{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:56:54Z","timestamp":1790693814738,"version":"4.1.0"},"reference-count":40,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Objective: Assess the effectiveness of physical therapy, including supervised physical exercise for body mass index (BMI) restoration; improving muscle strength and the psychological, behavioural, cognitive symptoms and quality of life in patients with anorexia nervosa (AN). Methods: A Systematic Review (SR) was conducted in the following scientific databases: Medline, PubMed, PEDro, PsychInfo, Cochrane Library plus, Nursing and Allied Health database, Scopus and Web of Science databases, from inception until November 2021. An assessment of the risk of bias and the certainty of evidence across studies was conducted. Articles were eligible if they followed randomized and non-randomized control trial designs with treatments based on physical therapy or exercise or physical activity in AN patients. Results: 496 records were screened, and after eligibility assessment, 6 studies from 8 articles were finally analysed. The studies, involving 176 AN patient (85.02% of patients), reported improvements in muscle strength, eating behaviour, eating attitude, mood and quality of life. Three studies included nutritional co-interventions and four studies included psychological therapy. None of the studies reported adverse effects. Conclusions: In two of the RCTs included in this SR, strength training and high intensity resistance improved the muscle strength of patients with AN. In addition, in two RCTs, improvements were observed in patients\u2019 attitudes towards their bodies after basic body awareness therapy or after full body massage and instruction to relax. In addition, quality of life improved in two studies, with stretching, isometrics, endurance cardiovascular and muscular exercising.<\/jats:p>","DOI":"10.3390\/ijerph192113921","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T11:53:51Z","timestamp":1666785231000},"page":"13921","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Physical Therapy Interventions in Patients with Anorexia Nervosa: A Systematic Review"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3068-8734","authenticated-orcid":false,"given":"Emilio","family":"Minano-Garrido","sequence":"first","affiliation":[{"name":"International School of Doctoral Studies, University of Murcia, 30100 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Catalan-Matamoros","sequence":"additional","affiliation":[{"name":"Department of Nursing, Physiotherapy and Medicine, and Health Research Centre, University of Almer\u00eda, 04120 Almer\u00eda, Spain"},{"name":"Institute for Culture and Technology, Madrid University Carlos III, 28903 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"G\u00f3mez-Conesa","sequence":"additional","affiliation":[{"name":"Research Group Research Methods and Evaluation in Social Sciences, Mare Nostrum Campus of International Excellence, University of Murcia, 30100 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s40337-015-0040-8","article-title":"Anorexia nervosa\u2013medical complications","volume":"3","author":"Mehler","year":"2015","journal-title":"J. Eat. Disord."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s40519-015-0202-3","article-title":"Medical complications of anorexia nervosa and their treatments: An update on some critical aspects","volume":"20","author":"Brown","year":"2015","journal-title":"Eat. Weight. Disord.-Stud. Anorex. Bulim. Obes."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.encep.2012.06.001","article-title":"Epidemiology of anorexia nervosa: A review","volume":"39","author":"Roux","year":"2013","journal-title":"L\u2019Enc\u00e9phale"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1097\/YCO.0000000000000739","article-title":"Incidence, prevalence and mortality of anorexia nervosa and bulimia nervosa","volume":"34","author":"Hoek","year":"2021","journal-title":"Curr. Opin. Psychiatry"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1176\/appi.ajp.2013.12070868","article-title":"A Longitudinal Investigation of Mortality in Anorexia Nervosa and Bulimia Nervosa","volume":"170","author":"Franko","year":"2013","journal-title":"Am. J. Psychiatry"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders, American Psychiatric Association. [5th ed.].","DOI":"10.1176\/appi.books.9780890425596"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1001\/archgenpsychiatry.2011.74","article-title":"Mortality rates in patients with anorexia nervosa and other eating disorders. A meta-analysis of 36 studies","volume":"68","author":"Arcelus","year":"2011","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1017\/S0033291700028166","article-title":"Ten-year follow-up of anorexia nervosa: Clinical course and outcome","volume":"25","author":"Eckert","year":"1995","journal-title":"Psychol. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"628","DOI":"10.3109\/09638288.2013.808271","article-title":"A systematic review of physical therapy interventions for patients with anorexia and bulemia nervosa","volume":"36","author":"Vancampfort","year":"2014","journal-title":"Disabil. Rehabil."},{"key":"ref_10","unstructured":"Rizk, M., Mattar, L., Kern, L., Berthoz, S., Duclos, J., Viltart, O., and Godart, N. (2020). Physical Activity in Eating Disorders: A Systematic Review. Nutrients, 12."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1037\/0033-2909.128.5.825","article-title":"Risk and maintenance factors for eating pathology: A meta-analytic review","volume":"128","author":"Stice","year":"2002","journal-title":"Psychol. Bull."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1002\/eat.22198","article-title":"Pathological motivations for exercise and eating disorder specific health-related quality of life","volume":"47","author":"Cook","year":"2014","journal-title":"Int. J. Eat. Disord."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1093\/nutrit\/nuw001","article-title":"Physical activity in patients with anorexia nervosa","volume":"74","author":"Achamrah","year":"2016","journal-title":"Nutr. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/erv.2377","article-title":"High Levels of Physical Activity in Anorexia Nervosa: A Systematic Review","volume":"23","author":"Giel","year":"2015","journal-title":"Eur. Eat. Disord. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"655","DOI":"10.2165\/00023210-200620080-00004","article-title":"Management of psychiatric comorbidity in anorexia nervosa and bulimia nervosa","volume":"20","author":"Woodside","year":"2006","journal-title":"CNS Drugs"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0193-953X(05)70232-X","article-title":"The Consequences and Costs of the Eating Disorders","volume":"24","author":"Agras","year":"2001","journal-title":"Psychiatr. Clin. N. Am."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1002\/erv.2679","article-title":"Gastrointestinal alterations in anorexia nervosa-A systematic review","volume":"27","author":"Schalla","year":"2019","journal-title":"Eur. Eat. Disord. Rev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/cen.14498","article-title":"Bone mineral density at extremely low weight in patients with anorexia nervosa","volume":"95","author":"Bemer","year":"2021","journal-title":"Clin. Endocrinol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.yclnex.2019.09.001","article-title":"Somatic complications and nutritional management of anorexia nervosa","volume":"28","author":"Gosseaume","year":"2019","journal-title":"Clin. Nutr. Exp."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1002\/eat.22736","article-title":"Long-term outcome of anorexia nervosa: Results from a large clinical longitudinal study","volume":"50","author":"Fichter","year":"2017","journal-title":"Int. J. Eat. Disord."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/pri.1637","article-title":"Considering the Role of Physical Therapists Within the Treatment and Rehabilitation of Individuals With Eating Disorders: An International Survey of Expert Clinicians","volume":"21","author":"Soundy","year":"2016","journal-title":"Physiother. Res. Int."},{"key":"ref_22","first-page":"801","article-title":"Spirometric parameters in malnourished girls with anorexia nervosa","volume":"59","author":"Ziora","year":"2008","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1080\/21662630.2013.798562","article-title":"Physiotherapy for patients with anorexia nervosa","volume":"1","author":"Probst","year":"2013","journal-title":"Adv. Eat. Disord."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"b2535","DOI":"10.1136\/bmj.b2535","article-title":"Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement","volume":"339","author":"Moher","year":"2009","journal-title":"BMJ"},{"key":"ref_25","unstructured":"(2004). ICD-10: International Statistical Classification of Diseases and Related Health Problems Tenth Revision, WHO Library. [2nd ed.]."},{"key":"ref_26","unstructured":"MeSH (2022, August 03). National Library of Medicine. In Physical Therapy Modalities; Rockville Pike, MD, USA 2006, Available online: https:\/\/www.ncbi.nlm.nih.gov\/mesh\/68026741."},{"key":"ref_27","first-page":"89","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"10","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Higgins, J.P.T., Thomas, J., Chandler, J., Cumpston, M., Li, T., Page, M.J., and Welch, V.A. (2019). Cochrane Handbook for Systematic Reviews of Interventions Version 6.0, John Wiley & Sons, Ltd.. [2019th ed.].","DOI":"10.1002\/9781119536604"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.jclinepi.2010.04.026","article-title":"GRADE guidelines: 1. Introduction\u2014GRADE evidence profiles and summary of findings tables","volume":"64","author":"Guyatt","year":"2011","journal-title":"J. Clin. Epidemiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/(SICI)1098-108X(200007)28:1<101::AID-EAT12>3.0.CO;2-V","article-title":"Pilot study of a graded exercise program for the treatment of anorexia nervosa","volume":"28","author":"Thien","year":"2000","journal-title":"Int. J. Eat. Disord."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1080\/106402601753454868","article-title":"Anorexia nervosa symptoms are reduced by massage therapy","volume":"9","author":"Hart","year":"2001","journal-title":"Eat. Disord."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.jadohealth.2009.09.001","article-title":"Does Resistance Training Improve the Functional Capacity and Well Being of Very Young Anorexic Patients? A Randomized Controlled Trial","volume":"46","author":"Gallardo","year":"2010","journal-title":"J. Adolesc. Health"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1177\/0269215510394223","article-title":"A pilot study on the effect of Basic Body Awareness Therapy in patients with eating disorders: A ran-domized controlled trial","volume":"25","year":"2011","journal-title":"Clin. Rehabil."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"346","DOI":"10.3109\/09638288.2015.1041612","article-title":"Muscle function and body composition profile in adolescents with restrictive anorexia nervosa: Does resistance training help?","volume":"38","year":"2016","journal-title":"Disabil. Rehabil."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s40519-015-0181-4","article-title":"Anthropometric changes in adolescents with anorexia nervosa in response to resistance training","volume":"20","year":"2015","journal-title":"Eat. Weight. Disord.-Stud. Anorex. Bulim. Obes."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1002\/eat.22251","article-title":"Resistance training enhances muscular performance in patients with anorexia nervosa: A rando-mized controlled trial","volume":"47","year":"2014","journal-title":"Int. J. Eat. Disord."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1002\/eat.22920","article-title":"A randomized controlled trial of the compuLsive Exercise Activity TheraPy (LEAP): A new approach to compulsive exercise in anorexia nervosa","volume":"51","author":"Hay","year":"2018","journal-title":"Int. J. Eat. Disord."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.physio.2012.05.006","article-title":"Is supervised exercise training safe in patients with anorexia nervosa? A meta-analysis","volume":"99","author":"Ng","year":"2013","journal-title":"Physiotherapy"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/erv.2789","article-title":"Effectiveness of exercise-based interventions in patients with anorexia nervosa: A systematic review","volume":"29","year":"2021","journal-title":"Eur. Eat. Disord. Rev."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.mhpa.2013.04.002","article-title":"Exercise in the care of patients with anorexia nervosa: A systematic review of the literature","volume":"6","author":"Moola","year":"2013","journal-title":"Ment. Health Phys. 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