{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:23:58Z","timestamp":1791908638563,"version":"4.3.4"},"reference-count":71,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T00:00:00Z","timestamp":1658793600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Ministry of Science and Technology, Executive Yuan, Taiwan","award":["MOST 111-2314-B-075-045"],"award-info":[{"award-number":["MOST 111-2314-B-075-045"]}]},{"name":"The Ministry of Science and Technology, Executive Yuan, Taiwan","award":["MOST 110-2314-B-075-016-MY3"],"award-info":[{"award-number":["MOST 110-2314-B-075-016-MY3"]}]},{"name":"The Ministry of Science and Technology, Executive Yuan, Taiwan","award":["V110C-082"],"award-info":[{"award-number":["V110C-082"]}]},{"name":"The Ministry of Science and Technology, Executive Yuan, Taiwan","award":["VGH111C-103"],"award-info":[{"award-number":["VGH111C-103"]}]},{"name":"The Ministry of Science and Technology, Executive Yuan, Taiwan","award":["VGH111A-009"],"award-info":[{"award-number":["VGH111A-009"]}]},{"name":"Taipei Veterans General Hospital","award":["MOST 111-2314-B-075-045"],"award-info":[{"award-number":["MOST 111-2314-B-075-045"]}]},{"name":"Taipei Veterans General Hospital","award":["MOST 110-2314-B-075-016-MY3"],"award-info":[{"award-number":["MOST 110-2314-B-075-016-MY3"]}]},{"name":"Taipei Veterans General Hospital","award":["V110C-082"],"award-info":[{"award-number":["V110C-082"]}]},{"name":"Taipei Veterans General Hospital","award":["VGH111C-103"],"award-info":[{"award-number":["VGH111C-103"]}]},{"name":"Taipei Veterans General Hospital","award":["VGH111A-009"],"award-info":[{"award-number":["VGH111A-009"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Polycystic ovary syndrome (PCOS) is a common metabolic problem in women of reproductive age. Evidence suggests pregnant women with PCOS may have a higher risk of the development of adverse pregnancy outcomes; however, the relationship between pre-pregnancy overweight\/obesity and pregnancy outcomes in women with PCOS remains uncertain. We try to clarify the relationship between pre-pregnancy overweight\/obesity and subsequent pregnancy outcomes. Therefore, we conducted this systematic review and meta-analysis. We used the databases obtained from the PubMed, Embase, Web of Science, and Cochrane databases, plus hand-searching, to examine the association between pre-pregnancy overweightness\/obesity and pregnancy outcomes in women with PCOS from inception to 4 February 2022. A total of 16 cohort studies, including 14 retrospective cohort studies (n = 10,496) and another two prospective cohort studies (n = 818), contributed to a total of 11,314 women for analysis. The meta-analysis showed significantly increased odds of miscarriage rate in PCOS women whose pre-pregnancy body mass index (BMI) is above overweight (OR 1.71 [95% CI 1.38\u20132.11]) or obese (OR 2.00 [95% CI 1.38\u20132.90]) under a random effect model. The tests for subgroup difference indicated the increased risk was consistent, regardless which body mass index cut-off for overweight (24 or 25 kg\/m2) or obesity (28 and 30 kg\/m2) was used. With the same strategies, we found that pregnant women in the control group significantly increased live birth rate compared with those pregnant women with PCOS as well as pre-pregnancy overweight\/obesity (OR 0.79 [95% CI 0.71\u20130.89], OR 0.78 [95% CI 0.67\u20130.91]). By contrast, we did not find any association between PCOS women with pre-pregnancy overweight\/obesity and preterm birth. Based on the aforementioned findings, the main critical factor contributing to a worse pregnancy outcome may be an early fetal loss in these PCOS women with pre-pregnancy overweight\/obesity. Since PCOS women with pre-pregnancy overweightness\/obesity were associated with worse pregnancy outcomes, we supposed that weight reduction before attempting pregnancy in the PCOS women with pre-pregnancy overweightness\/obesity may improve the subsequent pregnancy outcomes.<\/jats:p>","DOI":"10.3390\/ijerph19159094","type":"journal-article","created":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T22:03:42Z","timestamp":1658873022000},"page":"9094","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Association between Pre-Pregnancy Overweightness\/Obesity and Pregnancy Outcomes in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"19","author":[{"given":"Szu-Ting","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan"},{"name":"Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"},{"name":"Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8233-5493","authenticated-orcid":false,"given":"Chia-Hao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan"},{"name":"Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"},{"name":"Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Hsiang","family":"Ma","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"},{"name":"Department of Dermatology, Taipei Veterans General Hospital, Taipei 112, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Hsun","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan"},{"name":"Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"},{"name":"Department of Nursing, Taipei Veterans General Hospital, Taipei 112, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Jen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan"},{"name":"Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"},{"name":"Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Ling","family":"Lee","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"},{"name":"Department of Medicine, Cheng-Hsin General Hospital, Taipei 112, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6048-8541","authenticated-orcid":false,"given":"Peng-Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan"},{"name":"Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"},{"name":"Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"},{"name":"Department of Medical Research, China Medical University Hospital, Taichung 404, Taiwan"},{"name":"Female Cancer Foundation, Taipei 104, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1056\/NEJMcp1514916","article-title":"Polycystic Ovary Syndrome","volume":"375","author":"McCartney","year":"2016","journal-title":"N. 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