{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T08:10:08Z","timestamp":1762071008645,"version":"build-2065373602"},"reference-count":18,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,10,23]],"date-time":"2022-10-23T00:00:00Z","timestamp":1666483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Statin therapy can effectively reduce recurrent transient ischemic attack (TIA) risk. However, studies have reported that statin use is associated with incidence of diabetes mellitus (DM). Whether statin therapy remains associated with higher DM risk in patients with TIA remains unknown. This study investigated whether statin treatment influences incident DM risk in patients with TIA. We conducted a retrospective cohort study using the Longitudinal Health Insurance Database 2000. Participants who were newly diagnosed with TIA (ICD-9-CM code 435) from 1 January 1997 to 31 December 2011 were recruited. The Kaplan\u2013Meier method and Cox proportional risk model of time-dependent covariance were used. We enrolled 8342 patients with newly diagnosed TIA from 1 January 1997 to 31 December 2011. Of these, 1255 patients were classified as statin users and 7087 as nonusers. During the 14-year follow-up, the incidence of newly diagnosed DM was 0.545-fold lower in the statins group compared with nonusers (95% confidence interval [CI] = 0.457\u20130.650). According to cumulative defined daily doses (cDDDs), the adjusted hazard ratios for DM were 0.689, 0.594, and 0.463 when patients were treated with statins at cDDDs = 28\u201389, 90\u2013180, and &gt;180, respectively. In patients with TIA, statin use is associated with a lower incident DM risk compared with the nonuse of statins.<\/jats:p>","DOI":"10.3390\/ijerph192113770","type":"journal-article","created":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T04:40:36Z","timestamp":1666586436000},"page":"13770","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association between Statin Use and Diabetes Risk in Patients with Transient Ischemic Attack"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8667-6225","authenticated-orcid":false,"given":"Fu-Jun","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Public Health, China Medical University, No. 91, Hsueh-Shih Road, Taichung 404327, Taiwan"},{"name":"Centers for Disease Control Ministry of Health and Welfare, Taichung 40855, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Chien","family":"Yin","sequence":"additional","affiliation":[{"name":"Division of Respiratory Therapy, China Medical University Hospital, Taichung 404327, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1042-8302","authenticated-orcid":false,"given":"Pei-Yun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Public Health, China Medical University, No. 91, Hsueh-Shih Road, Taichung 404327, Taiwan"},{"name":"Department of Nursing, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli 35664, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8592-1367","authenticated-orcid":false,"given":"Min-Hua","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Dietetics, Yunlin Christian Hospital, Yunlin 64866, Taiwan"},{"name":"Department of Nutrition, China Medical University, Taichung 404327, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9104-4487","authenticated-orcid":false,"given":"Yi-Hao","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Respiratory Therapy, Asia University Hospital, Asia University, Taichung 41354, Taiwan"},{"name":"Department of Nursing, Asia University, Taichung 41354, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Chao","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Public Health, China Medical University, No. 91, Hsueh-Shih Road, Taichung 404327, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6242-5974","authenticated-orcid":false,"given":"Pau-Chung","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Public Health, National Taiwan University, Taipei 10617, Taiwan"},{"name":"National Institute of Environmental Health Sciences, Miaoli 35053, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung Y.","family":"Hsu","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404327, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s11883-018-0755-5","article-title":"Emergency Department (ED) Triage for Transient Ischemic Attack (TIA)","volume":"20","author":"Cereda","year":"2018","journal-title":"Curr. 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