{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T06:01:53Z","timestamp":1762063313986,"version":"build-2065373602"},"reference-count":29,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T00:00:00Z","timestamp":1660003200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Spanish Society of Family and Community Pharmacy (SEFAC)","award":["SEFAC 1.19"],"award-info":[{"award-number":["SEFAC 1.19"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>(1) Background: Heartburn and reflux discomfort are frequent reasons for consultation at the community pharmacy. To facilitate the assistance work of the community pharmacist and its coordination between different levels of care, a group of experts in Community Pharmacy, Primary Care, and Gastroenterology have recently worked on an algorithm to manage these symptoms in the community pharmacy (Professional Pharmaceutical Service). The objective of this study is to analyze the clinical and sociodemographic characteristics of patients with heartburn and\/or reflux-like symptoms who go to a community pharmacy, and to evaluate the clinical and humanistic results after the implementation of a Professional Pharmaceutical Service. (2) Methods: A pre-post study will be carried out to evaluate clinical and humanistic results after the implementation of a Professional Pharmaceutical Service. We will include 1200 patients who ask for advice or get a non-prescription medication due to acid and\/or reflux symptoms in 240 Spanish pharmacies. Clinical data will be collected at baseline and 15 days after the pharmaceutical intervention. The GERD Impact Scale (GIS) questionnaire will be applied to assess changes in heartburn\/reflux-like symptoms and quality of life after the intervention.<\/jats:p>","DOI":"10.3390\/ijerph19169807","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T02:42:53Z","timestamp":1660099373000},"page":"9807","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["EsReflux Protocol: Epidemiological Study of Heartburn and Reflux-like Symptoms in Spanish Community Pharmacies"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0937-5725","authenticated-orcid":false,"given":"Elsa","family":"L\u00f3pez-Pintor","sequence":"first","affiliation":[{"name":"Department of Engineering, Area of Pharmacy and Pharmaceutical Technology, Miguel Hernandez University, 03550 San Juan de Alicante, Spain"},{"name":"CIBER of Epidemiology and Public Health, CIBERESP, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Puig-Molt\u00f3","sequence":"additional","affiliation":[{"name":"Department of Engineering, Area of Pharmacy and Pharmaceutical Technology, Miguel Hernandez University, 03550 San Juan de Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1665-0860","authenticated-orcid":false,"given":"Blanca","family":"Lumbreras","sequence":"additional","affiliation":[{"name":"CIBER of Epidemiology and Public Health, CIBERESP, 28029 Madrid, Spain"},{"name":"Department of Public Health, History of Science and Gynecology, Miguel Hernandez University, 03550 San Juan de Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1053\/gast.2001.27997","article-title":"Unbuffered highly acidic gastric juice exists at the gastroesophageal junction after a meal","volume":"121","author":"Fletcher","year":"2001","journal-title":"Gastroenterology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.gastrohep.2013.11.001","article-title":"Puesta al d\u00eda en el reflujo gastroesof\u00e1gico","volume":"37","year":"2014","journal-title":"Gastroenterol. Y Hepatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/apt.12857","article-title":"Gaviscon Double Action Liquid (antacid & alginate) is more effective than antacid in controlling post-prandial oesophageal acid exposure in GERD patients: A double-blind crossover study","volume":"40","author":"Roman","year":"2014","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1046\/j.1365-2036.2000.00759.x","article-title":"Review article: Alginate-raft formulations in the treatment of heartburn and acid reflux","volume":"14","author":"Mandel","year":"2000","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1443-9573.2006.00266.x","article-title":"Non-erosive reflux disease, functional heartburn and gastroesophageal reflux disease; insights into pathophysiology and clinical presentation","volume":"7","author":"Quigley","year":"2006","journal-title":"Chin. J. Dig. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1157\/13127096","article-title":"Aspectos menos conocidos de la enfermedad por reflujo gastroesof\u00e1gico: Pirosis funcional y reflujo no \u00e1cido","volume":"31","author":"Garrigues","year":"2008","journal-title":"Gastroenterol. Hepatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1053\/j.gastro.2016.02.032","article-title":"Functional Gastrointestinal Disorders: History, Pathophysiology, Clinical Features, and Rome IV","volume":"150","author":"Drossman","year":"2016","journal-title":"Gastroenterology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1046\/j.1365-2036.2003.01769.x","article-title":"Symptoms of gastro-oesophageal reflux: Prevalence, severity, duration and associated factors in a Spanish population","volume":"19","author":"Rey","year":"2004","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1053\/j.gastro.2005.08.060","article-title":"Functional Esophageal Disorders","volume":"130","author":"Galmiche","year":"2006","journal-title":"Gastroenterology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1136\/gutjnl-2014-307843","article-title":"Global prevalence of, and risk factors for, uninvestigated dyspepsia: A meta-analysis","volume":"64","author":"Ford","year":"2015","journal-title":"Gut"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1097\/MEG.0b013e328310abe9","article-title":"Impact of gastroesophageal reflux disease on the quality of life of Spanish patients: The relevance of the biometric factors and the severity of symptoms","volume":"21","author":"Ponce","year":"2009","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1136\/gutjnl-2016-313589","article-title":"Global prevalence of, and risk factors for, gastro-oesophageal reflux symptoms: A meta-analysis","volume":"67","author":"Eusebi","year":"2018","journal-title":"Gut"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/1477-7525-7-90","article-title":"Impact of gastroesophageal reflux disease on work absenteeism, presenteeism and productivity in daily life: A European observational study","volume":"7","author":"Gisbert","year":"2009","journal-title":"Health Qual. Life Outcomes"},{"key":"ref_14","unstructured":"(2019). Actualizaci\u00f3n en El Manejo de Los Pacientes Con Acidez Y\/O Reflujo en Atenci\u00f3n Primaria Y Farmacia Comunitaria, Medea, Medical Education Agency, S.L.. [1st ed.]. Available online: https:\/\/www.campussefac.org\/product\/actualizacion-manejo-pacientes-con-acidez-o-reflujo-atencion-primaria-farmacia-comunitaria."},{"key":"ref_15","first-page":"214","article-title":"Gastroesophageal Reflux Disease (GERD)","volume":"115","author":"Clarrett","year":"2018","journal-title":"Mo. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1046\/j.1365-2036.2003.01679.x","article-title":"Contemporary understanding and management of reflux and constipation in the general population and pregnancy: A consensus meeting","volume":"18","author":"Tytgat","year":"2003","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1365-2036.2007.03565.x","article-title":"New algorithm for the treatment of gastro-oesophageal reflux disease","volume":"27","author":"Tytgat","year":"2008","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_18","unstructured":"(2022, August 06). LAW 16\/1997, of 25 April 1997, Regulating Pharmacy Office Services. B.O.E. n\u00ba 100 of 26 April 1997:13450-2. Available online: https:\/\/www.boe.es\/diario_boe\/txt.php?id=BOE-A-1997-9022."},{"key":"ref_19","first-page":"3","article-title":"Evaluation of the GERD Impact Scale, an international, validated patient questionnaire, in daily practice. Results of the ALEGRIA study","volume":"72","author":"Louis","year":"2009","journal-title":"Acta Gastro-Enterol. Belg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.gastrohep.2008.12.004","article-title":"Validation of the Reflux Disease Questionnaire (RDQ) and Gastrointestinal Impact Scale (GIS) in patients with gastroesophageal reflux disease in the Spanish population","volume":"32","author":"Nuevo","year":"2009","journal-title":"Gastroenterol. Hepatol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/MEG.0b013e328358bf74","article-title":"Systematic review of patient-reported outcome instruments for gastroesophageal reflux disease symptoms","volume":"25","author":"Vakil","year":"2013","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s10620-016-4440-7","article-title":"PRISM, a Patient-Reported Outcome Instrument, Accurately Measures Symptom Change in Refractory Gastroesophageal Reflux Disease","volume":"62","author":"Fuller","year":"2017","journal-title":"Dig. Dis. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.3109\/00365521.2012.712999","article-title":"Systematic review: Symptom assessment using patient-reported outcomes in gastroesophageal reflux disease and dyspepsia","volume":"47","author":"Chassany","year":"2012","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1111\/j.1365-2036.2011.04774.x","article-title":"Systematic review: The association between symptomatic response to proton pump inhibitors and health-related quality of life in patients with gastro-oesophageal reflux disease","volume":"34","author":"Becher","year":"2011","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1159\/000524766","article-title":"Gastrointestinal Quality of Life in Gastroesophageal Reflux Disease: A Systematic Review","volume":"103","author":"Fuchs","year":"2022","journal-title":"Digestion"},{"key":"ref_26","first-page":"591","article-title":"Validation of a questionnaire on patient satisfaction with the dispensing service in community pharmacies","volume":"39","author":"Carle","year":"2007","journal-title":"Atenci\u00f3n Primaria"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1177\/1352458516657441","article-title":"Measuring treatment satisfaction in MS: Is the Treatment Satisfaction Questionnaire for Medication fit for purpose?","volume":"23","author":"Vermersch","year":"2017","journal-title":"Mult. Scler."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1093\/ajhp\/60.13.1336","article-title":"Evaluation of a model for counseling patients with dyspepsia in Swedish community pharmacies","volume":"60","author":"Westerlund","year":"2003","journal-title":"Am. J. Health Syst. Pharm."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1177\/0897190012465992","article-title":"Retrospective analysis of estimated cost avoidance following pharmacist-provided medication therapy management services","volume":"26","author":"Branham","year":"2013","journal-title":"J. Pharm. Pract."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/16\/9807\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:06:19Z","timestamp":1760141179000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/16\/9807"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,9]]},"references-count":29,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2022,8]]}},"alternative-id":["ijerph19169807"],"URL":"https:\/\/doi.org\/10.3390\/ijerph19169807","relation":{},"ISSN":["1660-4601"],"issn-type":[{"type":"electronic","value":"1660-4601"}],"subject":[],"published":{"date-parts":[[2022,8,9]]}}}