{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T02:38:20Z","timestamp":1784255900053,"version":"3.55.0"},"reference-count":35,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T00:00:00Z","timestamp":1663632000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science Centre","award":["2017\/25\/B\/NZ5\/02338"],"award-info":[{"award-number":["2017\/25\/B\/NZ5\/02338"]}]},{"name":"National Science Centre","award":["2014\/15\/B\/NZ7\/00998"],"award-info":[{"award-number":["2014\/15\/B\/NZ7\/00998"]}]},{"name":"National Science Centre","award":["2021\/41\/B\/NZ7\/04341"],"award-info":[{"award-number":["2021\/41\/B\/NZ7\/04341"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Objective. We hypothesized that, in our REPRO_PL cohort, exposure to indoor allergens and lifestyle factors in early life are associated with risk of asthma, atopic dermatitis, and allergic rhinitis at ten years of age. Methods. We only examined children who had lived in the same house from birth. Children\u2019s exposure to tobacco smoke was assessed based on cotinine levels in urine. House dust samples were collected. Results. Higher Fel d1 concentration in house dust was associated with significantly higher risk of developing asthma at age 10 years (95% CI,10.87 to 20.93; p &lt; 0.001). Frequent house cleaning was associated with development of atopic dermatitis (odds ratio 0.61; 95% CI 0.37 to 0.99; p = 0.045). Clustering of exposure to HDM revealed two types of environment. Cluster 1, defined as lower HDM (dust), in contrast to Cluster 2, defined as higher HDM, was characterized by old-type windows, lower fungus and dampness levels, as well as more frequent house cleaning. Conclusion. Exposure to cat allergens and new-type buildings that limit air flow while increasing the condensation of steam on the windows and thereby stimulating the growth of fungi are risk factors for the development of asthma.<\/jats:p>","DOI":"10.3390\/ijerph191911884","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T22:36:44Z","timestamp":1663713404000},"page":"11884","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Home Environment in Early-Life and Lifestyle Factors Associated with Asthma and Allergic Diseases among Inner-City Children from the REPRO_PL Birth Cohort"],"prefix":"10.3390","volume":"19","author":[{"given":"Katarzyna","family":"Kapszewicz","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Allergy, Copernicus Memorial Hospital, Medical University of Lodz, Pabianicka Street 62, 93-513 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Podlecka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Allergy, Copernicus Memorial Hospital, Medical University of Lodz, Pabianicka Street 62, 93-513 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3212-2307","authenticated-orcid":false,"given":"Kinga","family":"Pola\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Allergy, Copernicus Memorial Hospital, Medical University of Lodz, Pabianicka Street 62, 93-513 Lodz, Poland"},{"name":"Department of Environmental and Occupational Health Hazards, Nofer Institute of Occupational Medicine, 91-348 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iwona","family":"Stelmach","sequence":"additional","affiliation":[{"name":"Podd\u0119bice Health Center, 99-200 Podd\u0119bice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2532-9983","authenticated-orcid":false,"given":"Pawel","family":"Majak","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology, Copernicus Memorial Hospital, Medical University of Lodz, 93-513 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Majkowska-Wojciechowska","sequence":"additional","affiliation":[{"name":"Department of Immunology and Allergy, Medical University of Lodz, 93-513 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogus\u0142aw","family":"Tymoniuk","sequence":"additional","affiliation":[{"name":"Department of Immunology and Allergy, Medical University of Lodz, 93-513 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8042-406X","authenticated-orcid":false,"given":"Joanna","family":"Jerzy\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Allergy, Copernicus Memorial Hospital, Medical University of Lodz, Pabianicka Street 62, 93-513 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Brzozowska","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Allergy, Copernicus Memorial Hospital, Medical University of Lodz, Pabianicka Street 62, 93-513 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1097\/ACI.0b013e328349b166","article-title":"Early life exposures: Impact on asthma and allergic disease","volume":"11","author":"Kozyrskyj","year":"2011","journal-title":"Curr. 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