{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T04:51:28Z","timestamp":1776401488553,"version":"3.51.2"},"reference-count":33,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,9,24]],"date-time":"2022-09-24T00:00:00Z","timestamp":1663977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Milan","award":["PSR2020"],"award-info":[{"award-number":["PSR2020"]}]},{"name":"University of Milan","award":["GR-2016-02361198"],"award-info":[{"award-number":["GR-2016-02361198"]}]},{"name":"University of Milan","award":["GR-2011-02346974"],"award-info":[{"award-number":["GR-2011-02346974"]}]},{"name":"University of Milan","award":["2015-0524"],"award-info":[{"award-number":["2015-0524"]}]},{"name":"University of Milan","award":["2015-0564"],"award-info":[{"award-number":["2015-0564"]}]},{"name":"University of Milan","award":["PHC-03-2015\/667837-2"],"award-info":[{"award-number":["PHC-03-2015\/667837-2"]}]},{"name":"University of Milan","award":["2017H5F943"],"award-info":[{"award-number":["2017H5F943"]}]},{"name":"University of Milan","award":["ER-2017-2364981"],"award-info":[{"award-number":["ER-2017-2364981"]}]},{"name":"University of Milan","award":["ERP-2017-23671155"],"award-info":[{"award-number":["ERP-2017-23671155"]}]},{"name":"Italian Ministry of Health","award":["PSR2020"],"award-info":[{"award-number":["PSR2020"]}]},{"name":"Italian Ministry of Health","award":["GR-2016-02361198"],"award-info":[{"award-number":["GR-2016-02361198"]}]},{"name":"Italian Ministry of Health","award":["GR-2011-02346974"],"award-info":[{"award-number":["GR-2011-02346974"]}]},{"name":"Italian Ministry of Health","award":["2015-0524"],"award-info":[{"award-number":["2015-0524"]}]},{"name":"Italian Ministry of Health","award":["2015-0564"],"award-info":[{"award-number":["2015-0564"]}]},{"name":"Italian Ministry of Health","award":["PHC-03-2015\/667837-2"],"award-info":[{"award-number":["PHC-03-2015\/667837-2"]}]},{"name":"Italian Ministry of Health","award":["2017H5F943"],"award-info":[{"award-number":["2017H5F943"]}]},{"name":"Italian Ministry of Health","award":["ER-2017-2364981"],"award-info":[{"award-number":["ER-2017-2364981"]}]},{"name":"Italian Ministry of Health","award":["ERP-2017-23671155"],"award-info":[{"award-number":["ERP-2017-23671155"]}]},{"name":"Fondazione Cariplo","award":["PSR2020"],"award-info":[{"award-number":["PSR2020"]}]},{"name":"Fondazione Cariplo","award":["GR-2016-02361198"],"award-info":[{"award-number":["GR-2016-02361198"]}]},{"name":"Fondazione Cariplo","award":["GR-2011-02346974"],"award-info":[{"award-number":["GR-2011-02346974"]}]},{"name":"Fondazione Cariplo","award":["2015-0524"],"award-info":[{"award-number":["2015-0524"]}]},{"name":"Fondazione Cariplo","award":["2015-0564"],"award-info":[{"award-number":["2015-0564"]}]},{"name":"Fondazione Cariplo","award":["PHC-03-2015\/667837-2"],"award-info":[{"award-number":["PHC-03-2015\/667837-2"]}]},{"name":"Fondazione Cariplo","award":["2017H5F943"],"award-info":[{"award-number":["2017H5F943"]}]},{"name":"Fondazione Cariplo","award":["ER-2017-2364981"],"award-info":[{"award-number":["ER-2017-2364981"]}]},{"name":"Fondazione Cariplo","award":["ERP-2017-23671155"],"award-info":[{"award-number":["ERP-2017-23671155"]}]},{"name":"H2020 REPROGRAM","award":["PSR2020"],"award-info":[{"award-number":["PSR2020"]}]},{"name":"H2020 REPROGRAM","award":["GR-2016-02361198"],"award-info":[{"award-number":["GR-2016-02361198"]}]},{"name":"H2020 REPROGRAM","award":["GR-2011-02346974"],"award-info":[{"award-number":["GR-2011-02346974"]}]},{"name":"H2020 REPROGRAM","award":["2015-0524"],"award-info":[{"award-number":["2015-0524"]}]},{"name":"H2020 REPROGRAM","award":["2015-0564"],"award-info":[{"award-number":["2015-0564"]}]},{"name":"H2020 REPROGRAM","award":["PHC-03-2015\/667837-2"],"award-info":[{"award-number":["PHC-03-2015\/667837-2"]}]},{"name":"H2020 REPROGRAM","award":["2017H5F943"],"award-info":[{"award-number":["2017H5F943"]}]},{"name":"H2020 REPROGRAM","award":["ER-2017-2364981"],"award-info":[{"award-number":["ER-2017-2364981"]}]},{"name":"H2020 REPROGRAM","award":["ERP-2017-23671155"],"award-info":[{"award-number":["ERP-2017-23671155"]}]},{"name":"PRIN","award":["PSR2020"],"award-info":[{"award-number":["PSR2020"]}]},{"name":"PRIN","award":["GR-2016-02361198"],"award-info":[{"award-number":["GR-2016-02361198"]}]},{"name":"PRIN","award":["GR-2011-02346974"],"award-info":[{"award-number":["GR-2011-02346974"]}]},{"name":"PRIN","award":["2015-0524"],"award-info":[{"award-number":["2015-0524"]}]},{"name":"PRIN","award":["2015-0564"],"award-info":[{"award-number":["2015-0564"]}]},{"name":"PRIN","award":["PHC-03-2015\/667837-2"],"award-info":[{"award-number":["PHC-03-2015\/667837-2"]}]},{"name":"PRIN","award":["2017H5F943"],"award-info":[{"award-number":["2017H5F943"]}]},{"name":"PRIN","award":["ER-2017-2364981"],"award-info":[{"award-number":["ER-2017-2364981"]}]},{"name":"PRIN","award":["ERP-2017-23671155"],"award-info":[{"award-number":["ERP-2017-23671155"]}]},{"name":"ERANET","award":["PSR2020"],"award-info":[{"award-number":["PSR2020"]}]},{"name":"ERANET","award":["GR-2016-02361198"],"award-info":[{"award-number":["GR-2016-02361198"]}]},{"name":"ERANET","award":["GR-2011-02346974"],"award-info":[{"award-number":["GR-2011-02346974"]}]},{"name":"ERANET","award":["2015-0524"],"award-info":[{"award-number":["2015-0524"]}]},{"name":"ERANET","award":["2015-0564"],"award-info":[{"award-number":["2015-0564"]}]},{"name":"ERANET","award":["PHC-03-2015\/667837-2"],"award-info":[{"award-number":["PHC-03-2015\/667837-2"]}]},{"name":"ERANET","award":["2017H5F943"],"award-info":[{"award-number":["2017H5F943"]}]},{"name":"ERANET","award":["ER-2017-2364981"],"award-info":[{"award-number":["ER-2017-2364981"]}]},{"name":"ERANET","award":["ERP-2017-23671155"],"award-info":[{"award-number":["ERP-2017-23671155"]}]},{"name":"RP-2017-ERACVD-OPERATION","award":["PSR2020"],"award-info":[{"award-number":["PSR2020"]}]},{"name":"RP-2017-ERACVD-OPERATION","award":["GR-2016-02361198"],"award-info":[{"award-number":["GR-2016-02361198"]}]},{"name":"RP-2017-ERACVD-OPERATION","award":["GR-2011-02346974"],"award-info":[{"award-number":["GR-2011-02346974"]}]},{"name":"RP-2017-ERACVD-OPERATION","award":["2015-0524"],"award-info":[{"award-number":["2015-0524"]}]},{"name":"RP-2017-ERACVD-OPERATION","award":["2015-0564"],"award-info":[{"award-number":["2015-0564"]}]},{"name":"RP-2017-ERACVD-OPERATION","award":["PHC-03-2015\/667837-2"],"award-info":[{"award-number":["PHC-03-2015\/667837-2"]}]},{"name":"RP-2017-ERACVD-OPERATION","award":["2017H5F943"],"award-info":[{"award-number":["2017H5F943"]}]},{"name":"RP-2017-ERACVD-OPERATION","award":["ER-2017-2364981"],"award-info":[{"award-number":["ER-2017-2364981"]}]},{"name":"RP-2017-ERACVD-OPERATION","award":["ERP-2017-23671155"],"award-info":[{"award-number":["ERP-2017-23671155"]}]},{"name":"SISA Lombardia and Fondazione SISA","award":["PSR2020"],"award-info":[{"award-number":["PSR2020"]}]},{"name":"SISA Lombardia and Fondazione SISA","award":["GR-2016-02361198"],"award-info":[{"award-number":["GR-2016-02361198"]}]},{"name":"SISA Lombardia and Fondazione SISA","award":["GR-2011-02346974"],"award-info":[{"award-number":["GR-2011-02346974"]}]},{"name":"SISA Lombardia and Fondazione SISA","award":["2015-0524"],"award-info":[{"award-number":["2015-0524"]}]},{"name":"SISA Lombardia and Fondazione SISA","award":["2015-0564"],"award-info":[{"award-number":["2015-0564"]}]},{"name":"SISA Lombardia and Fondazione SISA","award":["PHC-03-2015\/667837-2"],"award-info":[{"award-number":["PHC-03-2015\/667837-2"]}]},{"name":"SISA Lombardia and Fondazione SISA","award":["2017H5F943"],"award-info":[{"award-number":["2017H5F943"]}]},{"name":"SISA Lombardia and Fondazione SISA","award":["ER-2017-2364981"],"award-info":[{"award-number":["ER-2017-2364981"]}]},{"name":"SISA Lombardia and Fondazione SISA","award":["ERP-2017-23671155"],"award-info":[{"award-number":["ERP-2017-23671155"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>The COVID-19 pandemic poses major challenges to healthcare systems. We aimed to investigate the impact of the pandemic on prescription and adherence patterns of chronic cardiovascular therapies (lipid-lowering [LL], oral antidiabetic drugs [AD], and antihypertensives [AH]) using administrative pharmaceutical databases. For each treatment, two cohorts of prevalent cases in 2019 and 2020 were compared. We evaluated the percentage change in dispensed packages and treatment adherence as a proportion of days covered (PDC). For all therapies, an increase was observed during March\u2013April 2020 (LL: +4.52%; AD: +2.72%; AH: +1.09%), with a sharp decrease in May\u2013June 2020 (LL: \u22128.40%; AD: \u221212.09%; AH: \u221210.54%) compared to 2019. The impact of the COVID-19 pandemic on chronic cardiovascular treatments appears negligible on adherence: 533,414 patients showed high adherence to LL (PDC \u2265 80%) in January\u2013February 2020, and 2.29% became poorly adherent (PDC &lt; 20%) in the following four-month period (vs. 1.98% in 2019). A similar increase was also observed for AH (1.25% with poor adherence in 2020 vs. 0.93% in 2019). For AD, the increase was restrained (1.55% with poor adherence in 2020 vs. 1.37% in 2019). The rush to supply drugs at the beginning of lockdown preserved the continuity of chronic cardiovascular therapies.<\/jats:p>","DOI":"10.3390\/ijerph191912101","type":"journal-article","created":{"date-parts":[[2022,9,25]],"date-time":"2022-09-25T23:13:27Z","timestamp":1664147607000},"page":"12101","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Impact of the COVID-19 Pandemic on the Therapeutic Continuity among Outpatients with Chronic Cardiovascular Therapies"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5124-5361","authenticated-orcid":false,"given":"Manuela","family":"Casula","sequence":"first","affiliation":[{"name":"Epidemiology and Preventive Pharmacology Service (SEFAP), Department of Pharmacological and Biomolecular Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy"},{"name":"IRCCS MultiMedica, Via Milanese 300, Sesto S. Giovanni, 20099 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4231-4150","authenticated-orcid":false,"given":"Federica","family":"Galimberti","sequence":"additional","affiliation":[{"name":"IRCCS MultiMedica, Via Milanese 300, Sesto S. Giovanni, 20099 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marica","family":"Iommi","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences-Pharmacology Unit, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7107-243X","authenticated-orcid":false,"given":"Elena","family":"Olmastroni","sequence":"additional","affiliation":[{"name":"Epidemiology and Preventive Pharmacology Service (SEFAP), Department of Pharmacological and Biomolecular Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Rosa","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences-Hygiene and Biostatistics Unit, University of Bologna, Via San Giacomo, 40126 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mattia","family":"Altini","sequence":"additional","affiliation":[{"name":"Romagna Local Health Authority, Emilia-Romagna Region, Via A. De Gasperi 8, 48121 Ravenna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7593-2094","authenticated-orcid":false,"given":"Alberico L.","family":"Catapano","sequence":"additional","affiliation":[{"name":"Epidemiology and Preventive Pharmacology Service (SEFAP), Department of Pharmacological and Biomolecular Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy"},{"name":"IRCCS MultiMedica, Via Milanese 300, Sesto S. Giovanni, 20099 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Tragni","sequence":"additional","affiliation":[{"name":"Epidemiology and Preventive Pharmacology Service (SEFAP), Department of Pharmacological and Biomolecular Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7209-0426","authenticated-orcid":false,"given":"Elisabetta","family":"Poluzzi","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences-Pharmacology Unit, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,24]]},"reference":[{"key":"ref_1","unstructured":"(2022, September 20). Available online: https:\/\/www.who.int\/emergencies\/diseases\/novel-coronavirus-2019\/interactive-timeline."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.healthpol.2021.05.014","article-title":"On the management of COVID-19 pandemic in Italy","volume":"125","author":"Santeramo","year":"2021","journal-title":"Health Policy"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"10484","DOI":"10.1073\/pnas.2004978117","article-title":"Spread and dynamics of the COVID-19 epidemic in Italy: Effects of emergency containment measures","volume":"117","author":"Gatto","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1016\/j.jaccas.2020.03.012","article-title":"The Outbreak of COVID-19 in Italy: Fighting the Pandemic","volume":"2","author":"Indolfi","year":"2020","journal-title":"JACC Case Rep."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"583583","DOI":"10.3389\/fpubh.2020.583583","article-title":"Impact of SARS-CoV-2 on Provided Healthcare. Evidence from the Emergency Phase in Italy","volume":"8","author":"Cicchetti","year":"2020","journal-title":"Front. Public Health"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1056\/NEJMms2009984","article-title":"The Untold Toll\u2014The Pandemic\u2019s Effects on Patients without COVID-19","volume":"382","author":"Rosenbaum","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e2024984","DOI":"10.1001\/jamanetworkopen.2020.24984","article-title":"Changes in Health Services Use among Commercially Insured US Populations during the COVID-19 Pandemic","volume":"3","author":"Whaley","year":"2020","journal-title":"JAMA Netw. Open"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e119","DOI":"10.1093\/gerona\/glaa077","article-title":"COVID-19 through the Lens of Gerontology","volume":"75","author":"Anderson","year":"2020","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Santi, L., Golinelli, D., Tampieri, A., Farina, G., Greco, M., Rosa, S., Beleffi, M., Biavati, B., Campinoti, F., and Guerrini, S. (2021). Non-COVID-19 patients in times of pandemic: Emergency department visits, hospitalizations and cause-specific mortality in Northern Italy. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0248995"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"623904","DOI":"10.3389\/fpubh.2021.623904","article-title":"General Practitioners\u2019 Experiences during the First Phase of the COVID-19 Pandemic in Italy: A Critical Incident Technique Study","volume":"9","author":"Kurotschka","year":"2021","journal-title":"Front. Public Health"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.1093\/eurheartj\/eht295","article-title":"Adherence to cardiovascular therapy: A meta-analysis of prevalence and clinical consequences","volume":"34","author":"Chowdhury","year":"2013","journal-title":"Eur. Heart J."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Liu, M., Zheng, G., Cao, X., Chang, X., Zhang, N., Liang, G., Wang, A., Yu, Y., Yang, Y., and Zhao, Y. (2021). Better Medications Adherence Lowers Cardiovascular Events, Stroke, and All-Cause Mortality Risk: A Dose-Response Meta-Analysis. J. Cardiovasc. Dev. Dis., 8.","DOI":"10.3390\/jcdd8110146"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s41999-020-00313-2","article-title":"Medication adherence in the older adults with chronic multimorbidity: A systematic review of qualitative studies on patient\u2019s experience","volume":"11","author":"Maffoni","year":"2020","journal-title":"Eur. Geriatr. Med."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Karlsson, P., Nakitanda, A.O., Lofling, L., and Cesta, C.E. (2021). Patterns of prescription dispensation and over-the-counter medication sales in Sweden during the COVID-19 pandemic. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0253944"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Clement, J., Jacobi, M., and Greenwood, B.N. (2021). Patient access to chronic medications during the Covid-19 pandemic: Evidence from a comprehensive dataset of US insurance claims. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0249453"},{"key":"ref_16","first-page":"7","article-title":"The worldwide impact of telemedicine during COVID-19: Current evidence and recommendations for the future","volume":"1","author":"Omboni","year":"2022","journal-title":"Connect. Health"},{"key":"ref_17","first-page":"457","article-title":"Measuring concurrent adherence to multiple related medications","volume":"15","author":"Choudhry","year":"2009","journal-title":"Am. J. Manag. Care"},{"key":"ref_18","unstructured":"Sabat\u00e9, E. (2003). Adherence to Long-Term Therapies: Evidence for Action, World Health Organization."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/978-3-030-85113-2_6","article-title":"First Wave of COVID-19 Pandemic in Italy: Data and Evidence","volume":"1353","author":"Bezzini","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Ortenzi, F., Albanese, E., and Fadda, M. (2020). A Transdisciplinary Analysis of COVID-19 in Italy: The Most Affected Country in Europe. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17249488"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e001143","DOI":"10.1136\/fmch-2021-001143","article-title":"Analysis of primary care prescription trends in England during the COVID-19 pandemic compared against a predictive model","volume":"9","author":"Frazer","year":"2021","journal-title":"Fam. Med. Community Health"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/j.sapharm.2020.04.007","article-title":"Medication management and adherence during the COVID-19 pandemic: Perspectives and experiences from low-and middle-income countries","volume":"17","author":"Kretchy","year":"2021","journal-title":"Res. Soc. Adm. Pharm."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.4103\/ijo.IJO_164_21","article-title":"Impact of COVID-19 on follow-up and medication adherence in patients with glaucoma in a tertiary eye care centre in south India","volume":"69","author":"Subathra","year":"2021","journal-title":"Indian J. Ophthalmol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.japh.2021.11.013","article-title":"The impact of the COVID-19 pandemic on medical conditions and medication adherence in people with chronic diseases","volume":"62","author":"Ismail","year":"2022","journal-title":"J. Am. Pharm. Assoc."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"107833","DOI":"10.1016\/j.yebeh.2021.107833","article-title":"The impact of the coronavirus disease (COVID-19) pandemic on outpatient epilepsy care: An analysis of physician practices in Germany","volume":"117","author":"Mueller","year":"2021","journal-title":"Epilepsy Behav."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.21037\/atm-20-6016","article-title":"Medication adherence among patients with chronic obstructive pulmonary disease treated in a primary general hospital during the COVID-19 pandemic","volume":"8","author":"Zhang","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1097\/HCO.0b013e328347c150","article-title":"Medication adherence: Emerging use of technology","volume":"26","author":"Granger","year":"2011","journal-title":"Curr. Opin. Cardiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"685696","DOI":"10.3389\/fphar.2021.685696","article-title":"A Cross-Sectional Survey on Medication Management Practices for Noncommunicable Diseases in Europe during the Second Wave of the COVID-19 Pandemic","volume":"12","author":"Agh","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"100099","DOI":"10.1016\/j.lanepe.2021.100099","article-title":"Disparities in European healthcare system approaches to maintaining continuity of medication for non-communicable diseases during the COVID-19 outbreak","volume":"4","author":"Kardas","year":"2021","journal-title":"Lancet Reg. Health Eur."},{"key":"ref_30","unstructured":"Presidenza del Consiglio dei Ministri Dipartimento della Protezione Civile (2022, September 20). Ulteriori Interventi Urgenti di Protezione Civile in Relazione All\u2019emergenza Relativa al Rischio Sanitario Connesso All\u2019insorgenza di Patologie Derivanti da Agenti Virali Trasmissibili. (Ordinanza n. 651). (20A01769), Available online: https:\/\/www.trovanorme.salute.gov.it\/norme\/dettaglioAtto?id=73722.2020."},{"key":"ref_31","unstructured":"Ministero Dell\u2019economia e Delle Finanze (2022, September 20). Estensione della Dematerializzazione delle Ricette e dei Piani Terapeutici e Modalita\u2019 Alternative al Promemoria Cartaceo della Ricetta Elettronica. (20A01881), Available online: https:\/\/www.trovanorme.salute.gov.it\/norme\/dettaglioAtto?id=73790&articolo=2."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"109047","DOI":"10.1016\/j.diabres.2021.109047","article-title":"The experience of patients with diabetes with the use of telemedicine and teleassistance services during the COVID-19 pandemic in Italy: Factors associated with perceived quality and willingness to continue","volume":"180","author":"Maietti","year":"2021","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s40264-018-0732-5","article-title":"The Role of European Healthcare Databases for Post-Marketing Drug Effectiveness, Safety and Value Evaluation: Where Does Italy Stand?","volume":"42","author":"Trifiro","year":"2019","journal-title":"Drug Saf."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/19\/12101\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:38:51Z","timestamp":1760143131000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/19\/12101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,24]]},"references-count":33,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["ijerph191912101"],"URL":"https:\/\/doi.org\/10.3390\/ijerph191912101","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,24]]}}}