{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:45:56Z","timestamp":1787028356157,"version":"build-2736575974"},"reference-count":58,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,11,6]],"date-time":"2022-11-06T00:00:00Z","timestamp":1667692800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004738","name":"E-Da Hospital of the Republic of China, Taiwan","doi-asserted-by":"publisher","award":["EDAHP110002"],"award-info":[{"award-number":["EDAHP110002"]}],"id":[{"id":"10.13039\/501100004738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004738","name":"E-Da Hospital of the Republic of China, Taiwan","doi-asserted-by":"publisher","award":["EDAHI110001"],"award-info":[{"award-number":["EDAHI110001"]}],"id":[{"id":"10.13039\/501100004738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJERPH"],"abstract":"<jats:p>Objectives: Nonalcoholic fatty liver disease (NAFLD) has been associated with an increased risks of corrected QT (QTc) prolongation and left ventricular hypertrophy (LVH), both of which are associated with the development of cardiovascular disease. Rotating night shift work and a higher risk of incident NAFLD have been reported in male steelworkers. This study aimed to investigate the association of the severity of NAFLD with a prolonged QTc interval and LVH in a large cohort of Chinese male steelworkers. Methods: We examined baseline data of 2998 male steel workers aged 26 to 71 years at two plants. All workers at both plants received regular health assessments, including 12-lead ECG and echocardiography. Abdominal ultrasonography was performed to evaluate the severity of NAFLD. QTc prolongation was defined as follows: normal \u2264 430 ms, borderline 431\u2013450 ms, and abnormal \u2265 451 ms. LVH was defined as a left ventricular mass index (LVMI) &gt;131 g\/m2. Associations of NAFLD with an abnormal QTc interval and LVH were examined using univariate and multivariate analyses. Results: The QTc interval and the LVMI were significantly correlated with the NAFLD fibrosis score, and the severity of NAFLD was correlated with an abnormal QTc interval and LVH (p for trend &lt; 0.05). Multivariate analysis showed that in comparison to the workers without NAFLD, the odds ratios of having an abnormal QTc interval and LVH were 2.54 (95% CI: 1.22\u20135.39, p = 0.013) times and 2.23 (95% CI: 1.02\u20135.01, p = 0.044) times higher in the workers with moderate\/severe NAFLD. Conclusions: NAFLD may be closely associated with the risks of an abnormal QTc interval and LVH, suggesting that regular electrocardiogram and echocardiogram monitoring could be used to evaluate the risk of arrhythmia and LVH in male steelworkers with NAFLD.<\/jats:p>","DOI":"10.3390\/ijerph192114555","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T07:00:42Z","timestamp":1667890842000},"page":"14555","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Nonalcoholic Fatty Liver Disease Is Related to Abnormal Corrected QT Interval and Left Ventricular Hypertrophy in Chinese Male Steelworkers"],"prefix":"10.3390","volume":"19","author":[{"given":"Wei-Chin","family":"Hung","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, E-Da Hospital, Kaohsiung 82445, Taiwan"},{"name":"School of Medicine, College of Medicine, I-Shou University, Kaohsiung 82445, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6764-0374","authenticated-orcid":false,"given":"Teng-Hung","family":"Yu","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, E-Da Hospital, Kaohsiung 82445, Taiwan"},{"name":"School of Medicine, College of Medicine, I-Shou University, Kaohsiung 82445, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4530-9901","authenticated-orcid":false,"given":"Cheng-Ching","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, E-Da Hospital, Kaohsiung 82445, Taiwan"},{"name":"School of Medicine, College of Medicine, I-Shou University, Kaohsiung 82445, Taiwan"},{"name":"Division of Cardiology, Department of Internal Medicine, E-Da Cancer Hospital, Kaohsiung 82445, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thung-Lip","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, E-Da Hospital, Kaohsiung 82445, Taiwan"},{"name":"School of Medicine for International Students, College of Medicine, I-Shou University, Kaohsiung 82445, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Hua","family":"Tang","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Yuli Branch, Hualien 98142, Taiwan"},{"name":"Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4905-3408","authenticated-orcid":false,"given":"Chia-Chi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology, E-Da Hospital, Kaohsiung 82445, Taiwan"},{"name":"College of Medicine, I-Shou University, Kaohsiung 82445, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I-Cheng","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Occupational Medicine, E-Da Hospital, Kaohsiung 82445, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1217-5302","authenticated-orcid":false,"given":"Fu-Mei","family":"Chung","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, E-Da Hospital, Kaohsiung 82445, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yau-Jiunn","family":"Lee","sequence":"additional","affiliation":[{"name":"Lee\u2019s Endocrinologic Clinic, Pingtung 90000, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Chang","family":"Hsu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, E-Da Hospital, Kaohsiung 82445, Taiwan"},{"name":"Health Examination Center, E-Da Dachang Hospital, Kaohsiung 80794, Taiwan"},{"name":"The School of Chinese Medicine for Post Baccalaureate, College of Medicine, I-Shou University, Kaohsiung 82445, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1046\/j.1440-1746.2003.02989.x","article-title":"Non-alcoholic steatohepatitis: What is it, and why is it important in the Asia-Pacific region?","volume":"18","author":"Farrell","year":"2003","journal-title":"J. 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