{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T14:08:03Z","timestamp":1791727683925,"version":"4.3.4"},"reference-count":35,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,10,23]],"date-time":"2022-10-23T00:00:00Z","timestamp":1666483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>When a viral outbreak occurs, governments are obligated to protect their citizens from the diverse adverse effects of the disease. Health policymakers often have several interventions to consider based on the health of the population, as well as the cascading social and economic consequences of the possible mitigation strategies. The current outbreak of the monkeypox virus has elicited debate on the best mitigation strategy, especially given that most world economies are still recovering from the harsh economic effects of the COVID-19 pandemic. This paper sought to analyze the costs and benefits of three possible strategies and determine which option has the best health outcomes and positive economic effects. A case study of Jeddah was performed, whereby a model was simulated to determine the number of infections over 28 days based on one case of the monkeypox virus. Findings reveal that the vaccination provides the best intervention, as it effectively reduces the transmission rate and prevents loss of lives in the city. From the model, only three people were infected over the research period, while no deaths were reported. Although vaccination incurs a huge direct cost at the beginning, in the long run, it saves the economy from the disease\u2019s financial burden in terms of productivity loss from work absenteeism and premature deaths.<\/jats:p>","DOI":"10.3390\/ijerph192113789","type":"journal-article","created":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T04:40:36Z","timestamp":1666586436000},"page":"13789","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Cost\u2013Benefit Analysis of Interventions to Mitigate the Monkeypox Virus"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5460-3809","authenticated-orcid":false,"given":"Ali Mofleh","family":"ALSHAHRANI","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy, College of Pharmacy, TU, KSA, P.O. Box 888, Haweiah 21974, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,23]]},"reference":[{"key":"ref_1","unstructured":"Pekarsky, M. (2022, August 24). City, State Public Health Officials Confirm First Probable Case of Monkeypox Virus in Missouri, Available online: https:\/\/health.mo.gov\/news\/newsitem\/uuid\/2e7e061d-6f80-4e84-a278-cfb9ce6f23c1\/city-state-public-health-officials-confirm-first-probable-case-of-Monkeypox-virus-in-missouri#:~:text=On%20May%2018%2C%202022%2C%20a,orthopox%2FMonkeypox%20across%20multiple%20states."},{"key":"ref_2","unstructured":"Reuters (2022, August 24). Factbox: Monkeypox Cases around the World. Available online: https:\/\/www.reuters.com\/business\/healthcare-pharmaceuticals\/Monkeypox-cases-around-world-2022-05-23\/."},{"key":"ref_3","unstructured":"Centers for Disease Control and Prevention, CDC (2022, August 24). 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