{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:45:08Z","timestamp":1788583508681,"version":"build-2803163510"},"reference-count":27,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T00:00:00Z","timestamp":1657670400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Korea Health Industry Development Institute (KHIDI)","award":["HI20C2082"],"award-info":[{"award-number":["HI20C2082"]}]},{"name":"Korea Health Industry Development Institute (KHIDI)","award":["20012462"],"award-info":[{"award-number":["20012462"]}]},{"DOI":"10.13039\/501100003710","name":"Ministry of Health &amp; Welfare, Korea","doi-asserted-by":"publisher","award":["HI20C2082"],"award-info":[{"award-number":["HI20C2082"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Ministry of Health &amp; Welfare, Korea","doi-asserted-by":"publisher","award":["20012462"],"award-info":[{"award-number":["20012462"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003052","name":"Industrial Technology Innovation Program","doi-asserted-by":"publisher","award":["HI20C2082"],"award-info":[{"award-number":["HI20C2082"]}],"id":[{"id":"10.13039\/501100003052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003052","name":"Industrial Technology Innovation Program","doi-asserted-by":"publisher","award":["20012462"],"award-info":[{"award-number":["20012462"]}],"id":[{"id":"10.13039\/501100003052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Background: Falls are common in older adults and increase in recent years. This study aimed to examine the risk of falls associated with long-acting benzodiazepines (BZDs) or tricyclic antidepressants (TCAs) use in community-dwelling older adults. Methods: A nationwide population-based case\u2013crossover design was used. We screened information on 6,370,275 fall or fall fracture cases among community-dwelling elderly patients from the database of the national health insurance data warehouse in South Korea. We extracted the data of elderly patients who visited the hospital for a fall and were diagnosed with the first fall or fall fracture after prescription of long-acting BZDs (n = 1805) or TCAs (n = 554). The study used conditional logistic regression analysis to analyze the associations and stratified analysis by gender and age group to control for their confounding effects. Results: Risk of falls or fall fractures increased by more than two times after taking long-acting BZDs (odds ratio [OR] = 2.16; 95% confidence interval [CI] = 1.85\u20132.52) or TCAs (OR = 2.13; 95% CI = 1.62\u20132.83). The longer the prescription period of both, the higher the risk of falls or fall fractures was (\u226549 days for long-acting BZDs vs. \u2265 56 days for TCAs). Conclusions: Long-acting BZDs or TCAs should be avoided or prescribed for a shorter duration based on these adverse effects. Health care providers should focus on fall prevention practices in older adults who take such drugs.<\/jats:p>","DOI":"10.3390\/ijerph19148564","type":"journal-article","created":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T22:06:00Z","timestamp":1657749960000},"page":"8564","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Risk of Falls Associated with Long-Acting Benzodiazepines or Tricyclic Antidepressants Use in Community-Dwelling Older Adults: A Nationwide Population-Based Case\u2013Crossover Study"],"prefix":"10.3390","volume":"19","author":[{"given":"Inyoung","family":"Na","sequence":"first","affiliation":[{"name":"Graduate School, Kyung Hee University, Seoul 02447, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyoung","family":"Seo","sequence":"additional","affiliation":[{"name":"Graduate School, Kyung Hee University, Seoul 02447, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunjin","family":"Park","sequence":"additional","affiliation":[{"name":"Graduate School, Kyung Hee University, Seoul 02447, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1483-0633","authenticated-orcid":false,"given":"Jia","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Nursing Science, Kyung Hee University, Seoul 02447, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"875","DOI":"10.15585\/mmwr.mm6927a5","article-title":"Trends in nonfatal falls and fall-related injuries among adults aged \u2265 65 years\u2014United States, 2012\u20132018","volume":"69","author":"Moreland","year":"2020","journal-title":"MMWR Morb. 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