{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:18:21Z","timestamp":1788412701250,"version":"build-2803163510"},"reference-count":30,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T00:00:00Z","timestamp":1659484800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior\u2014Brazil (CAPES)","award":["Finance Code 001"],"award-info":[{"award-number":["Finance Code 001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>The Zika virus was responsible for an outbreak between 2015 and 2016 in Brazil: an alarming public health problem of international relevance. The Congenital Zika Syndrome (CZS) is often associated with manifestations that are responsible for cognitive and motor development delays and behavioral disorders. Thus, we aimed to characterize the clinical-epidemiological and familial context of those children and to identify factors associated with the risk of behavioral disorders using the Survey of Well-Being of Young Children questionnaire (SWYC). In total, 52 children diagnosed with CZS were evaluated. Logistic regressions were employed to assess predictive variables for behavioral alteration. Eighteen (35%) of the children presented a risk of behavioral alteration. Children born normocephalic were 36-fold more likely to present behavioral alteration (95% CI: 3.82 to 337.92, p = 0.002). Children with hearing and visual impairments showed reduced risks. In total, 35% percent of families reported food insecurity and 21% were at risk for maternal depression. Our findings suggest better social interactions and conditions to externalize reactions for children with CZS born normocephalic. The continuous assessment of these children and families may identify conditions associated with behavioral alteration and psychosocial vulnerabilities that help in decision-making, therefore optimizing patient\u2013family interactions.<\/jats:p>","DOI":"10.3390\/ijerph19159554","type":"journal-article","created":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T20:52:01Z","timestamp":1659559921000},"page":"9554","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Factors Associated with Behavioral Disorders in Children with Congenital Zika Syndrome and Their Families\u2014A Cross-Sectional Study"],"prefix":"10.3390","volume":"19","author":[{"given":"N\u00edvia Maria Rodrigues","family":"Arrais","sequence":"first","affiliation":[{"name":"Pediatrics Department, Universidade Federal do Rio Grande do Norte, Natal 59077-010, Brazil"},{"name":"Pediatrics Department, Universidade Federal de S\u00e3o Paulo\u2014UNIFESP, Sao Paulo 04021-001, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia Rodrigues Souza","family":"Maia","sequence":"additional","affiliation":[{"name":"Pediatrics Department, Universidade Federal do Rio Grande do Norte, Natal 59077-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8027-820X","authenticated-orcid":false,"given":"Nath\u00e1lia Allana","family":"de Amorim Rodrigues","sequence":"additional","affiliation":[{"name":"Physical Therapy Department, Universidade Federal do Rio Grande do Norte, Natal 59077-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafaela Silva","family":"Moreira","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Universidade Federal de Santa Catarina, Ararangua 88905-120, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria Azevedo","family":"de Almeida","sequence":"additional","affiliation":[{"name":"Physical Therapy Department, Universidade Federal do Rio Grande do Norte, Natal 59077-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6226-2837","authenticated-orcid":false,"given":"Silvana Alves","family":"Pereira","sequence":"additional","affiliation":[{"name":"Pediatrics Department, Universidade Federal do Rio Grande do Norte, Natal 59077-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Isabel","family":"de Moraes Pinto","sequence":"additional","affiliation":[{"name":"Pediatrics Department, Universidade Federal de S\u00e3o Paulo\u2014UNIFESP, Sao Paulo 04021-001, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Fran\u00e7a TL, B.D., Medeiros, W.R., Souza, N.L.D., Longo, E., Pereira, S.A., Fran\u00e7a TB, D.O., and Sousa, K.G. 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