{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:14:41Z","timestamp":1772064881507,"version":"3.50.1"},"reference-count":34,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2022,9,11]],"date-time":"2022-09-11T00:00:00Z","timestamp":1662854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Nihon University Research Grant-in-Aid for Early-Career Scientists","award":["22K15446"],"award-info":[{"award-number":["22K15446"]}]},{"name":"Nihon University Research Grant-in-Aid for Early-Career Scientists","award":["2022"],"award-info":[{"award-number":["2022"]}]},{"DOI":"10.13039\/501100001691","name":"Grants-in-Aid for Young Scientists of JSPS KAKENHI","doi-asserted-by":"publisher","award":["22K15446"],"award-info":[{"award-number":["22K15446"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Grants-in-Aid for Young Scientists of JSPS KAKENHI","doi-asserted-by":"publisher","award":["2022"],"award-info":[{"award-number":["2022"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Kawano Masanori Memorial Public Interest Incorporated Foundation for Promotion of Pediatrics","award":["22K15446"],"award-info":[{"award-number":["22K15446"]}]},{"name":"Kawano Masanori Memorial Public Interest Incorporated Foundation for Promotion of Pediatrics","award":["2022"],"award-info":[{"award-number":["2022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>There are no study reports to clarify the association between gestational age (GA) or anthropometric values at birth, and plasma cortisol levels in the blood of preterm infants at birth and at one month of age. This hospital-based retrospective cohort study included infants born at &lt;37 weeks\u2019 gestation between 2019 and 2021. First, the association between plasma cortisol level and GA or anthropometric values at birth (birth weight standard deviation score [SDS], birth length SDS, and birth head circumference SDS) was identified by regression and multiple regression analyses. Second, plasma cortisol levels in the umbilical cord at birth and at one month of age were compared between small-for-gestational age (SGA) and non-SGA infants. Sixty-one preterm infants were enrolled (SGA: 24 and non-SGA: 37). Plasma cortisol levels at birth were significantly associated with GA. Plasma cortisol levels at one month of age were associated with GA and birth head circumference SDS. Plasma cortisol levels at birth were significantly higher in SGA than non-SGA (p = 0.010). GA was an independent determinant of plasma cortisol levels at birth. SGA infants had a high plasma cortisol level at birth; resulting in speculation that a high plasma cortisol level at birth may predict abnormal neurological outcomes.<\/jats:p>","DOI":"10.3390\/ijerph191811448","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T22:53:46Z","timestamp":1663023226000},"page":"11448","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Association of Plasma Cortisol Levels with Gestational Age and Anthropometric Values at Birth in Preterm Infants"],"prefix":"10.3390","volume":"19","author":[{"given":"Masako","family":"Aoki","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo 173-8610, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuhiko","family":"Urakami","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo 173-8610, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0890-1626","authenticated-orcid":false,"given":"Nobuhiko","family":"Nagano","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo 173-8610, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoji","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo 173-8610, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5685-2670","authenticated-orcid":false,"given":"Ichiro","family":"Morioka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo 173-8610, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,11]]},"reference":[{"key":"ref_1","first-page":"4979","article-title":"Reduced placental 11beta-hydroxysteroid dehydrogenase type 2 mRNA levels in human pregnancies complicated by intrauterine growth restriction: An analysis of possible mechanisms","volume":"86","author":"McTernan","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_2","first-page":"378","article-title":"Developmental and functional biology of the primate fetal adrenal cortex","volume":"18","author":"Mesiano","year":"1997","journal-title":"Endocr. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"R791","DOI":"10.1152\/ajpregu.00194.2017","article-title":"Ovine uteroplacental and fetal metabolism during and after fetal cortisol overexposure in late gestation","volume":"314","author":"Vaughan","year":"2018","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"217.e1","DOI":"10.1016\/j.ajog.2012.12.014","article-title":"Multigenerational effects of fetal dexamethasone exposure on the hypothalamic-pituitary-adrenal axis of first- and second-generation female offspring","volume":"208","author":"Long","year":"2013","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S0140-6736(14)61490-2","article-title":"International standards for fetal growth based on serial ultrasound measurements: The fetal growth longitudinal study of the INTERGROWTH-21st project","volume":"384","author":"Papageorghiou","year":"2014","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e6368","DOI":"10.7717\/peerj.6368","article-title":"Intrauterine growth and the maturation process of adrenal function","volume":"7","author":"Iwata","year":"2019","journal-title":"PeerJ"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jpeds.2006.10.053","article-title":"Altered basal cortisol levels at 3, 6, 8 and 18 months in infants born at extremely low gestational age","volume":"150","author":"Grunau","year":"2007","journal-title":"J. Pediatr."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1542\/peds.107.3.494","article-title":"Association of plasma cortisol and chronic lung disease in preterm infants","volume":"107","author":"Banks","year":"2001","journal-title":"Pediatrics"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"F127","DOI":"10.1136\/adc.2002.021980","article-title":"Early pituitary-adrenal response and respiratory outcomes in preterm infants","volume":"89","author":"Ng","year":"2004","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"key":"ref_10","first-page":"923","article-title":"Cord blood cortisol levels and respiratory distress syndrome","volume":"31","author":"Srivastava","year":"1994","journal-title":"Indian Pediatr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0002-9378(76)90600-1","article-title":"Relationship between cortisol levels in umbilical cord plasma and development of the respiratory distress syndrome in premature newborn infants","volume":"125","author":"Sybulski","year":"1976","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1203\/PDR.0b013e31816c8fcc","article-title":"Comparison of serum cortisol concentrations in preterm infants with or without late-onset circulatory collapse due to adrenal insufficiency of prematurity","volume":"63","author":"Masumoto","year":"2008","journal-title":"Pediatr. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1111\/ped.12331","article-title":"New Japanese neonatal anthropometric charts for gestational age at birth","volume":"56","author":"Itabashi","year":"2014","journal-title":"Pediatr. Int."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.clinbiochem.2021.11.016","article-title":"Novel threshold value of midnight serum cortisol for diagnosis of hypercortisolism using the Roche Cortisol II assay","volume":"101","author":"Noel","year":"2022","journal-title":"Clin. Biochem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"33","DOI":"10.14390\/jsshp.HRP2018-014","article-title":"Outline of the new definition and classification of \u201cHypertensive Disorders of Pregnancy (HDP)\u201d; A revised JSSHP statement of 2005","volume":"6","author":"Watanabe","year":"2018","journal-title":"Hypertens. Res. Pregnancy"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"676","DOI":"10.2337\/dc10-0719","article-title":"International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy","volume":"33","author":"Metzger","year":"2010","journal-title":"Diabetes Care"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1111\/jdi.12848","article-title":"One-hour oral glucose tolerance test plasma glucose at gestational diabetes diagnosis is a common predictor of the need for insulin therapy in pregnancy and postpartum impaired glucose tolerance","volume":"9","author":"Nishikawa","year":"2018","journal-title":"J. Diabetes Investig."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1016\/j.ajog.2015.08.040","article-title":"Acute chorioamnionitis and funisitis: Definition, pathologic features, and clinical significance","volume":"213","author":"Kim","year":"2015","journal-title":"Am. J. Obs. Gynecol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.rcl.2017.02.006","article-title":"Respiratory distress in neonates: Underlying causes and current imaging assessment","volume":"55","author":"Liszewski","year":"2017","journal-title":"Radiol. Clin. North Am."},{"key":"ref_20","first-page":"35","article-title":"Chronic lung disease of the very low birth weight infant\u2014Is it preventable?","volume":"40","author":"Ogawa","year":"1998","journal-title":"Turk. J. Pediatr."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.braindev.2015.07.008","article-title":"Extremely preterm infants small for gestational age are at risk for motor impairment at 3 years corrected age","volume":"38","author":"Kato","year":"2016","journal-title":"Brain Dev."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0039-128X(96)00165-1","article-title":"Glucocorticoids, feto-placental 11 beta-hydroxysteroid dehydrogenase type 2, and the early life origins of adult disease","volume":"62","author":"Seckl","year":"1997","journal-title":"Steroids"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1113\/jphysiol.2006.105254","article-title":"Fetal programming of hypothalamo-pituitary-adrenal function: Prenatal stress and glucocorticoids","volume":"572","author":"Kapoor","year":"2006","journal-title":"J. Physiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"105223","DOI":"10.1016\/j.psyneuen.2021.105223","article-title":"Perinatal determinants of neonatal hair glucocorticoid concentrations","volume":"128","author":"Stoye","year":"2021","journal-title":"Psychoneuroendocrinology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"114","DOI":"10.4274\/jcrpe.1685","article-title":"Associations of prenatal and perinatal factors with cortisol diurnal pattern and reactivity to stress at preschool age among children living in poverty","volume":"7","author":"Elhassan","year":"2015","journal-title":"J. Clin. Res. Pediatr. Endocrinol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3429","DOI":"10.1210\/jc.2006-2223","article-title":"Hypothalamic-pituitary-adrenal axis function and the cellular immune response in former preterm children","volume":"92","author":"Krieger","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"4450","DOI":"10.1210\/jc.2018-01052","article-title":"Feeding-induced cortisol response in newborn infants","volume":"103","author":"Kinoshita","year":"2018","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.clp.2016.04.006","article-title":"Cardiovascular alterations and multiorgan dysfunction after birth asphyxia","volume":"4","author":"Polglase","year":"2016","journal-title":"Clin. Perinatol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1542\/peds.2003-0152-L","article-title":"Head circumference and body proportions before and during growth hormone treatment in short children who were born small for gestational age","volume":"114","author":"Arends","year":"2004","journal-title":"Pediatrics"},{"key":"ref_30","first-page":"89","article-title":"Subclassification of small for gestational age children with persistent short stature: Growth patterns and response to GH treatment","volume":"69","author":"Ester","year":"2008","journal-title":"Horm. Res."},{"key":"ref_31","first-page":"3696","article-title":"The expression of 11 beta-hydroxysteroid dehydrogenase type 2 is induced during trophoblast differentiation: Effects of hypoxia","volume":"87","author":"Hardy","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1210\/jc.2002-021378","article-title":"Placental 11 beta-hydroxysteroid dehydrogenase-2 and fetal cortisol\/cortisone shuttle in small preterm infants","volume":"88","author":"Kajantie","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_33","first-page":"CD001146","article-title":"Early (<8 days) postnatal corticosteroids for preventing chronic lung disease in preterm infants","volume":"5","author":"Doyle","year":"2014","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"S\u0142abuszewska-J\u00f3\u017cwiak, A., W\u0142odarczyk, M., Kilian, K., Rogulski, Z., Ciebiera, M., Szyma\u0144ska-Majchrzak, J., Zar\u0119ba, K., Szyma\u0144ski, J.K., Raczkiewicz, D., and Nowicka, G. (2020). Does the caesarean section impact on 11\u03b2 HSD2 and fetal cortisol?. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17155566"}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/18\/11448\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:29:36Z","timestamp":1760142576000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/18\/11448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,11]]},"references-count":34,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2022,9]]}},"alternative-id":["ijerph191811448"],"URL":"https:\/\/doi.org\/10.3390\/ijerph191811448","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,11]]}}}