{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:06:25Z","timestamp":1783112785147,"version":"3.54.6"},"reference-count":38,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2022,7,24]],"date-time":"2022-07-24T00:00:00Z","timestamp":1658620800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Tokyo Metropolitan Institute of Gerontology and JSPS KAKENHI","doi-asserted-by":"publisher","award":["20K11327"],"award-info":[{"award-number":["20K11327"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Inflammatory responses contribute to physical decline in older adults. Clinical studies have shown that the neutrophil-to-lymphocyte ratio (NLR), a marker of inflammation, is associated with physical decline. However, its association with physical function in community-dwelling older people is still unclear. Hence, we used cross-sectional data to investigate the relationship between NLR and physical function in community-dwelling older adults. Specifically, we analyzed data corresponding to 818 individuals (336 men and 482 women) aged \u2265 75 years, all of whom participated in comprehensive health examinations, including face-to-face interviews, biochemical analyses, and physical function tests. Using these data, we performed multivariable logistic regression analysis to assess the relationship between NLR and physical function, adjusting for sex, age, education, alcohol consumption, smoking, instrumental activity of daily living, body mass index, chronic disease, physical activity, serum albumin level, and depressive mood. The results showed that a higher NLR was associated with a lower grip strength, lower knee extension strength, and slower walking speed. Importantly, the relationship between NLR and physical function was maintained after adjusting for the confounding factors. Thus, we showed a significant association between NLR and physical function, supporting the use of NLR as a marker of physical function in community-dwelling older adults.<\/jats:p>","DOI":"10.3390\/ijerph19158996","type":"journal-article","created":{"date-parts":[[2022,7,24]],"date-time":"2022-07-24T22:49:02Z","timestamp":1658702942000},"page":"8996","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Association between Neutrophil-to-Lymphocyte Ratio and Physical Function in Older Adults: A Community-Based Cross-Sectional Study in Japan"],"prefix":"10.3390","volume":"19","author":[{"given":"Yuko","family":"Yoshida","sequence":"first","affiliation":[{"name":"Tokyo Metropolitan Institute of Gerontology, Tokyo 173-0015, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2680-7366","authenticated-orcid":false,"given":"Hajime","family":"Iwasa","sequence":"additional","affiliation":[{"name":"Tokyo Metropolitan Institute of Gerontology, Tokyo 173-0015, Japan"},{"name":"Department of Public Health, School of Medicine, Fukushima Medical University, Fukushima 960-1295, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hunkyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Tokyo Metropolitan Institute of Gerontology, Tokyo 173-0015, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Tokyo Metropolitan Institute of Gerontology, Tokyo 173-0015, Japan"},{"name":"Institute of Gerontology, J. F. Oberlin University, Tokyo 194-0294, Japan"},{"name":"National Center for Geriatrics and Gerontology, Obu 474-8511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1093\/ageing\/afu169","article-title":"Changes in gait performance over several years are associated with recurrent falls status in community-dwelling older women at high risk of fracture","volume":"44","author":"Scott","year":"2015","journal-title":"Age Ageing"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Chou, M.Y., Nishita, Y., Nakagawa, T., Tange, C., Tomida, M., Shimokata, H., Otsuka, R., Chen, L.K., and Arai, H. (2019). Role of gait speed and grip strength in predicting 10-year cognitive decline among community-dwelling older people. 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