{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T17:24:09Z","timestamp":1781717049559,"version":"3.54.5"},"reference-count":30,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T00:00:00Z","timestamp":1667347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>This systematic review aimed to investigate the effectiveness of hyaluronic acid (HA) on the clinical treatment outcomes of patients with gingival recession. A systematic search was performed in PubMed, Cochrane Central Register of Controlled Trials, Embase, Scopus, and Google Scholar for studies up to 15 August 2022. Two reviewers separately selected the papers for eligibility after conducting a thorough search. The study includes randomized controlled clinical trials in which participants were given HA in addition to periodontal treatment surgical procedures. The changes following the treatment protocol were evaluated for complete and mean root coverage as a primary outcome and gingival recession gain as the secondary outcome. Three articles met the eligibility criteria out of 557 titles. In periodontal surgery, HA exhibited better results in complete root coverage and mean root coverage when compared to the control group. Gingival recession reduction, clinical attachment level, and keratinized tissue gain were significantly increased compared to the control groups. However, the comparison presented in the following study might show heterogeneity among the studies and risk of bias in general. Given the scope of this analysis, results suggest that adjunctive treatment with HA gel for root coverage could be clinically beneficial.<\/jats:p>","DOI":"10.3390\/ijerph192114330","type":"journal-article","created":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T03:11:21Z","timestamp":1667445081000},"page":"14330","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Hyaluronic Acid: A New Approach for the Treatment of Gingival Recession\u2014A Systematic Review"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4174-907X","authenticated-orcid":false,"given":"Vini","family":"Mehta","sequence":"first","affiliation":[{"name":"Department of Public Health Dentistry, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Pune 411018, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerta","family":"Ka\u00e7ani","sequence":"additional","affiliation":[{"name":"Department of Prosthetic, Faculty of Dental Medicine, University of Medicine, 1005 Tirana, Albania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed M. Al","family":"Moaleem","sequence":"additional","affiliation":[{"name":"Department of Prosthetic Dental Science, College of Dentistry, Jazan University, Jazan 45142, Saudi Arabia"},{"name":"Faculty of Dentistry, University of Ibn Al-Nafis for Medical Sciences, Sana\u2019a 4337, Yemen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anwar Abdulkarim","family":"Almohammadi","sequence":"additional","affiliation":[{"name":"College of Dentistry, Taibah University, Al Madinah Al Munawwarah, Medina 41311, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malak Mohammed","family":"Alwafi","sequence":"additional","affiliation":[{"name":"College of Dentistry, Taibah University, Al Madinah Al Munawwarah, Medina 41311, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abduljabbar Khalil","family":"Mulla","sequence":"additional","affiliation":[{"name":"College of Dentistry, Taibah University, Al Madinah Al Munawwarah, Medina 41311, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahad Owaidh","family":"Alharbi","sequence":"additional","affiliation":[{"name":"College of Dentistry, Taibah University, Al Madinah Al Munawwarah, Medina 41311, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah Waleed","family":"Aljayyar","sequence":"additional","affiliation":[{"name":"College of Dentistry, Taibah University, Al Madinah Al Munawwarah, Medina 41311, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etleva","family":"Qeli","sequence":"additional","affiliation":[{"name":"Department of Conservative, Faculty of Dental Medicine, University of Medicine, 1005 Tirana, Albania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c7eljana","family":"Toti","sequence":"additional","affiliation":[{"name":"Department of Prosthetic, Faculty of Dental Medicine, University of Medicine, 1005 Tirana, Albania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1659-2453","authenticated-orcid":false,"given":"Agron","family":"Meto","sequence":"additional","affiliation":[{"name":"Department of Dentistry, University of Aldent, 1007 Tirana, Albania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0335-4165","authenticated-orcid":false,"given":"Luca","family":"Fiorillo","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Dental Sciences, Morphological and Functional Images, University of Messina, 98100 Messina, Italy"},{"name":"Multidisciplinary Department of Medical-Surgical and Odontostomatological Specialties, University of Campania \u201cLuigi Vanvitelli\u201d, 80121 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1902\/jop.1992.63.6.489","article-title":"The natural history of periodontal disease in man: Prevalence, severity, and extent of gingival recession","volume":"63","author":"Loe","year":"1992","journal-title":"J. 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