{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T17:39:12Z","timestamp":1775237952453,"version":"3.50.1"},"reference-count":64,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T00:00:00Z","timestamp":1665446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002261","name":"RFBR","doi-asserted-by":"publisher","award":["19-05-50064"],"award-info":[{"award-number":["19-05-50064"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002261","name":"RFBR","doi-asserted-by":"publisher","award":["20-015-00360"],"award-info":[{"award-number":["20-015-00360"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Background: Diesel exhaust particles (DEPs) are leading to a general increase in atopic diseases worldwide. However, it is still unknown whether DEPs induce systemic B-cell IgE class switching in secondary lymphoid organs or locally in the lungs in inducible bronchus-associated lymphoid tissue (iBALT). The aim of this work was to identify the exact site of DEP-mediated B-cell IgE class switching and pro-allergic antibody production. Methods: We immunized BALB\/c mice with different OVA doses (0.3 and 30 \u00b5g) intranasally in the presence and absence of two types of DEPs, SRM1650B and SRM2786. We used low (30 \u00b5g) and high (150 \u00b5g) DEP doses. Results: Only a high DEP dose induced IgE production, regardless of the particle type. Local IgE class switching was stimulated upon treatment with both types of particles with both low and high OVA doses. Despite the similar ability of the two standard DEPs to stimulate IgE production, their ability to induce iBALT formation and growth was markedly different upon co-administration with low OVA doses. Conclusions: DEP-induced local IgE class switching takes place in preexisting iBALTs independent of de novo iBALT formation, at least in the case of SRM1650B co-administered with low OVA doses.<\/jats:p>","DOI":"10.3390\/ijerph192013063","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T22:18:13Z","timestamp":1665526693000},"page":"13063","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["DEPs Induce Local Ige Class Switching Independent of Their Ability to Stimulate iBALT de Novo Formation"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2143-9824","authenticated-orcid":false,"given":"Dmitrii Borisovich","family":"Chudakov","sequence":"first","affiliation":[{"name":"Laboratory of Cell Interactions, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 16\/10 Miklukho-Maklaya Str., Moscow 117997, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3923-6304","authenticated-orcid":false,"given":"Mariya Vladimirovna","family":"Konovalova","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Interactions, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 16\/10 Miklukho-Maklaya Str., Moscow 117997, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena Igorevna","family":"Kashirina","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Interactions, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 16\/10 Miklukho-Maklaya Str., Moscow 117997, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7765-8324","authenticated-orcid":false,"given":"Olga Dmitrievna","family":"Kotsareva","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Interactions, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 16\/10 Miklukho-Maklaya Str., Moscow 117997, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5278-9937","authenticated-orcid":false,"given":"Marina Alexandrovna","family":"Shevchenko","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Interactions, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 16\/10 Miklukho-Maklaya Str., Moscow 117997, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daria Sergeevna","family":"Tsaregorodtseva","sequence":"additional","affiliation":[{"name":"Faculty of Medical Biology, Sechenov First Moscow State Medical University, 2 Bolshaya Pirogovskaya Str., Moscow 1194535, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gulnar Vaisovna","family":"Fattakhova","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Interactions, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 16\/10 Miklukho-Maklaya Str., Moscow 117997, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1080\/07853890701449354","article-title":"Triggers of IgE class switching and allergy development","volume":"39","author":"Poulsen","year":"2007","journal-title":"Ann. 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