{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T16:04:04Z","timestamp":1778342644910,"version":"3.51.4"},"reference-count":72,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T00:00:00Z","timestamp":1661817600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["OIA-1920920"],"award-info":[{"award-number":["OIA-1920920"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Hydraulic fracturing or fracking has led to a rapid growth of oil and gas production in the United States, but the impact of fracking on public health is an important but underresearched topic. We designed a methodology to study spatiotemporal correlations between the risk of fracking and stroke mortality. An annualized loss expectancy (ALE) model is applied to quantify the risk of fracking. The geographically and temporally weighted regression (GTWR) model is used to analyze spatiotemporal correlations of stroke mortality, fracking ALE, and nine other socioeconomic- and health-related factors. The analysis shows that fracking ALE is moderately correlated with stroke mortality at ages over 65 in most states of fracking, in addition to cardiovascular disease and drug overdose being positively correlated with stroke mortality. Furthermore, the correlations between fracking ALE and stroke mortality in men appear to be higher than in women near the Marcellus Shale, including Ohio, Pennsylvania, West Virginia, and Virginia, while stroke mortality among women is concentrated in the Great Plains, including Montana, Wyoming, New Mexico, and Oklahoma. Lastly, within two kilometers of the fracking mining activity, the level of benzene in the air was found to be significantly correlated with the fracking activity in Colorado.<\/jats:p>","DOI":"10.3390\/ijerph191710817","type":"journal-article","created":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T21:25:18Z","timestamp":1661894718000},"page":"10817","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Spatiotemporal Correlation Analysis of Hydraulic Fracturing and Stroke in the United States"],"prefix":"10.3390","volume":"19","author":[{"given":"Chuanbo","family":"Hu","sequence":"first","affiliation":[{"name":"Lane Department of Computer Science and Electrical Engineering, West Virginia University, Morgantown, WV 26505, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Management Information Systems, West Virginia University, Morgantown, WV 26505, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2562-0225","authenticated-orcid":false,"given":"Shuo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Washington University, St. Louis, MO 63110, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7711-7632","authenticated-orcid":false,"given":"Zhenduo","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Civil, Structural and Environmental Engineering, University at Buffalo, Buffalo, NY 14260, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0723-3830","authenticated-orcid":false,"given":"Amelia","family":"Adcock","sequence":"additional","affiliation":[{"name":"Department of Neurology, West Virginia University, Morgantown, WV 26505, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Simpkins","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, West Virginia University, Morgantown, WV 26505, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2067-2763","authenticated-orcid":false,"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Lane Department of Computer Science and Electrical Engineering, West Virginia University, Morgantown, WV 26505, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,30]]},"reference":[{"key":"ref_1","unstructured":"Gandossi, L., and Von Estorff, U. (2013). An overview of hydraulic fracturing and other formation stimulation technologies for shale gas production. Eur. Comm. Jt. Res. Cent. Tech. Rep., 26347."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"26","DOI":"10.2118\/1210-0026-JPT","article-title":"Hydraulic fracturing: History of an enduring technology","volume":"62","author":"Montgomery","year":"2010","journal-title":"J. Pet. Technol."},{"key":"ref_3","unstructured":"Kuuskraa, V., Stevens, S.H., and Moodhe, K.D. (2013). Technically Recoverable Shale Oil and Shale Gas Resources: An Assessment of 137 Shale Formations in 41 Countries Outside the United States."},{"key":"ref_4","unstructured":"U.S. Energy Information Administration (2016). Hydraulic Fracturing Accounts for About Half of Current U.S. Crude Oil Production."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.puhe.2013.07.005","article-title":"The implications of unconventional drilling for natural gas: A global public health concern","volume":"127","author":"Finkel","year":"2013","journal-title":"Public Health"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"117794","DOI":"10.1016\/j.jclepro.2019.117794","article-title":"Characterizing and modeling environmental emergency of unconventional oil and gas spills in the USA: Life-year versus spill factors","volume":"237","author":"Meng","year":"2019","journal-title":"J. Clean. Prod."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0140-6736(13)62700-2","article-title":"The health implications of fracking","volume":"383","author":"Kovats","year":"2014","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1146\/annurev-resource-110320-092648","article-title":"Economic, Environmental, and Health Impacts of the Fracking Boom","volume":"13","author":"Black","year":"2021","journal-title":"Annu. Rev. Resour. Econ."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Soyer, M., Kaminski, K., and Ziyanak, S. (2020). Socio-Psychological Impacts of Hydraulic Fracturing on Community Health and Well-Being. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17041186"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"150242","DOI":"10.1016\/j.scitotenv.2021.150242","article-title":"Volatile organic compounds (VOCs) in indoor air and tap water samples in residences of pregnant women living in an area of unconventional natural gas operations: Findings from the EXPERIVA study","volume":"805","author":"Whyte","year":"2022","journal-title":"Sci. Total. Environ."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"153586","DOI":"10.1016\/j.scitotenv.2022.153586","article-title":"Exposure risk assessment to organic compounds based on their concentrations in return water from shale gas developments","volume":"822","author":"Ma","year":"2022","journal-title":"Sci. Total. Environ."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.scitotenv.2016.12.045","article-title":"The impacts of fracking on the environment: A total environmental study paradigm","volume":"580","author":"Meng","year":"2017","journal-title":"Sci. Total. Environ."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.scitotenv.2012.02.018","article-title":"Human health risk assessment of air emissions from development of unconventional natural gas resources","volume":"424","author":"McKenzie","year":"2012","journal-title":"Sci. Total. Environ."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"8334","DOI":"10.1021\/es405118y","article-title":"A critical review of the risks to water resources from unconventional shale gas development and hydraulic fracturing in the United States","volume":"48","author":"Vengosh","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"109124","DOI":"10.1016\/j.envres.2020.109124","article-title":"Unconventional oil and gas development and health outcomes: A scoping review of the epidemiological research","volume":"182","author":"Deziel","year":"2020","journal-title":"Environ. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"153887","DOI":"10.1016\/j.scitotenv.2022.153887","article-title":"Detection and treatment of organic matters in hydraulic fracturing wastewater from shale gas extraction: A critical review","volume":"824","author":"Tao","year":"2022","journal-title":"Sci. Total. Environ."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.envpol.2018.05.013","article-title":"Rethink potential risks of toxic emissions from natural gas and oil mining","volume":"240","author":"Meng","year":"2018","journal-title":"Environ. Pollut."},{"key":"ref_18","first-page":"163","article-title":"Unconventional natural gas development and birth outcomes in Pennsylvania, USA","volume":"27","author":"Casey","year":"2016","journal-title":"Epidemiology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1001\/jamainternmed.2016.2436","article-title":"Association between unconventional natural gas development in the Marcellus Shale and asthma exacerbations","volume":"176","author":"Rasmussen","year":"2016","journal-title":"JAMA Intern. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1289\/EHP281","article-title":"Associations between unconventional natural gas development and nasal and sinus, migraine headache, and fatigue symptoms in Pennsylvania","volume":"125","author":"Tustin","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"11375","DOI":"10.1038\/s41598-018-29747-2","article-title":"Associations of unconventional natural gas development with depression symptoms and disordered sleep in Pennsylvania","volume":"8","author":"Casey","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"119644","DOI":"10.1016\/j.jclepro.2019.119644","article-title":"Key characteristics influencing risk perceptions of unconventional energy development","volume":"251","author":"Smith","year":"2020","journal-title":"J. Clean. Prod."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/01.NAJ.0000431272.83277.f4","article-title":"Fracking, the environment, and health","volume":"113","author":"Kaktins","year":"2013","journal-title":"AJN Am. J. Nurs."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1289\/ehp.11257","article-title":"Public Health and Air Pollution in Asia (PAPA): A multicity study of short-term effects of air pollution on mortality","volume":"116","author":"Wong","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s10653-015-9720-1","article-title":"Air pollution and public health: Emerging hazards and improved understanding of risk","volume":"37","author":"Kelly","year":"2015","journal-title":"Environ. Geochem. Health"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"106424","DOI":"10.1016\/j.buildenv.2019.106424","article-title":"Classification and mapping of urban canyon geometry using Google Street View images and deep multitask learning","volume":"167","author":"Hu","year":"2020","journal-title":"Build. Environ."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"460","DOI":"10.3322\/caac.21632","article-title":"Outdoor air pollution and cancer: An overview of the current evidence and public health recommendations","volume":"70","author":"Turner","year":"2020","journal-title":"CA Cancer J. Clin."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1146\/annurev-environ-031113-144051","article-title":"The environmental costs and benefits of fracking","volume":"39","author":"Jackson","year":"2014","journal-title":"Annu. Rev. Environ. Resour."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s40471-017-0097-9","article-title":"A review of the human health impacts of unconventional natural gas development","volume":"4","author":"Stacy","year":"2017","journal-title":"Curr. Epidemiol. Rep."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1161\/STROKEAHA.111.621904","article-title":"Stroke declines from third to fourth leading cause of death in the United States: Historical perspective and challenges ahead","volume":"42","author":"Towfighi","year":"2011","journal-title":"Stroke"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1161\/01.STR.26.7.1145","article-title":"The geography of stroke mortality in the United States and the concept of a stroke belt","volume":"26","author":"Lanska","year":"1995","journal-title":"Stroke"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.1161\/STROKEAHA.109.561688","article-title":"Factors explaining excess stroke prevalence in the US Stroke Belt","volume":"40","author":"Liao","year":"2009","journal-title":"Stroke"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S1474-4422(16)30073-4","article-title":"Global burden of stroke and risk factors in 188 countries, during 1990\u20132013: A systematic analysis for the Global Burden of Disease Study 2013","volume":"15","author":"Feigin","year":"2016","journal-title":"Lancet Neurol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1161\/STROKEAHA.119.024155","article-title":"Twenty years of progress toward understanding the stroke belt","volume":"51","author":"Howard","year":"2020","journal-title":"Stroke"},{"key":"ref_35","unstructured":"Srebotnjak, T., and Rotkin-Ellman, M. (2014). Fracking fumes: Air pollution from hydraulic fracturing threatens public health and communities. Nat. Resour. Def. Counc., Available online: https:\/\/legacy-assets.eenews.net\/open_files\/assets\/2014\/12\/16\/document_cw_01.pdf."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"k5163","DOI":"10.1136\/bmj.k5163","article-title":"Medical organisations must divest from fossil fuels","volume":"363","author":"Law","year":"2018","journal-title":"BMJ"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"115242","DOI":"10.1016\/j.taap.2020.115242","article-title":"Biological effects of inhaled hydraulic fracturing sand dust. VI. Cardiovascular effects","volume":"406","author":"Krajnak","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jenvman.2016.06.008","article-title":"Water acquisition and use during unconventional oil and gas development and the existing data challenges: Weld and Garfield counties, CO","volume":"181","author":"Oikonomou","year":"2016","journal-title":"J. Environ. Manag."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.scitotenv.2019.04.077","article-title":"Effects of \u2018pre-fracking\u2019operations on ambient air quality at a shale gas exploration site in rural North Yorkshire, England","volume":"673","author":"Purvis","year":"2019","journal-title":"Sci. Total. Environ."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e1603021","DOI":"10.1126\/sciadv.1603021","article-title":"Hydraulic fracturing and infant health: New evidence from Pennsylvania","volume":"3","author":"Currie","year":"2017","journal-title":"Sci. Adv."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.scitotenv.2015.02.030","article-title":"Spatial analysis of environment and population at risk of natural gas fracking in the state of Pennsylvania, USA","volume":"515","author":"Meng","year":"2015","journal-title":"Sci. Total. Environ."},{"key":"ref_42","first-page":"124","article-title":"Distance: A critical aspect for environmental impact assessment of hydraulic fracking","volume":"1","author":"Meng","year":"2014","journal-title":"Extr. Ind. Soc."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.1538-4632.1996.tb00936.x","article-title":"Geographically weighted regression: A method for exploring spatial nonstationarity","volume":"28","author":"Brunsdon","year":"1996","journal-title":"Geogr. Anal."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1080\/13658810802672469","article-title":"Geographically and temporally weighted regression for modeling spatio-temporal variation in house prices","volume":"24","author":"Huang","year":"2010","journal-title":"Int. J. Geogr. Inf. Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0140-6736(13)61953-4","article-title":"Global and regional burden of stroke during 1990\u20132010: Findings from the Global Burden of Disease Study 2010","volume":"383","author":"Feigin","year":"2014","journal-title":"Lancet"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1021\/acs.est.6b05749","article-title":"Unconventional oil and gas spills: Risks, mitigation priorities, and state reporting requirements","volume":"51","author":"Patterson","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"13","DOI":"10.2190\/NS.23.1.c","article-title":"Public health and high volume hydraulic fracturing","volume":"23","author":"Korfmacher","year":"2013","journal-title":"New Solut. J. Environ. Occup. Health Policy"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1080\/10807039.2011.605662","article-title":"Natural gas operations from a public health perspective","volume":"17","author":"Colborn","year":"2011","journal-title":"Hum. Ecol. Risk Assess. Int. J."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2190\/NS.22.1.e","article-title":"Impacts of gas drilling on human and animal health","volume":"22","author":"Bamberger","year":"2012","journal-title":"New Solut. J. Environ. Occup. Health Policy"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Bistarelli, S., Fioravanti, F., and Peretti, P. (2006, January 20\u201322). Defense trees for economic evaluation of security investments. Proceedings of the First International Conference on Availability, Reliability and Security (ARES\u201906), Vienna, Austria.","DOI":"10.1109\/ARES.2006.46"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.cose.2004.07.004","article-title":"ISRAM: Information security risk analysis method","volume":"24","author":"Karabacak","year":"2005","journal-title":"Comput. Secur."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"754","DOI":"10.4236\/ojs.2015.57075","article-title":"Variance inflation factor: As a condition for the inclusion of suppressor variable (s) in regression analysis","volume":"5","author":"Akinwande","year":"2015","journal-title":"Open J. Stat."},{"key":"ref_53","unstructured":"Kutner, M.H., Nachtsheim, C.J., Neter, J., and Wasserman, W. (2004). Applied Linear Regression Models, McGraw-Hill\/Irwin."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/biomet\/37.1-2.17","article-title":"Notes on continuous stochastic phenomena","volume":"37","author":"Moran","year":"1950","journal-title":"Biometrika"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.3390\/ijgi4042306","article-title":"Spatiotemporal data mining: A computational perspective","volume":"4","author":"Shekhar","year":"2015","journal-title":"ISPRS Int. J. Geo Inf."},{"key":"ref_56","first-page":"1","article-title":"Spatio-temporal enabled urban decision-making process modeling and visualization under the cyber-physical environment","volume":"58","author":"Wang","year":"2015","journal-title":"Sci. China Inf. Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3390\/ijgi6080251","article-title":"Event-driven distributed information resource-focusing service for emergency response in smart city with cyber-physical infrastructures","volume":"6","author":"Xiao","year":"2017","journal-title":"ISPRS Int. J. Geo Inf."},{"key":"ref_58","first-page":"1062","article-title":"A Process-oriented Risk Monitoring and Assessment Modeling Approach in Urban Public Safety","volume":"47","author":"Chuanbo","year":"2018","journal-title":"Acta Geod. Cartogr. Sin."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Wang, W., Hu, C., Chen, N., Xiao, C., and Jia, S. (2016). Spatio-Temporal Risk Assessment Process Modeling for Urban Hazard Events in Sensor Web Environment. ISPRS Int. J. Geo Inf., 5.","DOI":"10.3390\/ijgi5110203"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0167-7152(96)00128-9","article-title":"Unifying the derivations for the Akaike and corrected Akaike information criteria","volume":"33","author":"Cavanaugh","year":"1997","journal-title":"Stat. Probab. Lett."},{"key":"ref_61","first-page":"93","article-title":"Ordinary least squares","volume":"93","author":"Dismuke","year":"2006","journal-title":"Methods Des. Outcomes Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"418","DOI":"10.12998\/wjcc.v3.i5.418","article-title":"Cardiovascular risk factors for acute stroke: Risk profiles in the different subtypes of ischemic stroke","volume":"3","author":"Arboix","year":"2015","journal-title":"World J. Clin. Cases WJCC"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Avan, A., Digaleh, H., Di Napoli, M., Stranges, S., Behrouz, R., Shojaeianbabaei, G., Amiri, A., Tabrizi, R., Mokhber, N., and Spence, J.D. (2019). Socioeconomic status and stroke incidence, prevalence, mortality, and worldwide burden: An ecological analysis from the Global Burden of Disease Study 2017. BMC Med., 17.","DOI":"10.1186\/s12916-019-1397-3"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1161\/STROKEAHA.111.639732","article-title":"Socioeconomic status and stroke: An updated review","volume":"43","author":"Addo","year":"2012","journal-title":"Stroke"},{"key":"ref_65","unstructured":"Center, E.A.R.P. (2016). Fracking by the Numbers the Damage to Our Water, Land and Climate from a Decade of Dirty Drilling, Environment America Research and Policy Center."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1021\/acs.est.1c05081","article-title":"Assessing unconventional oil and gas exposure in the Appalachian basin: Comparison of exposure surrogates and residential drinking water measurements","volume":"56","author":"Clark","year":"2022","journal-title":"Environ. Sci. Technol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1289\/ehp.9120","article-title":"Autism spectrum disorders in relation to distribution of hazardous air pollutants in the San Francisco Bay area","volume":"114","author":"Windham","year":"2006","journal-title":"Environ. Health Perspect."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Benesty, J., Chen, J., Huang, Y., and Cohen, I. (2009). Pearson correlation coefficient. Noise Reduction in Speech Processing, Springer.","DOI":"10.1007\/978-3-642-00296-0_5"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Abplanalp, W., DeJarnett, N., Riggs, D.W., Conklin, D.J., McCracken, J.P., Srivastava, S., Xie, Z., Rai, S., Bhatnagar, A., and O\u2019Toole, T.E. (2017). Benzene exposure is associated with cardiovascular disease risk. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0183602"},{"key":"ref_70","first-page":"52","article-title":"Neurological and Biological Toxicity of Subchronic Exposure to Inhaled Benzene in Male Rats","volume":"11","author":"Alshareef","year":"2020","journal-title":"J. Biochem. Technol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1212\/01.WNL.0000144282.42222.DA","article-title":"Association of cholesterol with stroke risk varies in stroke subtypes and patient subgroups","volume":"63","author":"Tirschwell","year":"2004","journal-title":"Neurology"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2930","DOI":"10.1161\/01.STR.0000102171.91292.DC","article-title":"Cholesterol and the risk of ischemic stroke","volume":"34","author":"Bowman","year":"2003","journal-title":"Stroke"}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/17\/10817\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:20:28Z","timestamp":1760142028000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/17\/10817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,30]]},"references-count":72,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2022,9]]}},"alternative-id":["ijerph191710817"],"URL":"https:\/\/doi.org\/10.3390\/ijerph191710817","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,30]]}}}