU19\/03758"]}]},{"name":"Spanish Ministry of Economy and Competitiveness","award":["ED481D-2021\/016"],"award-info":[{"award-number":["ED481D-2021\/016"]}]},{"name":"European Regional Development Funds","award":["RTI2018-099574-B-C21"],"award-info":[{"award-number":["RTI2018-099574-B-C21"]}]},{"name":"European Regional Development Funds","award":["RTI2018-099574-B-C22"],"award-info":[{"award-number":["RTI2018-099574-B-C22"]}]},{"name":"European Regional Development Funds","award":["FPU19\/03758"],"award-info":[{"award-number":["FPU19\/03758"]}]},{"name":"European Regional Development Funds","award":["ED481D-2021\/016"],"award-info":[{"award-number":["ED481D-2021\/016"]}]},{"name":"Ministry of Universities","award":["RTI2018-099574-B-C21"],"award-info":[{"award-number":["RTI2018-099574-B-C21"]}]},{"name":"Ministry of Universities","award":["RTI2018-099574-B-C22"],"award-info":[{"award-number":["RTI2018-099574-B-C22"]}]},{"name":"Ministry of Universities","award":["FPU19\/03758"],"award-info":[{"award-number":["FPU19\/03758"]}]},{"name":"Ministry of Universities","award":["ED481D-2021\/016"],"award-info":[{"award-number":["ED481D-2021\/016"]}]},{"name":"Galician Regional Government","award":["RTI2018-099574-B-C21"],"award-info":[{"award-number":["RTI2018-099574-B-C21"]}]},{"name":"Galician Regional Government","award":["RTI2018-099574-B-C22"],"award-info":[{"award-number":["RTI2018-099574-B-C22"]}]},{"name":"Galician Regional Government","award":["FPU19\/03758"],"award-info":[{"award-number":["FPU19\/03758"]}]},{"name":"Galician Regional Government","award":["ED481D-2021\/016"],"award-info":[{"award-number":["ED481D-2021\/016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>The current research focuses on the adsorption\/desorption characteristics of the antibiotics ciprofloxacin (CIP) and trimethoprim (TRI) taking place in 17 agricultural soils, which are studied by means of batch-type experiments. The results show that adsorption was higher for CIP, with Freundlich KF values ranging between 1150 and 5086 Ln \u00b5mol1\u2212n kg\u22121, while they were between 29 and 110 Ln \u00b5mol1\u2212n kg\u22121 in the case of TRI. Other parameters, such as the Langmuir maximum adsorption capacity (qm(ads)), as well as the Kd parameter in the linear model and also the adsorption percentages, follow the same trend as KF. Desorption was lower for CIP (with KF(des) values in the range 1089\u20136234 Ln \u00b5mol1\u2212n kg\u22121) than for TRI (with KF(des) ranging between 26 and 138 Ln \u00b5mol1\u2212n kg\u22121). The higher irreversibility of CIP adsorption was also confirmed by its lower nF(des)\/nF(ads) ratios, compared to TRI. Regarding soil characteristics, it was evidenced that nitrogen and carbon contents, as well as mineral fractions, had the highest influence on the adsorption\/desorption process. These results can be considered relevant as regards the fate of both antibiotics when they reach the environment as pollutants and therefore could be considered in assessment procedures focused on environmental and public health aspects.<\/jats:p>","DOI":"10.3390\/ijerph19148426","type":"journal-article","created":{"date-parts":[[2022,7,10]],"date-time":"2022-07-10T22:48:00Z","timestamp":1657493280000},"page":"8426","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Ciprofloxacin and Trimethoprim Adsorption\/Desorption in Agricultural Soils"],"prefix":"10.3390","volume":"19","author":[{"given":"Luc\u00eda","family":"Rodr\u00edguez-L\u00f3pez","sequence":"first","affiliation":[{"name":"Soil Science and Agricultural Chemistry, Faculty of Sciences, University of Vigo, 32004 Ourense, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanesa","family":"Sant\u00e1s-Miguel","sequence":"additional","affiliation":[{"name":"Soil Science and Agricultural Chemistry, Faculty of Sciences, University of Vigo, 32004 Ourense, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2826-799X","authenticated-orcid":false,"given":"Raquel","family":"Cela-Dablanca","sequence":"additional","affiliation":[{"name":"Department of Soil Science and Agricultural Chemistry, Engineering Polytechnic School, University of Santiago de Compostela, 27002 Lugo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5373-1606","authenticated-orcid":false,"given":"Avelino","family":"N\u00fa\u00f1ez-Delgado","sequence":"additional","affiliation":[{"name":"Department of Soil Science and Agricultural Chemistry, Engineering Polytechnic School, University of Santiago de Compostela, 27002 Lugo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3470-2679","authenticated-orcid":false,"given":"Esperanza","family":"\u00c1lvarez-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Department of Soil Science and Agricultural Chemistry, Engineering Polytechnic School, University of Santiago de Compostela, 27002 Lugo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"P\u00e9rez-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Soil Science and Agricultural Chemistry, Faculty of Sciences, University of Vigo, 32004 Ourense, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9162-1587","authenticated-orcid":false,"given":"Manuel","family":"Arias-Est\u00e9vez","sequence":"additional","affiliation":[{"name":"Soil Science and Agricultural Chemistry, Faculty of Sciences, University of Vigo, 32004 Ourense, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"152864","DOI":"10.1016\/j.scitotenv.2021.152864","article-title":"Pharmaceutical residues in digested sewage sludge: Occurrence, seasonal variation and risk assessment for soil","volume":"817","author":"Ulvi","year":"2022","journal-title":"Sci. Total Environ."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.jhazmat.2018.07.092","article-title":"Human and veterinary antibiotics during composting of sludge or manure: Global perspectives on persistence, degradation, and resistance genes","volume":"359","author":"Ezzariai","year":"2018","journal-title":"J. Hazard. Mater."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jhazmat.2012.07.040","article-title":"Antibiotic resistance gene abundances associated with antibiotics and heavy metals in animal manures and agricultural soils adjacent to feedlots in Shanghai; China","volume":"235\u2013236","author":"Ji","year":"2012","journal-title":"J. Hazard. Mater."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e00125","DOI":"10.1016\/j.teac.2021.e00125","article-title":"Occurrence of pharmaceuticals and their metabolites in sewage sludge and soil: A review on their distribution and environmental risk assessment","volume":"30","author":"Santos","year":"2021","journal-title":"Trends Environ. Anal. Chem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.watres.2012.11.027","article-title":"Urban wastewater treatment plants as hotspots for the release of antibiotics in the environment: A review","volume":"47","author":"Michael","year":"2013","journal-title":"Water Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"101589","DOI":"10.1016\/j.eti.2021.101589","article-title":"Water-soluble polymers with the ability to remove amoxicillin as emerging pollutant from water","volume":"23","author":"Palacio","year":"2021","journal-title":"Environ. Technol. Innov."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"8442","DOI":"10.1007\/s11356-020-10972-0","article-title":"Antibiotics removal from aquatic environments: Adsorption of enrofloxacin, trimethoprim, sulfadiazine, and amoxicillin on vegetal powdered activated carbon","volume":"28","author":"Berges","year":"2020","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"105868","DOI":"10.1016\/j.jece.2021.105868","article-title":"Adsorption and removal of seven antibiotic compounds present in water with the use of biochar derived from the pyrolysis of organic waste feed-stocks","volume":"9","author":"Stylianou","year":"2021","journal-title":"J. Environ. Chem. Eng."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.chemosphere.2017.10.092","article-title":"Fluoroquinolones (FQs) in the environment: A review on their abundance, sorption and toxicity in soil","volume":"191","author":"Riaz","year":"2018","journal-title":"Chemosphere"},{"key":"ref_10","unstructured":"Food and Agriculture Organization of the United Nations (FAO) (2022, June 16). Available online: https:\/\/www.fao.org\/faostat\/en\/#rankings\/commodities_by_country."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1016\/j.envpol.2010.05.023","article-title":"Occurrence and source analysis of typical veterinary antibiotics in manure, soil, vegetables and groundwater from organic vegetable bases, northern China","volume":"158","author":"Hu","year":"2010","journal-title":"Environ. Pollut."},{"key":"ref_12","first-page":"1","article-title":"Antibiotic resistance genes in manure-amended paddy soils across eastern China: Occurrence and influencing factors","volume":"16","author":"Guo","year":"2021","journal-title":"Front. Environ. Sci. Eng."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"108608","DOI":"10.1016\/j.envres.2019.108608","article-title":"Antibiotic resistance gene distribution in agricultural fields and crops. A soil-to-food analysis","volume":"177","author":"Cerqueira","year":"2019","journal-title":"Environ. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.envint.2014.11.020","article-title":"Human health risk assessment of pharmaceuticals and personal care products in plant tissue due to biosolids and manure amendments, and wastewater irrigation","volume":"75","author":"Prosser","year":"2015","journal-title":"Environ. Int."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"151891","DOI":"10.1016\/j.scitotenv.2021.151891","article-title":"Occurrence of antibiotics in waters, removal by microalgae-based systems, and their toxicological effects: A review","volume":"813","author":"Yu","year":"2021","journal-title":"Sci. Total Environ."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.watres.2017.07.004","article-title":"The potential implications of reclaimed wastewater reuse for irrigation on the agricultural environment: The knowns and unknowns of the fate of antibiotics and antibiotic resistant bacteria and resistance genes\u2014A review","volume":"123","author":"Christou","year":"2017","journal-title":"Water Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.chemosphere.2018.09.083","article-title":"Sorption behaviors of antimicrobial and antiparasitic veterinary drugs on subtropical soils","volume":"214","author":"Rath","year":"2018","journal-title":"Chemosphere"},{"key":"ref_18","unstructured":"Tan, K.H. (1996). Soil Sampling, Preparation, and Analysis, Marcel Dekker."},{"key":"ref_19","unstructured":"Bingham, J.M. (1996). Cation exchange capacity and exchange coefficients. Methods of Soil Analysis. Part 3. Chemical Methods, ASA-SSSA."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Sparks, D.L. (1996). Aluminium. Methods of Soil Analysis Part 3. Chemical Methods, ASA-SSSA.","DOI":"10.2136\/sssabookser5.3"},{"key":"ref_21","first-page":"751","article-title":"Photocatalytic oxidation of ciprofloxacin under simulated sunlight","volume":"186","author":"Ali","year":"2010","journal-title":"J. Hazard. Mater."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"136118","DOI":"10.1016\/j.scitotenv.2019.136118","article-title":"A review of the occurrence of selected micropollutants and microorganisms in different raw and treated manure\u2014Environmental risk due to antibiotics after application to soil","volume":"707","author":"Ghirardini","year":"2019","journal-title":"Sci. Total Environ."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.scitotenv.2014.12.088","article-title":"Pharmaceuticals\u2019 sorptions relative to properties of thirteen different soils","volume":"511","author":"Grabic","year":"2015","journal-title":"Sci. Total Environ."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Rodr\u00edguez-L\u00f3pez, L., Cela-Dablanca, R., N\u00fa\u00f1ez-Delgado, A., \u00c1lvarez-Rodr\u00edguez, E., Fern\u00e1ndez-Calvi\u00f1o, D., and Arias-Est\u00e9vez, M. (2021). Photodegradation of Ciprofloxacin, Clarithromycin and Trimethoprim: Influence of pH and Humic Acids. Molecules, 26.","DOI":"10.3390\/molecules26113080"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/0021-9797(74)90252-5","article-title":"A general treatment and classification of the solute adsorption isotherm. I. Theoretical","volume":"47","author":"Giles","year":"1974","journal-title":"J. Colloid Interface Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.chemosphere.2013.03.018","article-title":"Sorption of fluoroquinolones and sulfonamides in 13 Brazilian soils","volume":"92","author":"Leal","year":"2013","journal-title":"Chemosphere"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/j.chemosphere.2010.06.012","article-title":"Competitive sorption and desorption behavior for the three fluoroquinolone antibiotics in a wastewater treatment wetland soil","volume":"80","author":"Conkle","year":"2010","journal-title":"Chemosphere"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s11270-007-9580-0","article-title":"Analysis and Sorption Behavior of Fluoroquinolones in Solid Matrices","volume":"190","author":"Uslu","year":"2007","journal-title":"Water Air Soil Pollut."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1021\/jf960215l","article-title":"Binding of Fluoroquinolone Carboxylic Acid Derivatives to Clay Minerals","volume":"45","author":"Nowara","year":"1997","journal-title":"J. Agric. Food Chem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s11783-015-0801-2","article-title":"Adsorption behavior of antibiotic in soil environment: A critical review","volume":"9","author":"Wang","year":"2015","journal-title":"Front. Environ. Sci. Eng."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.geoderma.2009.03.007","article-title":"pH-dependent ciprofloxacin sorption to soils: Interaction mechanisms and soil factors influencing sorption","volume":"151","author":"Vasudevan","year":"2009","journal-title":"Geoderma"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.indcrop.2018.10.051","article-title":"Adsorption of ciprofloxacin from water by pretreated oat hulls: Equilibrium, kinetic, and thermodynamic studies","volume":"127","author":"Movasaghi","year":"2018","journal-title":"Ind. Crop. Prod."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.jcis.2015.08.050","article-title":"Adsorption behavior and mechanisms of ciprofloxacin from aqueous solution by ordered mesoporous carbon and bamboo-based carbon","volume":"460","author":"Peng","year":"2015","journal-title":"J. Colloid Interface Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.scitotenv.2018.09.005","article-title":"Retention-release of ciprofloxacin and azithromycin in biosolids and biosolids-amended soils","volume":"650","author":"Sidhu","year":"2019","journal-title":"Sci. Total Environ."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1897\/08-587.1","article-title":"Estimating the sorption of pharmaceuticals based on their pharmacological distribution","volume":"28","author":"Williams","year":"2009","journal-title":"Environ. Toxicol. Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"5827","DOI":"10.1007\/s11356-014-2493-8","article-title":"Sorption-desorption and transport of trimethoprim and sulfonamide antibiotics in agricultural soil: Effect of soil type, dissolved organic matter, and pH","volume":"21","author":"Zhang","year":"2014","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.scitotenv.2014.10.117","article-title":"Joint antibacterial activity of soil-adsorbed antibiotics trimethoprim and sulfamethazine","volume":"506\u2013507","author":"Peng","year":"2015","journal-title":"Sci. Total Environ."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.envpol.2016.07.039","article-title":"Sim-ultaneous sorption of four ionisable pharmaceuticals in different horizons of three soil types","volume":"218","author":"Golovko","year":"2016","journal-title":"Environ. Pollut."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"133038","DOI":"10.1016\/j.chemosphere.2021.133038","article-title":"Sorption and desorption behavior of four antibiotics at concentrations simulating wastewater reuse in agricultural and forested soils","volume":"289","author":"Franklin","year":"2022","journal-title":"Chemosphere"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.clay.2014.06.015","article-title":"Equilibrium and kinetic adsorption of drugs on bentonite: Presence of surface active agents effect","volume":"101","author":"Salihi","year":"2014","journal-title":"Appl. Clay Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"110584","DOI":"10.1016\/j.ecoenv.2020.110584","article-title":"Estimation of adsorption\/desorption Freundlich\u2019s affinity coefficients for oxytetracycline and chloro-tetracycline from soil properties: Experimental data and pedotransfer functions","volume":"196","year":"2020","journal-title":"Ecotox. Environ. Safe."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.chemosphere.2019.06.121","article-title":"Adsorption\/desorption and transport of sulfadiazine, sulfachloropyridazine, and sulfamethazine, in acid agricultural soils","volume":"234","year":"2019","journal-title":"Chemosphere"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"112753","DOI":"10.1016\/j.envres.2022.112753","article-title":"Relevance of sorption in bio-reduction of amoxicillin taking place in forest and crop soils","volume":"208","author":"Barreiro","year":"2022","journal-title":"Environ. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1260\/0263-6174.32.2-3.153","article-title":"Sorption of Enrofloxacin and Ciprofloxacin in Agricultural Soils: Effect of Organic Matter","volume":"32","author":"Medeiros","year":"2014","journal-title":"Adsorpt. Sci. Technol."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/14\/8426\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:47:33Z","timestamp":1760140053000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/14\/8426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,10]]},"references-count":44,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2022,7]]}},"alternative-id":["ijerph19148426"],"URL":"https:\/\/doi.org\/10.3390\/ijerph19148426","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,10]]}}}