{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:18:36Z","timestamp":1780391916451,"version":"3.54.1"},"reference-count":60,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T00:00:00Z","timestamp":1664323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>The coexistence of chronic obstructive pulmonary disease (COPD) and cardiovascular disease is common and causes poor prognoses. Hyperlipidemia is the most common risk factor for cardiovascular disease, but the association between hyperlipidemia and COPD remains ambiguous. This study aimed to investigate the risk of COPD development in patients with hyperlipidemia. This retrospective cohort study used information from the National Health Insurance Research Database in Taiwan. We enrolled 21,790 patients with hyperlipidemia and 87,160 control patients without hyperlipidemia for comparison, with a follow-up period of over 10 years. The incidence of new-onset COPD was higher in patients with hyperlipidemia (36.14 per 1000 person-years) than in the controls (22.29 per 1000 person-years). Patients with hyperlipidemia were 1.48 times more likely to develop subsequent COPD than the controls without hyperlipidemia (95% confidence interval 1.44 to 1.53, p &lt; 0.001) following adjustments for age, sex, and comorbidities. In addition, nephropathy, hypertension, congestive heart failure, age, and sex (female) were potential risk factors for developing COPD in patients with hyperlipidemia. Patients with hyperlipidemia may have an increased risk of developing COPD.<\/jats:p>","DOI":"10.3390\/ijerph191912331","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T20:58:47Z","timestamp":1664398727000},"page":"12331","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Increased Risk of Chronic Obstructive Pulmonary Disease in Patients with Hyperlipidemia: A Nationwide Population-Based Cohort Study"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6889-8919","authenticated-orcid":false,"given":"Hao-Yu","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Family Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 813414, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Yu","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Taipei Veterans General Hospital, Taipei 112, Taiwan"},{"name":"School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hon-Jhe","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 813414, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8019-4148","authenticated-orcid":false,"given":"Ru-Yih","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 813414, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Kuo","family":"Hu","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, Chiayi Branch, Taichung Veterans General Hospital, Chiayi 600, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Che","family":"Shen","sequence":"additional","affiliation":[{"name":"School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"},{"name":"Department of Psychiatry, Chiayi Branch, Taichung Veterans General Hospital, Chiayi 600, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,28]]},"reference":[{"key":"ref_1","unstructured":"Hill, M.F., and Bordoni, B. (2021). Hyperlipidemia, StatPearls."},{"key":"ref_2","unstructured":"The Global Initiative for Chronic Obstructive Lung Disease (GOLD) (2021, November 11). 2021 GOLD Reports\u2014Global Initiative for Chronic Obstructive Lung Disease. Available online: https:\/\/goldcopd.org\/2021-gold-reports\/."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.pulmoe.2018.09.006","article-title":"COPD and cardiovascular disease","volume":"25","author":"Conde","year":"2019","journal-title":"Pulmonology"},{"key":"ref_4","unstructured":"Centers for Disease Control and Prevention (2012). Chronic obstructive pulmonary disease among adults\u2014United States, 2011. MMWR Morb. Mortal. Wkly. Rep., 61, 938\u2013943."},{"key":"ref_5","unstructured":"GBD 2015 Chronic Respiratory Disease Collaborators (2017). Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990\u20132015: A systematic analysis for the Global burden of disease study 2015. Lancet Respir. Med., 5, 691\u2013706."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/S0140-6736(07)61377-4","article-title":"International variation in the prevalence of COPD (the BOLD Study): A population-based prevalence study","volume":"370","author":"Buist","year":"2007","journal-title":"Lancet"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1161\/CIRCRESAHA.118.313237","article-title":"Emerging roles of vascular endothelium in metabolic homeostasis","volume":"123","author":"Pi","year":"2018","journal-title":"Circ. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3889\/oamjms.2016.060","article-title":"The level of cholesterol in COPD patients with severe and very severe stage of the disease","volume":"4","author":"Stojkovikj","year":"2016","journal-title":"Open Access Maced. J. Med. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.9734\/BJMMR\/2015\/18703","article-title":"Lipid profile status in chronic obstructive pulmonary disease and association with interleukin 8","volume":"9","author":"Mitra","year":"2015","journal-title":"Br. J. Med. Med. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2045894018758528","DOI":"10.1177\/2045894018758528","article-title":"COPD as an endothelial disorder: Endothelial injury linking lesions in the lungs and other organs? (2017 Grover Conference Series)","volume":"8","author":"Polverino","year":"2018","journal-title":"Pulm. Circ."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1377\/hlthaff.22.3.61","article-title":"Taiwan\u2019s new national health insurance program: Genesis and experience so far","volume":"22","author":"Cheng","year":"2003","journal-title":"Health Aff."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3389\/fphar.2018.00225","article-title":"Simvastatin therapy for drug repositioning to reduce the risk of prostate cancer mortality in patients with hyperlipidemia","volume":"9","author":"Chen","year":"2018","journal-title":"Front. Pharmacol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Hsu, T.W., Lee, P.S., Nfor, O.N., Lee, C.L., Chen, P.H., Tantoh, D.M., Lin, L.Y., Chou, M.C., Lee, Y.C., and Liaw, Y.P. (2019). The interaction between sex and hyperlipidemia on gout risk is modulated by HLA-B polymorphic variants in adult Taiwanese. Genes, 10.","DOI":"10.3390\/genes10030246"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1001\/jamainternmed.2015.3540","article-title":"Nationwide population science: Lessons from the Taiwan national health insurance research database","volume":"175","author":"Hsing","year":"2015","journal-title":"JAMA Intern. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.4187\/respcare.04796","article-title":"New predictor of atherosclerosis in subjects with COPD: Atherogenic indices","volume":"61","author":"Gunay","year":"2016","journal-title":"Respir. Care."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.jcma.2015.08.004","article-title":"Role of oxidative stress and serum lipid levels in stable chronic obstructive pulmonary disease","volume":"78","author":"Can","year":"2015","journal-title":"J. Chin. Med. Assoc."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1055\/s-0043-102578","article-title":"Platelet-derived NO in subjects affected by type 2 diabetes with and without complications: Is there any relationship with their offspring?","volume":"125","author":"Sabbatinelli","year":"2017","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1161\/CIRCULATIONAHA.105.602532","article-title":"Endothelial nitric oxide synthase in vascular disease: From marvel to menace","volume":"113","year":"2006","journal-title":"Circulation"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s11906-001-0081-z","article-title":"Antioxidants and endothelial dysfunction in hyperlipidemia","volume":"3","author":"Warnholtz","year":"2001","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Sabbatinelli, J., Orlando, P., Galeazzi, R., Silvestri, S., Cirilli, I., Marcheggiani, F., Dludla, P.V., Giuliani, A., Bonfigli, A.R., and Mazzanti, L. (2020). Ubiquinol ameliorates endothelial dysfunction in subjects with mild-to-moderate dyslipidemia: A randomized clinical trial. Nutrients, 12.","DOI":"10.3390\/nu12041098"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.hfc.2012.06.012","article-title":"Role of lipotoxicity in endothelial dysfunction","volume":"8","author":"Kim","year":"2012","journal-title":"Heart Fail. Clin."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.autrev.2010.07.016","article-title":"From endothelial dysfunction to atherosclerosis","volume":"9","author":"Sitia","year":"2010","journal-title":"Autoimmun. Rev."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1161\/CIRCULATIONAHA.105.563213","article-title":"Reciprocal relationships between insulin resistance and endothelial dysfunction: Molecular and pathophysiological mechanisms","volume":"113","author":"Kim","year":"2006","journal-title":"Circulation"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1161\/01.RES.0000163635.62927.34","article-title":"Adipose tissue, inflammation, and cardiovascular disease","volume":"96","author":"Berg","year":"2005","journal-title":"Circ. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1172\/JCI118709","article-title":"Obesity\/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance","volume":"97","author":"Steinberg","year":"1996","journal-title":"J. Clin. Invest."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1056\/NEJM199105303242203","article-title":"Impairment of endothelium-dependent pulmonary-artery relaxation in chronic obstructive lung disease","volume":"324","author":"Higenbottam","year":"1991","journal-title":"N. Engl. J. Med."},{"key":"ref_27","first-page":"L908","article-title":"Endothelial dysfunction in pulmonary arteries of patients with mild COPD","volume":"274","author":"Peinado","year":"1998","journal-title":"Am. J. Physiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1164\/rccm.200707-980OC","article-title":"Impaired flow-mediated dilation is associated with low pulmonary function and emphysema in ex-smokers: The Emphysema and Cancer Action Project (EMCAP) Study","volume":"176","author":"Barr","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1177\/0003319707306141","article-title":"Endothelial dysfunction in chronic obstructive pulmonary disease","volume":"59","author":"Moro","year":"2008","journal-title":"Angiology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1164\/rccm.200709-1412OC","article-title":"Determinants of systemic vascular function in patients with stable chronic obstructive pulmonary disease","volume":"178","author":"Eickhoff","year":"2008","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.mehy.2014.11.017","article-title":"Persistent endothelial dysfunction turns the frequent exacerbator COPD from respiratory disorder into a progressive pulmonary and systemic vascular disease","volume":"84","author":"Ruzic","year":"2015","journal-title":"Med. Hypotheses."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1164\/rccm.201003-0360OC","article-title":"Microalbuminuria and hypoxemia in patients with chronic obstructive pulmonary disease","volume":"182","author":"Casanova","year":"2010","journal-title":"Am. J. Respir. Crit. Care. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1164\/rccm.201609-1765OC","article-title":"A pilot study linking endothelial injury in lungs and kidneys in chronic obstructive pulmonary disease","volume":"195","author":"Polverino","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1161\/CIRCRESAHA.115.306301","article-title":"Endothelial cell dysfunction and the pathobiology of atherosclerosis","volume":"118","author":"Gimbrone","year":"2016","journal-title":"Circ. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1006\/jmcc.1998.0843","article-title":"Endothelial dysfunction in human disease","volume":"31","author":"Drexler","year":"1999","journal-title":"J. Mol. Cell Cardiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1161\/HYPERTENSIONAHA.109.148957","article-title":"Endothelial dysfunction and hypertension: Cause or effect?","volume":"55","author":"Quyyumi","year":"2010","journal-title":"Hypertension"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1161\/01.HYP.33.4.937","article-title":"A large blood pressure-raising effect of nitric oxide synthase inhibition in humans","volume":"33","author":"Sander","year":"1999","journal-title":"Hypertension"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1161\/01.HYP.0000237666.78217.47","article-title":"Elevated blood pressure in adolescent boys predicts endothelial dysfunction: The cardiovascular risk in young Finns study","volume":"48","author":"Juonala","year":"2006","journal-title":"Hypertension"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1097\/HJH.0b013e328330e89a","article-title":"Nitric oxide dysfunction in vascular endothelium and platelets: Role in essential hypertension","volume":"27","author":"Gkaliagkousi","year":"2009","journal-title":"J. Hypertens."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1161\/01.HYP.16.2.170","article-title":"Activation of endothelial L-arginine pathway in resistance arteries. Effect of age and hypertension","volume":"16","author":"Dohi","year":"1990","journal-title":"Hypertension"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1524-6175.2006.06032.x","article-title":"Nitric oxide in hypertension","volume":"8","author":"Hermann","year":"2006","journal-title":"J. Clin. Hypertens."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1038\/hr.2012.138","article-title":"Endothelial dysfunction and hypertension in aging","volume":"35","author":"Higashi","year":"2012","journal-title":"Hypertens. Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s10741-019-09881-3","article-title":"Role of endothelial dysfunction in heart failure","volume":"25","author":"Zuchi","year":"2020","journal-title":"Heart Fail Rev."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"3212","DOI":"10.1161\/01.CIR.92.11.3212","article-title":"Endothelial control of arterial distensibility is impaired in chronic heart failure","volume":"92","author":"Ramsey","year":"1995","journal-title":"Circulation"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1161\/01.CIR.0000153349.77489.CF","article-title":"Vascular endothelial dysfunction and mortality risk in patients with chronic heart failure","volume":"111","author":"Katz","year":"2005","journal-title":"Circulation"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1161\/01.CIR.84.4.1589","article-title":"Endothelium-dependent vasodilation is attenuated in patients with heart failure","volume":"84","author":"Kubo","year":"1991","journal-title":"Circulation"},{"key":"ref_47","first-page":"183","article-title":"Endothelial dysfunction: Cardiovascular risk factors, therapy, and outcome","volume":"1","author":"Hadi","year":"2005","journal-title":"Vasc. Health Risk Manag."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.arr.2009.07.002","article-title":"Endothelial dysfunction and aging: An update","volume":"9","author":"Herrera","year":"2010","journal-title":"Ageing Res. Rev."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1186\/1476-511X-10-211","article-title":"Endothelial dysfunction in the apolipoprotein E-deficient mouse: Insights into the influence of diet, gender and aging","volume":"10","author":"Meyrelles","year":"2011","journal-title":"Lipids Health Dis."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/0735-1097(94)90305-0","article-title":"Aging is associated with endothelial dysfunction in healthy men years before the age-related decline in women","volume":"24","author":"Celermajer","year":"1994","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"4692","DOI":"10.1210\/jc.2012-2244","article-title":"Endothelial function is impaired across the stages of the menopause transition in healthy women","volume":"97","author":"Moreau","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"H1569","DOI":"10.1152\/ajpheart.00396.2018","article-title":"Sex differences in endothelial function important to vascular health and overall cardiovascular disease risk across the lifespan","volume":"315","author":"Stanhewicz","year":"2018","journal-title":"Am. J. Physiol. Heart. Circ. Physiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S0140-6736(07)61380-4","article-title":"Global burden of COPD: Risk factors, prevalence, and future trends","volume":"370","author":"Mannino","year":"2007","journal-title":"Lancet"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1136\/thx.2006.062802","article-title":"Developing COPD: A 25 year follow up study of the general population","volume":"61","author":"Lange","year":"2006","journal-title":"Thorax"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1016\/S0140-6736(18)30841-9","article-title":"Prevalence and risk factors of chronic obstructive pulmonary disease in China (the China Pulmonary Health [CPH] study): A national cross-sectional study","volume":"391","author":"Wang","year":"2018","journal-title":"Lancet"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1164\/rccm.202005-1990OC","article-title":"Prevalence and population attributable risk for chronic airflow obstruction in a large multinational study","volume":"203","author":"Burney","year":"2020","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Wang, S., Xu, L., Jonas, J.B., You, Q.S., Wang, Y.X., and Yang, H. (2011). Prevalence and associated factors of dyslipidemia in the adult Chinese population. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0017326"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/qjmed\/hcu136","article-title":"The association between chronic obstructive pulmonary disease and Parkinson\u2019s disease: A nationwide population-based retrospective cohort study","volume":"108","author":"Li","year":"2015","journal-title":"Qjm"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.5665\/sleep.4808","article-title":"The use of benzodiazepine receptor agonists and risk of respiratory failure in patients with chronic obstructive pulmonary disease: A nationwide population-based case-control study","volume":"38","author":"Chen","year":"2015","journal-title":"Sleep"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jmii.2017.08.014","article-title":"Influenza vaccination and risk of respiratory failure in patients with chronic obstructive pulmonary disease: A nationwide population-based case-cohort study","volume":"52","author":"Huang","year":"2019","journal-title":"J. Microbiol. Immunol. Infect."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/19\/12331\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:41:03Z","timestamp":1760143263000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/19\/12331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,28]]},"references-count":60,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["ijerph191912331"],"URL":"https:\/\/doi.org\/10.3390\/ijerph191912331","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,28]]}}}