{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:40:18Z","timestamp":1787312418535,"version":"build-2736575974"},"reference-count":34,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T00:00:00Z","timestamp":1660521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"9\u00b0 Research Prize of Physiotherapy from the Universidad Pontificia de Comillas (Spain)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>The aim of this study was to assess the effectiveness of microcurrent therapy for healing pressure ulcers in aged people. A multicentric, randomized clinical trial was designed with a sham stimulation control. The experimental group received an intervention following a standardized protocol for curing ulcers combined with 10 h of microcurrent therapy daily for 25 days. The sham group received the same curing protocol plus a sham microcurrent stimulation. The studied healing-related variables were the Pressure Ulcer Scale for Healing (PUSH) and the surface, depth, grade, and number of ulcers that healed completely. Three evaluations were conducted: pre-intervention (T1), 14 days following the start of the intervention (T2), and 1 day after the intervention was completed (T3). In total, 30 participants met the inclusion criteria (n = 15 in each group). The improvement in the PUSH at T2 and T3 was 16.8% (CI95% 0.5\u201333.1) and 25.3% (CI95% 7.6\u201343.0) greater in the experimental group versus the sham control, respectively. The reduction in the wound area at T2 and T3 was 20.1% (CI95% 5.2\u201335.0) and 28.6% (CI95% 11.9\u201345.3) greater in the experimental group versus the control, respectively. Microcurrent therapy improves the healing of pressure ulcers in older adults, both quantitatively and qualitatively.<\/jats:p>","DOI":"10.3390\/ijerph191610045","type":"journal-article","created":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T03:33:20Z","timestamp":1660534400000},"page":"10045","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effectiveness of Microcurrent Therapy for Treating Pressure Ulcers in Older People: A Double-Blind, Controlled, Randomized Clinical Trial"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8760-3490","authenticated-orcid":false,"given":"Juan","family":"Avenda\u00f1o-Coy","sequence":"first","affiliation":[{"name":"Faculty of Physiotherapy and Nursing of Toledo, University of Castilla-La Mancha, 45071 Toledo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1298-6976","authenticated-orcid":false,"given":"Noelia M.","family":"Mart\u00edn-Espinosa","sequence":"additional","affiliation":[{"name":"Faculty of Physiotherapy and Nursing of Toledo, University of Castilla-La Mancha, 45071 Toledo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Ladri\u00f1\u00e1n-Maestro","sequence":"additional","affiliation":[{"name":"Rest Home Montes de Toledo, 45460 Manzaneque, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5542-4105","authenticated-orcid":false,"given":"Julio","family":"G\u00f3mez-Soriano","sequence":"additional","affiliation":[{"name":"Faculty of Physiotherapy and Nursing of Toledo, University of Castilla-La Mancha, 45071 Toledo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Isabel","family":"Su\u00e1rez-Miranda","sequence":"additional","affiliation":[{"name":"Nursing Home San Diego, 45600 Talavera de la Reina, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4308-7340","authenticated-orcid":false,"given":"Purificaci\u00f3n","family":"L\u00f3pez-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Faculty of Physiotherapy and Nursing of Toledo, University of Castilla-La Mancha, 45071 Toledo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"174","DOI":"10.4172\/2329-9126.1000174","article-title":"Pressure Ulcers in the Elderly, as a Public Health Problem","volume":"2","author":"Menzel","year":"2014","journal-title":"J. Gen. Pract."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"McGinnis, E., Briggs, M., Collinson, M., Wilson, L., Dealey, C., Brown, J., and Nixon, J. (2014). Pressure ulcer related pain in community populations: A prevalence survey. BMC Nurs., 13.","DOI":"10.1186\/1472-6955-13-16"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1111\/j.1532-5415.2009.02307.x","article-title":"Impact of Pressure Ulcers on Quality of Life in Older Patients: A Systematic Review","volume":"57","author":"Gorecki","year":"2009","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"50","DOI":"10.7748\/ns.30.16.50.s46","article-title":"Pressure ulcer prevention in frail older people","volume":"30","author":"Barry","year":"2015","journal-title":"Nurs. Stand."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.12968\/jowc.2017.26.Sup4.S4","article-title":"Cost-of-illness studies in chronic ulcers: A systematic review","volume":"26","author":"Chan","year":"2017","journal-title":"J. Wound Care"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/wrr.12134","article-title":"The mechanisms and evidence of efficacy of electrical stimulation for healing of pressure ulcer: A systematic review","volume":"22","author":"Kawasaki","year":"2014","journal-title":"Wound Repair Regen."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"370","DOI":"10.7326\/M14-1568","article-title":"Treatment of pressure ulcers: A clinical practice guideline from the American College of Physicians","volume":"162","author":"Qaseem","year":"2015","journal-title":"Ann. Intern. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1089\/wound.2013.0446","article-title":"Clinical Trials Involving Biphasic Pulsed Current, MicroCurrent, and\/or Low-Intensity Direct Current","volume":"3","author":"Houghton","year":"2014","journal-title":"Adv. Wound Care"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.semcdb.2008.12.009","article-title":"Electrical fields in wound healing\u2014An overriding signal that directs cell migration","volume":"20","author":"Zhao","year":"2009","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1177\/026119290102900611","article-title":"Electrical Stimulation of Transforming Growth Factor-\u03b21 Secretion by Human Dermal Fibroblasts and the U937 Human Monocytic Cell Line","volume":"29","author":"Todd","year":"2001","journal-title":"Altern. Lab. Anim."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1007\/BF02877766","article-title":"Ultra-low microcurrent therapy: A novel approach for treatment of chronic resistant wounds","volume":"24","author":"Lee","year":"2007","journal-title":"Adv. Ther."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.ASW.0000425942.32993.e9","article-title":"Use of wireless microcurrent stimulation for the treatment of diabetes-related wounds: 2 case reports","volume":"26","author":"Ramadhinara","year":"2013","journal-title":"Adv. Skin Wound Care."},{"key":"ref_13","first-page":"29","article-title":"Ultra-low microcurrent in the management of diabetes mellitus, hypertension and chronic wounds: Report of twelve cases and discussion of mechanism of action","volume":"7","author":"Lee","year":"2009","journal-title":"Int. J. Med Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1111\/iwj.12204","article-title":"Wireless micro current stimulation\u2013an innovative electrical stimulation method for the treatment of patients with leg and diabetic foot ulcers","volume":"12","author":"Wirsing","year":"2015","journal-title":"Int. Wound J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.3923\/jms.2007.1320.1324","article-title":"A study to detect the efficacy of Micro-current Electrical Therapy on decubitus wound","volume":"7","author":"Ullah","year":"2007","journal-title":"J. Med. Sci."},{"key":"ref_16","first-page":"224","article-title":"Efficacy of Modulated Microcurrent Stimulation in Pressure Ulcers Treatment: A Monocentric, Prospective, Double-Blind, Randomized Study","volume":"4","author":"Lessiani","year":"2014","journal-title":"J. Nov. Physiother."},{"key":"ref_17","unstructured":"National Pressure Ulcer Advisory Panel, and European Pressure Ulcer Advisory Panel (2009). Prevention and Treatment of Pressure Ulcers: Clinical Practice Guideline, National Pressure Ulcer Advisory Panel."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.gerinurse.2009.11.010","article-title":"Predictive Validity of the Braden Scale for Pressure Ulcer Risk in Elderly Residents of Long-Term Care Facilities","volume":"31","author":"Iri","year":"2010","journal-title":"Geriatr. Nurs."},{"key":"ref_19","unstructured":"World Medical Association (2013, January 16\u201319). Declaration of Helsinki. Ethical principles for medical research involving human subjects. Proceedings of the 64th WMA General Assembly, Fortaleza, Brazil."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1046\/j.1524-475X.11.s2.1.x","article-title":"Wound bed preparation: A systematic approach to wound management","volume":"11","author":"Schultz","year":"2003","journal-title":"Wound Repair Regen."},{"key":"ref_21","unstructured":"Blanco Zapata, R.M., L\u00f3pez Garc\u00eda, E., Quesada Ramos, C., and Garc\u00eda Rodr\u00edguez, M.R. (2015). Guide to Recommendations Based on Evidence in Prevention and Treatment of Pressure Ulcers in Adults, San Sebasti\u00e1n."},{"key":"ref_22","first-page":"2018","article-title":"Standardized Mini-Mental State Examination. Use and interpretation","volume":"47","author":"Vertesi","year":"2001","journal-title":"Can. Fam. Physician"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"M795","DOI":"10.1093\/gerona\/56.12.M795","article-title":"An Instrument to Measure Healing in Pressure UlcersDevelopment and Validation of the Pressure Ulcer Scale for Healing (PUSH)","volume":"56","author":"Stotts","year":"2001","journal-title":"J. Gerontol. Ser. A Biol. Sci. Med. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1046\/j.1524-475x.2001.00123.x","article-title":"Development of noninvasive and quantitative methodologies for the assessment of chronic ulcers and scars in humans","volume":"9","author":"Beauregard","year":"2001","journal-title":"Wound Repair Regen."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3109\/10601331003777444","article-title":"Blinding assessment in clinical trials: A review of statistical methods and a proposal of blinding assessment protocol","volume":"27","author":"Bang","year":"2010","journal-title":"Clin. Res. Regul. Aff."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/j.1600-0528.2009.00494.x","article-title":"Towards a proposal for assessment of blinding success in clinical trials: Up-to-date review","volume":"37","author":"Kolahi","year":"2009","journal-title":"Community Dent. Oral Epidemiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1002\/(SICI)1097-0258(19960715)15:13<1421::AID-SIM266>3.0.CO;2-H","article-title":"An index for assessing blindness in a multi-centre clinical trial: Disulfiram for alcohol cessation\u2014A VA cooperative study","volume":"15","author":"James","year":"1996","journal-title":"Stat. Med."},{"key":"ref_28","first-page":"268","article-title":"Electrical microcurrent stimulation therapy for wound healing: A meta-analysis of randomized clinical trials","volume":"31","year":"2021","journal-title":"J. Tissue Viability"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"230","DOI":"10.12968\/jowc.2018.27.4.230","article-title":"Cost-effectiveness of an electroceutical device in treating non-healing venous leg ulcers: Results of an RCT","volume":"27","author":"Guest","year":"2018","journal-title":"J. Wound Care"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"397","DOI":"10.4103\/1119-3077.201439","article-title":"Effectiveness of microcurrent therapy on sacral pressure ulcer: Our first experience","volume":"20","author":"Unal","year":"2017","journal-title":"Niger. J. Clin. Pract."},{"key":"ref_31","first-page":"37","article-title":"Antimicrobial effect of the microcurrent application after burns of 2\u00b0 degree induced in the skin of the back in Wistar mice","volume":"5","author":"Angeloti","year":"2013","journal-title":"Discov. Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"214","DOI":"10.12968\/jowc.2019.28.4.214","article-title":"Negative pressure wound therapy versus microcurrent electrical stimulation in wound healing in burns","volume":"28","author":"Ibrahim","year":"2019","journal-title":"J. Wound Care"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"10","DOI":"10.25270\/owm.2018.2.1029","article-title":"A Randomized, Controlled Clinical Study to Assess the Effect of Anodal and Cathodal Electrical Stimulation on Periwound Skin Blood Flow and Pressure Ulcer Size Reduction in Persons with Neurological Injuries","volume":"64","author":"Polak","year":"2018","journal-title":"Ostomy Wound Manag."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1172\/JCI32169","article-title":"Cellular and molecular basis of wound healing in diabetes","volume":"117","author":"Brem","year":"2007","journal-title":"J. Clin. Investig."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/16\/10045\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:08:45Z","timestamp":1760141325000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/16\/10045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,15]]},"references-count":34,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2022,8]]}},"alternative-id":["ijerph191610045"],"URL":"https:\/\/doi.org\/10.3390\/ijerph191610045","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,15]]}}}