{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:38:55Z","timestamp":1760243935566,"version":"build-2065373602"},"reference-count":46,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T00:00:00Z","timestamp":1666137600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Slovak Research and Development Agency (APVV)","award":["0447-12","1\/0637\/13","21-0355"],"award-info":[{"award-number":["0447-12","1\/0637\/13","21-0355"]}]},{"DOI":"10.13039\/501100006109","name":"Scientific Grant Agency of the Ministry of Education, Science, Research and Sport of the Slovak Republic","doi-asserted-by":"publisher","award":["0447-12","1\/0637\/13","21-0355"],"award-info":[{"award-number":["0447-12","1\/0637\/13","21-0355"]}],"id":[{"id":"10.13039\/501100006109","id-type":"DOI","asserted-by":"publisher"}]},{"name":"APVV","award":["0447-12","1\/0637\/13","21-0355"],"award-info":[{"award-number":["0447-12","1\/0637\/13","21-0355"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Background: Little research has been conducted into the effects of the combined manifestation of hyperuricemia and hyperhomocysteinemia on cardiometabolic risk factors and markers in young subjects. Methods: 1298 males and 1402 females, 14-to-20-year-olds, were classified into four groups: 1\/normouricemic\/normohomocysteinemic, 2\/normouricemic\/hyperhormohomocysteinemic, 3\/hyperuricemic\/normohomocysteinemic, and 4\/hyperuricemic\/hyperhomocysteinemic. Anthropometric measures, blood pressure, plasma glucose, insulin, lipids, markers of renal function, C-reactive protein, asymmetric dimethylarginine, and blood counts were determined. Results: Hyperuricemic males (but not females) had higher odds for hyperhomocysteinemia than normouricemic ones (OR: 1.8; 95% CI: 1.4\u20132.3; p &lt; 0.001). Homocysteine and uric acid levels correlated directly (males: r = 0.076, females: r = 0.120; p &lt; 0.01, both). Two-factor analysis of variance did not reveal a significant impact of hyperhomocysteinemia on any of the investigated cardiometabolic variables in females; in males, hyperuricemia and hyperhomocysteinemia showed a synergic effect on asymmetric dimethylarginine levels. Among four groups, subjects concurrently manifesting hyperuricemia and hyperhomocysteinemia did not presented the highest continuous metabolic syndrome score\u2014a proxy measure of cardiometabolic risk; neither the multivariate regression model indicated a concurrent significant effect of uric acid and homocysteine on continuous metabolic syndrome score in either sex. Conclusion: In young healthy subjects, hyperhomocysteinemia does not aggravate the negative health effects imposed by hyperuricemia.<\/jats:p>","DOI":"10.3390\/ijerph192013521","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T20:32:23Z","timestamp":1666211543000},"page":"13521","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Presence of Hyperhomocysteinemia Does Not Aggravate the Cardiometabolic Risk Imposed by Hyperuricemia in Young Individuals: A Retrospective Analysis of a Cross-Sectional Study"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9641-9265","authenticated-orcid":false,"given":"Katar\u00edna","family":"\u0160ebekov\u00e1","sequence":"first","affiliation":[{"name":"Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, 811 08 Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5880-666X","authenticated-orcid":false,"given":"Radana","family":"Gureck\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, 811 08 Bratislava, Slovakia"},{"name":"Institute of Medical Physics, Biophysics, Informatics and Telemedicine, Faculty of Medicine, Comenius University, 813 72 Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Repisk\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Physiology, Faculty of Medicine, Comenius University, 813 72 Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivana","family":"Koborov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, 811 08 Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u013dudmila","family":"Podrack\u00e1","sequence":"additional","affiliation":[{"name":"Departemnt of Pediatrics of the Faculty of Medicine, Comenius University and The National Institute of Children\u2019s Health, 833 40 Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6858","DOI":"10.1073\/pnas.78.11.6858","article-title":"Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: A hypothesis","volume":"78","author":"Ames","year":"1981","journal-title":"Proc. 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