{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:01:44Z","timestamp":1790640104916,"version":"4.1.0"},"reference-count":103,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2022,10,16]],"date-time":"2022-10-16T00:00:00Z","timestamp":1665878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"State Scholarship Foundation of Greece and the EU funding","award":["OPS5003404"],"award-info":[{"award-number":["OPS5003404"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>The identification of basic emotions plays an important role in social relationships and behaviors linked to survival. In neurodegenerative conditions such as Alzheimer\u2019s disease (AD), the ability to recognize emotions may already be impaired at early stages of the disease, such as the stage of Mild Cognitive Impairment (MCI). However, as regards vascular pathologies related to cognitive impairment, very little is known about emotion recognition in people bearing vascular risk factors (VRF). Therefore, the aim of the present study was to examine emotion recognition ability in the health continuum \u201chealthy advancing age\u2014advancing age with VRF\u2014MCI\u201d. The sample consisted of 106 adults divided in three diagnostic groups; 43 adults with MCI, 41 adults bearing one or more VRF, and 22 healthy controls of advancing age (HC). Since HC were more educated and younger than the other two groups, the age-group and level of educational were taken into account in the statistical analyses. A dynamic visual test was administered to examine recognition of basic emotions and emotionally neutral conditions. The results showed only a significant diagnostic group x educational level interaction as regards total emotion recognition ability, F (4, 28.910) = 4.117 p = 0.004 \u03b72 = 0.166. High educational level seems to contribute to a high-level-emotion-recognition-performance both in healthy adults of advancing age and in adults bearing vascular risk factors. Medium educational level appears to play the same role only in healthy adults. Neither educational level can help MCI people to enhance their significantly lower emotion recognition ability.<\/jats:p>","DOI":"10.3390\/ijerph192013366","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:04:55Z","timestamp":1665965095000},"page":"13366","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Emotion Recognition in a Health Continuum: Comparison of Healthy Adults of Advancing Age, Community Dwelling Adults Bearing Vascular Risk Factors and People Diagnosed with Mild Cognitive Impairment"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3809-0323","authenticated-orcid":false,"given":"Glykeria","family":"Tsentidou","sequence":"first","affiliation":[{"name":"Laboratory of Psychology, Department of Experimental and Cognitive Psychology, School of Psychology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"},{"name":"Laboratory of Neurodegenerative Diseases, Center for Interdisciplinary Research and Innovation (CIRI), Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0527-7143","authenticated-orcid":false,"given":"Despina","family":"Moraitou","sequence":"additional","affiliation":[{"name":"Laboratory of Psychology, Department of Experimental and Cognitive Psychology, School of Psychology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"},{"name":"Laboratory of Neurodegenerative Diseases, Center for Interdisciplinary Research and Innovation (CIRI), Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"},{"name":"Greek Association of Alzheimer\u2019s Disease and Related Disorders (GAADRD), 54643 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2072-8010","authenticated-orcid":false,"given":"Magdalini","family":"Tsolaki","sequence":"additional","affiliation":[{"name":"Laboratory of Neurodegenerative Diseases, Center for Interdisciplinary Research and Innovation (CIRI), Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"},{"name":"Greek Association of Alzheimer\u2019s Disease and Related Disorders (GAADRD), 54643 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1177\/2396987320918132","article-title":"High occurrence of impaired emotion recognition after ischemic stroke","volume":"5","author":"Aben","year":"2020","journal-title":"Eur. Stroke J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"389","DOI":"10.3389\/fnagi.2017.00389","article-title":"Behavioral and Neuroimaging Evidence for Facial Emotion Recognition in Elderly Korean Adults with Mild Cognitive Impairment, Alzheimer\u2019s Disease, and Frontotemporal Dementia","volume":"9","author":"Park","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"ref_3","first-page":"207","article-title":"Reconocimiento facial de emociones en trastornos neurol\u00f3gicos: Una revisi\u00f3n narrativa","volume":"69","author":"Quintero","year":"2019","journal-title":"Rev. Neurol."},{"key":"ref_4","first-page":"41","article-title":"Social cognition: The key factor predicting social outcome in people with schizophrenia?","volume":"7","author":"Harvey","year":"2010","journal-title":"Psychiatry"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/jnp.12263","article-title":"Measuring emotion recognition: Added value in diagnosing dementia of the Alzheimer\u2019s disease type","volume":"16","author":"Strijkert","year":"2021","journal-title":"J. Neuropsychol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Khosdelazad, S., Jorna, L.S., McDonald, S., Rakers, S.E., Huitema, R.B., Buunk, A.M., and Spikman, J.M. (2020). Comparing static and dynamic emotion recognition tests: Performance of healthy participants. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0241297"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1017\/S1041610215001520","article-title":"Facial emotion recognition in patients with subjective cognitive decline and mild cognitive impairment","volume":"28","author":"Pietschnig","year":"2015","journal-title":"Int. Psychogeriatr."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1037\/neu0000171","article-title":"Emotion perception after moderate-severe traumatic brain injury: The valence effect and the role of working memory, processing speed, and nonverbal reasoning","volume":"29","author":"Rosenberg","year":"2015","journal-title":"Neuropsychology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0278-2626(03)00009-5","article-title":"Dissociable neural systems for recognizing emotions","volume":"52","author":"Adolphs","year":"2003","journal-title":"Brain Cogn."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1093\/scan\/nss092","article-title":"Emotion unfolded by motion: A role for parietal lobe in decoding dynamic facial expressions","volume":"8","author":"Sarkheil","year":"2013","journal-title":"Soc Cogn Affect Neurosci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1017\/S1355617705050447","article-title":"Differential impairment in recognition of emotion across different media in people with severe traumatic brain injury","volume":"11","author":"McDonalds","year":"2005","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0959-4388(02)00301-X","article-title":"Neural systems for recognizing emotion","volume":"12","author":"Adolphs","year":"2002","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1098\/rstb.2002.1220","article-title":"Facial expressions, their communicatory functions and neuro\u2013cognitive substrates","volume":"358","author":"Blair","year":"2003","journal-title":"Philos. Trans. R. Soc. B Biol. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s10548-011-0171-4","article-title":"Converging Evidence for the Advantage of Dynamic Facial Expressions","volume":"24","author":"Arsalidou","year":"2011","journal-title":"Brain Topogr."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1006\/nimg.2002.1323","article-title":"Dissociable Neural Pathways Are Involved in the Recognition of Emotion in Static and Dynamic Facial Expressions","volume":"18","author":"Kiltsab","year":"2003","journal-title":"NeuroImage"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1093\/schbul\/sbn136","article-title":"Symptom Correlates of Static and Dynamic Facial Affect Processing in Schizophrenia: Evidence of a Double Dissociation?","volume":"36","author":"Johnston","year":"2008","journal-title":"Schizophr. Bull."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.cogbrainres.2004.01.008","article-title":"Enhanced neural activity in response to dynamic facial expressions of emotion: An fMRI study","volume":"20","author":"Sato","year":"2004","journal-title":"Cogn. Brain Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.cub.2010.11.042","article-title":"The Human Amygdala and the Induction and Experience of Fear","volume":"21","author":"Feinstein","year":"2011","journal-title":"Curr. Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"15089","DOI":"10.1523\/JNEUROSCI.0796-09.2009","article-title":"Damage to Association Fiber Tracts Impairs Recognition of the Facial Expression of Emotion","volume":"29","author":"Philippi","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1093\/scan\/nss041","article-title":"A voxel-based lesion study on facial emotion recognition after penetrating brain injury","volume":"8","author":"Monte","year":"2012","journal-title":"Soc. Cogn. Affect. Neurosci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"758212","DOI":"10.3389\/fncom.2021.758212","article-title":"Review on Emotion Recognition Based on Electroencephalography","volume":"15","author":"Liu","year":"2021","journal-title":"Front. Comput. Neurosci."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Liu, J., Wu, G., Luo, Y., Qiu, S., Yang, S., Li, W., and Bi, Y. (2020). EEG-Based Emotion Classification Using a Deep Neural Network and Sparse Autoencoder. Front. Syst. Neurosci., 14.","DOI":"10.3389\/fnsys.2020.00043"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/j.1749-6632.2001.tb05789.x","article-title":"EEG biofeedback treatment of ADD. A viable alternative to traditional medical in-tervention?","volume":"931","author":"Ramirez","year":"2010","journal-title":"Ann. N. Y. Acad."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/2096595819896200","article-title":"Ten challenges for EEG-based affective computing","volume":"5","author":"Hu","year":"2019","journal-title":"Brain Sci. Adv."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/j.clinph.2020.02.032","article-title":"An artificial intelligence-based EEG algorithm for detection of epileptiform EEG discharges: Validation against the diagnostic gold standard","volume":"131","author":"Kural","year":"2020","journal-title":"Clin. Neurophysiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1159\/000327979","article-title":"An Exploratory Study on Facial Emotion Recognition Capacity in Beginning Alzheimer\u2019s Disease","volume":"65","author":"Ostos","year":"2011","journal-title":"Eur. Neurol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1515\/tnsci-2015-0013","article-title":"Perception of emotions in mild cognitive impairment and Alzheimer\u2019s dementia: Does intensity matter?","volume":"6","author":"Elferink","year":"2015","journal-title":"Transl. Neurosci."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Dodich, A., Funghi, G., Meli, C., Pennacchio, M., Longo, C., Malaguti, M.C., Di Giacopo, R., Zappini, F., Turella, L., and Papagno, C. (2022). Deficits in Emotion Recognition and Theory of Mind in Parkinson\u2019s Disease Patients With and Without Cognitive Impairments. Front. Psychol., 13.","DOI":"10.3389\/fpsyg.2022.866809"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s12311-019-01099-1","article-title":"Cerebellar Volume Is Associated with Cognitive Decline in Mild Cognitive Impairment: Results from ADNI","volume":"19","author":"Lin","year":"2020","journal-title":"Cerebellum"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1093\/brain\/awh628","article-title":"Neuroanatomical correlates of behavioural disorders in dementia","volume":"128","author":"Rosen","year":"2005","journal-title":"Brain"},{"key":"ref_31","first-page":"1","article-title":"Emotional prosody recognition is impaired in Alzheimer\u2019s disease","volume":"14","author":"Amlerova","year":"2022","journal-title":"Alzheimer\u2019s Res. Ther."},{"key":"ref_32","first-page":"478","article-title":"A systematic review of facial emotion recognition in Alzhei-mer\u2019s disease: A developmental and gender perspective","volume":"37","author":"Redolat","year":"2021","journal-title":"Anales de Psicolog\u00eda"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1467-9280.2008.02068.x","article-title":"Happiness is a personal(ity) thing: The genetics of personality and well-being in a representative sample","volume":"19","author":"Weiss","year":"2008","journal-title":"Psychol. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1097\/WAD.0000000000000023","article-title":"How Preserved is Emotion Recognition in Alzheimer Disease Compared With Behavioral Variant Frontotemporal Dementia?","volume":"29","author":"Bertoux","year":"2015","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Sapey-Triomphe, L.-A., Heckemann, R.A., Boublay, N., Dorey, J.-M., H\u00e9naff, M.-A., Rouch, I., Padovan, C., Hammers, A., Krolak-Salmon, P., and Initiative, A.D.N. (2015). Neuroanatomical Correlates of Recognizing Face Expressions in Mild Stages of Alzheimer\u2019s Disease. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0143586"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1001\/archneur.62.7.1160","article-title":"Mild cognitive impairment as a clinical entity and treatment target","volume":"62","author":"Petersen","year":"2005","journal-title":"Arch. Neurol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1177\/0891988713491832","article-title":"Emotion Recognition in Mild Cognitive Impairment: Relationship to Psychosocial Disability and Caregiver Burden","volume":"26","author":"McCade","year":"2013","journal-title":"J. Geriatr. Psychiatry Neurol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/S0006-3223(03)00168-9","article-title":"Neurobiology of emotion perception I: The neural basis of normal emotion perception","volume":"54","author":"Phillips","year":"2003","journal-title":"Biol. Psychiatry"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.neuroimage.2004.07.006","article-title":"Global and local gray matter loss in mild cognitive impairment and Alzheimer\u2019s disease","volume":"23","author":"Karas","year":"2004","journal-title":"NeuroImage"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Hofer, S., and Alwin, D. (2008). Integrating health into cognitive aging research and theory: Quo Vadis?. Handbook of Cognitive Aging: Interdisciplinary Perspectives, SAGE Publications.","DOI":"10.4135\/9781412976589"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1093\/ageing\/afs193","article-title":"Smoking, hypercholesterolaemia and hypertension as risk factors for cognitive impairment in older adults","volume":"42","author":"Okusaga","year":"2012","journal-title":"Age Ageing"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1136\/jnnp-2021-327462","article-title":"CAIDE dementia risk score relates to severity and progression of cerebral small vessel disease in healthy midlife adults: The PREVENT-Dementia study","volume":"93","author":"Low","year":"2022","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s11065-014-9270-9","article-title":"How does it STAC up? Revisiting the scaffolding theory of aging and cognition","volume":"24","author":"Park","year":"2014","journal-title":"Neuropsychol. Rev."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in Alzheimer\u2019s disease","volume":"14","author":"Heneka","year":"2015","journal-title":"Lancet Neurol"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12916-014-0206-2","article-title":"The overlap between vascular disease and Alzheimer\u2019s disease - lessons from pathology","volume":"12","author":"Attems","year":"2014","journal-title":"BMC Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1590\/0004-282X20150009","article-title":"Facial expression recognition in Alzheimer\u2019s disease: A longitudinal study","volume":"73","author":"Torres","year":"2015","journal-title":"Arq. de Neuro-Psiquiatria"},{"key":"ref_47","first-page":"958","article-title":"Impaired Visual Emotion Recognition After Minor Ischemic Stroke","volume":"103","author":"Meeske","year":"2021","journal-title":"Arch. Phys. Med. Rehabilitation"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.3109\/02699052.2013.804203","article-title":"The relationship between facial affect recognition and cognitive functioning after traumatic brain injury","volume":"27","author":"Yim","year":"2013","journal-title":"Brain Inj."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Virtanen, M., Singh-Manoux, A., Batty, G., Ebmeier, K., Jokela, M., Harmer, C., and Kivimaki, M. (2017). The level of cognitive function and recognition of emotions in older adults. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0185513"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1159\/000068479","article-title":"Recognition of Facial Expressions and Emotional Situations in Patients with Dementia of the Alzheimer and Vascular Types","volume":"15","author":"Shimokawa","year":"2003","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"223","DOI":"10.3389\/fpsyg.2012.00223","article-title":"Neural Mechanisms of Reading Facial Emotions in Young and Older Adults","volume":"3","author":"Ebner","year":"2012","journal-title":"Front. Psychol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0022-3956(82)90033-4","article-title":"Development and validation of a geriatric depression screening scale: A preliminary report","volume":"17","author":"Yesavage","year":"1983","journal-title":"J. Psychiatr. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF03339814","article-title":"The validation of the short form of the Geriatric Depression Scale (GDS) in Greece","volume":"11","author":"Fountoulakis","year":"1999","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_54","unstructured":"Goodglass, H., and Kaplan, E. (1983). The Assessment of Aphasia and Related Disorders, Lea and Febiger."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","article-title":"The Montreal Cognitive Assessment, MoCA: A Brief Screening Tool For Mild Cognitive Impairment","volume":"53","author":"Nasreddine","year":"2005","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1177\/0891988719853046","article-title":"Normative data for the Montreal Cognitive Assessment in Greek older adults with subjective cognitive decline, mild cognitive impairment and dementia","volume":"32","author":"Poptsi","year":"2019","journal-title":"J. Geriatr. Psychiatry Neurol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1177\/1533317517698789","article-title":"Prevalence of Dementia, Depression, and Mild Cognitive Impairment in a Rural Area of the Island of Crete, Greece","volume":"32","author":"Tsolaki","year":"2017","journal-title":"Am. J. Alzheimer\u2019s Dis. Other Dementiasr"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1080\/09638280600646185","article-title":"Reliability and validity of The Awareness of Social Inference Test (TASIT): A clinical test of social perception","volume":"28","author":"McDonald","year":"2006","journal-title":"Disabil. Rehabil."},{"key":"ref_59","unstructured":"Ekman, P. (1973). Cross-Cultural Studies of Facial Expression. Darwin and Facial Expression: A Century of Research in Review, Academic Press."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1080\/09602010343000237","article-title":"The ecological validity of TASIT: A test of social perception","volume":"14","author":"McDonald","year":"2004","journal-title":"Neuropsychol. Rehabil."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/psyg.12016","article-title":"Older adults\u2019 decoding of emotions: Age-related differences in interpreting dynamic emotional displays and the well-preserved ability to recognize happiness","volume":"13","author":"Moraitou","year":"2013","journal-title":"Psychogeriatrics"},{"key":"ref_62","unstructured":"IBM Corp. (2016). IBM SPSS Statistics for Windows, Version 24.0, IBM Corp.. Released 2016."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-017-01150-x","article-title":"Earliest accumulation of \u03b2-amyloid occurs within the default-mode network and concurrently affects brain connectivity","volume":"8","author":"Palmqvist","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1093\/brain\/awv236","article-title":"The preclinical phase of the pathological process underlying sporadic Alzheimer\u2019s disease","volume":"138","author":"Braak","year":"2015","journal-title":"Brain"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3233\/JAD-190687","article-title":"Neuropathologic Correlates of White Matter Hyperintensities in a Community-Based Cohort of Older Adults","volume":"73","author":"Arfanakis","year":"2020","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_66","first-page":"001140","article-title":"What are White Matter Hyperintensities Made of?","volume":"4","author":"Wardlaw","year":"2015","journal-title":"J. Am. Hear. Assoc."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.neurobiolaging.2017.04.025","article-title":"Human anterolateral entorhinal cortex volumes are associated with cognitive decline in aging prior to clinical diagnosis","volume":"57","author":"Olsen","year":"2017","journal-title":"Neurobiol. Aging"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1016\/j.neuropsychologia.2009.02.028","article-title":"Event- related fMRI studies of episodic encoding and retrieval: Meta-analyses using activation likelihood estimation","volume":"47","author":"Spaniol","year":"2009","journal-title":"Neuropsychologia"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.maturitas.2013.06.011","article-title":"The influence of vascular risk factors on cognitive decline in patients with dementia: A systematic review","volume":"76","author":"Blom","year":"2013","journal-title":"Maturitas"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.jdiacomp.2013.04.004","article-title":"The influence of sub-clinical cardiovascular disease and related risk factors on cognition in type 2 diabetes mellitus: The DHS-Mind study","volume":"27","author":"Hugenschmidt","year":"2013","journal-title":"J. Di-abetes Complicat."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.2337\/dc12-0746","article-title":"Effects of type 2 diabetes on 12-year cognitive change: Results from the Maastricht aging study","volume":"36","author":"Spauwen","year":"2013","journal-title":"Diabetes Care"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neulet.2014.01.006","article-title":"Gray matter volume abnormalities in type 2 diabetes mellitus with and without mild cognitive impairment","volume":"562","author":"Zhang","year":"2014","journal-title":"Neurosci. Lett."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.diabres.2018.05.025","article-title":"Applicability of diagnostic constructs for cognitive impairment in patients with type 2 diabetes mellitus","volume":"142","author":"Groeneveld","year":"2018","journal-title":"Diabetes Res. Clin. Pr."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.physbeh.2018.12.012","article-title":"Resveratrol prevents cognitive deficits by attenuating oxidative damage and inflammation in rat model of streptozotocin diabetes induced vascular dementia","volume":"201","author":"Gocmeza","year":"2019","journal-title":"Physiol. Behav."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.yfrne.2018.10.001","article-title":"What magnetic resonance imaging reveals \u2013 A systematic review of the relationship between type II diabetes and associated brain distortions of structure and cognitive functioning","volume":"52","author":"Rosenberga","year":"2019","journal-title":"Front Neuroen-Docrinol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"149","DOI":"10.7326\/0003-4819-137-3-200208060-00006","article-title":"Apolipoprotein E \u03f54 Allele, Elevated Midlife Total Cholesterol Level, and High Midlife Systolic Blood Pressure Are Independent Risk Factors for Late-Life Alzheimer Disease","volume":"137","author":"Kivipelto","year":"2002","journal-title":"Ann. Intern. Med."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jalz.2018.07.222","article-title":"Vascular dysfunction\u2014The disregarded partner of Alzheimer\u2019s disease","volume":"15","author":"Sweeney","year":"2019","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_78","unstructured":"Pereira, G.A., Nunes, M.V.S., Alzola, P., and Contador, I. (2021). Cognitive reserve and brain maintenance in aging and dementia: An integrative review. Appl. Neuropsychol. Adult, 1\u201311."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"100916","DOI":"10.1016\/j.arr.2019.100916","article-title":"Inflammation and cerebral small vessel disease: A systematic review","volume":"53","author":"Low","year":"2019","journal-title":"Ageing Res. Rev."},{"key":"ref_80","first-page":"575","article-title":"Inflammation as a central mechanism in Alzheimer\u2019s disease","volume":"4","author":"Kinney","year":"2018","journal-title":"Alzheimer\u2019s Dementia: Transl. Res. Clin. Interv."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1002\/alz.12237","article-title":"Multimorbidity burden and dementia risk in older adults: The role of in-flammation and genetics","volume":"17","author":"Grande","year":"2021","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_82","first-page":"56","article-title":"Myelin and Physical Activity in Older Adults With Cerebral Small Vessel Disease and Mild Cognitive Impairment","volume":"119","author":"Silva","year":"2022","journal-title":"J. Gerontol. Ser. A"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s00401-009-0635-8","article-title":"Quantification of myelin loss in frontal lobe white matter in vascular dementia, Alzheimer\u2019s disease, and dementia with Lewy bodies","volume":"119","author":"Ihara","year":"2010","journal-title":"Acta Neuropathol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.nicl.2015.02.003","article-title":"White matter integrity in small vessel disease is related to cognition","volume":"7","author":"Tuladhar","year":"2015","journal-title":"NeuroImage: Clin."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Wada, S., Honma, M., Masaoka, Y., Yoshida, M., Koiwa, N., Sugiyama, H., Iizuka, N., Kubota, S., Kokudai, Y., and Yoshikawa, A. (2021). Volume of the right supramarginal gyrus is associated with a maintenance of emotion recognition ability. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0254623"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Meng, X., and D\u2019Arcy, C. (2012). Education and Dementia in the Context of the Cognitive Reserve Hypothesis: A Systematic Review with Meta-Analyses and Qualitative Analyses. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0038268"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Demenescu, L.R., Stan, A., Kortekaas, R., Van Der Wee, N.J.A., Veltman, D.J., Aleman, A., and Aleman, A. (2014). On the connection between level of education and the neural circuitry of emotion perception. Front. Hum. Neurosci., 8.","DOI":"10.3389\/fnhum.2014.00866"},{"key":"ref_88","first-page":"906","article-title":"Chbmp Crystallized and fluid intelligence are predicted by microstructure of specific white-matter tracts","volume":"41","author":"Jahanshahi","year":"2019","journal-title":"Hum. Brain Mapp."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1017\/S0033291717001490","article-title":"Meta-analysis of longitudinal studies of cognition in bipolar disorder: Comparison with healthy controls and schizophrenia","volume":"47","author":"Bora","year":"2017","journal-title":"Psychol. Med."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.archger.2009.09.023","article-title":"Impaired facial emotion recognition and preserved reactivity to facial expressions in people with severe dementia","volume":"49","author":"Guaita","year":"2009","journal-title":"Arch. Gerontol. Geriatr."},{"key":"ref_91","first-page":"418","article-title":"Functional atlas of emotional faces processing: A voxel-based meta-analysis of 105 functional magnetic resonance imaging studies","volume":"34","author":"Placentino","year":"2009","journal-title":"J. Psychiatry Neurosci."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1093\/cercor\/bhi044","article-title":"Regional Brain Changes in Aging Healthy Adults: General Trends, Individual Differences and Modifiers","volume":"15","author":"Raz","year":"2005","journal-title":"Cereb. Cortex"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.neubiorev.2006.07.001","article-title":"Differential aging of the brain: Patterns, cognitive correlates and modifiers","volume":"30","author":"Raz","year":"2006","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1037\/0882-7974.23.1.209","article-title":"Effects of age on detection of emotional information","volume":"23","author":"Leclerc","year":"2008","journal-title":"Psychol. Aging"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1037\/a0016952","article-title":"Selective attention to emotion in the aging brain","volume":"24","author":"Robertson","year":"2009","journal-title":"Psychol. Aging"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1037\/0882-7974.21.1.40","article-title":"Selective preference in visual fixation away from negative images in old age? An eye-tracking study","volume":"21","author":"Isaacowitz","year":"2006","journal-title":"Psychol. Aging"},{"key":"ref_97","unstructured":"Bengston, V., Gans, D., Putney, N., and Silverstein, M. (2009). The Role of Cognitive Control in Older Adults\u2019 Emotional Well-Being. Handbook of Theories of Aging, Springer."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"\u039coraitou, D., and Papantoniou, G. (2010). Mindfulness and Action Control in Young, Middle-Aged, and Old Adults: An Examination of Their Relationship to Attentional Bias towards Emotional Information. Res. Psychol., 591\u2013626.","DOI":"10.3280\/RIP2010-004007"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1037\/1528-3542.7.4.705","article-title":"Aging and goal-directed emotional attention: Distraction reverses emotional biases","volume":"7","author":"Knight","year":"2007","journal-title":"Emotion"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1037\/0882-7974.20.4.554","article-title":"Goal-directed memory: The role of cognitive control in older adults\u2019 emotional memory","volume":"20","author":"Mather","year":"2005","journal-title":"Psychol. Aging"},{"key":"ref_101","unstructured":"Gross, J.J. (2007). The Neural Architecture of Emotion Regulation. Handbook of Emotion Regulation, Guilford."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"325","DOI":"10.4236\/ojmp.2014.35034","article-title":"Decoding of Basic Emotions from Dynamic Visual Displays in Dementia: A Sign of Loss of Positivity Bias in Emotional Processing in Cognitively Unhealthy Aging?","volume":"03","author":"Gkinopoulos","year":"2014","journal-title":"Open J. Med Psychol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1037\/a0014607","article-title":"The feeling of uncertainty intensifies affective reactions","volume":"9","author":"Wilson","year":"2009","journal-title":"Emotion"}],"container-title":["International Journal of Environmental Research and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/20\/13366\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:55:20Z","timestamp":1760144120000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-4601\/19\/20\/13366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,16]]},"references-count":103,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["ijerph192013366"],"URL":"https:\/\/doi.org\/10.3390\/ijerph192013366","relation":{},"ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,16]]}}}