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Offline anti-epidemic work is the main battlefield of epidemic prevention and control. However, online epidemic information prevention and control cannot be ignored. The aim of this study was to identify reliable information sources and false epidemic information, as well as early warnings of public opinion about epidemic information that may affect social stability and endanger the people\u2019s lives and property. Based on the analysis of health and medical big data, epidemic information screening and public opinion prevention and control research were decomposed into two modules. Eight characteristics were extracted from the four levels of coarse granularity, fine granularity, emotional tendency, and publisher behavior, and another regulatory feature was added, to build a false epidemic information identification model. Five early warning indicators of public opinion were selected from the macro level and the micro level to construct the early warning model of public opinion about epidemic information. Finally, an empirical analysis on COVID-19 information was conducted using big data analysis technology.<\/jats:p>","DOI":"10.3390\/ijerph19169819","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T02:42:53Z","timestamp":1660099373000},"page":"9819","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A Study on Epidemic Information Screening, Prevention and Control of Public Opinion Based on Health and Medical Big Data: A Case Study of COVID-19"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7714-633X","authenticated-orcid":false,"given":"Jinhai","family":"Li","sequence":"first","affiliation":[{"name":"College of Information Engineering, Taizhou University, Taizhou 225300, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunlei","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Personnel, Taizhou University, Taizhou 225300, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinglong","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Management, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaming","family":"Pei","sequence":"additional","affiliation":[{"name":"School of Computer Science, The University of Sydney, Camperdown, NSW 2006, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youshi","family":"He","sequence":"additional","affiliation":[{"name":"School of Management, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,9]]},"reference":[{"key":"ref_1","first-page":"4","article-title":"A Summary of Theoretical Research on Internet Public Opinion Evolution, Early Warning and Coping at Nome and Abroad","volume":"37","author":"Wang","year":"2018","journal-title":"Libr. 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