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Cd is a toxic heavy metal without any known physiological function in the organism, leading to severe health threat to the population. Cd has a long half-life (10\u201330 years) and thus it represents serious concern as it to a great extent accumulates in organs or organelles where it often causes irreversible damage. Moreover, Cd contamination might further lead to certain carcinogenic and non-carcinogenic health risks. Therefore, its negative effect on population health has to be minimalized. As Cd is able to enter the body through the air, water, soil, and food chain one possible way to defend and eliminate Cd toxicities is via dietary supplements that aim to eliminate the adverse effects of Cd to the organism. Naturally occurring bioactive compounds in food or medicinal plants with beneficial, mostly antioxidant, anti-inflammatory, anti-aging, or anti-tumorigenesis impact on the organism, have been described to mitigate the negative effect of various contaminants and pollutants, including Cd. This study summarizes the curative effect of recently studied bioactive substances and mineral elements capable to alleviate the negative impact of Cd on various model systems, supposing that not only the Cd-derived health threat can be reduced, but also prevention and control of Cd toxicity and elimination of Cd contamination can be achieved in the future.<\/jats:p>","DOI":"10.3390\/ijerph191912380","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T22:53:19Z","timestamp":1664405599000},"page":"12380","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Curative Potential of Substances with Bioactive Properties to Alleviate Cd Toxicity: A Review"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3713-0717","authenticated-orcid":false,"given":"Miroslava","family":"Po\u017egajov\u00e1","sequence":"first","affiliation":[{"name":"AgroBioTech Research Centre, Slovak University of Agriculture in Nitra, Tr. 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Toxicol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10653-009-9273-2","article-title":"Cadmium Levels in Europe: Implications for Human Health","volume":"32","author":"Pan","year":"2010","journal-title":"Environ. Geochem. Health"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/1750-3841.14997","article-title":"Cadmium: Mitigation Strategies to Reduce Dietary Exposure","volume":"85","author":"Schaefer","year":"2020","journal-title":"J. Food Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1080\/09603123.2013.835032","article-title":"Cellular Mechanisms of Cadmium-Induced Toxicity: A Review","volume":"24","author":"Rani","year":"2014","journal-title":"Int. J. Environ. Health Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1289\/ehp.0901234","article-title":"Cadmium, Environmental Exposure, and Health Outcomes","volume":"118","author":"Satarug","year":"2010","journal-title":"Environ. Health Perspect."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Satarug, S. (2018). Dietary Cadmium Intake and Its Effects on Kidneys. Toxics, 6.","DOI":"10.3390\/toxics6010015"},{"key":"ref_8","unstructured":"FAO, World Health Organization, and WHO Expert Committee on Food Additives (2011). Evaluation of Certain Food Additives and Contaminants: Seventy-Third [73rd] Report of the Joint FAO\/WHO Expert Committee on Food Additives, World Health Organization. Available online: https:\/\/apps.who.int\/iris\/handle\/10665\/44515."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e394652","DOI":"10.1155\/2013\/394652","article-title":"Cadmium Toxicity and Treatment","volume":"2013","author":"Bernhoft","year":"2013","journal-title":"Sci. World J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.anireprosci.2015.01.007","article-title":"Toxic Effects of Cadmium on Testis of Birds and Mammals: A Review","volume":"155","author":"Maretta","year":"2015","journal-title":"Anim. Reprod. Sci."},{"key":"ref_11","first-page":"65","article-title":"Cadmium Toxicity Revisited: Focus on Oxidative Stress Induction and Interactions with Zinc and Magnesium","volume":"62","author":"Buha","year":"2011","journal-title":"Arch. Ind. Hyg. Toxicol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"114684","DOI":"10.1016\/j.taap.2019.114684","article-title":"Reproductive Toxicity of Acute Cd Exposure in Mouse: Resulting in Oocyte Defects and Decreased Female Fertility","volume":"379","author":"Cheng","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Wang, L., Xu, T., Lei, W., Liu, D., Li, Y., Xuan, R., and Ma, J. (2011). Cadmium-Induced Oxidative Stress and Apoptotic Changes in the Testis of Freshwater Crab, Sinopotamon henanense. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0027853"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0890-6238(03)00100-X","article-title":"Cadmium-Induced Damage to Primary Cultures of Rat Leydig Cells","volume":"17","author":"Yang","year":"2003","journal-title":"Reprod. Toxicol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"527","DOI":"10.3389\/fgene.2020.00527","article-title":"Toxicological Effects of Cadmium on Mammalian Testis","volume":"11","author":"Zhu","year":"2020","journal-title":"Front. Genet."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.toxlet.2004.07.015","article-title":"Cadmium at a Non-Toxic Dose Alters Gene Expression in Mouse Testes","volume":"154","author":"Zhou","year":"2004","journal-title":"Toxicol. Lett."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.chemosphere.2012.05.068","article-title":"Cadmium-Induced DNA Damage and Mutations in Arabidopsis Plantlet Shoots Identified by DNA Fingerprinting","volume":"89","author":"Liu","year":"2012","journal-title":"Chemosphere"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1093\/toxsci\/kfg208","article-title":"Cadmium-Induced Changes in Apoptotic Gene Expression Levels and DNA Damage in Mouse Embryos Are Blocked by Zinc","volume":"76","author":"Gustafson","year":"2003","journal-title":"Toxicol. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1007\/s10646-016-1653-7","article-title":"Cadmium Induced Oxidative Damage and Apoptosis in the Hepatopancreas of Meretrix Meretrix","volume":"25","author":"Xia","year":"2016","journal-title":"Ecotoxicology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.aquatox.2012.05.014","article-title":"Cadmium-Induced Oxidative Stress and Apoptosis in the Testes of Frog Rana limnocharis","volume":"122\u2013123","author":"Zhang","year":"2012","journal-title":"Aquat. Toxicol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.mrgentox.2014.10.002","article-title":"Cadmium-Induced Genotoxicity in Human Osteoblast-like Cells","volume":"775\u2013776","author":"Oliveira","year":"2014","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagenesis"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"111668","DOI":"10.1016\/j.ecoenv.2020.111668","article-title":"Effects of Cadmium on Osteoblast Cell Line: Exportin 1 Accumulation, p-JNK Activation, DNA Damage and Cell Apoptosis","volume":"208","author":"Ou","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Skipper, A., Sims, J.N., Yedjou, C.G., and Tchounwou, P.B. (2016). Cadmium Chloride Induces DNA Damage and Apoptosis of Human Liver Carcinoma Cells via Oxidative Stress. Int. J. Environ. Res. Public Health, 13.","DOI":"10.3390\/ijerph13010088"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1191\/0960327106ht590oa","article-title":"Molecular Mechanisms of Cadmium Induced Mutagenicity","volume":"25","author":"Fatur","year":"2006","journal-title":"Hum. Exp. Toxicol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.mrfmmm.2011.09.002","article-title":"Mechanisms of Cadmium Induced Genomic Instability","volume":"733","year":"2012","journal-title":"Mutat. Res. Fundam. Mol. Mech. Mutagenesis"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.bbrc.2004.06.102","article-title":"Cadmium Inhibits Human DNA Mismatch Repair in vivo","volume":"321","author":"Liberti","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/ng1172","article-title":"Cadmium Is a Mutagen That Acts by Inhibiting Mismatch Repair","volume":"34","author":"Jin","year":"2003","journal-title":"Nat. Genet."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"F255","DOI":"10.1152\/ajprenal.00273.2009","article-title":"Cadmium-Induced DNA Damage Triggers G2\/M Arrest via Chk1\/2 and Cdc2 in P53-Deficient Kidney Proximal Tubule Cells","volume":"298","author":"Bork","year":"2010","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"128277","DOI":"10.1016\/j.chemosphere.2020.128277","article-title":"Oxidative Stress, Cell Cycle Arrest, DNA Damage and Apoptosis in the Mud Crab (Scylla paramamosain) Induced by Cadmium Exposure","volume":"263","author":"Cheng","year":"2021","journal-title":"Chemosphere"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.tox.2007.10.005","article-title":"Oxidative Stress and DNA Damage Induced by Cadmium in the Human Keratinocyte HaCaT Cell Line: Role of Glutathione in the Resistance to Cadmium","volume":"243","author":"Nzengue","year":"2008","journal-title":"Toxicology"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.crvi.2008.03.009","article-title":"Cadmium-Induced Oxidative Stress and DNA Damage in Kidney of Pregnant Female Rats","volume":"331","author":"Chater","year":"2008","journal-title":"C. R. Biol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.tiv.2010.10.018","article-title":"Cadmium Chloride-Induced Oxidative Stress and DNA Damage in the Human Jurkat T Cell Line Is Not Linked to Intracellular Trace Elements Depletion","volume":"25","author":"Nemmiche","year":"2011","journal-title":"Toxicol. Vitr."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Sigel, A., Sigel, H., and Sigel, R.K. (2013). Cadmium and Cancer. Cadmium: From Toxicity to Essentiality, Springer. Metal Ions in Life Sciences.","DOI":"10.1007\/978-94-007-5179-8"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1080\/03601234.2019.1673613","article-title":"Impact of Cadmium and Nickel on Ion Homeostasis in the Yeast Schizosaccharomyces pombe","volume":"55","author":"Pozgajova","year":"2020","journal-title":"J. Environ. Sci. Health Part B"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s12011-016-0825-x","article-title":"Ameliorative Effects of Dietary Selenium Against Cadmium Toxicity Is Related to Changes in Trace Elements in Chicken Kidneys","volume":"176","author":"Zhang","year":"2017","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ecoenv.2018.03.071","article-title":"Effects of Cadmium on Calcium Homeostasis in the White-Rot Fungus Phanerochaete Chrysosporium","volume":"157","author":"Zhang","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1007\/s10265-016-0847-7","article-title":"Gene Expression Analysis of Metallothionein and Mineral Elements Uptake in Tomato (Solanum lycopersicum) Exposed to Cadmium","volume":"129","author":"Tekin","year":"2016","journal-title":"J. Plant Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1385\/BTER:84:1-3:155","article-title":"Effects of Ingestion of Cadmium-Polluted Rice or Low-Dose Cadmium-Supplemented Diet on the Endogenous Metal Balance in Female Rats","volume":"84","author":"Oishi","year":"2001","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Guan, D.-L., Ding, R.-R., Hu, X.-Y., Yang, X.-R., Xu, S.-Q., Gu, W., and Zhang, M. (2019). Cadmium-Induced Genome-Wide DNA Methylation Changes in Growth and Oxidative Metabolism in Drosophila melanogaster. BMC Genom., 20.","DOI":"10.1186\/s12864-019-5688-z"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.toxlet.2020.12.009","article-title":"Cadmium Causes Hepatopathy by Changing the Status of DNA Methylation in the Metabolic Pathway","volume":"340","author":"Ren","year":"2021","journal-title":"Toxicol. Lett."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0014-4827(03)00062-4","article-title":"Effects of Cadmium on DNA-(Cytosine-5) Methyltransferase Activity and DNA Methylation Status during Cadmium-Induced Cellular Transformation","volume":"286","author":"Takiguchi","year":"2003","journal-title":"Exp. Cell Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1111\/pce.12793","article-title":"Variation of DNA Methylation Patterns Associated with Gene Expression in Rice (Oryza sativa) Exposed to Cadmium","volume":"39","author":"Feng","year":"2016","journal-title":"Plant Cell Environ."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1080\/19440049.2022.2087921","article-title":"Probabilistic Determination of a Maximum Acceptable Level of Contaminant to Reduce the Risk of Overexposure for a Novel or Emerging Food: The Case of Cadmium in Edible Seaweed in the French Population","volume":"39","author":"Carne","year":"2022","journal-title":"Food Addit. Contam. Part A"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"128673","DOI":"10.1016\/j.chemosphere.2020.128673","article-title":"Health Risk Assessment of Total Exposure from Cadmium in South China","volume":"269","author":"Chen","year":"2021","journal-title":"Chemosphere"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1080\/10934529.2021.1915653","article-title":"Heavy Metals Drinking Water Contamination and Health Risk Assessment among Primary School Children of Pakistan","volume":"56","author":"Ahmed","year":"2021","journal-title":"J. Environ. Sci. Health Part A"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s10534-010-9351-z","article-title":"Role of Metallothionein in Cadmium Traffic and Toxicity in Kidneys and Other Mammalian Organs","volume":"23","author":"Breljak","year":"2010","journal-title":"Biometals"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Ruslee, S.S., Zaid, S.S.M., Bakrin, I.H., Goh, Y.M., and Mustapha, N.M. (2020). Protective Effect of Tualang Honey against Cadmium-Induced Morphological Abnormalities and Oxidative Stress in the Ovary of Rats. BMC Complement. Med. Ther., 20.","DOI":"10.1186\/s12906-020-02960-1"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.3945\/jn.109.120659","article-title":"Blood Cadmium Concentrations of Male Cigarette Smokers Are Inversely Associated with Fruit Consumption","volume":"140","author":"Kim","year":"2010","journal-title":"J. Nutr."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.fct.2015.01.001","article-title":"Protective Effect of Olive Oil and Colocynth Oil against Cadmium-Induced Oxidative Stress in the Liver of Wistar Rats","volume":"78","author":"Amamou","year":"2015","journal-title":"Food Chem. Toxicol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1999-3110-55-38","article-title":"Role of L-Ascorbate in Alleviating Abiotic Stresses in Crop Plants","volume":"55","author":"Venkatesh","year":"2014","journal-title":"Bot. Stud."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"19261","DOI":"10.1007\/s11356-019-05265-0","article-title":"Exogenous Application of Ascorbic Acid Mitigates Cadmium Toxicity and Uptake in Maize (Zea mays L.)","volume":"26","author":"Zhang","year":"2019","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ecoenv.2016.09.013","article-title":"Cadmium Stress Tolerance in Wheat Seedlings Induced by Ascorbic Acid Was Mediated by NO Signaling Pathways","volume":"135","author":"Wang","year":"2017","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"6547","DOI":"10.3389\/fpls.2020.586547","article-title":"Ascorbate-Mediated Modulation of Cadmium Stress Responses: Reactive Oxygen Species and Redox Status in Brassica napus","volume":"11","author":"Jung","year":"2020","journal-title":"Front. Plant Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"15380","DOI":"10.1007\/s11356-020-11480-x","article-title":"Ascorbic Acid Mitigates Cadmium-Induced Stress, and Contributes to Ionome Stabilization in Fission Yeast","volume":"28","year":"2021","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"14087","DOI":"10.1007\/s11356-019-04620-5","article-title":"The Protective Role of Ascorbic Acid in the Hepatotoxicity of Cadmium and Mercury in Rabbits","volume":"26","author":"Mumtaz","year":"2019","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"29266","DOI":"10.1007\/s11356-020-09011-9","article-title":"Cardiac Toxicity of Heavy Metals (Cadmium and Mercury) and Pharmacological Intervention by Vitamin C in Rabbits","volume":"27","author":"Ali","year":"2020","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s10534-010-9379-0","article-title":"Protective Effect of Ascorbic Acid on Cadmium-Induced Hypertension and Vascular Dysfunction in Mice","volume":"24","author":"Donpunha","year":"2011","journal-title":"Biometals"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Lee, G.Y., and Han, S.N. (2018). The Role of Vitamin E in Immunity. Nutrients, 10.","DOI":"10.3390\/nu10111614"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1002\/iub.1990","article-title":"Vitamin E\u2014The Next 100 Years","volume":"71","author":"Khadangi","year":"2019","journal-title":"IUBMB Life"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/B978-0-12-386960-9.00008-3","article-title":"Chapter Eight\u2014Vitamin E and Immunity","volume":"Volume 86","author":"Litwack","year":"2011","journal-title":"Vitamins & Hormones"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"23636","DOI":"10.1007\/s11356-017-9986-1","article-title":"The Role of Some Feed Additives in Fish Fed on Diets Contaminated with Cadmium","volume":"24","author":"Ayyat","year":"2017","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e9506543","DOI":"10.1155\/2018\/9506543","article-title":"Hepatoprotective Activity of Vitamin E and Metallothionein in Cadmium-Induced Liver Injury in Ctenopharyngodon idellus","volume":"2018","author":"Duan","year":"2018","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1007\/s10695-020-00771-2","article-title":"Protective Effects of Metallothionein and Vitamin E in the Trunk Kidney and Blood of Cadmium Poisoned Ctenopharyngodon idellus","volume":"46","author":"Huang","year":"2020","journal-title":"Fish Physiol. Biochem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"4675","DOI":"10.1007\/s12011-021-02606-4","article-title":"Protective Effect of Vitamin E on Cadmium-Induced Renal Oxidative Damage and Apoptosis in Rats","volume":"199","author":"Fang","year":"2021","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.sjbs.2011.07.004","article-title":"Vitamin E Attenuates Liver Injury Induced by Exposure to Lead, Mercury, Cadmium and Copper in Albino Mice","volume":"18","year":"2011","journal-title":"Saudi J. Biol. Sci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.toxrep.2016.07.005","article-title":"Calcium, Zinc and Vitamin E Ameliorate Cadmium-Induced Renal Oxidative Damage in Albino Wistar Rats","volume":"3","author":"Adi","year":"2016","journal-title":"Toxicol. Rep."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"111610","DOI":"10.1016\/j.ecoenv.2020.111610","article-title":"Vitamin E Protects against Cadmium-Induced Sub-Chronic Liver Injury Associated with the Inhibition of Oxidative Stress and Activation of Nrf2 Pathway","volume":"208","author":"Fang","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1080\/01480540802383200","article-title":"The Role of Vitamin C, Vitamin E, and Selenium on Cadmium-Induced Renal Toxicity of Rats","volume":"31","author":"Bolkent","year":"2008","journal-title":"Drug Chem. Toxicol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1089\/10966200360716625","article-title":"Effects of Vitamin E on Renal Dysfunction in Chronic Cadmium-Poisoned Rats","volume":"6","author":"Choi","year":"2003","journal-title":"J. Med. Food"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s00210-019-01736-w","article-title":"Protective Effects of Vitamin E on Cadmium-Induced Apoptosis in Rat Testes","volume":"393","author":"Amanpour","year":"2020","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"e4615384","DOI":"10.1155\/2021\/4615384","article-title":"Modulatory Role of Vitamin E on Proton Pump (ATPase) Activity of Cadmium Chloride-Induced Testicular Damage in Wistar Rats","volume":"2021","author":"Olaniyan","year":"2021","journal-title":"BioMed Res. Int."},{"key":"ref_72","first-page":"563","article-title":"Protective Influence of Vitamin E on Antioxidant Defense System in the Blood of Rats Treated with Cadmium","volume":"52","author":"Stajn","year":"2003","journal-title":"Physiol. Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1177\/0748233717725480","article-title":"Antioxidative and Haematoprotective Activity of Coenzyme Q10 and Vitamin E against Cadmium-Induced Oxidative Stress in Wistar Rats","volume":"33","year":"2017","journal-title":"Toxicol. Ind. Health"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s12011-007-0009-9","article-title":"Effects of Selenium and Vitamin E, in Add\u0131t\u0131on to Melatonin, Against Oxidative Stress Caused by Cadmium in Rats","volume":"118","author":"Konar","year":"2007","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_75","unstructured":"(2022, May 17). Scientific Opinion on Dietary Reference Values for selenium|EFSA. Available online: https:\/\/www.efsa.europa.eu\/en\/efsajournal\/pub\/3846."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"e7478523","DOI":"10.1155\/2017\/7478523","article-title":"Supplementation of Micronutrient Selenium in Metabolic Diseases: Its Role as an Antioxidant","volume":"2017","author":"Wang","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.ecoenv.2018.10.054","article-title":"Selenium and Zinc Protections against Metal-(Loids)-Induced Toxicity and Disease Manifestations: A Review","volume":"168","author":"Rahman","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s12011-019-01691-w","article-title":"The Role of Selenium in Arsenic and Cadmium Toxicity: An Updated Review of Scientific Literature","volume":"193","author":"Zwolak","year":"2020","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1007\/s12011-019-01682-x","article-title":"Selenium Mitigates Cadmium-Induced Adverse Effects on Trace Elements and Amino Acids Profiles in Chicken Pectoral Muscles","volume":"193","author":"Qu","year":"2020","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"114613","DOI":"10.1016\/j.envpol.2020.114613","article-title":"Selenium Mitigates Cadmium-Induced Crosstalk between Autophagy and Endoplasmic Reticulum Stress via Regulating Calcium Homeostasis in Avian Leghorn Male Hepatoma (LMH) Cells","volume":"265","author":"Zhang","year":"2020","journal-title":"Environ. Pollut."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1007\/s12011-018-1557-x","article-title":"The Protection of Selenium Against Cadmium-Induced Mitochondrial Damage via the Cytochrome P450 in the Livers of Chicken","volume":"190","author":"Cong","year":"2019","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"111329","DOI":"10.1016\/j.ecoenv.2020.111329","article-title":"Protective Effects of Selenium Yeast against Cadmium-Induced Necroptosis via Inhibition of Oxidative Stress and MAPK Pathway in Chicken Liver","volume":"206","author":"Wang","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s12011-016-0828-7","article-title":"Selenium Source Impacts Protection of Porcine Jejunal Epithelial Cells from Cadmium-Induced DNA Damage, with Maximum Protection Exhibited with Yeast-Derived Selenium Compounds","volume":"176","author":"Lynch","year":"2017","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"9490","DOI":"10.1007\/s11356-019-06628-3","article-title":"Selenium Supplementation Alleviates Cadmium-Induced Damages in Tall Fescue through Modulating Antioxidant System, Photosynthesis Efficiency, and Gene Expression","volume":"27","author":"Li","year":"2020","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"12476","DOI":"10.1007\/s11356-020-07751-2","article-title":"Selenium Mitigates Cadmium Toxicity by Preventing Oxidative Stress and Enhancing Photosynthesis and Micronutrient Availability on Radish (Raphanus sativus L.) Cv. Cherry Belle","volume":"27","author":"Behtash","year":"2020","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"110091","DOI":"10.1016\/j.ecoenv.2019.110091","article-title":"Foliar Application of Selenium and Zinc to Alleviate Wheat (Triticum aestivum L.) Cadmium Toxicity and Uptake from Cadmium-Contaminated Soil","volume":"190","author":"Wu","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_87","first-page":"102","article-title":"Zinc and Wound Healing: A Review of Zinc Physiology and Clinical Applications","volume":"29","author":"Kogan","year":"2017","journal-title":"Wounds"},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Gammoh, N.Z., and Rink, L. (2017). Zinc in Infection and Inflammation. Nutrients, 9.","DOI":"10.20944\/preprints201705.0176.v1"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jtemb.2006.01.006","article-title":"Zinc Requirements and the Risks and Benefits of Zinc Supplementation","volume":"20","author":"Maret","year":"2006","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1177\/0884533615570376","article-title":"Zinc: Physiology, deficiency, and parenteral nutrition","volume":"30","author":"Livingstone","year":"2015","journal-title":"Nutr. Clin. Pract."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/s41401-020-0396-4","article-title":"Zinc as a Countermeasure for Cadmium Toxicity","volume":"42","author":"Yu","year":"2021","journal-title":"Acta Pharm. Sin."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.tiv.2018.01.007","article-title":"Selenium and Zinc: Two Key Players against Cadmium-Induced Neuronal Toxicity","volume":"48","author":"Branca","year":"2018","journal-title":"Toxicol. Vitr."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Zhang, D., Liu, J., Gao, J., Shahzad, M., Han, Z., Wang, Z., Li, J., and Sj\u00f6linder, H. (2014). Zinc Supplementation Protects against Cadmium Accumulation and Cytotoxicity in Madin-Darby Bovine Kidney Cells. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0103427"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.chemosphere.2017.08.106","article-title":"Zinc Protects against Cadmium-Induced Toxicity by Regulating Oxidative Stress, Ions Homeostasis and Protein Synthesis","volume":"188","author":"Pan","year":"2017","journal-title":"Chemosphere"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1080\/01480545.2018.1461901","article-title":"Protective Role of Zinc against the Neurotoxicity Induced by Exposure to Cadmium during Gestation and Lactation Periods on Hippocampal Volume of Pups Tested in Early Adulthood","volume":"41","author":"Chemek","year":"2018","journal-title":"Drug Chem. Toxicol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"16282","DOI":"10.1007\/s11356-020-08074-y","article-title":"Mitigative Effects of Zinc on Cadmium-Induced Reproductive Toxicity in the Male Freshwater Crab Sinopotamon henanense","volume":"27","author":"Liu","year":"2020","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s12011-017-1218-5","article-title":"Cadmium Testicular Toxicity in Male Wistar Rats: Protective Roles of Zinc and Magnesium","volume":"185","author":"Babaknejad","year":"2018","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.reprotox.2016.06.005","article-title":"Protective Role of Zinc against the Toxicity Induced by Exposure to Cadmium during Gestation and Lactation on Testis Development","volume":"63","author":"Chemek","year":"2016","journal-title":"Reprod. Toxicol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.chemosphere.2019.06.209","article-title":"Protective Role of Zinc in Spodoptera Exigua Larvae under 135-Generational Cadmium Exposure","volume":"235","author":"Tarnawska","year":"2019","journal-title":"Chemosphere"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"6279","DOI":"10.1007\/s11356-019-04174-6","article-title":"A Critical Review on the Effects of Zinc at Toxic Levels of Cadmium in Plants","volume":"26","author":"Rizwan","year":"2019","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"115045","DOI":"10.1016\/j.envpol.2020.115045","article-title":"Effects of Zinc Application on Cadmium (Cd) Accumulation and Plant Growth through Modulation of the Antioxidant System and Translocation of Cd in Low- and High-Cd Wheat Cultivars","volume":"265","author":"Zhou","year":"2020","journal-title":"Environ. Pollut."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"110177","DOI":"10.1016\/j.ecoenv.2020.110177","article-title":"Zinc Oxide (ZnO) Nanoparticles Elevated Iron and Copper Contents and Mitigated the Bioavailability of Lead and Cadmium in Different Leafy Greens","volume":"191","author":"Sharifan","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s12011-017-1008-0","article-title":"Effects of Nano-Zinc on Biochemical Parameters in Cadmium-Exposed Rats","volume":"180","author":"Hejazy","year":"2017","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s00425-017-2664-1","article-title":"Effects of Calcium at Toxic Concentrations of Cadmium in Plants","volume":"245","author":"Huang","year":"2017","journal-title":"Planta"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1007\/s11356-012-1181-9","article-title":"Exogenously Applied Calcium Alleviates Cadmium Toxicity in Matricaria chamomilla L. Plants","volume":"20","author":"Farzadfar","year":"2013","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s00709-015-0810-9","article-title":"Calcium Alleviates Cadmium-Induced Inhibition on Root Growth by Maintaining Auxin Homeostasis in Arabidopsis Seedlings","volume":"253","author":"Li","year":"2016","journal-title":"Protoplasma"},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Zhang, S., Li, Q., Nazir, M.M., Ali, S., Ouyang, Y., Ye, S., and Zeng, F. (2020). Calcium Plays a Double-Edged Role in Modulating Cadmium Uptake and Translocation in Rice. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21218058"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"24748","DOI":"10.1007\/s11356-019-05779-7","article-title":"Calcium Amendment Improved the Performance of Fragrant Rice and Reduced Metal Uptake under Cadmium Toxicity","volume":"26","author":"Kanu","year":"2019","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1007\/s00709-020-01605-x","article-title":"Calcium and Ethylene Glycol Tetraacetic Acid Mitigate Toxicity and Alteration of Gene Expression Associated with Cadmium Stress in Chickpea (Cicer arietinum L.) Shoots","volume":"258","author":"Sakouhi","year":"2021","journal-title":"Protoplasma"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.plaphy.2020.10.007","article-title":"Calcium Has Protective Impact on Cadmium-Induced Toxicity in Lichens","volume":"156","author":"Dresler","year":"2020","journal-title":"Plant Physiol. Biochem."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"3202","DOI":"10.1016\/j.febslet.2014.07.001","article-title":"Calcium Signaling Mediates the Response to Cadmium Toxicity in Saccharomyces cerevisiae Cells","volume":"588","author":"Ruta","year":"2014","journal-title":"FEBS Lett."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"3541","DOI":"10.1111\/1462-2920.15237","article-title":"Calcium Protects Bacteria against Cadmium Stress via Reducing Nitric Oxide Production and Increasing Iron Acquisition","volume":"23","author":"Wu","year":"2021","journal-title":"Environ. Microbiol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.aquatox.2003.12.004","article-title":"A Protective Effect of Dietary Calcium against Acute Waterborne Cadmium Uptake in Rainbow Trout","volume":"67","author":"Baldisserotto","year":"2004","journal-title":"Aquat. Toxicol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"2954","DOI":"10.1897\/05-007R.1","article-title":"Calcium\/Cadmium Interactions at Uptake Surfaces in Rainbow Trout: Waterborne versus Dietary Routes of Exposure","volume":"24","author":"Franklin","year":"2005","journal-title":"Environ. Toxicol. Chem."},{"key":"ref_115","first-page":"385","article-title":"Calcium homeostasis in low and high calcium water acclimatized Oreochromis mossambicus exposed to ambient and dietary cadmium","volume":"28","author":"Pratap","year":"2007","journal-title":"J. Environ. Biol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1023\/A:1015212929481","article-title":"Effect of Dietary Calcium on Cadmium Absorption and Retention in Suckling Rats","volume":"15","author":"Piasek","year":"2002","journal-title":"Biometals"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Huang, X., Liu, T., Zhao, M., Fu, H., Wang, J., and Xu, Q. (2019). Protective Effects of Moderate Ca Supplementation against Cd-Induced Bone Damage under Different Population-Relevant Doses in Young Female Rats. Nutrients, 11.","DOI":"10.3390\/nu11040849"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"e22440","DOI":"10.1002\/jbt.22440","article-title":"Vitamin D3 and Calcium Cosupplementation Alleviates Cadmium Hepatotoxicity in the Rat: Enhanced Antioxidative and Anti-Inflammatory Actions by Remodeling Cellular Calcium Pathways","volume":"34","author":"Refaat","year":"2020","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"110052","DOI":"10.1016\/j.ecoenv.2019.110052","article-title":"Calcimimetic Compound NPS R-467 Protects against Chronic Cadmium-Induced Mouse Kidney Injury by Restoring Autophagy Process","volume":"189","author":"Gu","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"9999","DOI":"10.1007\/s11356-015-4187-2","article-title":"Effects of Selenium and Silicon on Enhancing Antioxidative Capacity in Ramie (Boehmeria nivea (L.) Gaud.) under Cadmium Stress","volume":"22","author":"Tang","year":"2015","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"136497","DOI":"10.1016\/j.scitotenv.2020.136497","article-title":"Foliage Application of Selenium and Silicon Nanoparticles Alleviates Cd and Pb Toxicity in Rice (Oryza sativa L.)","volume":"712","author":"Hussain","year":"2020","journal-title":"Sci. Total Environ."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.plaphy.2013.09.010","article-title":"Manganese-Mitigation of Cadmium Toxicity to Seedling Growth of Phytolacca Acinosa Roxb. Is Controlled by the Manganese\/Cadmium Molar Ratio under Hydroponic Conditions","volume":"73","author":"Liu","year":"2013","journal-title":"Plant Physiol. Biochem."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"68","DOI":"10.2478\/v10102-010-0013-3","article-title":"Protective Effect of Manganese in Cadmium-Induced Hepatic Oxidative Damage, Changes in Cadmium Distribution and Trace Elements Level in Mice","volume":"3","author":"Eybl","year":"2010","journal-title":"Interdiscip. Toxicol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.bbrc.2006.10.035","article-title":"Manganese Is Highly Effective in Protecting Cells from Cadmium Intoxication","volume":"351","author":"Martin","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_125","first-page":"247","article-title":"Effects of Oral and Intraperitoneal Magnesium Treatment against Cadmium-Induced Oxidative Stress in Plasma of Rats","volume":"63","author":"Buha","year":"2012","journal-title":"Arch. Ind. Hyg. Toxicol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/s12011-016-0671-x","article-title":"Protective Role of Zinc and Magnesium against Cadmium Nephrotoxicity in Male Wistar Rats","volume":"174","author":"Babaknejad","year":"2016","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_127","first-page":"872","article-title":"Protective Effect of Magnesium and Selenium on Cadmium Toxicity in the Isolated Perfused Rat Liver System","volume":"52","author":"Shahroozian","year":"2014","journal-title":"Acta Med. Iran."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1080\/10408390500511821","article-title":"Ferulic Acid and Its Position Among the Phenolic Compounds of Wheat","volume":"46","author":"Klepacka","year":"2006","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/nyas.13344","article-title":"Cytoprotective Effects of Dietary Flavonoids against Cadmium-Induced Toxicity","volume":"1398","author":"Li","year":"2017","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s11011-019-00413-4","article-title":"Rutin Alleviates Cadmium-Induced Neurotoxicity in Wistar Rats: Involvement of Modulation of Nucleotide-Degrading Enzymes and Monoamine Oxidase","volume":"34","author":"Oboh","year":"2019","journal-title":"Metab. Brain Dis."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1080\/13813455.2017.1411370","article-title":"Rutin Hydrate Ameliorates Cadmium Chloride-Induced Spatial Memory Loss and Neural Apoptosis in Rats by Enhancing Levels of Acetylcholine, Inhibiting JNK and ERK1\/2 Activation and Activating MTOR Signalling","volume":"124","author":"Khaleel","year":"2018","journal-title":"Arch. Physiol. Biochem."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"40643","DOI":"10.1007\/s11356-020-10113-7","article-title":"Synthesized Chrysin-Loaded Nanoliposomes Improves Cadmium-Induced Toxicity in Mice","volume":"27","author":"Beyrami","year":"2020","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_133","first-page":"e12966","article-title":"The Effect of Diosmin against Liver Damage Caused by Cadmium in Rats","volume":"43","author":"Eraslan","year":"2019","journal-title":"J. Food Biochem."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1293\/tox.2016-0026","article-title":"Quercetin Inhibited Cadmium-Induced Autophagy in the Mouse Kidney via Inhibition of Oxidative Stress","volume":"29","author":"Yuan","year":"2016","journal-title":"J. Toxicol. Pathol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"25278","DOI":"10.1007\/s11356-020-08947-2","article-title":"Protective Effect of Quercetin on Rat Testes against Cadmium Toxicity by Alleviating Oxidative Stress and Autophagy","volume":"27","author":"Wang","year":"2020","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"111743","DOI":"10.1016\/j.ecoenv.2020.111743","article-title":"Quercetin Alleviates Cadmium-Induced Autophagy Inhibition via TFEB-Dependent Lysosomal Restoration in Primary Proximal Tubular Cells","volume":"208","author":"Zhao","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s10534-020-00260-2","article-title":"Metabolomics Analysis of the Effects of Quercetin on Renal Toxicity Induced by Cadmium Exposure in Rats","volume":"34","author":"Guan","year":"2021","journal-title":"Biometals"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/s12011-018-1255-8","article-title":"Protective Effects of Quercetin Against Cadmium Chloride-Induced Oxidative Injury in Goat Sperm and Zygotes","volume":"185","author":"Mao","year":"2018","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"9632","DOI":"10.1007\/s11356-019-04283-2","article-title":"Cadmium Level in Brain Correlates with Memory Impairment in F1 and F2 Generation Mice: Improvement with Quercetin","volume":"26","author":"Halder","year":"2019","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.cbi.2019.05.040","article-title":"Hesperetin Relieves Cisplatin-Induced Acute Kidney Injury by Mitigating Oxidative Stress, Inflammation and Apoptosis","volume":"308","author":"Chen","year":"2019","journal-title":"Chem. Biol. Interact."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Khan, A., Ikram, M., Hahm, J.R., and Kim, M.O. (2020). Antioxidant and Anti-Inflammatory Effects of Citrus Flavonoid Hesperetin: Special Focus on Neurological Disorders. Antioxidants, 9.","DOI":"10.3390\/antiox9070609"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1177\/0748233716665301","article-title":"Neuroprotective Efficacy of Hesperetin against Cadmium Induced Oxidative Stress in the Brain of Rats","volume":"33","author":"Shagirtha","year":"2017","journal-title":"Toxicol. Ind. Health"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1111\/bph.13627","article-title":"Effects of Anthocyanins on the Prevention and Treatment of Cancer","volume":"174","author":"Lin","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1361779","DOI":"10.1080\/16546628.2017.1361779","article-title":"Anthocyanidins and Anthocyanins: Colored Pigments as Food, Pharmaceutical Ingredients, and the Potential Health Benefits","volume":"61","author":"Khoo","year":"2017","journal-title":"Food Nutr. Res."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"543","DOI":"10.18388\/abp.2003_3707","article-title":"Effect of Anthocyanins on Selected Biochemical Parameters in Rats Exposed to Cadmium","volume":"50","author":"Kowalczyk","year":"2003","journal-title":"Acta Biochim. Pol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.fct.2019.04.033","article-title":"Cyanidin-3-O-Glucoside Protects against Cadmium-Induced Dysfunction of Sex Hormone Secretion via the Regulation of Hypothalamus-Pituitary-Gonadal Axis in Male Pubertal Mice","volume":"129","author":"Li","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"404","DOI":"10.3945\/an.113.005603","article-title":"Effect of Citrus Flavonoids, Naringin and Naringenin, on Metabolic Syndrome and Their Mechanisms of Action","volume":"5","author":"Alam","year":"2014","journal-title":"Adv. Nutr."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"e21915","DOI":"10.1002\/jbt.21915","article-title":"Naringin Abates Adverse Effects of Cadmium-Mediated Hepatotoxicity: An Experimental Study Using HepG2 Cells","volume":"31","author":"Rathi","year":"2017","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1177\/0748233711407241","article-title":"Influence of Naringin on Cadmium-Induced Genomic Damage in Human Lymphocytes in vitro","volume":"28","author":"Aydemir","year":"2012","journal-title":"Toxicol. Ind. Health"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1080\/10937404.2020.1860842","article-title":"Potential Protective Roles of Curcumin against Cadmium-Induced Toxicity and Oxidative Stress","volume":"24","author":"Park","year":"2021","journal-title":"J. Toxicol. Environ. Health Part B"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/jat.1124","article-title":"The Influence of Curcumin and Manganese Complex of Curcumin on Cadmium-Induced Oxidative Damage and Trace Elements Status in Tissues of Mice","volume":"26","author":"Eybl","year":"2006","journal-title":"J. Appl. Toxicol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1177\/0960327119895564","article-title":"Curcumin Protects the Testis against Cadmium-Induced Histopathological Damages and Oxidative Stress in Mice","volume":"39","author":"Momeni","year":"2020","journal-title":"Hum. Exp. Toxicol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1080\/10408398.2011.653458","article-title":"The Bioactivity and Toxicological Actions of Carvacrol","volume":"55","author":"Suntres","year":"2015","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"110835","DOI":"10.1016\/j.fct.2019.110835","article-title":"Carvacrol Inhibits Cadmium Toxicity through Combating against Caspase Dependent\/Independent Apoptosis in PC12 cells","volume":"134","author":"Banik","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"20631","DOI":"10.1007\/s11356-019-05420-7","article-title":"Influence of Ferulic Acid Consumption in Ameliorating the Cadmium-Induced Liver and Renal Oxidative Damage in Rats","volume":"26","author":"Sanjeev","year":"2019","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Ullah, R., Ikram, M., Park, T.J., Ahmad, R., Saeed, K., Alam, S.I., Rehman, I.U., Khan, A., Khan, I., and Jo, M.G. (2021). Vanillic Acid, a Bioactive Phenolic Compound, Counteracts LPS-Induced Neurotoxicity by Regulating c-Jun N-Terminal Kinase in Mouse Brain. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22010361"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1007\/s11011-020-00545-y","article-title":"Vanillin and Vanillic Acid Modulate Antioxidant Defense System via Amelioration of Metabolic Complications Linked to Fe2+-Induced Brain Tissues Damage","volume":"35","author":"Salau","year":"2020","journal-title":"Metab. Brain Dis."},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Punvittayagul, C., Chariyakornkul, A., Jarukamjorn, K., and Wongpoomchai, R. (2021). Protective Role of Vanillic Acid against Diethylnitrosamine- and 1,2-Dimethylhydrazine-Induced Hepatocarcinogenesis in Rats. Molecules, 26.","DOI":"10.3390\/molecules26092718"},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Bhuyan, M.H.M.B., Parvin, K., Mohsin, S.M., Mahmud, J.A., Hasanuzzaman, M., and Fujita, M. (2020). Modulation of Cadmium Tolerance in Rice: Insight into Vanillic Acid-Induced Upregulation of Antioxidant Defense and Glyoxalase Systems. Plants, 9.","DOI":"10.3390\/plants9020188"},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Guo, B., Liu, C., Liang, Y., Li, N., and Fu, Q. (2019). Salicylic Acid Signals Plant Defence against Cadmium Toxicity. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20122960"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.ecoenv.2019.01.078","article-title":"Foliar Application of Salicylic Acid Alleviate the Cadmium Toxicity by Modulation the Reactive Oxygen Species in Potato","volume":"172","author":"Li","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3389\/fpls.2016.00571","article-title":"Abscisic Acid and Abiotic Stress Tolerance in Crop Plants","volume":"7","author":"Sah","year":"2016","journal-title":"Front. Plant Sci."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"e9270","DOI":"10.7717\/peerj.9270","article-title":"Foliar Application of Abscisic Acid Mitigates Cadmium Stress and Increases Food Safety of Cadmium-Sensitive Lettuce (Lactuca sativa L.) Genotype","volume":"8","author":"Dawuda","year":"2020","journal-title":"PeerJ"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"3863","DOI":"10.1007\/s00018-017-2609-7","article-title":"Melatonin as a Mitochondria-Targeted Antioxidant: One of Evolution\u2019s Best Ideas","volume":"74","author":"Reiter","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1111\/plb.13093","article-title":"Melatonin Mitigates Cadmium and Aluminium Toxicity through Modulation of Antioxidant Potential in Brassica napus L","volume":"22","author":"Sami","year":"2020","journal-title":"Plant Biol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"111403","DOI":"10.1016\/j.ecoenv.2020.111403","article-title":"Alleviation of Cadmium-Induced Phytotoxicity and Growth Improvement by Exogenous Melatonin Pretreatment in Mallow (Malva parviflora) Plants","volume":"206","author":"Tousi","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1093\/treephys\/tpaa024","article-title":"Exogenous Melatonin Alleviates Cadmium Uptake and Toxicity in Apple Rootstocks","volume":"40","author":"He","year":"2020","journal-title":"Tree Physiol."},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Ni, J., Wang, Q., Shah, F.A., Liu, W., Wang, D., Huang, S., Fu, S., and Wu, L. (2018). Exogenous Melatonin Confers Cadmium Tolerance by Counterbalancing the Hydrogen Peroxide Homeostasis in Wheat Seedlings. Molecules, 23.","DOI":"10.3390\/molecules23040799"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"15394","DOI":"10.1007\/s11356-020-11689-w","article-title":"Melatonin Alleviates Cadmium Toxicity by Reducing Nitric Oxide Accumulation and IRT1 Expression in Chinese Cabbage Seedlings","volume":"28","author":"Wang","year":"2021","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"6981","DOI":"10.1007\/s11356-019-07283-4","article-title":"Melatonin and Nitric Oxide Enhance Cadmium Tolerance and Phytoremediation Efficiency in Catharanthus roseus (L.) G. Don","volume":"27","author":"Nabaei","year":"2020","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"10563","DOI":"10.1021\/acs.jafc.9b02404","article-title":"Melatonin Inhibits Cadmium Translocation and Enhances Plant Tolerance by Regulating Sulfur Uptake and Assimilation in Solanum lycopersicum L","volume":"67","author":"Hasan","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"127263","DOI":"10.1016\/j.foodchem.2020.127263","article-title":"Melatonin Enhances the Cadmium Tolerance of Mushrooms through Antioxidant-Related Metabolites and Enzymes","volume":"330","author":"Gao","year":"2020","journal-title":"Food Chem."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s12958-019-0502-y","article-title":"Melatonin Attenuates Cadmium-Induced Ovulatory Dysfunction by Suppressing Endoplasmic Reticulum Stress and Cell Apoptosis","volume":"17","author":"Yang","year":"2019","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"159","DOI":"10.4103\/1735-5362.223801","article-title":"The Protective Role of Melatonin in Cadmium-Induced Proliferation of Ovarian Cancer Cells","volume":"13","author":"Ataei","year":"2018","journal-title":"Res. Pharm. Sci."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"e12597","DOI":"10.1111\/jpi.12597","article-title":"Melatonin Prevents Cadmium-Induced Bone Damage: First Evidence on an Improved Osteogenic\/Adipogenic Differentiation Balance of Mesenchymal Stem Cells as Underlying Mechanism","volume":"67","author":"Knani","year":"2019","journal-title":"J. Pineal Res."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1007\/s12011-020-02247-z","article-title":"Melatonin Ameliorates Cadmium-Induced Affective and Cognitive Impairments and Hippocampal Oxidative Stress in Rat","volume":"199","author":"Lamtai","year":"2021","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"e12389","DOI":"10.1111\/jpi.12389","article-title":"Melatonin Alleviates Cadmium-Induced Liver Injury by Inhibiting the TXNIP-NLRP3 Inflammasome","volume":"62","author":"Cao","year":"2017","journal-title":"J. Pineal Res."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"e5391014","DOI":"10.1155\/2018\/5391014","article-title":"Therapeutic Potential of Fulvic Acid in Chronic Inflammatory Diseases and Diabetes","volume":"2018","author":"Winkler","year":"2018","journal-title":"J. Diabetes Res."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.scitotenv.2013.09.044","article-title":"Impact of Humic\/Fulvic Acid on the Removal of Heavy Metals from Aqueous Solutions Using Nanomaterials: A Review","volume":"468\u2013469","author":"Tang","year":"2014","journal-title":"Sci. Total Environ."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1002\/ptr.5319","article-title":"The Antiinflammatory Properties of Humic Substances: A Mini Review","volume":"29","year":"2015","journal-title":"Phytother. Res."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ecoenv.2018.08.064","article-title":"Exogenous Foliar Application of Fulvic Acid Alleviate Cadmium Toxicity in Lettuce (Lactuca sativa L.)","volume":"167","author":"Wang","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"5981","DOI":"10.1007\/s11356-019-07117-3","article-title":"Senna Alexandrina Extract Supplementation Reverses Hepatic Oxidative, Inflammatory, and Apoptotic Effects of Cadmium Chloride Administration in Rats","volume":"27","author":"Wang","year":"2020","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.toxrep.2019.06.013","article-title":"Hepato-Renal Protective Effects of Egyptian Purslane Extract against Experimental Cadmium Toxicity in Rats with Special Emphasis on the Functional and Histopathological Changes","volume":"6","author":"Seif","year":"2019","journal-title":"Toxicol. Rep."},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"M\u0119\u017cy\u0144ska, M., Brz\u00f3ska, M.M., Rogalska, J., and Pi\u0142at-Marcinkiewicz, B. (2019). Extract from Aronia melanocarpa L. Berries Prevents Cadmium-Induced Oxidative Stress in the Liver: A Study in A Rat Model of Low-Level and Moderate Lifetime Human Exposure to This Toxic Metal. Nutrients, 11.","DOI":"10.20944\/preprints201811.0160.v1"},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Koz\u0142owska, M., Brz\u00f3ska, M.M., Rogalska, J., and Galicka, A. (2020). The Impact of a Polyphenol-Rich Extract from the Berries of Aronia melanocarpa L. on Collagen Metabolism in the Liver: A Study in an in vivo Model of Human Environmental Exposure to Cadmium. Nutrients, 12.","DOI":"10.3390\/nu12092766"},{"key":"ref_186","doi-asserted-by":"crossref","unstructured":"D\u0105browski, A., Onopiuk, B.M., Car, H., Onopiuk, P., D\u0105browska, Z.N., Rogalska, J., Brz\u00f3ska, M.M., and D\u0105browska, E. (2020). Beneficial Impact of an Extract from the Berries of Aronia melanocarpa L. on the Oxidative-Reductive Status of the Submandibular Gland of Rats Exposed to Cadmium. Antioxidants, 9.","DOI":"10.3390\/antiox9020185"},{"key":"ref_187","doi-asserted-by":"crossref","unstructured":"Borowska, S., Brz\u00f3ska, M.M., Ga\u0142a\u017cyn-Sidorczuk, M., and Rogalska, J. (2017). Effect of an Extract from Aronia melanocarpa L. Berries on the Body Status of Zinc and Copper under Chronic Exposure to Cadmium: An in vivo Experimental Study. Nutrients, 9.","DOI":"10.3390\/nu9121374"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.fct.2014.09.013","article-title":"The Potential Protective Role of Physalis peruviana L. Fruit in Cadmium-Induced Hepatotoxicity and Nephrotoxicity","volume":"74","author":"Dkhil","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"567","DOI":"10.3109\/15376516.2014.955230","article-title":"Mimosa (Mimosa caesalpiniifolia) Prevents Oxidative DNA Damage Induced by Cadmium Exposure in Wistar Rats","volume":"24","author":"Silva","year":"2014","journal-title":"Toxicol. Mech. Methods"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"10829","DOI":"10.1007\/s11356-018-1329-3","article-title":"Effects of Spirulina platensis on DNA Damage and Chromosomal Aberration against Cadmium Chloride-Induced Genotoxicity in Rats","volume":"25","author":"Aly","year":"2018","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jtemb.2015.08.006","article-title":"Purple Carrot Extract Protects against Cadmium Intoxication in Multiple Organs of Rats: Genotoxicity, Oxidative Stress and Tissue Morphology Analyses","volume":"33","author":"Claudio","year":"2016","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"767","DOI":"10.5603\/FM.a2020.0003","article-title":"The Potential Gonadoprotective Effects of Grape Seed Extract against the Histopathological Alterations Elicited in an Animal Model of Cadmium-Induced Testicular Toxicity","volume":"79","author":"Morsi","year":"2020","journal-title":"Folia Morphol."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.3892\/mmr.2016.4928","article-title":"Protective Effect of Grape Seed Extract against Cadmium-Induced Testicular Dysfunction","volume":"13","author":"Alkhedaide","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1177\/0748233714566874","article-title":"Protective Effects of Grape Seed Extract on Cadmium-Induced Testicular Damage, Apoptosis, and Endothelial Nitric Oxide Synthases Expression in Rats","volume":"32","author":"Tascioglu","year":"2016","journal-title":"Toxicol. Ind. Health"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"BSR20180515","DOI":"10.1042\/BSR20180515","article-title":"The Molecular and Biochemical Insight View of Grape Seed Proanthocyanidins in Ameliorating Cadmium-Induced Testes-Toxicity in Rat Model: Implication of PI3K\/Akt\/Nrf-2 Signaling","volume":"39","author":"Bashir","year":"2019","journal-title":"Biosci. Rep."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1177\/0394632016651447","article-title":"Neuroprotective Effect of Grape Seed Extract against Cadmium Toxicity in Male Albino Rats","volume":"29","author":"Attia","year":"2016","journal-title":"Int. J. Immunopathol. Pharm."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jnutbio.2016.03.001","article-title":"Grape Seed Proanthocyanidins Protects against Cadmium Induced Oxidative Pancreatitis in Rats by Attenuating Oxidative Stress, Inflammation and Apoptosis via Nrf-2\/HO-1 Signaling","volume":"32","author":"Bashir","year":"2016","journal-title":"J. Nutr. Biochem."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.biopha.2017.05.006","article-title":"Potential Ameliorative Effects of Grape Seed-Derived Polyphenols against Cadmium Induced Prostatic Deficits","volume":"91","author":"Lei","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.etap.2013.07.006","article-title":"The Protective Effect of Grape Seed Procyanidin Extract against Cadmium-Induced Renal Oxidative Damage in Mice","volume":"36","author":"Chen","year":"2013","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1002\/ar.23320","article-title":"Ameliorative Effect of Grape Seed Proanthocyanidin Extract on Cadmium-Induced Meiosis Inhibition During Oogenesis in Chicken Embryos","volume":"299","author":"Hou","year":"2016","journal-title":"Anat. Rec."}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/19\/12380\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:41:28Z","timestamp":1760143288000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/19\/12380"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,28]]},"references-count":200,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["ijerph191912380"],"URL":"https:\/\/doi.org\/10.3390\/ijerph191912380","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,28]]}}}