{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:21:54Z","timestamp":1787959314528,"version":"build-2784847793"},"reference-count":86,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T00:00:00Z","timestamp":1664323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"H.W. and J. Hector Foundation","award":["MED1710"],"award-info":[{"award-number":["MED1710"]}]},{"name":"Manfred Roth Foundation","award":["MED1710"],"award-info":[{"award-number":["MED1710"]}]},{"name":"Research Foundation for Medicine at the University Hospital Erlangen","award":["MED1710"],"award-info":[{"award-number":["MED1710"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Initially, we aimed to investigate the impact of a one-year worksite low-volume, high-intensity interval training (LOW-HIIT) on cardiometabolic health in 114 sedentary office workers. Due to the COVID-19 pandemic outbreak, LOW-HIIT was discontinued after 6 months and participants were followed up for 6 months to analyze physical activity\/exercise behavior and outcome changes during lockdown. Health examinations, including cardiopulmonary exercise testing and the assessment of cardiometabolic markers were performed baseline (T-1), after 6 months (T-2, termination of worksite LOW-HIIT) and 12 months (T-3, follow-up). Cycle ergometer LOW-HIIT (5 \u00d7 1 min at 85\u201395% HRmax) was performed 2\u00d7\/week. For follow-up analyses, participants were classified into three groups: HIIT-group (continued home-based LOW-HIIT), EX-group (continued other home-based exercises), and NO-EX-group (discontinued LOW-HIIT\/exercise). At T-2, VO2max (+1.5 mL\/kg\/min, p = 0.002), mean arterial blood pressure (MAB, \u22124 mmHg, p &lt; 0.001), HbA1c (\u22120.2%, p = 0.005) and self-reported quality of life (QoL, +5 points, p &lt; 0.001) were improved. At T-3, HIIT-group maintained VO2max and QoL and further improved MAB. EX-group maintained MAB and QoL but experienced a VO2max decrease. In NON-EX, VO2max, MAB and QoL deteriorated. We conclude that LOW-HIIT can be considered a promising option to improve cardiometabolic health in real-life conditions and to mitigate physical inactivity-related negative health impacts during lockdowns.<\/jats:p>","DOI":"10.3390\/ijerph191912308","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T20:58:47Z","timestamp":1664398727000},"page":"12308","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Very Low-Volume, High-Intensity Interval Training Mitigates Negative Health Impacts of COVID-19 Pandemic-Induced Physical Inactivity"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8049-1775","authenticated-orcid":false,"given":"Dejan","family":"Reljic","sequence":"first","affiliation":[{"name":"Hector-Center for Nutrition, Exercise and Sports, Department of Medicine 1, University Hospital Erlangen, Friedrich-Alexander University Erlangen-N\u00fcrnberg, 91054 Erlangen, Germany"},{"name":"German Center Immunotherapy (DZI), University Hospital Erlangen, Friedrich-Alexander University Erlangen-N\u00fcrnberg, 91054 Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalena","family":"Eichhorn","sequence":"additional","affiliation":[{"name":"Hector-Center for Nutrition, Exercise and Sports, Department of Medicine 1, University Hospital Erlangen, Friedrich-Alexander University Erlangen-N\u00fcrnberg, 91054 Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3021-8022","authenticated-orcid":false,"given":"Hans J.","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Hector-Center for Nutrition, Exercise and Sports, Department of Medicine 1, University Hospital Erlangen, Friedrich-Alexander University Erlangen-N\u00fcrnberg, 91054 Erlangen, Germany"},{"name":"German Center Immunotherapy (DZI), University Hospital Erlangen, Friedrich-Alexander University Erlangen-N\u00fcrnberg, 91054 Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus F.","family":"Neurath","sequence":"additional","affiliation":[{"name":"German Center Immunotherapy (DZI), University Hospital Erlangen, Friedrich-Alexander University Erlangen-N\u00fcrnberg, 91054 Erlangen, Germany"},{"name":"Department of Medicine 1, University Hospital Erlangen, Friedrich-Alexander University Erlangen-N\u00fcrnberg, 91054 Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3432-7488","authenticated-orcid":false,"given":"Yurdag\u00fcl","family":"Zopf","sequence":"additional","affiliation":[{"name":"Hector-Center for Nutrition, Exercise and Sports, Department of Medicine 1, University Hospital Erlangen, Friedrich-Alexander University Erlangen-N\u00fcrnberg, 91054 Erlangen, Germany"},{"name":"German Center Immunotherapy (DZI), University Hospital Erlangen, Friedrich-Alexander University Erlangen-N\u00fcrnberg, 91054 Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1016\/S0140-6736(17)31634-3","article-title":"The effect of physical activity on mortality and cardiovascular disease in 130,000 people from 17 high-income, middle-income, and low-income countries: The PURE study","volume":"390","author":"Lear","year":"2017","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0140-6736(12)61031-9","article-title":"Effect of physical inactivity on major non-communicable diseases worldwide: An analysis of burden of disease and life expectancy","volume":"380","author":"Lee","year":"2012","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1001\/jamainternmed.2020.6331","article-title":"Association of physical activity intensity with mortality: A National Cohort Study of 403,681 US adults","volume":"181","author":"Wang","year":"2021","journal-title":"JAMA Intern. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/S0140-6736(11)60749-6","article-title":"Minimum amount of physical activity for reduced mortality and extended life expectancy: A prospective cohort study","volume":"378","author":"Wen","year":"2011","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.pcad.2014.09.011","article-title":"Physical activity and cardiorespiratory fitness as major markers of cardiovascular risk: Their independent and interwoven importance to health status","volume":"57","author":"Myers","year":"2015","journal-title":"Prog. Cardiovasc. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e1077","DOI":"10.1016\/S2214-109X(18)30357-7","article-title":"Worldwide trends in insufficient physical activity from 2001 to 2016: A pooled analysis of 358 population-based surveys with 1.9 million participants","volume":"6","author":"Guthold","year":"2018","journal-title":"Lancet Glob. Health"},{"key":"ref_7","first-page":"100","article-title":"Lack of time is the consistent barrier to physical activity and exercise in 18 to 64 year-old males and females from both South Carolina and Southern Ontario","volume":"5","author":"Cavallini","year":"2020","journal-title":"J. Phys. Act. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.bjpt.2016.04.003","article-title":"Predictors of perceived barriers to physical activity in the general adult population: A cross-sectional study","volume":"21","author":"Pinillos","year":"2017","journal-title":"Braz. J. Phys. Ther."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Hoare, E., Stavreski, B., Jennings, G.L., and Kingwell, B.A. (2017). Exploring motivation and barriers to physical activity among active and inactive Australian adults. Sports, 5.","DOI":"10.3390\/sports5030047"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1113\/JP276849","article-title":"Physiological basis of brief vigorous exercise to improve health","volume":"598","author":"Gibala","year":"2020","journal-title":"J. Physiol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Atakan, M.M., Li, Y., Ko\u015far, \u015e.N., Turnag\u00f6l, H.H., and Yan, X. (2021). Evidence-based effects of high-intensity interval training on exercise capacity and health: A review with historical perspective. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18137201"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"De Oliveira Teles, G., da Silva, C.S., Rezende, V.R., and Rebelo, A.C.S. (2022). Acute effects of high-intensity interval training on diabetes mellitus: A systematic review. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19127049"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"S1273","DOI":"10.1007\/s40279-014-0259-6","article-title":"Physiological and health-related adaptations to low-volume interval training: Influences of nutrition and sex","volume":"44","author":"Gibala","year":"2014","journal-title":"Sport. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1139\/apnm-2013-0187","article-title":"Is high-intensity interval training a time-efficient exercise strategy to improve health and fitness?","volume":"39","author":"Gillen","year":"2014","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1007\/s40279-019-01167-w","article-title":"The effect of low-volume high-intensity interval training on body composition and cardiorespiratory fitness: A systematic review and meta-analysis","volume":"49","author":"Sultana","year":"2019","journal-title":"Sport. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1007\/s00421-018-3845-8","article-title":"Effects of low-volume high-intensity interval training in a community setting: A pilot study","volume":"118","author":"Reljic","year":"2018","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Reljic, D., Dieterich, W., Herrmann, H.J., Neurath, M.F., and Zopf, Y. (2022). \u201cHIIT the Inflammation\u201d: Comparative effects of low-volume interval training and resistance exercises on inflammatory indices in obese metabolic syndrome patients undergoing caloric restriction. Nutrients, 14.","DOI":"10.3390\/nu14101996"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1186\/s12967-020-02592-6","article-title":"Low-volume high-intensity interval training improves cardiometabolic health, work ability and well-being in severely obese individuals: A randomized-controlled trial sub-study","volume":"18","author":"Reljic","year":"2020","journal-title":"J. Transl. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.1038\/s41598-021-82372-4","article-title":"Effects of very low volume high intensity versus moderate intensity interval training in obese metabolic syndrome patients: A randomized controlled study","volume":"11","author":"Reljic","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_20","first-page":"927","article-title":"Very low-volume interval training improves nonalcoholic fatty liver disease fibrosis score and cardiometabolic health in adults with obesity and metabolic syndrome","volume":"72","author":"Reljic","year":"2021","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Reljic, D., Herrmann, H.J., Jakobs, B., Dieterich, W., Mougiakakos, D., Neurath, M.F., and Zopf, Y. (2022). Feasibility, safety, and preliminary efficacy of very low-volume interval training in advanced cancer patients. Med. Sci. Sports Exerc.","DOI":"10.1249\/MSS.0000000000002989"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Shepherd, S.O., Wilson, O.J., Taylor, A.S., Th\u00f8gersen-Ntoumani, C., Adlan, A.M., Wagenmakers, A.J.M., and Shaw, C.S. (2015). Low-volume high-intensity interval training in a gym setting improves cardio-metabolic and psychological health. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0139056"},{"key":"ref_23","first-page":"181","article-title":"Interventions to reduce sedentary behavior and increase physical activity during productive work: A systematic review","volume":"42","author":"Commissaris","year":"2016","journal-title":"Scand. J. Work Environ. Health"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Grimani, A., Aboagye, E., and Kwak, L. (2019). The effectiveness of workplace nutrition and physical activity interventions in improving productivity, work performance and workability: A systematic review. BMC Public Health, 19.","DOI":"10.1186\/s12889-019-8033-1"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1136\/oemed-2014-102678","article-title":"The impact of onsite workplace health-enhancing physical activity interventions on worker productivity: A systematic review","volume":"72","author":"Pereira","year":"2015","journal-title":"Occup. Environ. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/s13679-016-0205-z","article-title":"Effectiveness of workplace weight management interventions: A systematic review","volume":"5","author":"Weerasekara","year":"2016","journal-title":"Curr. Obes. Rep."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Batrakoulis, A., and Fatouros, I.G. (2022). Psychological adaptations to high-intensity interval training in overweight and obese adults: A topical review. Sports, 10.","DOI":"10.3390\/sports10050064"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1136\/bjsports-2015-095705","article-title":"High-intensity interval training: Key data needed to bridge the gap from laboratory to public health policy","volume":"50","author":"Gray","year":"2016","journal-title":"Brit. J. Sport. Med."},{"key":"ref_29","unstructured":"American College of Sports Medicine (2010). ACSM\u2019s Guidelines for Exercise Testing and Prescription, Lippincott Williams & Wilkins. [8th ed.]."},{"key":"ref_30","first-page":"e426","article-title":"2017 ACC\/AHA\/AAPA\/ABC\/ACPM\/ AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Executive Summary: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"138","author":"Whelton","year":"2018","journal-title":"Circulation"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/ejcn.2017.27","article-title":"Quantification of whole-body and segmental skeletal muscle mass using phase-sensitive 8-electrode medical bioelectrical impedance devices","volume":"71","author":"Jensen","year":"2017","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_32","first-page":"1558","article-title":"Optimizing the exercise protocol for cardiopulmonary assessment","volume":"55","author":"Buchfuhrer","year":"1983","journal-title":"J. Appl. Physiol. Respir. Environ. Exerc. Physiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1249\/00005768-199509000-00009","article-title":"Criteria for maximal oxygen uptake: Review and commentary","volume":"27","author":"Howley","year":"1995","journal-title":"Med. Sci. Sport. Exer."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1055\/s-2008-1026080","article-title":"Ratings of perceived exertion and heart rates during shortterm cycle exercise and their use in a new cycling strength test","volume":"3","author":"Borg","year":"1982","journal-title":"Int. J. Sport. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1055\/s-2004-830514","article-title":"A conceptual framework for performance diagnosis and training prescription from submaximal gas exchange parameters\u2014Theory and application","volume":"26","author":"Meyer","year":"2005","journal-title":"Int. J. Sport. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1007\/s10198-019-01054-1","article-title":"Health-related quality of life measured with the EQ-5D-5L: Estimation of normative index values based on a representative German population sample and value set","volume":"20","author":"Grochtdreis","year":"2019","journal-title":"Eur. J. Health Econ."},{"key":"ref_37","first-page":"79","article-title":"Mitglieder des Arbeitsgruppe. Instruments for measuring the effects of early intervention on maintaining and restoring ability to work in Germany: Opinion of an interdisciplinary working group","volume":"80","author":"Amler","year":"2018","journal-title":"Gesundheitswesen"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1097\/01.psy.0000151491.80178.78","article-title":"The Perceived Stress Questionnaire (PSQ) reconsidered: Validation and reference values from different clinical and healthy adult samples","volume":"67","author":"Fliege","year":"2005","journal-title":"Psychosom. Med."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Mazzoni, A.S., Nordin, K., Berntsen, S., Demmelmaier, I., and Igelstr\u00f6m, H. (2017). Comparison between logbook-reported and objectively-assessed physical activity and sedentary time in breast cancer patients: An agreement study. BMC Sport. Sci. Med. Rehabil., 9.","DOI":"10.1186\/s13102-017-0072-2"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"50","DOI":"10.2522\/ptj.20120123","article-title":"Level of agreement between methods for measuring moderate to vigorous physical activity and sedentary time in people with obstructive sleep apnea and obesity","volume":"93","author":"Emtner","year":"2013","journal-title":"Phys Ther."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"S498","DOI":"10.1097\/00005768-200009001-00009","article-title":"Compendium of physical activities: An update of activity codes and MET intensities","volume":"32","author":"Ainsworth","year":"2000","journal-title":"Med. Sci. Sport. Exerc."},{"key":"ref_42","unstructured":"World Health Organization (2010). Global Recommendations on Physical Activity for Health, World Health Organization."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"838","DOI":"10.3389\/fpsyg.2016.00838","article-title":"Dropping out or keeping up? Early dropouts, late-dropouts, and maintainers differ in their automatic evaluations of exercise already before a 14-week exercise course","volume":"7","author":"Antoniewicz","year":"2016","journal-title":"Front. Psychol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Buckworth, J., and Dishman, R.K. (2013). Exercise Psychology, Human Kinetics.","DOI":"10.5040\/9781492595502"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ypmed.2016.02.037","article-title":"Adherence to community based group exercise interventions for older people: A mixed-methods systematic review","volume":"87","author":"Farrance","year":"2016","journal-title":"Prev. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"250423","DOI":"10.1155\/2013\/250423","article-title":"Dropouts and compliance in exercise interventions targeting bone mineral density in adults: A meta-analysis of randomized controlled trials","volume":"2013","author":"Kelley","year":"2013","journal-title":"J. Osteoporos."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1097\/HCR.0b013e31826be485","article-title":"Predictors of exercise intervention dropout in sedentary individuals with type 2 diabetes","volume":"32","author":"Nam","year":"2012","journal-title":"J. Cardiopulm. Rehabil. Prev."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1111\/sms.13452","article-title":"Prevalence and predictors of dropout from high-intensity interval training in sedentary individuals: A meta-analysis","volume":"29","author":"Reljic","year":"2019","journal-title":"Scand. J. Med. Sci. Sport."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1146\/annurev-publhealth-031210-101151","article-title":"Physical activity for health: What kind? How much? How intense? On top of what?","volume":"32","author":"Powell","year":"2011","journal-title":"Annu. Rev. Public Health"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1001\/jamainternmed.2016.8014","article-title":"Association of \u201cweekend warrior\u201d and other leisure time physical activity patterns with risks for all-cause, cardiovascular disease, and cancer mortality","volume":"177","author":"Lee","year":"2017","journal-title":"JAMA Intern. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"S446","DOI":"10.1097\/00005768-200106001-00013","article-title":"Individual differences in response to regular physical activity","volume":"33","author":"Bouchard","year":"2001","journal-title":"Med. Sci. Sport. Exerc."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1161\/01.CIR.0000024413.15949.ED","article-title":"Prediction of long-term prognosis in 12 169 men referred for cardiac rehabilitation","volume":"106","author":"Kavanagh","year":"2002","journal-title":"Circulation"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1111\/sms.14007","article-title":"The importance of ventilatory thresholds to define aerobic exercise intensity in cardiac patients and healthy subjects","volume":"31","author":"Anselmi","year":"2021","journal-title":"Scand. J. Med. Sci. Sport."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1113\/JP281210","article-title":"Low-volume high-intensity interval training for cardiometabolic health","volume":"600","author":"Sabag","year":"2022","journal-title":"J. Physiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/s40279-015-0321-z","article-title":"The impact of high-intensity interval training versus moderate-intensity continuous training on vascular function: A systematic review and meta-analysis","volume":"45","author":"Ramos","year":"2015","journal-title":"Sport. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1136\/bmj.b1665","article-title":"Use of blood pressure lowering drugs in the prevention of cardiovascular disease: Meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies","volume":"338","author":"Law","year":"2009","journal-title":"BMJ"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1136\/bmj.322.7277.15","article-title":"Glycated haemoglobin, diabetes, and mortality in men in Norfolk cohort of european prospective investigation of cancer and nutrition (EPIC-Norfolk)","volume":"322","author":"Khaw","year":"2001","journal-title":"BMJ"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1016\/j.socscimed.2009.02.028","article-title":"The effects of exercise interventions on quality of life in clinical and healthy populations; a meta-analysis","volume":"68","author":"Gillison","year":"2009","journal-title":"Soc. Sci. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1080\/02640414.2019.1706829","article-title":"Can high-intensity interval training improve physical and mental health outcomes? A meta-review of 33 systematic reviews across the lifespan","volume":"38","author":"Martland","year":"2020","journal-title":"J. Sport. Sci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.neubiorev.2019.09.040","article-title":"Physical activity and depression: Towards understanding the antidepressant mechanisms of physical activity","volume":"107","author":"Kandola","year":"2019","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1113\/JP275021","article-title":"HIITing the brain with exercise: Mechanisms, consequences and practical recommendations","volume":"598","author":"Alverley","year":"2020","journal-title":"J. Physiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1007\/s00421-021-04746-w","article-title":"Long-term high-intensity interval training increases serum neurotrophic factors in elderly overweight and obese Chinese adults","volume":"121","author":"Li","year":"2021","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"292","DOI":"10.7570\/jomes20074","article-title":"Psycho-physiological responses to a 4-Month high-intensity interval training-centered multidisciplinary weight-loss intervention in adolescents with obesity","volume":"29","author":"Khammassi","year":"2020","journal-title":"J. Obes. Metab. Syndr."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"o348","DOI":"10.1136\/bmj.o348","article-title":"Lack of physical activity is a global problem","volume":"376","author":"Haseler","year":"2022","journal-title":"BMJ"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Togni, G., Puccinelli, P.J., Costa, T., Seffrin, A., de Lira, C.A.B., Vancini, R.L., Santos, D.D.A.T., Nikolaidis, P.T., Knechtle, B., and Andrade, M.S. (2021). Factors associated with reduction in physical activity during the COVID-19 pandemic in S\u00e3o Paulo, Brazil: An internet-based survey conducted in June 2020. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph182111397"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Wunsch, K., Kienberger, K., and Niessner, C. (2022). Changes in physical activity patterns due to the Covid-19 pandemic: A systematic review and meta-analysis. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19042250"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"767","DOI":"10.7326\/M20-2665","article-title":"Worldwide effect of COVID-19 on physical activity: A descriptive study","volume":"173","author":"Tison","year":"2020","journal-title":"Ann. Intern. Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1177\/1012690220934335","article-title":"Sport and exercise in times of self-quarantine: How Germans changed their behaviour at the beginning of the Covid-19 pandemic","volume":"56","author":"Mutz","year":"2021","journal-title":"Int. Rev. Soc. Sport"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"901763","DOI":"10.3389\/fpubh.2022.901763","article-title":"Physical activity behavior during and after COVID-19 stay-at-home orders-a longitudinal study in the Austrian, German, and Italian Alps","volume":"10","author":"Schnitzer","year":"2022","journal-title":"Front. Public Health"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Meyer, J., McDowell, C., Lansing, J., Brower, C., Smith, L., Tully, M., and Herring, M. (2020). Changes in physical activity and sedentary behavior in response to COVID-19 and their associations with mental health in 3052 US adults. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17186469"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1007\/s40279-021-01468-z","article-title":"Is physical activity associated with less depression and anxiety during the COVID-19 pandemic? A rapid systematic review","volume":"51","author":"Wolf","year":"2021","journal-title":"Sport. Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1136\/bjsports-2021-104080","article-title":"Physical inactivity is associated with a higher risk for severe COVID-19 outcomes: A study in 48 440 adult patients","volume":"55","author":"Sallis","year":"2021","journal-title":"Br. J. Sport. Med."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"572718","DOI":"10.3389\/fphys.2020.572718","article-title":"A preventive role of exercise across the Coronavirus 2 (SARS-CoV-2) pandemic","volume":"11","author":"Wang","year":"2020","journal-title":"Front. Physiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1152\/japplphysiol.00415.2017","article-title":"Effects of strict prolonged bed rest on cardiorespiratory fitness: Systematic review and meta-analysis","volume":"123","author":"Aarts","year":"2017","journal-title":"J. Appl. Physiol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1161\/01.HYP.0000184225.05629.51","article-title":"Effects of endurance training on blood pressure, blood pressure-regulating mechanisms, and cardiovascular risk factors","volume":"46","author":"Cornelissen","year":"2005","journal-title":"Hypertension"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/j.1440-1681.1993.tb01729.x","article-title":"Five year prospective study on blood pressure and maximal oxygen uptake","volume":"20","author":"Sawada","year":"1993","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1001\/jama.298.14.1685","article-title":"Psychological stress and disease","volume":"298","author":"Cohen","year":"2007","journal-title":"JAMA"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"844057","DOI":"10.3389\/fpsyg.2022.844057","article-title":"The impact of the COVID-19 pandemic on health, quality of life and intrafamilial relations\u2014a population-based survey in Germany","volume":"13","author":"Klein","year":"2022","journal-title":"Front. Psychol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.3961\/jpmph.2013.46.S.S28","article-title":"Physical activity and quality of life","volume":"46","author":"Gill","year":"2013","journal-title":"J. Prev. Med. Public Health"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1520-037X.2005.02791.x","article-title":"Moderate or vigorous intensity exercise: Which is better for improving aerobic fitness?","volume":"8","author":"Swain","year":"2004","journal-title":"Prev. Cardiol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1079\/PHN2002427","article-title":"Addressing overreporting on the International Physical Activity Questionnaire (IPAQ) telephone survey with a population sample","volume":"6","author":"Rzewnicki","year":"2003","journal-title":"Public Health Nutr."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"e13490","DOI":"10.1111\/ijcp.13490","article-title":"Effect of high-intensity interval training and continuous endurance training on peak oxygen uptake among seniors aged 65 or older: A meta-analysis of randomized controlled trials","volume":"74","author":"Bouaziz","year":"2020","journal-title":"Int. J. Clin. Pract."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1111\/obr.12317","article-title":"The effects of high-intensity interval training on glucose regulation and insulin resistance: A meta-analysis","volume":"16","author":"Jelleyman","year":"2015","journal-title":"Obes. Rev."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"e13239","DOI":"10.1111\/obr.13239","article-title":"Effect of different types of regular exercise on physical fitness in adults with overweight or obesity: Systematic review and meta-analyses","volume":"22","author":"Pramono","year":"2021","journal-title":"Obes. Rev."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.jsams.2019.01.013","article-title":"Effects of different protocols of high intensity interval training for VO2max improvements in adults: A meta-analysis of randomised controlled trials","volume":"22","author":"Wen","year":"2019","journal-title":"J. Sci. Med. Sport."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1249\/MSS.0000000000001188","article-title":"Brief intense stair climbing improves cardiorespiratory fitness","volume":"49","author":"Allison","year":"2017","journal-title":"Med. Sci. Sport. 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