{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T10:34:50Z","timestamp":1782124490556,"version":"3.54.5"},"reference-count":61,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T00:00:00Z","timestamp":1660003200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Peripheral artery disease (PAD) increases the risk of diabetes, while diabetes increases the risk of PAD, and certain symptoms in each disease increase the risk of contracting the other. This review aims to shed light on this harmful interplay between the two disorders, with an emphasis on the phenotype of a patient with both diabetes and PAD, and whether treatment should be individualized in this high-risk population. In addition, current guideline recommendations for the treatment of PAD were analyzed, in an attempt to establish the differences and evidence gaps across a population suffering from these two interconnected disorders.<\/jats:p>","DOI":"10.3390\/ijerph19169801","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T02:42:53Z","timestamp":1660099373000},"page":"9801","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Approaches to Peripheral Artery Disease in Diabetes: Are There Any Differences?"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5540-3478","authenticated-orcid":false,"given":"Alexandru","family":"Achim","sequence":"first","affiliation":[{"name":"Medical 1 Clinic, Department of Interventional Cardiology, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d, 400000 Cluj-Napoca, Romania"},{"name":"\u201dNiculae Stancioiu\u201d Heart Institute, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d, 400000 Cluj-Napoca, Romania"},{"name":"Klinik f\u00fcr Kardiologie, Medizinische Universit\u00e4tsklinik, Kantonsspital Baselland, 4410 Liestal, Switzerland"},{"name":"Internal Medicine Department, Division of Invasive Cardiology, University of Szeged, 6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6939-9898","authenticated-orcid":false,"given":"Agata","family":"Stanek","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Angiology and Physical Medicine, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Batorego 15 St., 41-902 Bytom, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u0103lin","family":"Homorodean","sequence":"additional","affiliation":[{"name":"Medical 1 Clinic, Department of Interventional Cardiology, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d, 400000 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3010-5650","authenticated-orcid":false,"given":"Mihail","family":"Spinu","sequence":"additional","affiliation":[{"name":"Medical 1 Clinic, Department of Interventional Cardiology, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d, 400000 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8819-7690","authenticated-orcid":false,"given":"Horea Lauren\u0163iu","family":"Onea","sequence":"additional","affiliation":[{"name":"Medical 1 Clinic, Department of Interventional Cardiology, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d, 400000 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3847-0940","authenticated-orcid":false,"given":"Leontin","family":"Laz\u0103r","sequence":"additional","affiliation":[{"name":"Medical 1 Clinic, Department of Interventional Cardiology, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d, 400000 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u0103d\u0103lin","family":"Marc","sequence":"additional","affiliation":[{"name":"\u201dNiculae Stancioiu\u201d Heart Institute, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d, 400000 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2474-5723","authenticated-orcid":false,"given":"Zolt\u00e1n","family":"Ruzsa","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Division of Invasive Cardiology, University of Szeged, 6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1886-9375","authenticated-orcid":false,"given":"Dan Mircea","family":"Olinic","sequence":"additional","affiliation":[{"name":"Medical 1 Clinic, Department of Interventional Cardiology, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d, 400000 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.jcmg.2008.12.010","article-title":"Thoracic aortic calcium versus coronary artery calcium for the prediction of coronary heart disease and cardiovascular disease events","volume":"2","author":"Wong","year":"2009","journal-title":"JACC Cardiovasc. 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