{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:13:51Z","timestamp":1787508831342,"version":"build-2736575974"},"reference-count":128,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T00:00:00Z","timestamp":1657929600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"RTI Global Gender Center and by the National Institute on Drug Abuse","award":["R01DA049612"],"award-info":[{"award-number":["R01DA049612"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Heavy alcohol consumption and other drug use are prominent across Africa and increase the risk of exposure to violence, HIV acquisition, and other life-threatening injuries. This review synthesizes evidence on alcohol and other drug (AOD) interventions in Africa; evaluates the differences between interventions that do and do not specifically target populations that use AODs; and highlights the impact of comprehensive vs. brief interventions and those that address syndemic issues from a gender and contextualized lens. Literature searches were conducted to identify research outcomes of randomized interventions published between January 2010 and May 2022 that address AOD use in Africa. Thirty-five full-text articles were included in this review. Most of the identified research studies were concentrated in a few countries. Most studies were conducted in South Africa. Many of the studies comprised brief interventions. However, the most comprehensive interventions were the most effective for AOD outcomes. Several studies indicated the importance of addressing AOD use alongside gender-based violence, mental health needs, gender roles, and other social determinants that affect health outcomes. Intervening on AOD use and addressing social determinants from a gender and contextually relevant perspective is essential to ensuring the long-term health and well-being of people in Africa.<\/jats:p>","DOI":"10.3390\/ijerph19148661","type":"journal-article","created":{"date-parts":[[2022,7,17]],"date-time":"2022-07-17T22:57:06Z","timestamp":1658098626000},"page":"8661","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Gender and Context Matter: Behavioral and Structural Interventions for People Who Use Alcohol and Other Drugs in Africa"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5146-6463","authenticated-orcid":false,"given":"Wendee M.","family":"Wechsberg","sequence":"first","affiliation":[{"name":"Substance Use, Gender and Applied Research Program, RTI International, Research Triangle Park, NC 27709, USA"},{"name":"Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA"},{"name":"Department of Psychology, North Carolina State University, Raleigh, NC 27695, USA"},{"name":"Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC 27708, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isa","family":"van der Drift","sequence":"additional","affiliation":[{"name":"Substance Use, Gender and Applied Research Program, RTI International, Research Triangle Park, NC 27709, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittni N.","family":"Howard","sequence":"additional","affiliation":[{"name":"Substance Use, Gender and Applied Research Program, RTI International, Research Triangle Park, NC 27709, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0235-6716","authenticated-orcid":false,"given":"Bronwyn","family":"Myers","sequence":"additional","affiliation":[{"name":"Alcohol Tobacco and Other Drug Research Unit, South African Medical Research Council, Cape Town 7580, South Africa"},{"name":"Department of Psychiatry and Mental Health, University of Cape Town, Cape Town 7701, South Africa"},{"name":"Curtin enAble Institute, Faculty of Health Sciences, Curtin University, Perth 6102, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicia A.","family":"Browne","sequence":"additional","affiliation":[{"name":"Substance Use, Gender and Applied Research Program, RTI International, Research Triangle Park, NC 27709, USA"},{"name":"Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney Peasant","family":"Bonner","sequence":"additional","affiliation":[{"name":"Substance Use, Gender and Applied Research Program, RTI International, Research Triangle Park, NC 27709, USA"},{"name":"Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5400-0565","authenticated-orcid":false,"given":"Tara","family":"Carney","sequence":"additional","affiliation":[{"name":"Alcohol Tobacco and Other Drug Research Unit, South African Medical Research Council, Cape Town 7580, South Africa"},{"name":"Department of Psychiatry and Mental Health, University of Cape Town, Cape Town 7701, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Ndirangu","sequence":"additional","affiliation":[{"name":"Substance Use, Gender and Applied Research Program, RTI International, Research Triangle Park, NC 27709, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3882-2953","authenticated-orcid":false,"given":"Yukiko","family":"Washio","sequence":"additional","affiliation":[{"name":"Substance Use, Gender and Applied Research Program, RTI International, Research Triangle Park, NC 27709, USA"},{"name":"Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19122, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,16]]},"reference":[{"key":"ref_1","first-page":"E1","article-title":"Social and cultural contexts of alcohol use","volume":"38","author":"Sudhinaraset","year":"2015","journal-title":"Alcohol Res. 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