{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T15:31:50Z","timestamp":1781019110962,"version":"3.54.1"},"reference-count":50,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T00:00:00Z","timestamp":1667433600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Gedeon Richter","award":["4700168520KK\/186\/2016"],"award-info":[{"award-number":["4700168520KK\/186\/2016"]}]},{"name":"ELKH-DE Cerebrovascular Research Group","award":["4700168520KK\/186\/2016"],"award-info":[{"award-number":["4700168520KK\/186\/2016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Both lisinopril and enalapril are angiotensin-converting enzyme (ACE) drugs and widely used in the treatment of hypertension. Enalapril does not cross the blood\u2013brain barrier, but lisinopril is centrally active. Our goal was to find out if there was a link between the actual concentration of ACE inhibitors and cognition and if there was a detectable difference between the two types of ACE inhibitors. Asymptomatic, non-treated patients were diagnosed by screening and the hypertension was confirmed by ambulatory blood pressure monitoring (ABPM). A battery of cognitive tests was used to assess the impact of randomly assigning participants to receive either lisinopril or enalapril. All neurocognitive functions were measured, especially the most affected by conditions of compromised perfusion pressures, such as hypertension, which are attention and executive functions. The lisinopril concentration showed a significant inverse correlation with mosaic test (coeff. = \u22120.5779) and seemed to have a significant negative effect on perceptual motor skills (coeff. = \u22120.5779), complex attention (coeff. = \u22120.5104) and learning (coeff. = \u22120.5202). Compared with enalapril, lisinopril is less successful in improving the components of cognitive functions.<\/jats:p>","DOI":"10.3390\/ijerph192114375","type":"journal-article","created":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T03:53:07Z","timestamp":1667447587000},"page":"14375","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Correlation between Two Angiotensin-Converting Enzyme Inhibitor\u2019s Concentrations and Cognition"],"prefix":"10.3390","volume":"19","author":[{"given":"Attila","family":"Nagy","sequence":"first","affiliation":[{"name":"Department of Health Informatics, Faculty of Health Sciences, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9ka","family":"M\u00e1jer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enik\u0151","family":"Csikai","sequence":"additional","affiliation":[{"name":"Doctoral School of Health Sciences, Institute of Behavioral Science, Faculty of General Medicine, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrienn","family":"Dobos","sequence":"additional","affiliation":[{"name":"Department of Forensic Toxicology, Hungarian Institute for Forensic Sciences, 1903 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e1bor","family":"S\u00fcvegh","sequence":"additional","affiliation":[{"name":"Department of Forensic Toxicology, Hungarian Institute for Forensic Sciences, 1903 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Csiba","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,3]]},"reference":[{"key":"ref_1","unstructured":"(2022, August 01). 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