{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:25:36Z","timestamp":1791588336725,"version":"4.3.4"},"reference-count":45,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Open Access Publication Fund of the University of Wuerzburg"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Medication-related osteonecrosis of the jaw (MRONJ) represents an adverse side effect of antiresorptive and antiangiogenic medications. It is associated with impaired quality of life, oral health, and oral function and can be classified into various stages. The purpose of this prospective clinical study is to evaluate the impact of stages I and II MRONJ on oral-health-related quality of life (OHRQoL) and related parameters. Patients\u2019 OHRQoL, satisfaction with life, oral discomfort, and oral health were assessed using the German version of the Oral Health Impact Profile (OHIP-G49), visual analog scales (VAS), and Satisfaction with Life Scale (SWLS) at baseline (T0), 10 days (T1), and 3 months after treatment (T2) in 36 patients. Data were analyzed using Kolmogorov\u2013Smirnov test, two-way mixed ANOVAs, and follow-up Mann\u2013Whitney U tests. The impact of treatment effects on the original seven OHIP domain structures and the recently introduced four-dimensional OHIP structure were evaluated using linear regression analysis. Thirty-six patients received surgical MRONJ treatment. Before treatment, patients\u2019 perceived OHRQoL, oral discomfort, oral health, and satisfaction with life were negatively affected by MRONJ. Surgical treatment significantly improved OHRQoL and related parameters (all p \u2264 0.012). This improvement was greater in patients with higher impairment at T0. OHRQoL and oral restrictions were still impaired after treatment in patients who needed prosthetic treatment. The four-dimensional structure revealed valuable information beyond the standard seven OHIP domains. Increased awareness of MRONJ risks and an interdisciplinary treatment approach for MRONJ patients are needed.<\/jats:p>","DOI":"10.3390\/ijerph191811709","type":"journal-article","created":{"date-parts":[[2022,9,18]],"date-time":"2022-09-18T23:39:22Z","timestamp":1663544362000},"page":"11709","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Oral-Health-Related Quality of Life in Patients with Medication-Related Osteonecrosis of the Jaw: A Prospective Clinical Study"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7223-934X","authenticated-orcid":false,"given":"Anna","family":"Winter","sequence":"first","affiliation":[{"name":"Department of Prosthodontics, Julius Maximilian University W\u00fcrzburg, Pleicherwall 2, 97070 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0550-2440","authenticated-orcid":false,"given":"Stefan M.","family":"Schulz","sequence":"additional","affiliation":[{"name":"Department of Behavioural Medicine and Principles of Human Biology for the Health Sciences, Trier University, Universit\u00e4tsring 15, 54296 Trier, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Schmitter","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Julius Maximilian University W\u00fcrzburg, Pleicherwall 2, 97070 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman C.","family":"Brands","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Plastic Surgery, University Hospital W\u00fcrzburg, Pleicherwall 2, 97070 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9452-9380","authenticated-orcid":false,"given":"Anton","family":"Straub","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Plastic Surgery, University Hospital W\u00fcrzburg, Pleicherwall 2, 97070 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"K\u00fcbler","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Plastic Surgery, University Hospital W\u00fcrzburg, Pleicherwall 2, 97070 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Borgmann","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Plastic Surgery, University Hospital W\u00fcrzburg, Pleicherwall 2, 97070 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Plastic Surgery, University Hospital W\u00fcrzburg, Pleicherwall 2, 97070 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.jcms.2020.09.008","article-title":"Pentoxifylline and tocopherol protocol to treat medication-related osteonecrosis of the jaw: A systematic literature review","volume":"48","author":"Cavalcante","year":"2020","journal-title":"J. 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