{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T22:26:06Z","timestamp":1779143166306,"version":"3.51.4"},"reference-count":28,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T00:00:00Z","timestamp":1662681600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fu Jen Catholic University","award":["A0110152"],"award-info":[{"award-number":["A0110152"]}]},{"name":"Fu Jen Catholic University","award":["MOST109-2221-E030-011-MY3"],"award-info":[{"award-number":["MOST109-2221-E030-011-MY3"]}]},{"name":"Ministry of Science and Technology","award":["A0110152"],"award-info":[{"award-number":["A0110152"]}]},{"name":"Ministry of Science and Technology","award":["MOST109-2221-E030-011-MY3"],"award-info":[{"award-number":["MOST109-2221-E030-011-MY3"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Background: There are several possible links that have been used to claim that osteoporosis and peripheral artery disease (PAD) are associated; however, the solid evidence is not sufficient. This study aimed to use the Taiwan National Health Insurance Research Database (NHIRD) to determine if osteoporosis is associated with peripheral artery disease (PAD). Method: NHIRD records from 23 million patients were collected to recruit two matched cohort groups: 64,562 patients with and 64,562 patients without osteoporosis. To compare the crude hazard ratio (HR) and the incidence rate ratio between the two cohort groups for PAD, the Cox model was used. Result: With an adjusted HR of 1.18 (95% CI, 1.08\u20131.29), the osteoporosis cohort group had a significantly greater risk for PAD than the group without osteoporosis. The cumulative incidence of PAD in the cohort group was also statistically higher than it was in the group without osteoporosis (1.71% and 1.39%; p \u2264 0.0001, log-rank) over the 10-year follow-up period. In addition, the osteoporotic patients with ischemic stroke, chronic obstructive pulmonary disease (COPD), and congestive heart failure (CHF) had a significantly increased risk of PAD based on subgroup analysis. Conclusions: There was a positive association between osteoporosis and the development of PAD, as patients with osteoporosis had an increased incidence of PAD over time.<\/jats:p>","DOI":"10.3390\/ijerph191811327","type":"journal-article","created":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T04:54:41Z","timestamp":1662699281000},"page":"11327","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Association between Osteoporosis and Peripheral Artery Disease: A Population-Based Longitudinal Follow-Up Study in Taiwan"],"prefix":"10.3390","volume":"19","author":[{"given":"De-Kai","family":"Syu","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Fu Jen Catholic University Hospital, Fu Jen Catholic University, No. 69, Guizi Rd., Taishan Dist., New Taipei City 24352, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Hua","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Fu Jen Catholic University Hospital, Fu Jen Catholic University, No. 69, Guizi Rd., Taishan Dist., New Taipei City 24352, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping-Chun","family":"Yeh","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Fu Jen Catholic University Hospital, Fu Jen Catholic University, No. 69, Guizi Rd., Taishan Dist., New Taipei City 24352, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsung-Lin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Fu Jen Catholic University Hospital, Fu Jen Catholic University, No. 69, Guizi Rd., Taishan Dist., New Taipei City 24352, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Feng","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Fu Jen Catholic University Hospital, Fu Jen Catholic University, No. 69, Guizi Rd., Taishan Dist., New Taipei City 24352, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0872-8664","authenticated-orcid":false,"given":"Yen-Chun","family":"Huang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Business Administration, College of Management, Fu Jen Catholic University, No. 510, Zhongzheng Rd., Xinzhuang Dist., New Taipei City 242062, Taiwan"},{"name":"Artificial Intelligence Development Center, Fu Jen Catholic University, No. 510, Zhongzheng Rd., Xin-Zhuang Dist., New Taipei City 242062, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching-Chuan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Fu Jen Catholic University Hospital, Fu Jen Catholic University, No. 69, Guizi Rd., Taishan Dist., New Taipei City 24352, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8278-0033","authenticated-orcid":false,"given":"Mingchih","family":"Chen","sequence":"additional","affiliation":[{"name":"Graduate Institute of Business Administration, College of Management, Fu Jen Catholic University, No. 510, Zhongzheng Rd., Xinzhuang Dist., New Taipei City 242062, Taiwan"},{"name":"Artificial Intelligence Development Center, Fu Jen Catholic University, No. 510, Zhongzheng Rd., Xin-Zhuang Dist., New Taipei City 242062, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"8295054","DOI":"10.1155\/2019\/8295054","article-title":"Burden of Coronary Artery Disease and Peripheral Artery Disease: A Literature Review","volume":"2019","author":"Bauersachs","year":"2019","journal-title":"Cardiovasc. 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