{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T06:42:30Z","timestamp":1776408150723,"version":"3.51.2"},"reference-count":53,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T00:00:00Z","timestamp":1664236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ARS Auvergne-Rh\u00f4ne-Alpes"},{"name":"ARS Nouvelle Aquitaine"},{"name":"French Ministry of Health"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Background: There is a lack of knowledge regarding the actionable key predictive factors of homelessness in psychiatric populations. Therefore, we used a machine learning model to explore the REHABase database (for rehabilitation database\u2014n = 3416), which is a cohort of users referred to French psychosocial rehabilitation centers in France. Methods: First, we analyzed whether the different risk factors previously associated with homelessness in mental health were also significant risk factors in the REHABase. In the second step, we used unbiased classification and regression trees to determine the key predictors of homelessness. Post hoc analyses were performed to examine the importance of the predictors and to explore the impact of cognitive factors among the participants. Results:\u00a0First, risk factors that were previously found to be associated with homelessness were also significant risk factors in the REHABase. Among all the variables studied with a machine learning approach, the most robust variable in terms of predictive value was the nature of the psychotropic medication (sex\/sex relative mean predictor importance: 22.8, \u03c3 = 3.4). Post hoc analyses revealed that first-generation antipsychotics (15.61%; p &lt; 0.05 FDR corrected), loxapine (16.57%; p &lt; 0.05 FWER corrected) and hypnotics (17.56%; p &lt; 0.05 FWER corrected) were significantly associated with homelessness. Antidepressant medication was associated with a protective effect against housing deprivation (9.21%; p &lt; 0.05 FWER corrected). Conclusions: Psychotropic medication was found to be an important predictor of homelessness in our REHABase cohort, particularly loxapine and hypnotics. On the other hand, the putative protective effect of antidepressants confirms the need for systematic screening of depression and anxiety in the homeless population.<\/jats:p>","DOI":"10.3390\/ijerph191912268","type":"journal-article","created":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T23:12:12Z","timestamp":1664320332000},"page":"12268","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Actionable Predictive Factors of Homelessness in a Psychiatric Population: Results from the REHABase Cohort Using a Machine Learning Approach"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0462-4705","authenticated-orcid":false,"given":"Guillaume","family":"Lio","sequence":"first","affiliation":[{"name":"Centre d\u2019Excellence Autisme iMIND, p\u00f4le HU-ADIS, H\u00f4pital le Vinatier, 69678 Bron, France"},{"name":"Equipe \u00abDisorders of the Brain\u00bb, Institut Marc Jeannerod, UMR 5229, CNRS & Universit\u00e9 Lyon 1, 69100 Villeurbanne, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malek","family":"Ghazzai","sequence":"additional","affiliation":[{"name":"Centre d\u2019Excellence Autisme iMIND, p\u00f4le HU-ADIS, H\u00f4pital le Vinatier, 69678 Bron, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Haesebaert","sequence":"additional","affiliation":[{"name":"P\u00f4le Centre Rive Gauche, H\u00f4pital Le Vinatier, 69678 Bron, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Dubreucq","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de Saint-Etienne, 42270 Saint-Priest-en-Jarez, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9l\u00e8ne","family":"Verdoux","sequence":"additional","affiliation":[{"name":"H\u00f4pital Charles Perrens, Universit\u00e9 de Bordeaux, 33405 Talence, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e9lia","family":"Quiles","sequence":"additional","affiliation":[{"name":"H\u00f4pital Charles Perrens, Universit\u00e9 de Bordeaux, 33405 Talence, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nemat","family":"Jaafari","sequence":"additional","affiliation":[{"name":"CREATIV & URC Pierre Deniker, Centre Hospitalier Laborit, Universit\u00e9 de Poitiers, 86000 Poitiers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Ch\u00e9reau-Boudet","sequence":"additional","affiliation":[{"name":"Centre R\u00e9f\u00e9rent Conjoint de R\u00e9habilitation (CRCR), Centre Hospitalier Universitaire de Clermont-Ferrand, 63000 Clermont-Ferrand, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilie","family":"Legros-Lafarge","sequence":"additional","affiliation":[{"name":"Centre R\u00e9f\u00e9rent de R\u00e9habilitation Psychosociale de Limoges (C2RL), 87000 Limoges, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Guillard-Bouhet","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Laborit, 86000 Poitiers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Massoubre","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de Saint-Etienne, 42270 Saint-Priest-en-Jarez, France"},{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Saint-Etienne, 42023 Saint-Etienne, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Gouache","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Alpes-Is\u00e8re, 38120 Saint Egr\u00e8ve, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8943-0212","authenticated-orcid":false,"given":"Julien","family":"Plasse","sequence":"additional","affiliation":[{"name":"P\u00f4le Centre Rive Gauche, H\u00f4pital Le Vinatier, 69678 Bron, France"},{"name":"Centre Ressource de R\u00e9habilitation Psychosociale et de Rem\u00e9diation Cognitive (CRR), CH le Vinatier et Institut Marc Jeannerod, UMR 5229 & Universit\u00e9 Lyon 1, 69100 Bron, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Barbalat","sequence":"additional","affiliation":[{"name":"P\u00f4le Centre Rive Gauche, H\u00f4pital Le Vinatier, 69678 Bron, France"},{"name":"Centre Ressource de R\u00e9habilitation Psychosociale et de Rem\u00e9diation Cognitive (CRR), CH le Vinatier et Institut Marc Jeannerod, UMR 5229 & Universit\u00e9 Lyon 1, 69100 Bron, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2894-5108","authenticated-orcid":false,"given":"Nicolas","family":"Franck","sequence":"additional","affiliation":[{"name":"P\u00f4le Centre Rive Gauche, H\u00f4pital Le Vinatier, 69678 Bron, France"},{"name":"Centre Ressource de R\u00e9habilitation Psychosociale et de Rem\u00e9diation Cognitive (CRR), CH le Vinatier et Institut Marc Jeannerod, UMR 5229 & Universit\u00e9 Lyon 1, 69100 Bron, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3663-8447","authenticated-orcid":false,"given":"Caroline","family":"Demily","sequence":"additional","affiliation":[{"name":"Centre d\u2019Excellence Autisme iMIND, p\u00f4le HU-ADIS, H\u00f4pital le Vinatier, 69678 Bron, France"},{"name":"Equipe \u00abDisorders of the Brain\u00bb, Institut Marc Jeannerod, UMR 5229, CNRS & Universit\u00e9 Lyon 1, 69100 Villeurbanne, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,27]]},"reference":[{"key":"ref_1","unstructured":"Busch-Geertsema, V., Edgar, W., O\u2019Sullivan, E., and Pleace, N. 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