{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:11:22Z","timestamp":1790892682320,"version":"4.1.0"},"reference-count":44,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T00:00:00Z","timestamp":1664323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior-Brazil","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior-Brazil","award":["141536\/2016-0"],"award-info":[{"award-number":["141536\/2016-0"]}]},{"name":"National Council for Scientific and Technological Development of Brazil","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"National Council for Scientific and Technological Development of Brazil","award":["141536\/2016-0"],"award-info":[{"award-number":["141536\/2016-0"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>People living with HIV (PWH) experience an accelerated reduction in bone mineral content (BMC), and a high risk of osteopenia and osteoporosis. Anthropometry is an accurate and low-cost method that can be used to monitor changes in body composition in PWH. To date, no studies have used anthropometry to estimate BMC in PWH. To propose and validate sex-specific anthropometric models to predict BMC in PWH. This cross-sectional study enrolled 104 PWH (64 males) aged &gt;18 years at a local university hospital. BMC was measured using dual energy X-ray absorptiometry (DXA). Anthropometric measures were collected. We used linear regression analysis to generate the models. Cross-validations were conducted using the \u201cleave one out\u201d, from the predicted residual error sum of squares (PRESS) method. Bland\u2013Altman plots were used to explore distributions of errors. We proposed models with high coefficient of determination and reduced standard error of estimate for males (r2 = 0.70; SEE = 199.97 g; Q2PRESS = 0.67; SEEPRESS = 208.65 g) and females (r2 = 0.65; SEE = 220.96 g; Q2PRESS = 0.62; SEEPRESS = 221.90 g). Our anthropometric predictive models for BMC are valid, practical, and a low-cost alternative to monitoring bone health in PWH.<\/jats:p>","DOI":"10.3390\/ijerph191912336","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T20:58:47Z","timestamp":1664398727000},"page":"12336","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Bone Mineral Content Estimation in People Living with HIV: Prediction and Validation of Sex-Specific Anthropometric Models"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1697-9183","authenticated-orcid":false,"given":"Igor Massari","family":"Correia","sequence":"first","affiliation":[{"name":"School of Physical Education and Sport of Ribeirao Preto, University of Sao Paulo at Ribeirao Preto, Sao Paulo 14040-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9127-3001","authenticated-orcid":false,"given":"Anderson Marliere","family":"Navarro","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Sao Paulo at Ribeirao Preto, Sao Paulo 14049-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8212-9032","authenticated-orcid":false,"given":"J\u00e9ssica Fernanda","family":"Corr\u00eaa Cordeiro","sequence":"additional","affiliation":[{"name":"College of Nursing, University of Sao Paulo at Ribeirao Preto, Sao Paulo 14040-902, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0020-4682","authenticated-orcid":false,"given":"Euripedes Barsanulfo Gon\u00e7alves","family":"Gomide","sequence":"additional","affiliation":[{"name":"College of Nursing, University of Sao Paulo at Ribeirao Preto, Sao Paulo 14040-902, Brazil"},{"name":"Anthropometry, Training and Sport Study and Research Group, School of Physical Education and Sport of Ribeirao Preto, University of Sao Paulo at Ribeirao Preto, Sao Paulo 14040-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa Fernanda","family":"Mazzonetto","sequence":"additional","affiliation":[{"name":"School of Physical Education and Sport of Ribeirao Preto, University of Sao Paulo at Ribeirao Preto, Sao Paulo 14040-900, Brazil"},{"name":"Anthropometry, Training and Sport Study and Research Group, School of Physical Education and Sport of Ribeirao Preto, University of Sao Paulo at Ribeirao Preto, Sao Paulo 14040-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alcivandro","family":"de Sousa Oliveira","sequence":"additional","affiliation":[{"name":"School of Physical Education and Sport of Ribeirao Preto, University of Sao Paulo at Ribeirao Preto, Sao Paulo 14040-900, Brazil"},{"name":"Anthropometry, Training and Sport Study and Research Group, School of Physical Education and Sport of Ribeirao Preto, University of Sao Paulo at Ribeirao Preto, Sao Paulo 14040-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6320-7784","authenticated-orcid":false,"given":"Emerson","family":"Sebasti\u00e3o","sequence":"additional","affiliation":[{"name":"Health and Exercise Research Group, Department of Kinesiology and Physical Education, Northern Illinois University, Dekalb, IL 60115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno Augusto","family":"Aguilar","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Sao Paulo at Ribeirao Preto, Sao Paulo 14049-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"de Andrade","sequence":"additional","affiliation":[{"name":"College of Nursing, University of Sao Paulo at Ribeirao Preto, Sao Paulo 14040-902, Brazil"},{"name":"Department, Human Exposome and Infectious Diseases Network (HEID), Ribeirao Preto, Sao Paulo 14040-902, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7327-0800","authenticated-orcid":false,"given":"Dalmo Roberto Lopes","family":"Machado","sequence":"additional","affiliation":[{"name":"School of Physical Education and Sport of Ribeirao Preto, University of Sao Paulo at Ribeirao Preto, Sao Paulo 14040-900, Brazil"},{"name":"College of Nursing, University of Sao Paulo at Ribeirao Preto, Sao Paulo 14040-902, Brazil"},{"name":"Anthropometry, Training and Sport Study and Research Group, School of Physical Education and Sport of Ribeirao Preto, University of Sao Paulo at Ribeirao Preto, Sao Paulo 14040-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0055-4682","authenticated-orcid":false,"given":"Andr\u00e9 Pereira","family":"dos Santos","sequence":"additional","affiliation":[{"name":"School of Physical Education and Sport of Ribeirao Preto, University of Sao Paulo at Ribeirao Preto, Sao Paulo 14040-900, Brazil"},{"name":"College of Nursing, University of Sao Paulo at Ribeirao Preto, Sao Paulo 14040-902, Brazil"},{"name":"Anthropometry, Training and Sport Study and Research Group, School of Physical Education and Sport of Ribeirao Preto, University of Sao Paulo at Ribeirao Preto, Sao Paulo 14040-900, Brazil"},{"name":"Department, Human Exposome and Infectious Diseases Network (HEID), Ribeirao Preto, Sao Paulo 14040-902, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,28]]},"reference":[{"key":"ref_1","unstructured":"UNAIDS Brasil (2022, March 11). Estat\u00edsticas. Available online: https:\/\/unaids.org.br\/estatisticas\/."},{"key":"ref_2","unstructured":"WHO (2022, September 09). Number of People (All Ages) Living with HIV-Estimates by WHO Region. Available online: https:\/\/apps.who.int\/gho\/data\/view.main.22100WHO."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.jmii.2018.08.017","article-title":"Monitoring Early Developed Low Bone Mineral Density in HIV-Infected Patients by Intact Parathyroid Hormone and Circulating Fibroblast Growth Factor 23","volume":"52","author":"Chen","year":"2019","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Vlot, M.C., Grijsen, M.L., Prins, J.M., de Jongh, R.T., de Jonge, R., den Heijer, M., and Heijboer, A.C. (2018). Effect of antiretroviral therapy on bone turnover and bone mineral density in men with primary HIV-1 infection. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0193679"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1007\/s00198-017-4305-8","article-title":"Reduced Bone Mineral Density in Human Immunodeficiency Virus-Infected Individuals: A Meta-Analysis of Its Prevalence and Risk Factors","volume":"29","author":"Goh","year":"2018","journal-title":"Osteoporos. Int."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.medmal.2018.02.009","article-title":"Prevalence and Risk Factors for Low Bone Mineral Density in Antiretroviral Therapy-Naive HIV-Infected Young Men","volume":"48","author":"Paccou","year":"2018","journal-title":"Med. Mal. Infect."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.atherosclerosis.2018.08.046","article-title":"CKD, Arterial Calcification, Atherosclerosis and Bone Health: Inter-Relationships and Controversies","volume":"278","author":"Reiss","year":"2018","journal-title":"Atherosclerosis"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1111\/apa.15046","article-title":"Longitudinal Changes in Bone Mineral Density in Children with Inflammatory Bowel Diseases","volume":"109","author":"Shenkar","year":"2020","journal-title":"Acta Paediatr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1053\/j.ackd.2006.10.005","article-title":"Chronic Kidney Disease\u2013Mineral-Bone Disorder: A New Paradigm","volume":"14","author":"Moe","year":"2007","journal-title":"Adv. Chronic Kidney Dis."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Serafim, A.P., Dur\u00e3es, R.S., Rocca, C.C., Gon\u00e7alves, P.D., Saffi, F., Cappellozza, A., Paulino, M., Dumas-Diniz, R., Brissos, S., and Brites, R. (2021). Exploratory study on the psychological impact of COVID-19 on the general Brazilian population. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0245868"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"De Sire, A., Ferrillo, M., Lippi, L., Agostini, F., de Sire, R., Ferrara, P.E., Raguso, G., Riso, S., Roccuzzo, A., and Ronconi, G. (2022). Sarcopenic Dysphagia, Malnutrition, and Oral Frailty in Elderly: A Comprehensive Review. Nutrients, 14.","DOI":"10.3390\/nu14050982"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Chan, C.Y., Subramaniam, S., Chin, K.-Y., Ima-Nirwana, S., Muhammad, N., Fairus, A., Ng, P.Y., Aini, J.N., Aziz, N.A., and Mohamed, N. (2022). Effect of a Screening and Education Programme on Knowledge, Beliefs, and Practices Regarding Osteoporosis among Malaysians. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19106072"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Kim, B., Kim, G., Kim, E., Park, J., Isobe, T., Mori, Y., and Oh, S. (2022). The Anthropometric Measure \u2018A Body Shape Index\u2019 May Predict the Risk of Osteoporosis in Middle-Aged and Older Korean People. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19084926"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.jocd.2015.06.001","article-title":"Prediction of Areal Bone Mineral Density and Bone Mineral Content in Children and Adolescents Living With HIV Based on Anthropometric Variables","volume":"19","author":"Petroski","year":"2016","journal-title":"J. Clin. Densitom."},{"key":"ref_15","first-page":"410","article-title":"Dual energy X-ray absorptimetry: Fundamentals, methodology, and clinical applications","volume":"54","author":"Ramos","year":"2012","journal-title":"Radiolog\u00eda"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Dos Santos, A.P., Navarro, A.M., Schwingel, A., Alves, T.C., Abdalla, P.P., Venturini, A.C.R., de Santana, R.C., and Machado, D.R.L. (2018). Lipodystrophy Diagnosis in People Living with HIV\/AIDS: Prediction and Validation of Sex-Specific Anthropometric Models. BMC Public Health, 18.","DOI":"10.1186\/s12889-018-5707-z"},{"key":"ref_17","unstructured":"IBGE (2022, September 09). Caracter\u00edsticas \u00c9tnico-Raciais da Popula\u00e7\u00e3o: Classifica\u00e7\u00f5es e Identidades, Available online: https:\/\/biblioteca.ibge.gov.br\/index.php\/biblioteca-catalogo?view=detalhes&id=284235."},{"key":"ref_18","unstructured":"Lohman, T.G., Roche, A.F., and Martorell, R. (1988). Anthropometric Standardization Reference Manual, Human Kinetics Books."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1093\/ajcn\/72.3.796","article-title":"Total-body skeletal muscle mass: Development and cross-validation of anthropometric prediction models","volume":"72","author":"Lee","year":"2000","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/ajpa.1330040302","article-title":"The testing of physical efficiency","volume":"4","author":"Matiegka","year":"1921","journal-title":"Am. J. Phys. Anthropol."},{"key":"ref_21","unstructured":"Norton, K., Olds, T., and Albernaz, N.M.F. (2005). Antropom\u00e9trica: Um Livro Sobre Medidas Corporais para o Esporte e Cursos da \u00c1rea de Sa\u00fade, UNSW Press."},{"key":"ref_22","unstructured":"Brosamler, G.A. (1988). Mathematical Proceedings of the Cambridge Philosophical Society, Cambridge University Press."},{"key":"ref_23","unstructured":"Myers, R.H. (1990). Classical and Modern Regression with Applications, Duxbury\/Thompson Learning."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0140-6736(86)90837-8","article-title":"Statistical methods for assessing agreement between two methods of clinical measurement","volume":"327","author":"Bland","year":"1986","journal-title":"Lancet"},{"key":"ref_25","unstructured":"Johnson, R.A., and Wichern, D.W. (2002). Applied Multivariate Statistical Analysis, Prentice Hall."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12981-017-0162-y","article-title":"Bone Mineral Density in People Living with HIV: A Narrative Review of the Literature","volume":"14","author":"Kruger","year":"2017","journal-title":"AIDS Res. Ther."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/B978-0-12-415853-5.00046-7","article-title":"Estrogen deficiency, postmenopausal osteoporosis, and age-related bone loss","volume":"1","author":"Khosla","year":"2013","journal-title":"Osteoporosis"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1016\/S0140-6736(02)08706-8","article-title":"Pathogenesis of Bone Fragility in Women and Men","volume":"359","author":"Seeman","year":"2002","journal-title":"Lancet"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1172\/JCI106062","article-title":"Effect of sex hormones on bone in primary osteoporosis","volume":"48","author":"Riggs","year":"1969","journal-title":"J. Clin. Investig."},{"key":"ref_30","first-page":"1315","article-title":"Anthropometric Cutoff Points to Identify Lipodystrophy Characteristics in People Living with HIV\/AIDS: An Observational Study","volume":"36","author":"Santos","year":"2019","journal-title":"Nutr. Hosp."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1007\/BF01623782","article-title":"Guidelines for Diagnosis and Management of Osteoporosis. The European Foundation for Osteoporosis and Bone Disease","volume":"7","author":"Kanis","year":"1997","journal-title":"Osteoporos. Int."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.1210\/jc.2008-0828","article-title":"Fracture prevalence among human immunodeficiency virus (HIV)-infected versus non-HIV-infected patients in a large US healthcare system","volume":"93","author":"Triant","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1097\/QAI.0b013e318289bb7e","article-title":"Functional Impairment Is Associated with Low Bone and Muscle Mass among Persons Aging with HIV Infection","volume":"63","author":"Erlandson","year":"2013","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1177\/135965350801300103","article-title":"Contribution of mitochondrial dysfunction and oxidative stress to cellular premature senescence induced by antiretroviral thymidine analogues","volume":"13","author":"Caron","year":"2008","journal-title":"Antivir. Ther."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.rbr.2017.06.001","article-title":"Brazilian Guidelines for the Diagnosis and Treatment of Postmenopausal Osteoporosis","volume":"57","author":"Radominski","year":"2017","journal-title":"Rev. Bras. Reumatol. Engl. Ed."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1007\/s00198-005-1841-4","article-title":"Gender Differences in Relationships between Body Composition Components, Their Distribution and Bone Mineral Density: A Cross-Sectional Opposite Sex Twin Study","volume":"16","author":"Makovey","year":"2005","journal-title":"Osteoporos. Int."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s007740300003","article-title":"Relative Contribution of Lean and Fat Mass Component to Bone Mineral Density in Males","volume":"21","author":"Douchi","year":"2003","journal-title":"J. Bone Miner. Metab."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1210\/jc.2006-0572","article-title":"Relationship of Obesity with Osteoporosis","volume":"92","author":"Zhao","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S8756-3282(02)00864-5","article-title":"Relationships among Body Mass, Its Components, and Bone","volume":"31","author":"Reid","year":"2002","journal-title":"Bone"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41413-020-0102-7","article-title":"Aging and Menopause Reprogram Osteoclast Precursors for Aggressive Bone Resorption","volume":"8","author":"Olesen","year":"2020","journal-title":"Bone Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s00198-018-4725-0","article-title":"Associations between Radius Low-Frequency Axial Ultrasound Velocity and Bone Fragility in Elderly Men and Women","volume":"30","author":"Biver","year":"2019","journal-title":"Osteoporos. Int."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Lalli, P., Mautino, C., Busso, C., Bardesono, F., Di Monaco, M., Lippi, L., and Minetto, M.A. (2022). Reproducibility and Accuracy of the Radiofrequency Echographic Multi-Spectrometry for Femoral Mineral Density Estimation and Discriminative Power of the Femoral Fragility Score in Patients with Primary and Disuse-Related Osteoporosis. J. Clin. Med., 11.","DOI":"10.3390\/jcm11133761"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ultras.2018.11.012","article-title":"Can low-frequency guided waves at the tibia paired with machine learning differentiate between healthy and osteopenic\/osteoporotic subjects? A pilot study","volume":"94","author":"Vogl","year":"2019","journal-title":"Ultrasonics"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s00198-010-1253-y","article-title":"Development and use of FRAX\u00ae in osteoporosis","volume":"21","author":"Kanis","year":"2010","journal-title":"Osteoporos. Int."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/19\/12336\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:41:06Z","timestamp":1760143266000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/19\/12336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,28]]},"references-count":44,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["ijerph191912336"],"URL":"https:\/\/doi.org\/10.3390\/ijerph191912336","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,28]]}}}